A Amsterdam

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. ncbi request reprint TADG-12 as an early marker in the development of pancreatic ductal adenocarcinoma (PDAC): Involvement of insulin containing cells
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 234 Herzl Street, Rehovot 76100, Israel Electronic address
    Acta Histochem 116:781-7. 2014
  2. doi request reprint Modulation of c-kit expression in pancreatic adenocarcinoma: a novel stem cell marker responsible for the progression of the disease
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 234 Herzl Street, Rehovot 76100, Israel Electronic address
    Acta Histochem 116:197-203. 2014
  3. doi request reprint Two initiation sites of early detection of colon cancer revealed by localization of pERK1/2 in the nuclei or in aggregates at the perinuclear region of the tumor cells
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Acta Histochem 115:569-76. 2013
  4. doi request reprint Localization of the stem cell markers LGR5 and Nanog in the normal and the cancerous human ovary and their inter-relationship
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 234, Herzl Street, Rehovot 76100, Israel
    Acta Histochem 115:330-8. 2013
  5. doi request reprint Differential localization of LGR5 and Nanog in clusters of colon cancer stem cells
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 234, Herzl Street, Rehovot 76100, Israel
    Acta Histochem 115:320-9. 2013
  6. doi request reprint LGR5 and Nanog identify stem cell signature of pancreas beta cells which initiate pancreatic cancer
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 234, Herzl Street, Rehovot 76100, Israel
    Biochem Biophys Res Commun 433:157-62. 2013
  7. doi request reprint Use of multiple biomarkers for the localization and characterization of colon cancer stem cells by indirect immunocytochemistry
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Int J Oncol 41:285-91. 2012
  8. doi request reprint Differential staining of γ synuclein in poorly differentiated compared to highly differentiated colon cancer cells
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Oncol Rep 27:1451-4. 2012
  9. doi request reprint Two initiation sites of early detection of colon cancer, revealed by localization of pERK1/2 in the nuclei or in aggregates at the perinuclear region of tumor cells
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Int J Oncol 40:782-8. 2012
  10. ncbi request reprint The anti-inflammatory action of glucocorticoids is mediated by cell type specific regulation of apoptosis
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 76100, Rehovot, Israel
    Mol Cell Endocrinol 189:1-9. 2002

Collaborators

Detail Information

Publications57

  1. ncbi request reprint TADG-12 as an early marker in the development of pancreatic ductal adenocarcinoma (PDAC): Involvement of insulin containing cells
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 234 Herzl Street, Rehovot 76100, Israel Electronic address
    Acta Histochem 116:781-7. 2014
    ..The present findings may assist in early detection of PDAC as well as targeting of TADG-12 in order to attenuate the rapid progression of the disease. ..
  2. doi request reprint Modulation of c-kit expression in pancreatic adenocarcinoma: a novel stem cell marker responsible for the progression of the disease
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 234 Herzl Street, Rehovot 76100, Israel Electronic address
    Acta Histochem 116:197-203. 2014
    ..The use of specific drugs that can attenuate the kinase activity of c-kit or target KRAS expressing cancer cells should be tested in order to attenuate the progression of this lethal disease. ..
  3. doi request reprint Two initiation sites of early detection of colon cancer revealed by localization of pERK1/2 in the nuclei or in aggregates at the perinuclear region of the tumor cells
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Acta Histochem 115:569-76. 2013
    ....
  4. doi request reprint Localization of the stem cell markers LGR5 and Nanog in the normal and the cancerous human ovary and their inter-relationship
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 234, Herzl Street, Rehovot 76100, Israel
    Acta Histochem 115:330-8. 2013
    ..Moreover, targeting of Nanog by inhibitory miRNA or other means may assist in treating this disease...
  5. doi request reprint Differential localization of LGR5 and Nanog in clusters of colon cancer stem cells
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 234, Herzl Street, Rehovot 76100, Israel
    Acta Histochem 115:320-9. 2013
    ..Alternatively, combined application of specific inhibitory miRNAs to Nanog and to LGR5 expression may assist therapeutically...
  6. doi request reprint LGR5 and Nanog identify stem cell signature of pancreas beta cells which initiate pancreatic cancer
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 234, Herzl Street, Rehovot 76100, Israel
    Biochem Biophys Res Commun 433:157-62. 2013
    ..This discovery may facilitate treatment of this devastating cancer...
