Benjamin Dekel

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. ncbi Regenerative medicine and stem cell therapy
    Benjamin Dekel
    Department of Pediatrics, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 8:60. 2006
  2. doi Schimke immuno-osseous dysplasia: expression of SMARCAL1 in blood and kidney provides novel insight into disease phenotype
    Benjamin Dekel
    Department of Pediatrics, Laboratory of Regenerative and Developmental Nephrology, Safra Children s Hospital, Sheba Medical Center, 52621, Israel
    Pediatr Res 63:398-403. 2008
  3. ncbi Multiple imprinted and stemness genes provide a link between normal and tumor progenitor cells of the developing human kidney
    Benjamin Dekel
    Department of Pediatrics, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Cancer Res 66:6040-9. 2006
  4. ncbi Reactivation of NCAM1 defines a subpopulation of human adult kidney epithelial cells with clonogenic and stem/progenitor properties
    Ella Buzhor
    Pediatric Stem Cell Research Institute, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Ramat Gan, Israel Sheba Center for Regenerative Medicine, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Ramat Gan, Israel
    Am J Pathol 183:1621-33. 2013
  5. pmc The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets
    Naomi Pode-Shakked
    Pediatric Stem Cell Research Institute, Edmond and LiliSafra Children s Hospital, Sheba Medical Center, Ramat Gan, Israel
    EMBO Mol Med 5:18-37. 2013
  6. ncbi Developmental tumourigenesis: NCAM as a putative marker for the malignant renal stem/progenitor cell population
    Naomi Pode-Shakked
    Department of Pediatrics and Pediatric Stem Cell Research Institute, Sheba Medical Center, Tel Hashomer, Israel
    J Cell Mol Med 13:1792-808. 2009
  7. pmc Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease
    Orit Harari-Steinberg
    The Pediatric Stem Cell Research Institute, Edmond and Lily Safra Children s Hospital, Sheba Center for Regenerative Medicine, Sheba Medical Center, Ramat Gan, Israel
    EMBO Mol Med 5:1556-68. 2013
  8. doi Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes
    Sally Metsuyanim
    Department of Pediatrics and Pediatric Stem Cell Research Institute, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    Stem Cells 26:1808-17. 2008
  9. doi Familial autosomal recessive renal tubular acidosis: importance of early diagnosis
    Asaf Vivante
    Department of Pediatrics, Talpiot Medical Leadership Program, Edmond and Lily Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Nephron Physiol 119:p31-9. 2011
  10. pmc Chromatin-modifying agents reactivate embryonic renal stem/progenitor genes in human adult kidney epithelial cells but abrogate dedifferentiation and stemness
    Dorit Omer
    The Pediatric Stem Cell Research Institute, Edmond and Lily Safra Children s Hospital, Sheba Center for Regenerative Medicine, Sheba Medical Center, Tel Hashomer, Israel
    Cell Reprogram 15:281-92. 2013

Collaborators

Detail Information

Publications40

  1. ncbi Regenerative medicine and stem cell therapy
    Benjamin Dekel
    Department of Pediatrics, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 8:60. 2006
  2. doi Schimke immuno-osseous dysplasia: expression of SMARCAL1 in blood and kidney provides novel insight into disease phenotype
    Benjamin Dekel
    Department of Pediatrics, Laboratory of Regenerative and Developmental Nephrology, Safra Children s Hospital, Sheba Medical Center, 52621, Israel
    Pediatr Res 63:398-403. 2008
    ..Thus, disease severity within the same family might be modified by the splicing machinery. The renal expression pattern of SMARCAL1 explains a broader spectrum of renal disease in SIOD than previously described...
  3. ncbi Multiple imprinted and stemness genes provide a link between normal and tumor progenitor cells of the developing human kidney
    Benjamin Dekel
    Department of Pediatrics, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Cancer Res 66:6040-9. 2006
    ..Thus, multiple imprinted and stemness genes that function to expand the renal progenitor cell population may lead to evolution and maintenance of WT...
  4. ncbi Reactivation of NCAM1 defines a subpopulation of human adult kidney epithelial cells with clonogenic and stem/progenitor properties
    Ella Buzhor
    Pediatric Stem Cell Research Institute, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Ramat Gan, Israel Sheba Center for Regenerative Medicine, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Ramat Gan, Israel
    Am J Pathol 183:1621-33. 2013
    ..The ability to influence an endogenous regenerative response via NCAM1 targeting may lead to novel therapeutics for renal diseases...
