Mike Fainzilber

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. pmc From synapse to nucleus and back again--communication over distance within neurons
    Mike Fainzilber
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 31:16045-8. 2011
  2. ncbi request reprint Tracking in the Wlds--the hunting of the SIRT and the luring of the Draper
    Mike Fainzilber
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    Neuron 50:819-21. 2006
  3. pmc From neurotrophins to immunotrophins. NGF 2002: The 7th international conference on NGF and related molecules
    Mike Fainzilber
    Laboratory of Molecular Neurobiology, Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    EMBO Rep 3:1029-34. 2002
  4. ncbi request reprint Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome
    Francisca C Bronfman
    Molecular Neurobiology Group, Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Neurosci 23:3209-20. 2003
  5. pmc Axonal transcription factors signal retrogradely in lesioned peripheral nerve
    Keren Ben-Yaakov
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    EMBO J 31:1350-63. 2012
  6. pmc Signaling to transcription networks in the neuronal retrograde injury response
    Izhak Michaelevski
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    Sci Signal 3:ra53. 2010
  7. pmc STK25 protein mediates TrkA and CCM2 protein-dependent death in pediatric tumor cells of neural origin
    Barbara Costa
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Biol Chem 287:29285-9. 2012
  8. ncbi request reprint Neurotrophic activities of trk receptors conserved over 600 million years of evolution
    Gad Beck
    Department of Biological Chemistry, Molecular Neurobiology Group, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Neurobiol 60:12-20. 2004
  9. ncbi request reprint Vimentin binding to phosphorylated Erk sterically hinders enzymatic dephosphorylation of the kinase
    Eran Perlson
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Mol Biol 364:938-44. 2006
  10. pmc Subcellular knockout of importin β1 perturbs axonal retrograde signaling
    Rotem Ben Tov Perry
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Neuron 75:294-305. 2012