  7. doi request reprint Use of multiple biomarkers for the localization and characterization of colon cancer stem cells by indirect immunocytochemistry
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Int J Oncol 41:285-91. 2012
    ..Thus, they can serve as multiple biomarkers for the localization of colon cancer stem cells by indirect immunofluorescence...
  8. doi request reprint Differential staining of γ synuclein in poorly differentiated compared to highly differentiated colon cancer cells
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Oncol Rep 27:1451-4. 2012
    ....
  9. doi request reprint Two initiation sites of early detection of colon cancer, revealed by localization of pERK1/2 in the nuclei or in aggregates at the perinuclear region of tumor cells
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Int J Oncol 40:782-8. 2012
    ....
  10. ncbi request reprint The anti-inflammatory action of glucocorticoids is mediated by cell type specific regulation of apoptosis
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 76100, Rehovot, Israel
    Mol Cell Endocrinol 189:1-9. 2002
    ....
  11. ncbi request reprint Cell-specific regulation of apoptosis by glucocorticoids: implication to their anti-inflammatory action
    Abraham Amsterdam
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Biochem Pharmacol 64:843-50. 2002
    ..Moreover, the complementary action of glucocorticoids provides a new insight to the therapeutic potential of these hormones...
  12. doi request reprint Epiregulin as a marker for the initial steps of ovarian cancer development
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Int J Oncol 39:1165-72. 2011
    ..Moreover, the cytoplasmic aggregation of Ep may suggest a specific mechanism of the release of this growth factor to the extracellular space in order to exert its autocrine and paracrine effect on the family of the EGF receptors...
  13. ncbi request reprint Analysis of signal transduction stimulated by gonadotropins in granulosa cells
    A Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell Endocrinol 202:77-80. 2003
    ..Steroidogenic factor-1 and DAX-1 may be involved in the regulation of the MAPK-dependent attenuation of steroidogenesis, since they exhibit sites that could be potentially phosphorylated by the MAPK cascade...
  14. ncbi request reprint Novel genes regulated by gonadotropins in granulosa cells: new perspectives on their physiological functions
    A Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Mol Cell Endocrinol 202:133-7. 2003
    ....
  15. doi request reprint Nuclear localization of phosphorylated ERK1 and ERK2 as markers for the progression of ovarian cancer
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Int J Oncol 39:649-56. 2011
    ....
  16. ncbi request reprint Mechanisms of gonadotropin desensitization
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 76100, Rehovot, Israel
    Mol Cell Endocrinol 187:69-74. 2002
    ....
  17. ncbi request reprint Steroidogenesis and apoptosis in the mammalian ovary
    Abraham Amsterdam
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Steroids 68:861-7. 2003
    ..This unique apoptotic pathway assures cyclicity of estradiol and progesterone release in the estrous/menstruous cycle even during the initial stages of apoptosis...
  18. ncbi request reprint Alternative pathways of ovarian apoptosis: death for life
    A Amsterdam
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Biochem Pharmacol 66:1355-62. 2003
    ..This unique apoptotic pathway assures the cyclicity of estradiol and progesterone release in the estrus/menstrus cycle even during the initial stage of apoptosis...
  19. ncbi request reprint Apoptosis of granulosa cells and female infertility in achondroplastic mice expressing mutant fibroblast growth factor receptor 3G374R
    A Amsterdam
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Endocrinol 15:1610-23. 2001
    ..Moreover, it is suggested that the infertile phenotype is partially due to defects in the pituitary-gonadal axis...
  20. ncbi request reprint The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis
    R Seger
    Departments of Biological Regulation and Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 71600, Israel
    J Biol Chem 276:13957-64. 2001
    ..The activation of ERK by gonadotropins as well as by other agents may be a key mechanism for the modulation of gonadotropin-induced steroidogenesis...
  21. ncbi request reprint Leptin attenuates follicular apoptosis and accelerates the onset of puberty in immature rats
    B Almog
    Department of Molecular Cell Biology, Weizmann Institute of Science, 76100 Rehovot, Israel
    Mol Cell Endocrinol 183:179-91. 2001
    ..Our data suggests that leptin may be involved in accelerating follicular maturation by attenuating follicular atresia and increasing the ratio of Bcl-2/Bax...
  22. ncbi request reprint EGF-like factor epiregulin and amphiregulin expression is regulated by gonadotropins/cAMP in human ovarian follicular cells
    S Freimann
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Biochem Biophys Res Commun 324:829-34. 2004
    ..It is suggested that upregulation of the epiregulin and amphiregulin expression is part of the signal transduction pathway which leads to ovulation and luteinization in the human ovary...
