Research Topics
Genomes and Genes | Sven BergmannSummaryAffiliation: Weizmann Institute of Science Country: Israel Publications
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Detail Information
Publications
Iterative signature algorithm for the analysis of large-scale gene expression dataSven Bergmann
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
Phys Rev E Stat Nonlin Soft Matter Phys 67:031902. 2003..This result is confirmed by numerical analyses based on in silico expression data. We discuss briefly results obtained by applying our algorithm to expression data from the yeast Saccharomyces cerevisiae...
The evolving doublecortin (DCX) superfamilyOrly Reiner
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
BMC Genomics 7:188. 2006....
Rewiring of the yeast transcriptional network through the evolution of motif usageJan Ihmels
Department of Molecular Genetics and Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel
Science 309:938-40. 2005..Our results shed new light on the genetic mechanisms underlying the large-scale evolution of transcriptional networks...
Comparative gene expression analysis by differential clustering approach: application to the Candida albicans transcription programJan Ihmels
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
PLoS Genet 1:e39. 2005..Our study provides a comprehensive framework for comparative gene expression analysis and a rich source of hypotheses for uncharacterized open reading frames and putative cis-regulatory elements in C. albicans...
Defining transcription modules using large-scale gene expression dataJan Ihmels
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
Bioinformatics 20:1993-2003. 2004..It furthermore has the advantage over both methods of capturing overlapping modules in the presence of combinatorial regulation. SUPPLEMENTARY INFORMATION: http://www.weizmann.ac.il/~barkai/modules..
Similarities and differences in genome-wide expression data of six organismsSven Bergmann
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
PLoS Biol 2:E9. 2004..Our results demonstrate the potential of combining sequence and expression data for improving functional gene annotation and expanding our understanding of how gene expression and diversity evolved...
Revealing modular organization in the yeast transcriptional networkJan Ihmels
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel
Nat Genet 31:370-7. 2002..Our results provide functional predictions for numerous genes, identify relations between modules and present a global view on the transcriptional network...
Challenges and prospects in the analysis of large-scale gene expression dataJan H Ihmels
Department of Molecular Genetics, Weizmann Institute, 76100 Rehovot, Israel
Brief Bioinform 5:313-27. 2004..Biological questions that have been addressed using the Signature Algorithm are highlighted and a summary of other important methods from the literature is provided...
Common and divergent roles for members of the mouse DCX superfamilyFrédéric M Coquelle
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
Cell Cycle 5:976-83. 2006..The sub-specialization of some members due to confined intracellular localization, and protein interactions may explain the success of this superfamily...
Pre-steady-state decoding of the Bicoid morphogen gradientSven Bergmann
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
PLoS Biol 5:e46. 2007..This can explain the surprisingly small shifts in gap and pair-rule gene expression domains observed in response to alterations in bcd dosage...
A modular approach for integrative analysis of large-scale gene-expression and drug-response dataZoltan Kutalik
Department of Medical Genetics, University of Lausanne, Rue de Bugnon 27 DGM 328, CH 1005 Lausanne, Switzerland
Nat Biotechnol 26:531-9. 2008..Co-modules provide insights into possible mechanisms of action for a wide range of drugs and suggest new targets for therapy...
Investigations on the ORF 167L of lymphocystis disease virus (Iridoviridae)Sandra Essbauer
Institute of Zoology, Fishery Biology and Fish Diseases, LMU University of Munich, Kaulbachstrasse 37, D 80539 Munich, Germany
Virus Genes 28:19-39. 2004..The myxomavirus M-T2 protein, a poxviral TNFR homologue, was also shown not to have TNFR-like functions but to be involved in the apoptosis signal cascade...
Comparative genome hybridization reveals widespread aneuploidy in Candida albicans laboratory strainsAnna Selmecki
Department of Genetics, Cell Biology and Development, University of Minnesota, MN, USA
Mol Microbiol 55:1553-65. 2005..albicans strains. Furthermore, they highlight the high level of genome instability in C. albicans laboratory strains exposed to the stress of transformation and counterselection on 5-fluoro-orotic acid...
