Affiliation: Weizmann Institute of Science
Shalev M, Elson A. The roles of protein tyrosine phosphatases in bone-resorbing osteoclasts. Biochim Biophys Acta. 2018;: pubmed publisher
..Characterizing the functions of PTPs in osteoclasts is essential for complete molecular level understanding of bone resorption and for designing novel therapeutic approaches for treating bone disease. ..
Finkelshtein E, Lotinun S, Levy Apter E, Arman E, den Hertog J, Baron R, et al
. Protein tyrosine phosphatases ? and ? perform nonredundant roles in osteoclasts. Mol Biol Cell. 2014;25:1808-18 pubmed publisher
..We conclude that PTPs ? and ? play distinct roles in osteoclasts and that the N-terminus of cyt-PTPe, in particular serine 2, is critical for its function in these cells. ..
Levy Apter E, Finkelshtein E, Vemulapalli V, Li S, Bedford M, Elson A. Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase Ïµ in osteoclasts. J Biol Chem. 2014;289:36048-58 pubmed publisher
..We conclude that GRB2 physically links cyt-PTPe with Src and enables cyt-PTPe to activate Src downstream of activated integrins in OCLs. ..
Finkelshtein E, Levy Apter E, Elson A. Production of Osteoclasts for Studying Protein Tyrosine Phosphatase Signaling. Methods Mol Biol. 2016;1447:283-300 pubmed publisher
Elson A. Stepping out of the shadows: Oncogenic and tumor-promoting protein tyrosine phosphatases. Int J Biochem Cell Biol. 2018;96:135-147 pubmed publisher
..This review summarizes the known transforming and tumor-promoting activities of the classical, tyrosine specific PTPs and highlights their potential as drug targets for cancer therapy. ..