Ido Amit

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. Cohen M, Matcovitch O, David E, Barnett Itzhaki Z, Keren Shaul H, Blecher Gonen R, et al. Chronic exposure to TGFβ1 regulates myeloid cell inflammatory response in an IRF7-dependent manner. EMBO J. 2014;33:2906-21 pubmed publisher
    ..These results highlight the key role of tissue-specific environmental factors in determining the fate of resident myeloid-derived cells under both physiological and pathological conditions. ..
  2. Blecher Gonen R, Bost P, Hilligan K, David E, Salame T, Roussel E, et al. Single-Cell Analysis of Diverse Pathogen Responses Defines a Molecular Roadmap for Generating Antigen-Specific Immunity. Cell Syst. 2019;8:109-121.e6 pubmed publisher
    ..Our systems immunology approach sheds light on early events in innate immune responses and may help further development of safe and efficient vaccines. ..
  3. Li H, van der Leun A, Yofe I, Lubling Y, Gelbard Solodkin D, van Akkooi A, et al. Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma. Cell. 2019;176:775-789.e18 pubmed publisher
    ..Our data demonstrate that CD8 T cells previously defined as exhausted are in fact a highly proliferating, clonal, and dynamically differentiating cell population within the human tumor microenvironment. ..
  4. Ledergor G, Weiner A, Zada M, Wang S, Cohen Y, Gatt M, et al. Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma. Nat Med. 2018;24:1867-1876 pubmed publisher
    ..Our work establishes single cell RNA sequencing for dissecting blood malignancies and devising detailed molecular characterization of tumor cells in symptomatic and asymptomatic patients. ..
  5. Cohen M, Giladi A, Gorki A, Solodkin D, Zada M, Hladik A, et al. Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting. Cell. 2018;175:1031-1044.e18 pubmed publisher
    ..Together, our study demonstrates how whole-tissue signaling interaction map on the single-cell level can broaden our understanding of cellular networks in health and disease. ..
  6. Jaitin D, Keren Shaul H, Elefant N, Amit I. Each cell counts: Hematopoiesis and immunity research in the era of single cell genomics. Semin Immunol. 2015;27:67-71 pubmed publisher
    ..In the near future, the accuracy of single-cell genomics will ultimately enable precise diagnostics and treatment of multiple hematopoietic and immune related diseases. ..
  7. Bornstein C, Nevo S, Giladi A, Kadouri N, Pouzolles M, Gerbe F, et al. Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells. Nature. 2018;559:622-626 pubmed publisher
    ..Overall, our study provides a comprehensive characterization of the thymic stroma and identifies a new tuft-like TEC population, which is critical for shaping the immune niche in the thymus. ..
  8. Bornstein C, Winter D, Barnett Itzhaki Z, David E, Kadri S, Garber M, et al. A negative feedback loop of transcription factors specifies alternative dendritic cell chromatin States. Mol Cell. 2014;56:749-62 pubmed publisher
    ..More broadly, our study proposes a general paradigm that allows closely related cells with a similar set of signal-dependent factors to generate differential and persistent enhancer landscapes. ..
  9. Giladi A, Paul F, Herzog Y, Lubling Y, Weiner A, Yofe I, et al. Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis. Nat Cell Biol. 2018;20:836-846 pubmed publisher
    ..Our transcriptional map defines a reference network model for blood progenitors and their differentiation trajectories during normal and perturbed haematopoiesis. ..

More Information

Publications20

  1. Steuerman Y, Cohen M, Peshes Yaloz N, Valadarsky L, Cohn O, David E, et al. Dissection of Influenza Infection In Vivo by Single-Cell RNA Sequencing. Cell Syst. 2018;6:679-691.e4 pubmed publisher
    ..These findings open new avenues for targeted therapy aimed exclusively at infected cells. ..
  2. Deczkowska A, Keren Shaul H, Weiner A, Colonna M, Schwartz M, Amit I. Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration. Cell. 2018;173:1073-1081 pubmed publisher
  3. Giladi A, Amit I. Single-Cell Genomics: A Stepping Stone for Future Immunology Discoveries. Cell. 2018;172:14-21 pubmed publisher
    ..In this Perspective, we consider recent and forthcoming technological and analytical advances in single-cell genomics and the potential impact of those advances on the future of immunology research and immunotherapy. ..
  4. Gury BenAri M, Thaiss C, Serafini N, Winter D, Giladi A, Lara Astiaso D, et al. The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome. Cell. 2016;166:1231-1246.e13 pubmed publisher
  5. Mildner A, Schönheit J, Giladi A, David E, Lara Astiaso D, Lorenzo Vivas E, et al. Genomic Characterization of Murine Monocytes Reveals C/EBP? Transcription Factor Dependence of Ly6C- Cells. Immunity. 2017;46:849-862.e7 pubmed publisher
    ..Mechanistically, C/EBP? bound the Nr4a1 promoter and controlled expression of this established monocyte survival factor. ..
  6. Jaitin D, Weiner A, Yofe I, Lara Astiaso D, Keren Shaul H, David E, et al. Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq. Cell. 2016;167:1883-1896.e15 pubmed publisher
    ..This study establishes CRISP-seq as a broadly applicable, comprehensive, and unbiased approach for elucidating mammalian regulatory circuits. ..
  7. Talmi Frank D, Altboum Z, Solomonov I, Udi Y, Jaitin D, Klepfish M, et al. Extracellular Matrix Proteolysis by MT1-MMP Contributes to Influenza-Related Tissue Damage and Mortality. Cell Host Microbe. 2016;20:458-470 pubmed publisher
    ..This study highlights the importance of tissue resilience in surviving infection and the potential of such host-pathogen therapy combinations for respiratory infections. ..
  8. Deczkowska A, Matcovitch Natan O, Tsitsou Kampeli A, Ben Hamo S, Dvir Szternfeld R, Spinrad A, et al. Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner. Nat Commun. 2017;8:717 pubmed publisher
    ..Here the authors show that the chronic presence of type I interferon in aged mouse brain impedes cognitive ability by altering microglia transcriptome and limiting Mef2C, a microglia 'off' signal. ..
  9. Keren Shaul H, Spinrad A, Weiner A, Matcovitch Natan O, Dvir Szternfeld R, Ulland T, et al. A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease. Cell. 2017;169:1276-1290.e17 pubmed publisher
    ..This unique microglia-type has the potential to restrict neurodegeneration, which may have important implications for future treatment of AD and other neurodegenerative diseases. VIDEO ABSTRACT. ..
  10. Paul F, Arkin Y, Giladi A, Jaitin D, Kenigsberg E, Keren Shaul H, et al. Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors. Cell. 2015;163:1663-77 pubmed publisher
    ..These data establish a reference model and general framework for studying hematopoiesis at single-cell resolution. ..
  11. Lavin Y, Winter D, Blecher Gonen R, David E, Keren Shaul H, Merad M, et al. Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell. 2014;159:1312-26 pubmed publisher
    ..These results provide a comprehensive view of macrophage regulatory landscape and highlight the importance of the microenvironment, along with pioneer factors in orchestrating identity and plasticity. ..