Research Topics
| Benjamin DekelSummaryAffiliation: Weizmann Institute of Science Country: Israel Publications
| Collaborators
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Detail Information
Publications
Schimke immuno-osseous dysplasia: expression of SMARCAL1 in blood and kidney provides novel insight into disease phenotypeBenjamin Dekel
Department of Pediatrics, Laboratory of Regenerative and Developmental Nephrology, Safra Children s Hospital, Sheba Medical Center, 52621, Israel
Pediatr Res 63:398-403. 2008..Thus, disease severity within the same family might be modified by the splicing machinery. The renal expression pattern of SMARCAL1 explains a broader spectrum of renal disease in SIOD than previously described...
Regenerative medicine and stem cell therapyBenjamin Dekel
Department of Pediatrics, Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel
Isr Med Assoc J 8:60. 2006- Multiple imprinted and stemness genes provide a link between normal and tumor progenitor cells of the developing human kidneyBenjamin Dekel
Department of Pediatrics, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Cancer Res 66:6040-9. 2006..Thus, multiple imprinted and stemness genes that function to expand the renal progenitor cell population may lead to evolution and maintenance of WT... - Developmental tumourigenesis: NCAM as a putative marker for the malignant renal stem/progenitor cell populationNaomi Pode-Shakked
Department of Pediatrics and Pediatric Stem Cell Research Institute, Sheba Medical Center, Tel Hashomer, Israel
J Cell Mol Med 13:1792-808. 2009..Thus, we suggest NCAM as a marker for the WT progenitor cell population. These findings provide novel insights into the cellular hierarchy of WT, having possible implications for future therapeutic options... - Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genesSally Metsuyanim
Department of Pediatrics and Pediatric Stem Cell Research Institute, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
Stem Cells 26:1808-17. 2008..We suggest a link between polycomb activation and epigenetic alterations of the renal progenitor population in initiation and progression of renal cancer... - Molecular assessment of thymic capacities in patients with Schimke immuno-osseous dysplasiaAtar Lev
Cancer Research Center, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv, Israel
Clin Immunol 133:375-81. 2009..High thymic expression of SMARCAL1 mRNA raises the possibility of its importance in thymus maintenance and function... - Kidney spheroids recapitulate tubular organoids leading to enhanced tubulogenic potency of human kidney-derived cellsElla Buzhor
Sheba Medical Center, Pediatric Stem Cell Research Institute, Edmond and Lili Safra Children s Hospital, Tel Hashomer, Israel
Tissue Eng Part A 17:2305-19. 2011..Thus, generation of a tubular organoid in hKEpC spheroids may provide a functional benefit for kidney-derived cells in vivo... - Molecular evaluation of circulating endothelial progenitor cells in children undergoing hemodialysis and after kidney transplantationSally Metsuyanim
Department of Pediatrics and the Pediatric Stem Cell Research Institute, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
Pediatr Res 65:221-5. 2009..Prospective studies are required to link this expression pattern and its restoration in transplanted patients to cardiovascular outcome... - Wilms tumor--a renal stem cell malignancy?Naomi Pode-Shakked
Pediatric Stem Cell Research Institute, Edmond and Lili Safra Children s Hospital, Sheba Center for Regenerative Medicine, Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Pediatr Nephrol 26:1535-43. 2011.... 
Analysis of circulating hem-endothelial marker RNA levels in preterm infantsTzipora Strauss
Neonatal Department, Chaim Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel
BMC Pediatr 9:42. 2009..This study aims to determine circulating RNA levels of hem-endothelial marker genes in peripheral blood of preterm infants and begin to correlate these findings with prenatal complications...- Engraftment of human early kidney precursorsBenjamin Dekel
Developmental Biology Laboratory, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
Transpl Immunol 12:241-7. 2004..Nevertheless, in order for these transplants to be applicable for human transplantation, both a functional urinary anastomosis and derivation of blood supply sufficient to correct biochemical abnormalities remain to be established... - Concise review: Kidney stem/progenitor cells: differentiate, sort out, or reprogram?Oren Pleniceanu
Pediatric Stem Cell Research Institute, Sheba Medical Center, Tel Hashomer, Israel
Stem Cells 28:1649-60. 2010.... - Renal Hypodysplasia Associates with a Wnt4 Variant that Causes Aberrant Canonical Wnt SignalingAsaf Vivante
Pediatric Stem Cell Research Institute, Edmond and Lily Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, 52621, Israel
J Am Soc Nephrol 24:550-8. 2013..In conclusion, heterozygous WNT4 variants are likely to play a causative role in renal hypodysplasia... - Expression of stem cell markers in the human fetal kidneySally Metsuyanim
Department of Pediatrics and Pediatric Stem Cell Research Institute, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
PLoS ONE 4:e6709. 2009..These results and concepts provide a framework for developing cell selection strategies for human renal cell-based therapies... - Profiling gene expression in kidney developmentBenjamin Dekel
Developmental Biology Laboratory, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
Nephron Exp Nephrol 95:e1-6. 2003.... - Kidney, blood, and endothelium: developmental expression of stem cell leukemia during nephrogenesisBenjamin Dekel
Developmental Biology Laboratory, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Kidney Int 65:1162-9. 2004..Here we characterize the expression of SCL along with its distinct 3' hematopoietic and endothelial enhancer (SCL 3'En) during kidney development... - Engraftment and differentiation of human metanephroi into functional mature nephrons after transplantation into mice is accompanied by a profile of gene expression similar to normal human kidney developmentBenjamin Dekel