  23. doi request reprint EGF-like growth factors as LH mediators in the human corpus luteum
    I Ben-Ami
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Hum Reprod 24:176-84. 2009
    ..This study aims to investigate the role of epidermal growth factor-like ligands, amphiregulin (Ar) and epiregulin (Ep), in regulation of apoptosis in luteinized human granulosa cells...
  24. ncbi request reprint Leptin modulates the glucocorticoid-induced ovarian steroidogenesis
    D Barkan
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Endocrinology 140:1731-8. 1999
    ..A direct action of leptin on the ovary is an additional element of a regulatory network that maintains the homeostasis of steroid production...
  25. ncbi request reprint PGE2 up-regulates EGF-like growth factor biosynthesis in human granulosa cells: new insights into the coordination between PGE2 and LH in ovulation
    I Ben-Ami
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Mol Hum Reprod 12:593-9. 2006
    ..The negative effect of nimesulide on the ovulatory process may be due to the reduction of Ar and Ep biosynthesis, which implies a possible collaborative role between PGE(2) and LH on their induction...
  26. ncbi request reprint Induction of Ad4BP/SF-1, steroidogenic acute regulatory protein, and cytochrome P450scc enzyme system expression in newly established human granulosa cell lines
    K Hosokawa
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Endocrinology 139:4679-87. 1998
    ..Only moderate reduction in ADX staining was evident in cells costimulated with FK and TPA. These unique cell lines can provide a useful model for the investigation of induced steroidogenesis in human granulosa cells...
  27. pmc Introduction of a gonadotropin receptor expression plasmid into immortalized granulosa cells leads to reconstitution of hormone-dependent steroidogenesis
    B S Suh
    Department of Hormone Research, Weizmann Institute of Science, Rehovot
    J Cell Biol 119:439-50. 1992
    ....
  28. ncbi request reprint Establishment of FSH-responsive cell lines by transfection of pre-ovulatory human granulosa cells with mutated p53 (p53val135) and Ha-ras genes
    K Tajima
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Hum Reprod 8:48-57. 2002
    ..Moreover, this system lends itself to studies on cross-talk between the endocrine and paracrine factors that control these processes...
  29. ncbi request reprint Role of laminin in ovarian cancer tumor growth and metastasis via regulation of Mdm2 and Bcl-2 expression
    Y Yoshida
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Int J Oncol 18:913-21. 2001
    ..IKVAV probably enhances tumor growth and metastasis by another mechanism...
  30. ncbi request reprint Induction of polycystic ovary by testosterone in immature female rats: Modulation of apoptosis and attenuation of glucose/insulin ratio
    R Beloosesky
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Int J Mol Med 14:207-15. 2004
    ..Moreover, normal/low glucose and high insulin blood levels in the testosterone treated rats raises the possibility that elevated androgens can lead to insulin resistance in this experimental PCOS model...
  31. ncbi request reprint The proteasome inhibitor MG132 promotes accumulation of the steroidogenic acute regulatory protein (StAR) and steroidogenesis
    K Tajima
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    FEBS Lett 490:59-64. 2001
    ....
  32. ncbi request reprint Activation of multiple signal transduction pathways by glucocorticoids: protection of ovarian follicular cells against apoptosis
    R Sasson
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 76100, Rehovot, Israel
    Biochem Biophys Res Commun 311:1047-56. 2003
    ..Moreover, for the first time we show that protein phosphorylation, cell-cell contact, and intracellular communication are important mediators in glucocorticoid protection against apoptosis in ovarian follicular cells...
  33. ncbi request reprint Gonadotrophin-induced gene regulation in human granulosa cells obtained from IVF patients. Modulation of steroidogenic genes, cytoskeletal genes and genes coding for apoptotic signalling and protein kinases
    R Sasson
    Department of Molecular Cell Biology, The Weizmann Institute of Science Rehovot, 76100, Israel
    Mol Hum Reprod 10:299-311. 2004
    ..These proteins may be involved in a unique alternative pathway of ovarian cell death. Such a pathway could temporarily preserve the mitochondria and progesterone production during the initial stages of granulosa cell apoptosis...