Collaborators

Detail Information

Publications38

  1. pmc From synapse to nucleus and back again--communication over distance within neurons
    Mike Fainzilber
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 31:16045-8. 2011
    ....
  2. ncbi request reprint Tracking in the Wlds--the hunting of the SIRT and the luring of the Draper
    Mike Fainzilber
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    Neuron 50:819-21. 2006
    ....
  3. pmc From neurotrophins to immunotrophins. NGF 2002: The 7th international conference on NGF and related molecules
    Mike Fainzilber
    Laboratory of Molecular Neurobiology, Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    EMBO Rep 3:1029-34. 2002
  4. ncbi request reprint Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome
    Francisca C Bronfman
    Molecular Neurobiology Group, Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Neurosci 23:3209-20. 2003
    ..These data suggest that signaling endosomes containing activated p75 are involved in neurotrophin signaling, and that such endosomes may be temporally and spatially distinct from those containing trk receptors...
  5. pmc Axonal transcription factors signal retrogradely in lesioned peripheral nerve
    Keren Ben-Yaakov
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    EMBO J 31:1350-63. 2012
    ..Hence, retrograde transport of TFs from axonal lesion sites provides a direct link between axon and nucleus...
  6. pmc Signaling to transcription networks in the neuronal retrograde injury response
    Izhak Michaelevski
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    Sci Signal 3:ra53. 2010
    ..Our data indicate that nerve injury responses are controlled by multiple regulatory components, and suggest that network redundancies provide robustness to the injury response...
  7. pmc STK25 protein mediates TrkA and CCM2 protein-dependent death in pediatric tumor cells of neural origin
    Barbara Costa
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Biol Chem 287:29285-9. 2012
    ..These findings delineate a death-signaling pathway downstream of neurotrophic receptor tyrosine kinases that may provide targets for therapeutic intervention in pediatric tumors of neural origin...
  8. ncbi request reprint Neurotrophic activities of trk receptors conserved over 600 million years of evolution
    Gad Beck
    Department of Biological Chemistry, Molecular Neurobiology Group, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Neurobiol 60:12-20. 2004
    ..Thus, Ltrk is required for neuronal survival, suggesting that trophic activities of the trk receptor family originated before the divergence of molluscan and vertebrate lineages approximately 600 million years ago...
  9. ncbi request reprint Vimentin binding to phosphorylated Erk sterically hinders enzymatic dephosphorylation of the kinase
    Eran Perlson
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Mol Biol 364:938-44. 2006
    ..Thus, a soluble intermediate filament fragment interacts with a signaling kinase and protects it from dephosphorylation by calcium-dependent steric hindrance...
  10. pmc Subcellular knockout of importin β1 perturbs axonal retrograde signaling
    Rotem Ben Tov Perry
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Neuron 75:294-305. 2012
    ..Thus, localized translation of Importin β1 mRNA enables separation of cytoplasmic and nuclear transport functions of importins and is required for efficient retrograde signaling in injured axons...
  11. pmc Axoplasm isolation from peripheral nerve
    Ida Rishal
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    Dev Neurobiol 70:126-33. 2010
    ..We show that this new procedure reduces serum and glial cell contamination and facilitates proteomic analyses of axonal contents...
  12. pmc A motor-driven mechanism for cell-length sensing
    Ida Rishal
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    Cell Rep 1:608-16. 2012
    ..Moreover, similar length increases were observed in mouse embryonic fibroblasts upon partial downregulation of dynein heavy chain 1.Thus, molecular motors critically influence cell length sensing and growth control...
  13. pmc Functional consequences of necdin nucleocytoplasmic localization
    Anat Lavi-Itzkovitz
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    PLoS ONE 7:e33786. 2012
    ..Necdin, a MAGE family protein expressed primarily in the nervous system, has been shown to interact with both nuclear and cytoplasmic proteins, but the mechanism of its nucleocytoplasmic transport are unknown...
  14. pmc Axonal transport proteomics reveals mobilization of translation machinery to the lesion site in injured sciatic nerve
    Izhak Michaelevski
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    Mol Cell Proteomics 9:976-87. 2010
    ..The analyses reveal extensive changes in both anterograde and retrograde transport proteomes in injured peripheral axons and emphasize the importance of RNA binding and translational machineries in the axonal response to injury...
  15. pmc Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve
    Dmitry Yudin
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    Neuron 59:241-52. 2008
    ..Thus, neurons employ localized mechanisms of Ran regulation to control retrograde injury signaling in peripheral nerve...
  16. ncbi request reprint Integration of retrograde axonal and nuclear transport mechanisms in neurons: implications for therapeutics
    Shlomit Hanz
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    Neuroscientist 10:404-8. 2004
    ....
  17. ncbi request reprint The p75 neurotrophin receptor interacts with multiple MAGE proteins
    Marianna Tcherpakov
    Molecular Neurobiology Group, Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Biol Chem 277:49101-4. 2002
    ..These findings indicate that diverse MAGE family members can interact with the p75 receptor and highlight type II MAGE proteins as a potential family of interactors for signaling proteins containing type II death domains...
  18. ncbi request reprint Differential proteomics reveals multiple components in retrogradely transported axoplasm after nerve injury
    Eran Perlson
    Molecular Neurobiology Group, Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    Mol Cell Proteomics 3:510-20. 2004
    ..These results implicate regulated proteolysis in the formation of retrograde injury signaling complexes after nerve lesion and suggest that this signaling modality utilizes a wide range of protein components...
  19. ncbi request reprint A genome wide screening approach for membrane-targeted proteins
    Hanna Jaaro
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    Mol Cell Proteomics 4:328-33. 2005
    ..Two sequences were found to represent gene families not found to date in invertebrate genomes, emphasizing the need for whole genome sequences from mollusks and indeed from representatives of all major invertebrate phyla...
  20. doi request reprint Ran on tracks--cytoplasmic roles for a nuclear regulator
    Dmitry Yudin