Department of Pediatrics, Sheba Medical Center, Tel Hashomer, Israel 52621
J Am Soc Nephrol 13:977-90. 2002..Understanding of the molecular regulation of the transplanted developing metanephroi might lead to the development of strategies aimed at increasing the levels of specific genes, nephron endowment, and graft function... - The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targetsNaomi Pode-Shakked
Pediatric Stem Cell Research Institute, Edmond and LiliSafra Children s Hospital, Sheba Medical Center, Ramat Gan, Israel
EMBO Mol Med 5:18-37. 2013..Complete eradication of WT in multiple xenograft models was achieved with a human NCAM antibody drug conjugate. The existence of CIC/CSCs in WT provides new therapeutic targets... - In situ activation pattern of Met docking site following renal injury and hypertrophyBenjamin Dekel
Department of Pediatrics, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Nephrol Dial Transplant 18:1493-504. 2003..The multifunctional docking site in the C-terminal domain mediates the signal of phosphorylated Met receptors to multiple transducers. The tyrosine at position 1356 of the Met docking site is crucial for cell motility and morphogenesis... - Expression of SDF-1/CXCR4 in injured human kidneysDanny Lotan
Department of Pediatric Nephrology, Sackler Faculty of Medicine, Tel Aviv University, Sheba Medical Center, Tel Hashomer 52621, Israel
Pediatr Nephrol 23:71-7. 2008..A contribution of SDF-1alpha for influx of CXCR4(+) cells in the vicinity of arcuate vessels is suggested only in human ATN... - Common perinatal insults diminish cord blood RANTESBenjamin Dekel
Department of Pediatric Intensive Care, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
Biol Neonate 82:70-2. 2002.... - T cells from newborn humans are fully capable of developing into cytotoxic T lymphocyte effector cells in adoptive hostsHadar Marcus
Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
Transplantation 73:803-10. 2002..Any reduction in the observed GVHD associated with cord blood transplants might therefore represent a quantitative difference in the total number of T cells infused... - Human and porcine early kidney precursors as a new source for transplantationBenjamin Dekel
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
Nat Med 9:53-60. 2003..Our data pinpoint a window of human and pig kidney organogenesis that may be optimal for transplantation in humans... - Embryonic committed stem cells as a solution to kidney donor shortageBenjamin Dekel
Weizmann Institute of Science, Department of Immunology, Rehovot, Israel
Expert Opin Biol Ther 4:443-54. 2004.... - Eradication of B-CLL by autologous and allogeneic host nonreactive anti-third-party CTLsFabian D Arditti
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Blood 105:3365-71. 2005..Taken together, these results suggest that allogeneic or autologous host nonreactive anti-third-party CTLs may represent a new therapeutic approach for patients with B-CLL... - Embryonic pig liver, pancreas, and lung as a source for transplantation: optimal organogenesis without teratoma depends on distinct time windowsSmadar Eventov-Friedman
Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
Proc Natl Acad Sci U S A 102:2928-33. 2005.... - Transplantation of human hematopoietic stem cells into ischemic and growing kidneys suggests a role in vasculogenesis but not tubulogenesisBenjamin Dekel
Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
Stem Cells 24:1185-93. 2006..Efforts should be made to identify additional stem cell sources applicable for kidney growth and regeneration... - Transcriptional link between blood and bone: the stem cell leukemia gene and its +19 stem cell enhancer are active in bone cellsJohn E Pimanda
Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, United Kingdom
Mol Cell Biol 26:2615-25. 2006.... - Embryonic pig pancreatic tissue transplantation for the treatment of diabetesSmadar Eventov-Friedman
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
PLoS Med 3:e215. 2006.... - Isolation and characterization of nontubular sca-1+lin- multipotent stem/progenitor cells from adult mouse kidneyBenjamin Dekel
Weizmann Institute of Science, Department of Immunology, Rehovot, Israel
J Am Soc Nephrol 17:3300-14. 2006..These data define a unique phenotype for adult kidney-derived cells, which have potential as stem cells and may contribute to the regeneration of injured kidneys... - Splicing defect in RFXANK results in a moderate combined immunodeficiency and long-duration clinical courseBenjamin Dekel
INSERM U396, Centre de Recherches Biomedicales des Cordeliers, 15 rue de l'Ecole de Medecine, 75006 Paris, France
Immunogenetics 55:530-9. 2003..We thus propose that the common feature displayed by mildly immunodeficient patients is the leakiness of the mutations, which might allow a local or temporal expression of MHC class II molecules... - Human colon adenocarcinoma in the SCID/CB6 radiation chimera is susceptible to adoptive transfer of allogeneic human peripheral blood mononuclear cellsFabian D Arditti
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
J Hematother Stem Cell Res 11:883-93. 2002..We suggest that this novel model of human colon carcinoma affords the opportunity for in vivo evaluation of different preclinical treatment modalities, particularly, those involving manipulation with immune effector cells... - Embryonic porcine liver as a source for transplantation: advantage of intact liver implants over isolated hepatoblasts in overcoming homeostatic inhibition by the quiescent host liverHelena Katchman
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
Stem Cells 26:1347-55. 2008..The marked proliferation and functional maturation exhibited by the pig fetal liver fragments suggests that it could afford a preferable source for transplantation...