  34. ncbi request reprint Establishment and characterization of steroidogenic granulosa cells expressing beta(2)-adrenergic receptor: regulation of adrenodoxin and steroidogenic acute regulatory protein by adrenergic agents
    N Selvaraj
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 76100, Rehovot, Israel
    Mol Cell Endocrinol 168:53-63. 2000
    ..Thus, this cell line could serve as a good model system to study catecholamine mediated regulation of growth and differentiation of granulosa cells and the role of oncogenes in this process...
  35. ncbi request reprint Drug development for ovarian hyper-stimulation and anti-cancer treatment: blocking of gonadotropin signaling for epiregulin and amphiregulin biosynthesis
    S Freimann
    Department of Molecular Cell Biology, The Weizmann Institute of Science Rehovot, Rehovot, Israel
    Biochem Pharmacol 68:989-96. 2004
    ....
  36. ncbi request reprint Differentiation-controlled synthesis and binding of thrombospondin to granulosa cells
    M Dreyfus
    Department of Polymer Research, Weizmann Institute of Science, Rehovot, Israel
    Endocrinology 130:2565-70. 1992
    ....
  37. ncbi request reprint Expression of heparanase, Mdm2, and erbB2 in ovarian cancer
    S Ginath
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Int J Oncol 18:1133-44. 2001
    ..Although heparanase activity seems to play an essential role in tumor progression, expression of oncogenes, such as erbB2 and Mdm2 seems to play the dominant role in the development of ovarian cancer...
  38. ncbi request reprint Pleiotropic anti-apoptotic activity of glucocorticoids in ovarian follicular cells
    R Sasson
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Biochem Pharmacol 66:1393-401. 2003
    ..The anti-apoptotic effect of GC may play an important role in the healing process of the ovulatory follicle subsequent to follicular rupture and its rapid conversion to an active corpus luteum...
  39. ncbi request reprint Gonadotropin-releasing hormone activates phospholipase D in ovarian granulosa cells. Possible role in signal transduction
    M Liscovitch
    Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel
    J Biol Chem 264:11762-7. 1989
    ..Phospholipase D activity can be independently regulated also by protein kinase C. The possible interrelationships between phospholipase D and other phospholipases which may be activated by GnRH in these ovarian cells are discussed...
  40. ncbi request reprint Partial sequencing of the rat steroidogenic acute regulatory protein message from immortalized granulosa cells: regulation by gonadotropins and isoproterenol
    N Selvaraj
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Mol Cell Endocrinol 123:171-7. 1996
    ..In addition, we find that the rat StAR cDNA exhibit a high degree of homology with the mouse and human sequences...
  41. ncbi request reprint Induction of apoptosis in granulosa cells by TNF alpha and its attenuation by glucocorticoids involve modulation of Bcl-2
    Ravid Sasson
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Biochem Biophys Res Commun 294:51-9. 2002
    ....
  42. ncbi request reprint Down-regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen-activated protein kinase activation and modulation of DAX-1 and steroidogenic factor-1
    Kimihisa Tajima
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 71600, Israel
    J Clin Endocrinol Metab 88:2288-99. 2003
    ..Moreover, modulation of DAX-1 and SF-1 intracellular levels in these cells suggests that these transcription factors could be involved in MAPK suppression of StAR expression...
  43. ncbi request reprint Novel function of ovarian growth factors: combined studies by DNA microarray, biochemical and physiological approaches
    Ido Ben-Ami
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Hum Reprod 12:413-9. 2006
    ..Future investigations using DNA microarray technique may reveal the repertoire of genes activated in Ar- and Ep-stimulated cumulus cells and may help elucidate the molecular basis of ovulation...
  44. ncbi request reprint Desensitization to gonadotropic hormones: a model system for the regulation of a G-protein-coupled receptor with 7-transmembrane spanning regions
    Liron Hirsh
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Biochem Biophys Res Commun 326:1-6. 2005
    ..A common and diverse feature of the mechanism of desensitization in other G-coupled-7-transmembrane receptor system is also discussed...
  45. ncbi request reprint Novel genes modulated by FSH in normal and immortalized FSH-responsive cells: new insights into the mechanism of FSH action
    Ravid Sasson
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    FASEB J 17:1256-66. 2003
    ....
  46. ncbi request reprint Ovarian transcriptomes as a tool for a global approach of genes modulated by gonadotropic hormones in human ovarian granulosa cells
    Sarit Friedmann
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Endocrine 26:259-65. 2005
    ..However, because of the pitfalls in interpreting the data other approaches, for example, Northern blots and RT-PCR must be conducted in parallel to verify the validity of the data...
