Alexander D Bershadsky

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. ncbi request reprint Assembly and mechanosensory function of focal adhesions: experiments and models
    Alexander D Bershadsky
    Department of Molecular Cell Biology, The Weizmann Institute of Science, P O Box 26, Rehovot 76100, Israel
    Eur J Cell Biol 85:165-73. 2006
  2. pmc Analysis of the local organization and dynamics of cellular actin networks
    Weiwei Luo
    Mechanobiology Institute, National University of Singapore, Singapore 117411, Republic of Singapore
    J Cell Biol 202:1057-73. 2013
  3. pmc Comparative dynamics of retrograde actin flow and focal adhesions: formation of nascent adhesions triggers transition from fast to slow flow
    Antonina Y Alexandrova
    Ecole Polytechnique Federale de Lausanne, Laboratory of Cell Biophysics, Lausanne, Switzerland
    PLoS ONE 3:e3234. 2008
  4. pmc Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism
    D Riveline
    Laboratory of Physical Spectrometry (CNRS, UMR 5588, Joseph Fourier University, French National Center for Scientific Research, BP87, , France
    J Cell Biol 153:1175-86. 2001
  5. ncbi request reprint Adhesion-dependent cell mechanosensitivity
    Alexander D Bershadsky
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Annu Rev Cell Dev Biol 19:677-95. 2003
  6. ncbi request reprint Allicin inhibits cell polarization, migration and division via its direct effect on microtubules
    Masha Prager-Khoutorsky
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Cell Motil Cytoskeleton 64:321-37. 2007
  7. ncbi request reprint It depends on the hinge: a structure-functional analysis of galectin-8, a tandem-repeat type lectin
    Yifat Levy
    Department of Chemical Services, The Weizmann Institute of Science, Rehovot 76100, Israel
    Glycobiology 16:463-76. 2006
  8. pmc Physical model for self-organization of actin cytoskeleton and adhesion complexes at the cell front
    Tom Shemesh
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Biophys J 102:1746-56. 2012
  9. doi request reprint Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing
    Masha Prager-Khoutorsky
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Cell Biol 13:1457-65. 2011
  10. ncbi request reprint Caldesmon effects on the actin cytoskeleton and cell adhesion in cultured HTM cells
    Inna Grosheva
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Exp Eye Res 82:945-58. 2006

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Assembly and mechanosensory function of focal adhesions: experiments and models
    Alexander D Bershadsky
    Department of Molecular Cell Biology, The Weizmann Institute of Science, P O Box 26, Rehovot 76100, Israel
    Eur J Cell Biol 85:165-73. 2006
    ..Since microtubules are known to promote FA disassembly, the Dia1-mediated effect on microtubule dynamics may possibly play a role in the negative feedback loop controlling size and turnover of FAs...
  2. pmc Analysis of the local organization and dynamics of cellular actin networks
    Weiwei Luo
    Mechanobiology Institute, National University of Singapore, Singapore 117411, Republic of Singapore
    J Cell Biol 202:1057-73. 2013
    ..We suggest that such networks are critical for connecting distant parts of the cell to maintain the mechanical coherence of the cytoplasm...
  3. pmc Comparative dynamics of retrograde actin flow and focal adhesions: formation of nascent adhesions triggers transition from fast to slow flow
    Antonina Y Alexandrova
    Ecole Polytechnique Federale de Lausanne, Laboratory of Cell Biophysics, Lausanne, Switzerland
    PLoS ONE 3:e3234. 2008
    ..Extension of the cell edge thus proceeds through a cycle of lamellipodium protrusion, formation of new FAs, advance of the lamellum, and protrusion of the lamellipodium from the new base...
  4. pmc Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism
    D Riveline
    Laboratory of Physical Spectrometry (CNRS, UMR 5588, Joseph Fourier University, French National Center for Scientific Research, BP87, , France
    J Cell Biol 153:1175-86. 2001
    ..Our experiments show that integrin-containing focal complexes behave as individual mechanosensors exhibiting directional assembly in response to local force...
  5. ncbi request reprint Adhesion-dependent cell mechanosensitivity
    Alexander D Bershadsky
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Annu Rev Cell Dev Biol 19:677-95. 2003
    ....
  6. ncbi request reprint Allicin inhibits cell polarization, migration and division via its direct effect on microtubules
    Masha Prager-Khoutorsky
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Cell Motil Cytoskeleton 64:321-37. 2007
    ..Thus, allicin is a potent microtubule-disrupting reagent interfering with tubulin polymerization by reaction with tubulin SH groups...
