Research Topics
Genomes and GenesSpecies | Avri Ben-Ze'evSummaryAffiliation: Weizmann Institute of Science Country: Israel Publications
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Detail Information
Publications
Epithelial-mesenchymal transition and the invasive potential of tumorsNancy Gavert
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
Trends Mol Med 14:199-209. 2008..A deeper understanding of these mechanisms should allow both better diagnosis and the development of specific treatments for invasive cancer...
L1-CAM in cancerous tissuesNancy Gavert
Weizmann Institute of Science, Department of Molecular Cell Biology, Rehovot, Israel
Expert Opin Biol Ther 8:1749-57. 2008..While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and in a variety of cancer cells, including some common types of human cancer...- The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the growth and tumorigenic ability of colon cancer cellsShani Raveh
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
J Cell Biochem 108:326-36. 2009..Our results suggest that various IgCAM receptor families play different roles in affecting the tumorigenic function of the same cells, and that Necl1 and Necl4 can fulfill a tumor suppressive role... - Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cellsNancy Gavert
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
J Cell Sci 123:2135-43. 2010..Furthermore, we found that L1, ezrin and phosphorylated p65 are co-expressed at the invasive front in human CRC tissue, indicating that L1-mediated activation of NF-kappaB signaling involving ezrin is a major route of CRC progression... - L1 cell adhesion molecule (L1CAM) in invasive tumorsShani Raveh
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel
Cancer Lett 282:137-45. 2009..We review the role of L1CAM in cancer progression with particular emphasis on colon cancer, and the potential of anti-L1CAM antibodies as a therapeutic tool for cancer... - L1-mediated colon cancer cell metastasis does not require changes in EMT and cancer stem cell markersNancy Gavert
Department of Molecular Cell Biology, Weizmann Institute of Science, P O Box 26, Rehovot 76100, Israel
Mol Cancer Res 9:14-24. 2011..The results suggest that L1-mediated metastasis of CRC cells does not require changes in EMT and CSC markers and operates by activating NF-κβ signaling... - beta-Catenin signaling in biological control and cancerNancy Gavert
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
J Cell Biochem 102:820-8. 2007.... - Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasisNancy Gavert
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
Cancer Res 67:7703-12. 2007..These results indicate that there is a gene program induced by L1-CAM in colon cancer cells that is also present in colorectal cancer tissue and suggest that L1-CAM can serve as target for colon cancer therapy... 
L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancersNancy Gavert
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel
J Cell Biol 168:633-42. 2005..The transmembrane localization and shedding of L1 by metalloproteases could be useful for detection and as target for colon cancer therapy...- Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancerDanijela Vignjevic
UMR 144 Centre National de la Recherche Scientifique and Department of Pathology, Institut Curie, 25 rue d Ulm, 75248 Paris Cedex 05, France
Cancer Res 67:6844-53. 2007..We propose that genes involved in cell migration and invasion, such as fascin1, could serve as novel targets for metastasis prevention...