Ronen Alon

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. ncbi request reprint Right on the spot. Chemokine triggering of integrin-mediated arrest of rolling leukocytes
    Carlo Laudanna
    Department of Pathology, University of Verona, Italy
    Thromb Haemost 95:5-11. 2006
  2. doi request reprint A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells
    Tanja Nicole Hartmann
    The Weizmann Institute of Science, Rehovot, 76100, Israel
    J Leukoc Biol 84:1130-40. 2008
  3. pmc A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets
    Ronit Pasvolsky
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Exp Med 204:1571-82. 2007
  4. doi request reprint Blood vessels pattern heparan sulfate gradients between their apical and basolateral aspects
    Liat Stoler-Barak
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    PLoS ONE 9:e85699. 2014
  5. doi request reprint Chemokine-triggered leukocyte arrest: force-regulated bi-directional integrin activation in quantal adhesive contacts
    Ronen Alon
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Curr Opin Cell Biol 24:670-6. 2012
  6. ncbi request reprint Trapped versus soluble chemokines: functions in leukocyte adhesion and motility
    Ronen Alon
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Immunity 33:654-6. 2010
  7. pmc Chemokine arrest signals to leukocyte integrins trigger bi-directional-occupancy of individual heterodimers by extracellular and cytoplasmic ligands
    Ronen Alon
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Cell Adh Migr 4:211-4. 2010
  8. doi request reprint Chemokine signaling to lymphocyte integrins under shear flow
    Ronen Alon
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Microcirculation 16:3-16. 2009
  9. pmc Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain
    Ronen Alon
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 171:1073-84. 2005
  10. doi request reprint Cells on the run: shear-regulated integrin activation in leukocyte rolling and arrest on endothelial cells
    Ronen Alon
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Curr Opin Cell Biol 20:525-32. 2008

Detail Information

Publications67

  1. ncbi request reprint Right on the spot. Chemokine triggering of integrin-mediated arrest of rolling leukocytes
    Carlo Laudanna
    Department of Pathology, University of Verona, Italy
    Thromb Haemost 95:5-11. 2006
    ....
  2. doi request reprint A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells
    Tanja Nicole Hartmann
    The Weizmann Institute of Science, Rehovot, 76100, Israel
    J Leukoc Biol 84:1130-40. 2008
    ..Our findings suggest that although CXCR7 is not an intrinsic signaling receptor for CXCL12 on lymphocytes or CD34(+) cells, its blocking can be useful for therapeutic interference with CXCR4-mediated activation of integrins...
  3. pmc A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets
    Ronit Pasvolsky
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Exp Med 204:1571-82. 2007
    ..Chemokine-triggered VLA-4 adhesiveness in T lymphocytes was partially defective as well. These studies identify CalDAG-GEFI as a critical regulator of inside-out integrin activation in human T lymphocytes, neutrophils, and platelets...
  4. doi request reprint Blood vessels pattern heparan sulfate gradients between their apical and basolateral aspects
    Liat Stoler-Barak
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    PLoS ONE 9:e85699. 2014
    ..We propose that chemokine gradients between the lumenal and ablumenal sides of vessels could be favored by these sharp HS scaffold gradients. ..
  5. doi request reprint Chemokine-triggered leukocyte arrest: force-regulated bi-directional integrin activation in quantal adhesive contacts
    Ronen Alon
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Curr Opin Cell Biol 24:670-6. 2012
    ....
  6. ncbi request reprint Trapped versus soluble chemokines: functions in leukocyte adhesion and motility
    Ronen Alon
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Immunity 33:654-6. 2010
    ..2010) provide in vivo evidence that heparan sulfate glycosaminoglycans (GAGs) are indispensable for immobilization and function of major chemokines required for leukocyte adhesion to and crossing through blood and lymphatic vessels...
  7. pmc Chemokine arrest signals to leukocyte integrins trigger bi-directional-occupancy of individual heterodimers by extracellular and cytoplasmic ligands
    Ronen Alon
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Cell Adh Migr 4:211-4. 2010
    ....
  8. doi request reprint Chemokine signaling to lymphocyte integrins under shear flow
    Ronen Alon
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Microcirculation 16:3-16. 2009
    ..In this article, we present an overview of both early and recent shear-flow studies of integrin activation in lymphocytes and discuss future perspectives of integrin activation research in vitro and in vivo...
  9. pmc Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain
    Ronen Alon
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 171:1073-84. 2005
    ....
  10. doi request reprint Cells on the run: shear-regulated integrin activation in leukocyte rolling and arrest on endothelial cells
    Ronen Alon
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Curr Opin Cell Biol 20:525-32. 2008
    ..Different leukocyte subsets appear to use different modalities of integrin activation during rolling and arrest at distinct endothelial sites...
  11. ncbi request reprint Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells
    Ronen Alon
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    Immunity 26:17-27. 2007
    ..Evidence suggests that preformed cytoskeletal anchorage rather than free integrin mobility is key for force-enhanced integrin activation by chemokines and TCR signals...