  5. pmc The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets
    Naomi Pode-Shakked
    Pediatric Stem Cell Research Institute, Edmond and LiliSafra Children s Hospital, Sheba Medical Center, Ramat Gan, Israel
    EMBO Mol Med 5:18-37. 2013
    ..Complete eradication of WT in multiple xenograft models was achieved with a human NCAM antibody drug conjugate. The existence of CIC/CSCs in WT provides new therapeutic targets...
  6. ncbi Developmental tumourigenesis: NCAM as a putative marker for the malignant renal stem/progenitor cell population
    Naomi Pode-Shakked
    Department of Pediatrics and Pediatric Stem Cell Research Institute, Sheba Medical Center, Tel Hashomer, Israel
    J Cell Mol Med 13:1792-808. 2009
    ..Thus, we suggest NCAM as a marker for the WT progenitor cell population. These findings provide novel insights into the cellular hierarchy of WT, having possible implications for future therapeutic options...
  7. pmc Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease
    Orit Harari-Steinberg
    The Pediatric Stem Cell Research Institute, Edmond and Lily Safra Children s Hospital, Sheba Center for Regenerative Medicine, Sheba Medical Center, Ramat Gan, Israel
    EMBO Mol Med 5:1556-68. 2013
    ..These findings constitute the first definition of an intrinsic nephron precursor population, with major potential for cell-based therapeutic strategies and modelling of kidney disease. ..
  8. doi Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes
    Sally Metsuyanim
    Department of Pediatrics and Pediatric Stem Cell Research Institute, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    Stem Cells 26:1808-17. 2008
    ..We suggest a link between polycomb activation and epigenetic alterations of the renal progenitor population in initiation and progression of renal cancer...
  9. doi Familial autosomal recessive renal tubular acidosis: importance of early diagnosis
    Asaf Vivante
    Department of Pediatrics, Talpiot Medical Leadership Program, Edmond and Lily Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Nephron Physiol 119:p31-9. 2011
    ..We reviewed the clinical features of patients with mutations in two genes causing RTA and evaluated their developmental expression assuming that timing, symptom severity and complications may be related to its occurrence...
  10. pmc Chromatin-modifying agents reactivate embryonic renal stem/progenitor genes in human adult kidney epithelial cells but abrogate dedifferentiation and stemness
    Dorit Omer
    The Pediatric Stem Cell Research Institute, Edmond and Lily Safra Children s Hospital, Sheba Center for Regenerative Medicine, Sheba Medical Center, Tel Hashomer, Israel
    Cell Reprogram 15:281-92. 2013
    ....
  11. doi Molecular assessment of thymic capacities in patients with Schimke immuno-osseous dysplasia
    Atar Lev
    Cancer Research Center, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv, Israel
    Clin Immunol 133:375-81. 2009
    ..High thymic expression of SMARCAL1 mRNA raises the possibility of its importance in thymus maintenance and function...
  12. pmc A human integrin-α3 mutation confers major renal developmental defects
    Rachel Shukrun
    Pediatric Stem Cell Research Institute, Edmond and Lili Safra Children s Hospital, Sheba Medical Center, Ramat Gan, Israel Sheba Centers for Regenerative Medicine and Cancer Research, Sheba Medical Center, Ramat Gan, Israel Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 9:e90879. 2014
    ....
  13. pmc Renal hypodysplasia associates with a WNT4 variant that causes aberrant canonical WNT signaling
    Asaf Vivante
    Department of Pediatrics, Talpiot Medical Leadership Program, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Am Soc Nephrol 24:550-8. 2013
    ..In conclusion, heterozygous WNT4 variants are likely to play a causative role in renal hypodysplasia...
  14. doi Kidney spheroids recapitulate tubular organoids leading to enhanced tubulogenic potency of human kidney-derived cells
    Ella Buzhor
    Sheba Medical Center, Pediatric Stem Cell Research Institute, Edmond and Lili Safra Children s Hospital, Tel Hashomer, Israel
    Tissue Eng Part A 17:2305-19. 2011
    ..Thus, generation of a tubular organoid in hKEpC spheroids may provide a functional benefit for kidney-derived cells in vivo...
  15. doi Wilms tumor--a renal stem cell malignancy?
    Naomi Pode-Shakked
    Pediatric Stem Cell Research Institute, Edmond and Lili Safra Children s Hospital, Sheba Center for Regenerative Medicine, Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Pediatr Nephrol 26:1535-43. 2011
    ....
