Affiliation: Weizmann Institute of Science
Ezra Nevo G, Prestori F, Locatelli F, Soda T, Ten Brinke M, Engel M, et al
. Cerebellar Learning Properties Are Modulated by the CRF Receptor. J Neurosci. 2018;38:6751-6765 pubmed publisher
..Here, we explored the behavioral and cellular effect of granular cell-specific ablation of CRFR1 We found a profound effect on learning both at the cellular and behavioral levels without an effect on baseline motor skills. ..
Ezra Nevo G, Volk N, Ramot A, Kuehne C, Tsoory M, Deussing J, et al
. Inferior olive CRF plays a role in motor performance under challenging conditions. Transl Psychiatry. 2018;8:107 pubmed publisher
..Taken together our results indicate a role for IO-CRF in challenge-induced motor responses. ..
Elliott E, Manashirov S, Zwang R, Gil S, Tsoory M, Shemesh Y, et al
. Dnmt3a in the Medial Prefrontal Cortex Regulates Anxiety-Like Behavior in Adult Mice. J Neurosci. 2016;36:730-40 pubmed publisher
..We suggest that mPFC-Dnmt3a levels mediates anxiety-like behavior, which may be a primary molecular link between chronic stress and the development of anxiety disorders, including post-traumatic stress disorder. ..
Schroeder M, Drori Y, Ben Efraim Y, Chen A. Hypothalamic miR-219 regulates individual metabolic differences in response to diet-induced weight cycling. Mol Metab. 2018;9:176-186 pubmed publisher
..In contrast, over-expression of miR-219 resulted in moderation of the metabolic syndrome phenotype. Our results suggest a role for miR-219 in the mediation of the metabolic phenotype resulting from repeated weight cycling. ..
Volk N, Paul E, Haramati S, Eitan C, Fields B, Zwang R, et al
. MicroRNA-19b associates with Ago2 in the amygdala following chronic stress and regulates the adrenergic receptor beta 1. J Neurosci. 2014;34:15070-82 pubmed publisher
..These findings suggest a key role for miR-19b in modulating behavioral responses to chronic stress and Adrb1 as an important target of miR-19b in stress-linked brain regions. ..
Kuperman Y, Weiss M, Dine J, Staikin K, Golani O, Ramot A, et al
. CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting. Cell Metab. 2016;23:1185-1199 pubmed publisher
..Thus, CRFR1, in a subset of AgRP neurons, plays a regulatory role that enables appropriate sympathetic nervous system activation and consequently protects the organism from hypothermia and hypoglycemia. ..
Volk N, Pape J, Engel M, Zannas A, Cattane N, Cattaneo A, et al
. Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress. Cell Rep. 2016;17:1882-1891 pubmed publisher
..Taken together, our results support an important role for microRNA-15a in stress adaptation and the pathogenesis of stress-related psychopathologies. ..
Schroeder M, Jakovcevski M, Polacheck T, Lebow M, Drori Y, Engel M, et al
. A Methyl-Balanced Diet Prevents CRF-Induced Prenatal Stress-Triggered Predisposition to Binge Eating-like Phenotype. Cell Metab. 2017;25:1269-1281.e6 pubmed publisher
..We provide experimental evidence for long-term epigenetic abnormalities stemming from PNS in predisposing female offspring to BE disorder as well as a potential non-invasive prevention strategy. ..