  47. ncbi request reprint Stimulation of apoptosis in human granulosa cells from in vitro fertilization patients and its prevention by dexamethasone: involvement of cell contact and bcl-2 expression
    Ravid Sasson
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Clin Endocrinol Metab 87:3441-51. 2002
    ..Moreover, the integrity of gap junctions and the actin cytoskeleton as well as elevated levels of Bcl-2 may play an important role in the suppression of apoptosis of human granulosa cells...
  48. ncbi request reprint Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis
    Y R Hadari
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel weizmann ac il
    J Cell Sci 113:2385-97. 2000
    ..Binding of galectin-8 modulates integrin interactions with the extracellular matrix and thus regulates cell adhesion and cell survival...
  49. ncbi request reprint Leptin induces ovulation in GnRH-deficient mice
    Dalit Barkan
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    FASEB J 19:133-5. 2005
    ..These data show that on top of its role as an inducer of GnRH secretion, leptin may elicit an LH-independent ovulation...
  50. ncbi request reprint Differential expression of genes coding for EGF-like factors and ADAMTS1 following gonadotropin stimulation in normal and transformed human granulosa cells
    Sarit Freimann
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Biochem Biophys Res Commun 333:935-43. 2005
    ....
  51. ncbi request reprint Luteinizing hormone-induced extracellular-signal regulated kinase activation differently modulates progesterone and androstenedione production in bovine theca cells
    Kimihisa Tajima
    Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Matsuoka, Fukui 910 1193, Japan
    Endocrinology 146:2903-10. 2005
    ..Furthermore, modulation of ERK phosphorylation involves control of thecal steroidogenesis via modulation of the expression of steroidogenic acute regulatory protein and P450c17...
  52. ncbi request reprint Effects of ovarian theca cells on apoptosis and proliferation of granulosa cells: changes during bovine follicular maturation
    Kimihisa Tajima
    Department of Obstetrics and Gynecology, Fukui Medical University, Fukui 910 1193, Japan
    Biol Reprod 66:1635-9. 2002
    ..The present study suggests that theca cells regulate the fate of granulosa cells throughout the follicular maturation process by secreting factors that suppress apoptosis...
  53. doi request reprint The configuration of the alpha and beta subunit domains in single-chain bovine LH analogs influences the secretion and steroidogenic response
    Moran Grinberg
    Department of Clinical Pharmacology, The Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Mol Cell Endocrinol 283:83-95. 2008
    ..Our data demonstrate major differences in steroid balance following stimulation of the receptor with structural LH analogs and provide further insight into gonadotrophin regulation of ovarian steroid production...
  54. ncbi request reprint WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cells
    Bilgin Gurates
    Departments of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Illinois at Chicago, 820 S Wood Street, M C 808, Chicago, IL 60612, USA
    Mol Cell Endocrinol 208:61-75. 2003
    ..Given the characterized roles of these transcription factors in gonadal development and function, modulation of SF-1 action by WT1 and DAX-1 may represent an important key mechanism in steroidogenesis...
  55. ncbi request reprint Silencing of ZnT-1 expression enhances heavy metal influx and toxicity
    Ehud Ohana
    Department of Physiology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, 84105, Israel
    J Mol Med (Berl) 84:753-63. 2006
    ..Taken together, our results indicate that endogenously-expressed ZnT-1, by modulating LTCC, has a dual role: regulating calcium influx, and attenuating Cd(2+) and Zn(2+) permeation and toxicity in neurons and other cell types...
  56. ncbi request reprint Characterization of biologically active bovine pituitary FSH purified by immunoaffinity chromatography using a monoclonal antibody
    Vitaliano Borromeo
    Department of Veterinary Pathology, Hygiene and Health, Biochemistry and Physiology Unit, University of Milan, Via Celoria 10, I 20133 Milan, Italy
    Gen Comp Endocrinol 139:179-89. 2004
    ....
  57. pmc FSH regulates acetycholine production by ovarian granulosa cells
    Artur Mayerhofer
    Anatomisches Institut der Universität München, Deutschland
    Reprod Biol Endocrinol 4:37. 2006
    ..To gain further insights into the possible role of ACh in the ovary, we examined ChAT expression in the gland before and after birth, as well as in adults, and studied the regulation of ACh production by FSH...