  7. ncbi request reprint It depends on the hinge: a structure-functional analysis of galectin-8, a tandem-repeat type lectin
    Yifat Levy
    Department of Chemical Services, The Weizmann Institute of Science, Rehovot 76100, Israel
    Glycobiology 16:463-76. 2006
    ..These results provide evidence that cooperative interactions between the two CRDs and the "hinge" domain are required for the proper functioning of galectin-8...
  8. pmc Physical model for self-organization of actin cytoskeleton and adhesion complexes at the cell front
    Tom Shemesh
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Biophys J 102:1746-56. 2012
    ..The model recovers the asynchronous fluctuations and outward bulging of the cell edge, and the dependence of the edge protrusion velocity on the rate of the nascent adhesion generation, the membrane tension, and the substrate rigidity...
  9. doi request reprint Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing
    Masha Prager-Khoutorsky
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Cell Biol 13:1457-65. 2011
    ..We propose that the different stages of cell polarization are regulated by multiple, PTK-dependent molecular checkpoints that jointly control cell contractility and focal-adhesion-mediated mechanosensing...
  10. ncbi request reprint Caldesmon effects on the actin cytoskeleton and cell adhesion in cultured HTM cells
    Inna Grosheva
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Exp Eye Res 82:945-58. 2006
    ..Inducing such changes in the contractility and actin cytoskeleton of HTM cells in glaucomatous eyes in vivo could produce a therapeutically useful increase in outflow facility...
  11. ncbi request reprint Live-cell monitoring of tyrosine phosphorylation in focal adhesions following microtubule disruption
    Jochen Kirchner
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    J Cell Sci 116:975-86. 2003
    ..Our findings suggest that protein recruitment and growth of focal adhesions are an immediate and direct result of increased contractility induced by microtubule disruption, whereas tyrosine phosphorylation is activated later...
  12. ncbi request reprint Mammalian diaphanous-related formin Dia1 controls the organization of E-cadherin-mediated cell-cell junctions
    Letizia Carramusa
    Department of Molecular Cell Biology, The Weizmann Institute of Science, PO Box 26, Rehovot 76100, Israel
    J Cell Sci 120:3870-82. 2007
    ..Thus, Dia1 localizes to and controls cadherin-mediated junctions in a RhoA-dependent manner...
  13. doi request reprint Environmental sensing through focal adhesions
    Benjamin Geiger
    Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Rev Mol Cell Biol 10:21-33. 2009
    ....
  14. ncbi request reprint Sustained induction of ERK, protein kinase B, and p70 S6 kinase regulates cell spreading and formation of F-actin microspikes upon ligation of integrins by galectin-8, a mammalian lectin
    Yifat Levy
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 278:14533-42. 2003
    ..They further suggest that downstream effectors of PI3K, including PKB and p70 S6 kinase, in part mediate cell adhesion, spreading, and microspike formation induced by galectin-8...
  15. pmc Integrin-matrix clusters form podosome-like adhesions in the absence of traction forces
    Cheng Han Yu
    Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore Electronic address
    Cell Rep 5:1456-68. 2013
    ..We propose that adhesion structures can be modulated by traction force development and that production of PIP3 stimulates podosome formation and subsequent RhoA downregulation in the absence of traction force. ..
  16. pmc Focal adhesions as mechanosensors: a physical mechanism
    Tom Shemesh
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel
    Proc Natl Acad Sci U S A 102:12383-8. 2005
    ..We define here specific conditions that can lead to the different regimes of FA assembly, including growth, steady state, and disassembly...
  17. ncbi request reprint Caldesmon transgene expression disrupts focal adhesions in HTM cells and increases outflow facility in organ-cultured human and monkey anterior segments
    B Ann True Gabelt
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53792, USA
    Exp Eye Res 82:935-44. 2006
    ..This suggests that over-expression of the caldesmon gene in the TM may be an effective approach for the gene therapy of glaucoma...
  18. pmc A novel mechanism of actin filament processive capping by formin: solution of the rotation paradox
    Tom Shemesh
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel
    J Cell Biol 170:889-93. 2005
    ..In this regime, elastic energy does not exceed feasible values, and supercoiling of actin filaments is prevented...
  19. pmc Processive capping by formin suggests a force-driven mechanism of actin polymerization
    Michael M Kozlov
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Cell Biol 167:1011-7. 2004
    ..Furthermore, the pulling force increases the polymerization rate. The suggested mechanism of force-driven polymerization could be a key element in a variety of cellular mechanosensing devices...