Avri Ben-Ze'ev

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. pmc Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK
    Maralice Conacci-Sorrell
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 163:847-57. 2003
  2. pmc L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel
    J Cell Biol 168:633-42. 2005
  3. doi Epithelial-mesenchymal transition and the invasive potential of tumors
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Trends Mol Med 14:199-209. 2008
  4. ncbi Regulation of p53: intricate loops and delicate balances
    Moshe Oren
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Ann N Y Acad Sci 973:374-83. 2002
  5. ncbi The shed ectodomain of Nr-CAM stimulates cell proliferation and motility, and confers cell transformation
    Maralice Conacci-Sorrell
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Cancer Res 65:11605-12. 2005
  6. doi The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells
    Shani Raveh
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biochem 108:326-36. 2009
  7. ncbi Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Cancer Res 67:7703-12. 2007
  8. ncbi L1-CAM in cancerous tissues
    Nancy Gavert
    Weizmann Institute of Science, Department of Molecular Cell Biology, Rehovot, Israel
    Expert Opin Biol Ther 8:1749-57. 2008
  9. ncbi Downregulation of beta-catenin by p53 involves changes in the rate of beta-catenin phosphorylation and Axin dynamics
    Elina Levina
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Oncogene 23:4444-53. 2004
  10. ncbi PML is a target gene of beta-catenin and plakoglobin, and coactivates beta-catenin-mediated transcription
    Michael Shtutman
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Cancer Res 62:5947-54. 2002

Collaborators

Detail Information

Publications18

  1. pmc Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK
    Maralice Conacci-Sorrell
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 163:847-57. 2003
    ..This autoregulation of E-cadherin by cell-cell adhesion involving Slug, beta-catenin and ERK could be important in tumorigenesis...
  2. pmc L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel
    J Cell Biol 168:633-42. 2005
    ..The transmembrane localization and shedding of L1 by metalloproteases could be useful for detection and as target for colon cancer therapy...
  3. doi Epithelial-mesenchymal transition and the invasive potential of tumors
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Trends Mol Med 14:199-209. 2008
    ..A deeper understanding of these mechanisms should allow both better diagnosis and the development of specific treatments for invasive cancer...
  4. ncbi Regulation of p53: intricate loops and delicate balances
    Moshe Oren
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Ann N Y Acad Sci 973:374-83. 2002
    ..Genetic alterations characteristic of cancer are capable of severely distorting this balance, thereby overriding the tumor suppressor effects of p53 in a manner that facilitates neoplastic conversion...
  5. ncbi The shed ectodomain of Nr-CAM stimulates cell proliferation and motility, and confers cell transformation
    Maralice Conacci-Sorrell
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Cancer Res 65:11605-12. 2005
    ..Stable expression of the Nr-CAM ectodomain in NIH3T3 cells conferred cell transformation and tumorigenesis in mice, suggesting that the metalloprotease-mediated shedding of Nr-CAM is a principal route for promoting oncogenesis by Nr-CAM...
  6. doi The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells
    Shani Raveh
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biochem 108:326-36. 2009
    ..Our results suggest that various IgCAM receptor families play different roles in affecting the tumorigenic function of the same cells, and that Necl1 and Necl4 can fulfill a tumor suppressive role...
  7. ncbi Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Cancer Res 67:7703-12. 2007
    ..These results indicate that there is a gene program induced by L1-CAM in colon cancer cells that is also present in colorectal cancer tissue and suggest that L1-CAM can serve as target for colon cancer therapy...
  8. ncbi L1-CAM in cancerous tissues
    Nancy Gavert
    Weizmann Institute of Science, Department of Molecular Cell Biology, Rehovot, Israel
    Expert Opin Biol Ther 8:1749-57. 2008
    ..While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and in a variety of cancer cells, including some common types of human cancer...
  9. ncbi Downregulation of beta-catenin by p53 involves changes in the rate of beta-catenin phosphorylation and Axin dynamics
    Elina Levina
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Oncogene 23:4444-53. 2004
    ..These results suggest that p53 induces a faster mobilization of Axin into the degradation complex thereby enhancing beta-catenin turnover as part of a protective mechanism against the development of cancer...
  10. ncbi PML is a target gene of beta-catenin and plakoglobin, and coactivates beta-catenin-mediated transcription
    Michael Shtutman
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Cancer Res 62:5947-54. 2002
    ....
  11. doi Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    J Cell Sci 123:2135-43. 2010
    ..Furthermore, we found that L1, ezrin and phosphorylated p65 are co-expressed at the invasive front in human CRC tissue, indicating that L1-mediated activation of NF-kappaB signaling involving ezrin is a major route of CRC progression...
  12. doi L1-mediated colon cancer cell metastasis does not require changes in EMT and cancer stem cell markers
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, P O Box 26, Rehovot 76100, Israel
    Mol Cancer Res 9:14-24. 2011
    ..The results suggest that L1-mediated metastasis of CRC cells does not require changes in EMT and CSC markers and operates by activating NF-κβ signaling...
  13. pmc The cadherin-catenin adhesion system in signaling and cancer
    Maralice Conacci-Sorrell
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Clin Invest 109:987-91. 2002
  14. pmc Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis
    Maralice E Conacci-Sorrell
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Genes Dev 16:2058-72. 2002
    ..The results indicate that induction of Nr-CAM transcription by beta-catenin or plakoglobin plays a role in melanoma and colon cancer tumorigenesis, probably by promoting cell growth and motility...
  15. doi L1 cell adhesion molecule (L1CAM) in invasive tumors
    Shani Raveh
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel
    Cancer Lett 282:137-45. 2009
    ..We review the role of L1CAM in cancer progression with particular emphasis on colon cancer, and the potential of anti-L1CAM antibodies as a therapeutic tool for cancer...
  16. ncbi beta-Catenin signaling in biological control and cancer
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biochem 102:820-8. 2007
    ....
  17. ncbi Regulation of p53: intricate loops and delicate balances
    Moshe Oren
    Department of Molecular Cell Biology, The Weizmann Institute of Science, P O Box 26, Rehovot, Israel
    Biochem Pharmacol 64:865-71. 2002
    ..Genetic alterations characteristic of cancer are capable of severely distorting this balance, thereby overriding the tumor suppressor effects of p53 in a manner that facilitates neoplastic conversion...
  18. ncbi Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer
    Danijela Vignjevic
    UMR 144 Centre National de la Recherche Scientifique and Department of Pathology, Institut Curie, 25 rue d Ulm, 75248 Paris Cedex 05, France
    Cancer Res 67:6844-53. 2007
    ..We propose that genes involved in cell migration and invasion, such as fascin1, could serve as novel targets for metastasis prevention...