Affiliation: Weizmann Institute of Science
Schreiber L, Raanan C, Amsterdam A. CD24 and Nanog identify stem cells signature of ovarian epithelium and cysts that may develop to ovarian cancer. Acta Histochem. 2014;116:399-406 pubmed publisher
..Finally, since CD24 is exposed on the surface of the cancer cells, it may be highly beneficial to target these cells with antibodies to CD24 conjugated to cytotoxic drugs for more efficient treatment of this malignant disease. ..
Amsterdam A, Raanan C, Schreiber L, Freyhan O, Fabrikant Y, Melzer E, et al
. Differential localization of LGR5 and Nanog in clusters of colon cancer stem cells. Acta Histochem. 2013;115:320-9 pubmed publisher
..Alternatively, combined application of specific inhibitory miRNAs to Nanog and to LGR5 expression may assist therapeutically. ..
Amsterdam A, Tajima K, Frajese V, Seger R. Analysis of signal transduction stimulated by gonadotropins in granulosa cells. Mol Cell Endocrinol. 2003;202:77-80 pubmed
..Steroidogenic factor-1 and DAX-1 may be involved in the regulation of the MAPK-dependent attenuation of steroidogenesis, since they exhibit sites that could be potentially phosphorylated by the MAPK cascade. ..
Amsterdam A, Shpigner L, Raanan C, Schreiber L, Melzer E, Seger R. Dynamic distribution of ERK, p38 and JNK during the development of pancreatic ductal adenocarcinoma. Acta Histochem. 2014;116:1434-42 pubmed publisher
..It is suggested that using inhibitors to protein kinases may attenuate the progression of the disease. ..
Amsterdam A, Hanoch T, Dantes A, Tajima K, Strauss J, Seger R. Mechanisms of gonadotropin desensitization. Mol Cell Endocrinol. 2002;187:69-74 pubmed
Amsterdam A, Shezen E, Raanan C, Slilat Y, Ben Arie A, Prus D, et al
. Epiregulin as a marker for the initial steps of ovarian cancer development. Int J Oncol. 2011;39:1165-72 pubmed publisher
..Moreover, the cytoplasmic aggregation of Ep may suggest a specific mechanism of the release of this growth factor to the extracellular space in order to exert its autocrine and paracrine effect on the family of the EGF receptors. ..
Amsterdam A, Shezen E, Raanan C, Schreiber L, Slilat Y, Fabrikant Y, et al
. Differential staining of ? synuclein in poorly differentiated compared to highly differentiated colon cancer cells. Oncol Rep. 2012;27:1451-4 pubmed publisher
Amsterdam A, Raanan C, Schreiber L, Freyhan O, Schechtman L, Givol D. Localization of the stem cell markers LGR5 and Nanog in the normal and the cancerous human ovary and their inter-relationship. Acta Histochem. 2013;115:330-8 pubmed publisher
..Moreover, targeting of Nanog by inhibitory miRNA or other means may assist in treating this disease. ..
Amsterdam A, Raanan C, Polin N, Melzer E, Givol D, Schreiber L. Modulation of c-kit expression in pancreatic adenocarcinoma: a novel stem cell marker responsible for the progression of the disease. Acta Histochem. 2014;116:197-203 pubmed publisher
..The use of specific drugs that can attenuate the kinase activity of c-kit or target KRAS expressing cancer cells should be tested in order to attenuate the progression of this lethal disease. ..