  16. ncbi Molecular evaluation of circulating endothelial progenitor cells in children undergoing hemodialysis and after kidney transplantation
    Sally Metsuyanim
    Department of Pediatrics and the Pediatric Stem Cell Research Institute, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    Pediatr Res 65:221-5. 2009
    ..Prospective studies are required to link this expression pattern and its restoration in transplanted patients to cardiovascular outcome...
  17. pmc Analysis of circulating hem-endothelial marker RNA levels in preterm infants
    Tzipora Strauss
    Neonatal Department, Chaim Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel
    BMC Pediatr 9:42. 2009
    ..This study aims to determine circulating RNA levels of hem-endothelial marker genes in peripheral blood of preterm infants and begin to correlate these findings with prenatal complications...
  18. ncbi Engraftment of human early kidney precursors
    Benjamin Dekel
    Developmental Biology Laboratory, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    Transpl Immunol 12:241-7. 2004
    ..Nevertheless, in order for these transplants to be applicable for human transplantation, both a functional urinary anastomosis and derivation of blood supply sufficient to correct biochemical abnormalities remain to be established...
  19. pmc Concise review: Kidney stem/progenitor cells: differentiate, sort out, or reprogram?
    Oren Pleniceanu
    Pediatric Stem Cell Research Institute, Sheba Medical Center, Tel Hashomer, Israel
    Stem Cells 28:1649-60. 2010
    ....
  20. pmc Expression of stem cell markers in the human fetal kidney
    Sally Metsuyanim
    Department of Pediatrics and Pediatric Stem Cell Research Institute, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 4:e6709. 2009
    ..These results and concepts provide a framework for developing cell selection strategies for human renal cell-based therapies...
  21. ncbi Engraftment and differentiation of human metanephroi into functional mature nephrons after transplantation into mice is accompanied by a profile of gene expression similar to normal human kidney development
    Benjamin Dekel
    Department of Pediatrics, Sheba Medical Center, Tel Hashomer, Israel 52621
    J Am Soc Nephrol 13:977-90. 2002
    ..Understanding of the molecular regulation of the transplanted developing metanephroi might lead to the development of strategies aimed at increasing the levels of specific genes, nephron endowment, and graft function...
  22. ncbi Profiling gene expression in kidney development
    Benjamin Dekel
    Developmental Biology Laboratory, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    Nephron Exp Nephrol 95:e1-6. 2003
    ....
  23. ncbi Kidney, blood, and endothelium: developmental expression of stem cell leukemia during nephrogenesis
    Benjamin Dekel
    Developmental Biology Laboratory, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Kidney Int 65:1162-9. 2004
    ..Here we characterize the expression of SCL along with its distinct 3' hematopoietic and endothelial enhancer (SCL 3'En) during kidney development...
  24. ncbi Targeted therapy aimed at cancer stem cells: Wilms' tumor as an example
    Rachel Shukrun
    Pediatric Stem Cell Research Institute, Edmond and Lily Safra Children s Hospital, Sheba Medical Center, Ramat Gan, Tel Hashomer, 52621, Israel
    Pediatr Nephrol 29:815-23; quiz 821. 2014
    ..The loss of CSCs abolishes the tumor's ability to sustain and propagate, hence, causing tumor degradation with minimal damage to normal tissue. ..
  25. doi Bitterness of glucose/galactose: novel mutations in the SLC5A1 gene
    Ben Pode-Shakked
    Metabolic Disease Unit, Edmond and Lily Safra Children s Hospital, Sheba Medical Center, Tel Hashomer Genetics Institute, Assaf Harofeh Medical Center, Zerifin, Israel University of Istanbul, Cerrahpasa Medical Faculty, Department of Pediatrics, Division of Metabolic Diseases, Istanbul, Turkey Department of Biological Resources Engineering, University of Maryland, College Park Pediatric Stem Cell Research Institute, Edmond and Lily Safra Children s Hospital, Sheba Medical Center Pediatric Gastroenterology and Nutrition Unit, Edmond and Lily Safra Children s Hospital
    J Pediatr Gastroenterol Nutr 58:57-60. 2014
    ....
  26. ncbi Expression of SDF-1/CXCR4 in injured human kidneys
    Danny Lotan
    Department of Pediatric Nephrology, Sackler Faculty of Medicine, Tel Aviv University, Sheba Medical Center, Tel Hashomer 52621, Israel
    Pediatr Nephrol 23:71-7. 2008
    ..A contribution of SDF-1alpha for influx of CXCR4(+) cells in the vicinity of arcuate vessels is suggested only in human ATN...