  12. doi request reprint Chemokine triggered integrin activation and actin remodeling events guiding lymphocyte migration across vascular barriers
    Ronen Alon
    Department of Immunology, The Weizmann Institute of Science, Rehovot, 76100 Israel
    Exp Cell Res 317:632-41. 2011
    ..We will review here major findings and open questions related to these sequential guiding activities of endothelial presented chemokines, focusing mainly on lymphocyte-endothelial interactions as a paradigm for other leukocytes...
  13. doi request reprint Kindlin-3 is required for the stabilization of TCR-stimulated LFA-1:ICAM-1 bonds critical for lymphocyte arrest and spreading on dendritic cells
    Sara W Feigelson
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Blood 117:7042-52. 2011
    ..We suggest that Kindlin-3 selectively contributes to a final TCR-triggered outside-in stabilization of bonds generated between chemokine-primed LFA-1 molecules and cell-surface ICAM-1...
  14. ncbi request reprint Chemokine stimulation of lymphocyte alpha 4 integrin avidity but not of leukocyte function-associated antigen-1 avidity to endothelial ligands under shear flow requires cholesterol membrane rafts
    Revital Shamri
    Department of Immunology, Weizmann Institute of Science, Rehovot, 76100 Israel
    J Biol Chem 277:40027-35. 2002
    ..Our results provide the first evidence that a particular chemokine/GPCR pair can activate different integrins on the same cell using distinct G(i) protein-associated machineries segregated within defined membrane compartments...
  15. ncbi request reprint Membranal cholesterol is not required for L-selectin adhesiveness in primary lymphocytes but controls a chemokine-induced destabilization of L-selectin rolling adhesions
    Oren Dwir
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Immunol 179:1030-8. 2007
    ..Thus, the regulation of L-selectin by cholesterol-enriched microdomains varies with the cell type as well as with the identity of the destabilizing chemokine...
  16. ncbi request reprint Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1
    Eugenia Manevich
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Biol Chem 282:25338-48. 2007
    ....
  17. ncbi request reprint A novel genetic leukocyte adhesion deficiency in subsecond triggering of integrin avidity by endothelial chemokines results in impaired leukocyte arrest on vascular endothelium under shear flow
    Ronen Alon
    Department of Immunology, The Weizmann Institute of Science Rehovot, Israel
    Blood 101:4437-45. 2003
    ..This syndrome is the first example of a human integrin-activation deficiency associated with defective GPCR stimulation of integrin avidity at subsecond contacts, a key step in leukocyte arrest on vascular endothelium under shear flow...
  18. ncbi request reprint Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines
    Revital Shamri
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Immunol 6:497-506. 2005
    ..These data show that chemokine-triggered lymphocyte adhesiveness involves a previously unrecognized extension step that primes LFA-1 for ligand binding and firm adhesion...
  19. doi request reprint Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions
    Eugenia Manevich-Mendelson
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    Blood 114:2344-53. 2009
    ..Deletion of the putative beta(1) Kindlin-3 binding site also retained VLA-4 adhesiveness. Thus, our study provides the first evidence that Kindlin-3 is more critical to LFA-1 than to VLA-4-adhesive functions in human lymphocytes...
  20. ncbi request reprint Enzymatically quiescent heparanase augments T cell interactions with VCAM-1 and extracellular matrix components under versatile dynamic contexts
    Ilya Sotnikov
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Immunol 172:5185-93. 2004
    ..These findings add another dimension to the known versatility of heparanase as a key regulator of T cell activities during inflammation, both in the context of the vasculature and at extravascular sites...
  21. ncbi request reprint RhoA is involved in LFA-1 extension triggered by CXCL12 but not in a novel outside-in LFA-1 activation facilitated by CXCL9
    Ronit Pasvolsky
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Immunol 180:2815-23. 2008
    ....
  22. ncbi request reprint Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces
    Eilon Woolf
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Immunol 8:1076-85. 2007
    ..Thus, lymph node chemokines that promote motility and strongly activate lymphocyte integrins under shear forces fail to stimulate stable integrin adhesiveness in extravascular shear-free environments...
  23. pmc Avidity enhancement of L-selectin bonds by flow: shear-promoted rotation of leukocytes turn labile bonds into functional tethers
    Oren Dwir
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 163:649-59. 2003
    ..L-selectin tethers appear adapted to undergo rapid avidity enhancement by cellular transport, a specialized mechanism not used by any other known adhesion receptor...
  24. ncbi request reprint DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not transendothelial migration
    Ziv Shulman
    Department of Immunology, The Weizmann Institute of Science, Rehovot, 76100, Israel
    Blood 108:2150-8. 2006
    ....
  25. ncbi request reprint Anti-inflammatory effects of an inflammatory chemokine: CCL2 inhibits lymphocyte homing by modulation of CCL21-triggered integrin-mediated adhesions
    Liat Flaishon
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Blood 112:5016-25. 2008
    ..Thus, pM levels of circulating CCL2 can exert global suppressive effects on T-cell trafficking and differentiation within peripheral lymph nodes, and may be clinically beneficial as an anti-inflammatory agent...