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Cell Sci 122:587-93. 2009
    ..Thus, the Ran GTPase system can act as a spatial regulator of importin-dependent transport and signaling in distal cytoplasm, and as a regulator of cytoskeletal dynamics at sites that are distant from the nucleus...
  21. doi request reprint CCM2 mediates death signaling by the TrkA receptor tyrosine kinase
    Liraz Harel
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    Neuron 63:585-91. 2009
    ..Combined high expression levels of CCM2 and TrkA are correlated with long-term survival in a large cohort of human neuroblastoma patients. Thus, CCM2 is a key mediator of TrkA-dependent cell death in pediatric neuroblastic tumors...
  22. doi request reprint On the death Trk
    Liraz Harel
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    Dev Neurobiol 70:298-303. 2010
    ..Thus, mechanistic clues to the enigma of trk-induced cell death have begun to emerge. Detailed elucidation of these mechanisms and their in vivo physiological significance will be of keen interest for future research...
  23. ncbi request reprint From snails to sciatic nerve: Retrograde injury signaling from axon to soma in lesioned neurons
    Eran Perlson
    Molecular Neurobiology Group, Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Neurobiol 58:287-94. 2004
    ....
  24. doi request reprint Retrograde signaling in axonal regeneration
    Ida Rishal
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    Exp Neurol 223:5-10. 2010
    ..Encouraging recent data suggest that it may be possible to apply this emerging understanding of retrograde signaling mechanisms to activate intrinsic regeneration mechanisms also in growth-refractory central neurons...
  25. doi request reprint Retrograde injury signaling in lesioned axons
    Keren Ben-Yaakov
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    Results Probl Cell Differ 48:327-38. 2009
    ..This chapter reviews the progress on understanding the different mechanistic aspects of the axonal response to injury, and how the information is conveyed from the injury site to the cell body to initiate regeneration...
  26. ncbi request reprint Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve
    Eran Perlson
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    Neuron 45:715-26. 2005
    ..Thus, soluble vimentin enables spatial translocation of pErk by importins and dynein in lesioned nerve...
  27. doi request reprint WIS-NeuroMath enables versatile high throughput analyses of neuronal processes
    Ida Rishal
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    Dev Neurobiol 73:247-56. 2013
    ..WIS-NeuroMath is freely available to academic users, providing a versatile and cost-effective range of solutions for quantifying neurite growth, branching, regeneration, or degeneration under different experimental paradigms...
  28. ncbi request reprint Building complex brains--missing pieces in an evolutionary puzzle
    Hanna Jaaro
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    Brain Behav Evol 68:191-5. 2006
    ..Cephalopod mollusks represent the most complex nervous systems outside the vertebrate lineage, thus we suggest that genome sequencing of different mollusk models will provide useful insights into the evolution of complex brains...
  29. ncbi request reprint Retrograde signaling in injured nerve--the axon reaction revisited
    Shlomit Hanz
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Neurochem 99:13-9. 2006
    ....
  30. ncbi request reprint The prodomain of a secreted hydrophobic mini-protein facilitates its export from the endoplasmic reticulum by hitchhiking on sorting receptors
    Silvestro G Conticello
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Biol Chem 278:26311-4. 2003
    ..Thus, the prodomain in a secreted hydrophobic protein acts as a tag that can facilitate its ER export by a hitchhiking mechanism...
  31. pmc Can molecular motors drive distance measurements in injured neurons?
    Naaman Kam
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    PLoS Comput Biol 5:e1000477. 2009
    ..This could potentially allow a neuron to dynamically sense the relative lengths of its processes on an ongoing basis, enabling appropriate metabolic output from cell body to processes...
  32. doi request reprint Nuclear transport factors in neuronal function
    Rotem Ben Tov Perry
    Dept of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    Semin Cell Dev Biol 20:600-6. 2009
    ....
  33. ncbi request reprint Nerve growth factor-induced p75-mediated death of cultured hippocampal neurons is age-dependent and transduced through ceramide generated by neutral sphingomyelinase
    Adi B Brann
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Biol Chem 277:9812-8. 2002
    ..These data indicate an initiating role of ceramide generated by neutral sphingomyelinase in the diverse neuronal responses induced by binding of neurotrophins to p75...
  34. ncbi request reprint Genetic models meet trophic mechanisms: EGF family members are gliatrophins in Drosophila
    Gad Beck
    Department of Biological Chemistry, Weizmann Institute of Science, 76100, Rehovot, Israel
    Neuron 33:673-5. 2002
    ..Fly genetics thus promises new insights on trophic signaling mechanisms and confirms that trophic regulation of cell survival is an evolutionarily ancient mechanism for building the nervous system...
  35. ncbi request reprint Axoplasmic importins enable retrograde injury signaling in lesioned nerve
    Shlomit Hanz
    Molecular Neurobiology Group, Department of Biological Chemistry, Weizmann Institute of Science, 76100, Rehovot, Israel
    Neuron 40:1095-104. 2003
    ..These data suggest a model whereby lesion-induced upregulation of axonal importin beta may enable retrograde transport of signals that modulate the regeneration of injured neurons...
  36. doi request reprint Cell length sensing for neuronal growth control
    Christin A Albus
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    Trends Cell Biol 23:305-10. 2013
    ..This model might explain intrinsic limits on elongating neuronal growth and provides a mechanistic framework for determining the connections between genome expression and cellular growth rates in neurons. ..
  37. pmc Multi-tasking by the p75 neurotrophin receptor: sortilin things out?
    Francisca C Bronfman
    Center for Cellular Regulation and Pathology, Department of Physiological Science, Faculty of Biological Sciences, P Catholic University of Chile, Alameda 340, Santiago, Chile
    EMBO Rep 5:867-71. 2004
    ..We therefore argue that cell-biology-driven approaches are now required to make sense of p75 signalling...
  38. ncbi request reprint Rabies virus glycoprotein (RVG) is a trimeric ligand for the N-terminal cysteine-rich domain of the mammalian p75 neurotrophin receptor
    Christelle Langevin
    Laboratoire de Virologie Moleculaire et Structurale, Centre National de la Recherche Scientifique Institut National de la Recherche Agronomique, 91198 Gif sur Yvette, France
    J Biol Chem 277:37655-62. 2002
    ....