  27. ncbi In situ activation pattern of Met docking site following renal injury and hypertrophy
    Benjamin Dekel
    Department of Pediatrics, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Nephrol Dial Transplant 18:1493-504. 2003
    ..The multifunctional docking site in the C-terminal domain mediates the signal of phosphorylated Met receptors to multiple transducers. The tyrosine at position 1356 of the Met docking site is crucial for cell motility and morphogenesis...
  28. ncbi Common perinatal insults diminish cord blood RANTES
    Benjamin Dekel
    Department of Pediatric Intensive Care, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Biol Neonate 82:70-2. 2002
    ....
  29. ncbi T cells from newborn humans are fully capable of developing into cytotoxic T lymphocyte effector cells in adoptive hosts
    Hadar Marcus
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Transplantation 73:803-10. 2002
    ..We investigated the in vivo function of human cord blood mononuclear cells (CBMC) after their adoptive transfer into lethally irradiated BALB/c radioprotected with severe combined immunodeficiency (SCID) mouse bone marrow...
  30. ncbi Human and porcine early kidney precursors as a new source for transplantation
    Benjamin Dekel
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    Nat Med 9:53-60. 2003
    ..Our data pinpoint a window of human and pig kidney organogenesis that may be optimal for transplantation in humans...
  31. ncbi Embryonic committed stem cells as a solution to kidney donor shortage
    Benjamin Dekel
    Weizmann Institute of Science, Department of Immunology, Rehovot, Israel
    Expert Opin Biol Ther 4:443-54. 2004
    ....
  32. ncbi Eradication of B-CLL by autologous and allogeneic host nonreactive anti-third-party CTLs
    Fabian D Arditti
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Blood 105:3365-71. 2005
    ..Taken together, these results suggest that allogeneic or autologous host nonreactive anti-third-party CTLs may represent a new therapeutic approach for patients with B-CLL...
  33. pmc Embryonic pig liver, pancreas, and lung as a source for transplantation: optimal organogenesis without teratoma depends on distinct time windows
    Smadar Eventov-Friedman
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 102:2928-33. 2005
    ....
  34. ncbi Transplantation of human hematopoietic stem cells into ischemic and growing kidneys suggests a role in vasculogenesis but not tubulogenesis
    Benjamin Dekel
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Stem Cells 24:1185-93. 2006
    ..Efforts should be made to identify additional stem cell sources applicable for kidney growth and regeneration...
  35. pmc Transcriptional link between blood and bone: the stem cell leukemia gene and its +19 stem cell enhancer are active in bone cells
    John E Pimanda
    Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, United Kingdom
    Mol Cell Biol 26:2615-25. 2006
    ....
  36. pmc Embryonic pig pancreatic tissue transplantation for the treatment of diabetes
    Smadar Eventov-Friedman
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    PLoS Med 3:e215. 2006
    ..In the present study we examined growth potential, functionality, and immunogenicity of pig embryonic pancreatic tissue harvested at different gestational ages...
  37. ncbi Isolation and characterization of nontubular sca-1+lin- multipotent stem/progenitor cells from adult mouse kidney
    Benjamin Dekel
    Weizmann Institute of Science, Department of Immunology, Rehovot, Israel
    J Am Soc Nephrol 17:3300-14. 2006
    ..These data define a unique phenotype for adult kidney-derived cells, which have potential as stem cells and may contribute to the regeneration of injured kidneys...
  38. ncbi Splicing defect in RFXANK results in a moderate combined immunodeficiency and long-duration clinical course
    Thomas Prod'homme
    INSERM U396, Centre de Recherches Biomedicales des Cordeliers, 15 rue de l Ecole de Medecine, 75006 Paris, France
    Immunogenetics 55:530-9. 2003
    ..We thus propose that the common feature displayed by mildly immunodeficient patients is the leakiness of the mutations, which might allow a local or temporal expression of MHC class II molecules...
  39. ncbi Human colon adenocarcinoma in the SCID/CB6 radiation chimera is susceptible to adoptive transfer of allogeneic human peripheral blood mononuclear cells
    Fabian D Arditti
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Hematother Stem Cell Res 11:883-93. 2002
    ..We suggest that this novel model of human colon carcinoma affords the opportunity for in vivo evaluation of different preclinical treatment modalities, particularly, those involving manipulation with immune effector cells...
  40. doi Embryonic porcine liver as a source for transplantation: advantage of intact liver implants over isolated hepatoblasts in overcoming homeostatic inhibition by the quiescent host liver
    Helena Katchman
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    Stem Cells 26:1347-55. 2008
    ..The marked proliferation and functional maturation exhibited by the pig fetal liver fragments suggests that it could afford a preferable source for transplantation...