Ariel Cohen

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. ncbi request reprint Dynamic proteomics of individual cancer cells in response to a drug
    A A Cohen
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Science 322:1511-6. 2008
  2. pmc Quantitative digital in situ senescence-associated β-galactosidase assay
    Liran I Shlush
    Laboratory of Molecular Medicine, Rappaport Faculty of Medicine and Research Institute, Technion, Haifa, Israel
    BMC Cell Biol 12:16. 2011
  3. ncbi request reprint Generation of a fluorescently labeled endogenous protein library in living human cells
    Alex Sigal
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Protoc 2:1515-27. 2007
  4. doi request reprint Using bleach-chase to measure protein half-lives in living cells
    Naama Geva-Zatorsky
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Nat Protoc 7:801-11. 2012
  5. doi request reprint Proteome half-life dynamics in living human cells
    Eran Eden
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Science 331:764-8. 2011
  6. ncbi request reprint Variability and memory of protein levels in human cells
    Alex Sigal
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100 Israel
    Nature 444:643-6. 2006
  7. pmc Dynamic proteomics of human protein level and localization across the cell cycle
    Shlomit Farkash-Amar
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    PLoS ONE 7:e48722. 2012
  8. doi request reprint Noise genetics: inferring protein function by correlating phenotype with protein levels and localization in individual human cells
    Shlomit Farkash-Amar
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    PLoS Genet 10:e1004176. 2014
  9. ncbi request reprint Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins
    Alex Sigal
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Methods 3:525-31. 2006

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Dynamic proteomics of individual cancer cells in response to a drug
    A A Cohen
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Science 322:1511-6. 2008
    ..We identify proteins whose dynamics differ widely between cells, in a way that corresponds to the outcomes-cell death or survival. This opens the way to understanding molecular responses to drugs in individual cells...
  2. pmc Quantitative digital in situ senescence-associated β-galactosidase assay
    Liran I Shlush
    Laboratory of Molecular Medicine, Rappaport Faculty of Medicine and Research Institute, Technion, Haifa, Israel
    BMC Cell Biol 12:16. 2011
    ..Furthermore the role of cellular senescence (CS) in vivo remains unclear mainly due to the ambiguity of current cellular markers in identifying CS of individual cells in tissues...
  3. ncbi request reprint Generation of a fluorescently labeled endogenous protein library in living human cells
    Alex Sigal
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Protoc 2:1515-27. 2007
    ....
  4. doi request reprint Using bleach-chase to measure protein half-lives in living cells
    Naama Geva-Zatorsky
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Nat Protoc 7:801-11. 2012
    ..The duration of the protocol is 4-5 d. The method may be applicable to a wide range of fluorescently tagged proteins and cell lines...
  5. doi request reprint Proteome half-life dynamics in living human cells
    Eran Eden
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Science 331:764-8. 2011
    ..This approach opens a way to understand proteome half-life dynamics in living cells...
  6. ncbi request reprint Variability and memory of protein levels in human cells
    Alex Sigal
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100 Israel
    Nature 444:643-6. 2006
    ..The persistent memory for protein levels that we found might underlie individuality in cell behaviour and could set a timescale needed for signals to affect fully every member of a cell population...
  7. pmc Dynamic proteomics of human protein level and localization across the cell cycle
    Shlomit Farkash-Amar
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    PLoS ONE 7:e48722. 2012
    ..Most of the cell-cycle dependent proteins exhibit changes in cellular localization. Such changes can be a useful tool in the regulation of the cell-cycle being fast and efficient...
  8. doi request reprint Noise genetics: inferring protein function by correlating phenotype with protein levels and localization in individual human cells
    Shlomit Farkash-Amar
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    PLoS Genet 10:e1004176. 2014
    ..We recovered 30 known motility genes, and validated several novel ones by mild knockdown experiments. Noise genetics can complement standard genetics for a variety of phenotypes. ..
  9. ncbi request reprint Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins
    Alex Sigal
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Methods 3:525-31. 2006
    ..This approach to dynamic proteomics can aid in discovery and accurate quantification of the extensive regulation of protein concentration and localization in individual living cells...