Avri Ben-Ze'ev

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. pmc Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK
    Maralice Conacci-Sorrell
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 163:847-57. 2003
  2. doi Epithelial-mesenchymal transition and the invasive potential of tumors
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Trends Mol Med 14:199-209. 2008
  3. ncbi Regulation of p53: intricate loops and delicate balances
    Moshe Oren
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Ann N Y Acad Sci 973:374-83. 2002
  4. ncbi The shed ectodomain of Nr-CAM stimulates cell proliferation and motility, and confers cell transformation
    Maralice Conacci-Sorrell
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Cancer Res 65:11605-12. 2005
  5. doi The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells
    Shani Raveh
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biochem 108:326-36. 2009
  6. ncbi Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Cancer Res 67:7703-12. 2007
  7. ncbi L1-CAM in cancerous tissues
    Nancy Gavert
    Weizmann Institute of Science, Department of Molecular Cell Biology, Rehovot, Israel
    Expert Opin Biol Ther 8:1749-57. 2008
  8. ncbi Downregulation of beta-catenin by p53 involves changes in the rate of beta-catenin phosphorylation and Axin dynamics
    Elina Levina
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Oncogene 23:4444-53. 2004
  9. ncbi PML is a target gene of beta-catenin and plakoglobin, and coactivates beta-catenin-mediated transcription
    Michael Shtutman
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Cancer Res 62:5947-54. 2002
  10. pmc Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    J Cell Sci 123:2135-43. 2010

Collaborators

Detail Information

Publications18

  1. pmc Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK
    Maralice Conacci-Sorrell
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 163:847-57. 2003
    ..This autoregulation of E-cadherin by cell-cell adhesion involving Slug, beta-catenin and ERK could be important in tumorigenesis...
  2. doi Epithelial-mesenchymal transition and the invasive potential of tumors
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Trends Mol Med 14:199-209. 2008
    ..A deeper understanding of these mechanisms should allow both better diagnosis and the development of specific treatments for invasive cancer...
  3. ncbi Regulation of p53: intricate loops and delicate balances
    Moshe Oren
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Ann N Y Acad Sci 973:374-83. 2002
    ..Genetic alterations characteristic of cancer are capable of severely distorting this balance, thereby overriding the tumor suppressor effects of p53 in a manner that facilitates neoplastic conversion...
  4. ncbi The shed ectodomain of Nr-CAM stimulates cell proliferation and motility, and confers cell transformation
    Maralice Conacci-Sorrell
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Cancer Res 65:11605-12. 2005
    ..Stable expression of the Nr-CAM ectodomain in NIH3T3 cells conferred cell transformation and tumorigenesis in mice, suggesting that the metalloprotease-mediated shedding of Nr-CAM is a principal route for promoting oncogenesis by Nr-CAM...
  5. doi The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells
    Shani Raveh
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biochem 108:326-36. 2009
    ..Our results suggest that various IgCAM receptor families play different roles in affecting the tumorigenic function of the same cells, and that Necl1 and Necl4 can fulfill a tumor suppressive role...
  6. ncbi Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Cancer Res 67:7703-12. 2007
    ..These results indicate that there is a gene program induced by L1-CAM in colon cancer cells that is also present in colorectal cancer tissue and suggest that L1-CAM can serve as target for colon cancer therapy...
  7. ncbi L1-CAM in cancerous tissues
    Nancy Gavert
    Weizmann Institute of Science, Department of Molecular Cell Biology, Rehovot, Israel
    Expert Opin Biol Ther 8:1749-57. 2008
    ..While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and in a variety of cancer cells, including some common types of human cancer...
  8. ncbi Downregulation of beta-catenin by p53 involves changes in the rate of beta-catenin phosphorylation and Axin dynamics
    Elina Levina
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Oncogene 23:4444-53. 2004
    ..These results suggest that p53 induces a faster mobilization of Axin into the degradation complex thereby enhancing beta-catenin turnover as part of a protective mechanism against the development of cancer...
  9. ncbi PML is a target gene of beta-catenin and plakoglobin, and coactivates beta-catenin-mediated transcription
    Michael Shtutman
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Cancer Res 62:5947-54. 2002
    ....
  10. pmc Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    J Cell Sci 123:2135-43. 2010
    ..Furthermore, we found that L1, ezrin and phosphorylated p65 are co-expressed at the invasive front in human CRC tissue, indicating that L1-mediated activation of NF-kappaB signaling involving ezrin is a major route of CRC progression...
  11. doi L1-mediated colon cancer cell metastasis does not require changes in EMT and cancer stem cell markers
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, P O Box 26, Rehovot 76100, Israel
    Mol Cancer Res 9:14-24. 2011
    ..The results suggest that L1-mediated metastasis of CRC cells does not require changes in EMT and CSC markers and operates by activating NF-κβ signaling...
  12. pmc L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel
    J Cell Biol 168:633-42. 2005
    ..The transmembrane localization and shedding of L1 by metalloproteases could be useful for detection and as target for colon cancer therapy...
  13. pmc The cadherin-catenin adhesion system in signaling and cancer
    Maralice Conacci-Sorrell
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Clin Invest 109:987-91. 2002
  14. doi L1 cell adhesion molecule (L1CAM) in invasive tumors
    Shani Raveh
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel
    Cancer Lett 282:137-45. 2009
    ..We review the role of L1CAM in cancer progression with particular emphasis on colon cancer, and the potential of anti-L1CAM antibodies as a therapeutic tool for cancer...
  15. ncbi beta-Catenin signaling in biological control and cancer
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biochem 102:820-8. 2007
    ....
  16. pmc Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis
    Maralice E Conacci-Sorrell
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Genes Dev 16:2058-72. 2002
    ..The results indicate that induction of Nr-CAM transcription by beta-catenin or plakoglobin plays a role in melanoma and colon cancer tumorigenesis, probably by promoting cell growth and motility...
  17. ncbi Regulation of p53: intricate loops and delicate balances
    Moshe Oren
    Department of Molecular Cell Biology, The Weizmann Institute of Science, P O Box 26, Rehovot, Israel
    Biochem Pharmacol 64:865-71. 2002
    ..Genetic alterations characteristic of cancer are capable of severely distorting this balance, thereby overriding the tumor suppressor effects of p53 in a manner that facilitates neoplastic conversion...
  18. ncbi Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer
    Danijela Vignjevic
    UMR 144 Centre National de la Recherche Scientifique and Department of Pathology, Institut Curie, 25 rue d Ulm, 75248 Paris Cedex 05, France
    Cancer Res 67:6844-53. 2007
    ..We propose that genes involved in cell migration and invasion, such as fascin1, could serve as novel targets for metastasis prevention...