  26. doi request reprint Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen
    Eugenia Manevich-Mendelson
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Blood 116:5907-18. 2010
    ....
  27. pmc Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin
    Ziv Shulman
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Immunity 30:384-96. 2009
    ..We propose that shear forces exerted on HA-LFA-1 trigger adhesive and invasive filopodia at apical endothelial surfaces and thereby promote lymphocyte crawling and probing for TEM sites...
  28. doi request reprint Occupancy of lymphocyte LFA-1 by surface-immobilized ICAM-1 is critical for TCR- but not for chemokine-triggered LFA-1 conversion to an open headpiece high-affinity state
    Sara W Feigelson
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Immunol 185:7394-404. 2010
    ....
  29. doi request reprint Pathways implicated in stem cell migration: the SDF-1/CXCR4 axis
    Yaron Vagima
    Immunology Department, The Weizmann Institute of Science, Rehovot, Israel
    Methods Mol Biol 750:277-89. 2011
    ..Finally, other stem cell features such as stem cell survival and proliferation, are also dependent on the SDF-1/CXCR4 axis...
  30. doi request reprint Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots
    Ziv Shulman
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    Nat Immunol 13:67-76. 2012
    ..Thus, effector T lymphocytes can cross inflamed barriers through contact-guided consumption of intraendothelial chemokines without surface-deposited chemokines or extraendothelial chemokine gradients...
  31. pmc Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells
    Isabelle Petit
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Clin Invest 115:168-76. 2005
    ..Our results demonstrate a central role for PKC-zeta in SDF-1-dependent regulation of hematopoietic stem and progenitor cell motility and development...
  32. ncbi request reprint LAD-III, a leukocyte adhesion deficiency syndrome associated with defective Rap1 activation and impaired stabilization of integrin bonds
    Tatsuo Kinashi
    Department of Immunology, The Weizmann Institute of Science, Rehovot, 76100, Israel
    Blood 103:1033-6. 2004
    ..This is a first report of an inherited Rap1 activation defect associated with a pathologic disorder in leukocyte integrin function, we herein term it "LAD-III."..
  33. ncbi request reprint The CD81 tetraspanin facilitates instantaneous leukocyte VLA-4 adhesion strengthening to vascular cell adhesion molecule 1 (VCAM-1) under shear flow
    Sara W Feigelson
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel 76100
    J Biol Chem 278:51203-12. 2003
    ....
  34. ncbi request reprint Chemoattractant signals and beta 2 integrin occupancy at apical endothelial contacts combine with shear stress signals to promote transendothelial neutrophil migration
    Guy Cinamon
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Immunol 173:7282-91. 2004
    ....
  35. ncbi request reprint From rolling to arrest on blood vessels: leukocyte tap dancing on endothelial integrin ligands and chemokines at sub-second contacts
    Ronen Alon
    Department of Immunology, Weizmann Institute of Science, Rehovot, 76100 Israel
    Semin Immunol 14:93-104. 2002
    ..We discuss potential regulatory mechanisms by which a given set of chemokine receptors and integrins may interact to rapidly generate high avidity, shear-resistant integrin-mediated leukocyte arrest on vascular endothelium...
  36. doi request reprint Real-time analysis of integrin-dependent transendothelial migration and integrin-independent interstitial motility of leukocytes
    Ziv Shulman
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Methods Mol Biol 757:31-45. 2012
    ..Following fixation, subcellular changes in the distribution of integrin subsets and of specific integrin-associated adaptors can be further dissected by immunofluorescence tools and by ultrastructural electron microscopic analysis...
  37. doi request reprint The integrin coactivator Kindlin-3 is not required for lymphocyte diapedesis
    Shmuel J Cohen
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel and
    Blood 122:2609-17. 2013
    ..This is the first in vivo demonstration that Kindlin-3-stabilized integrin adhesions, although essential for lymphocyte arrest on blood vessels and interstitial motility, are not obligatory for leukocyte diapedesis. ..
  38. doi request reprint Chapter 14. Real-time in vitro assays for studying the role of chemokines in lymphocyte transendothelial migration under physiologic flow conditions
    Ziv Shulman
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Methods Enzymol 461:311-32. 2009
    ..After fixation, subcellular changes in the redistribution of these key molecules can be further dissected by immunofluorescence tools and by ultrastructural analysis based on scanning and transmission electron microscopy...
  39. ncbi request reprint CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow
    Abraham Avigdor
    Immunology Department, The Weizmann Institute of Science, Rehovot, Israel
    Blood 103:2981-9. 2004
    ..Taken together, our data suggest a key role for CD44 and HA in SDF-1-dependent transendothelial migration of HSCs/HPCs and their final anchorage within specific niches of the BM...
  40. ncbi request reprint Chemokine induction of integrin adhesiveness on rolling and arrested leukocytes local signaling events or global stepwise activation?
    Ronen Alon
    Department of Immunology, Weizmann Institute of Science, Rehovot, 76100 Israel
    Microcirculation 10:297-311. 2003
    ..We propose that these two mechanisms are differentially used by distinct leukocyte subsets at various vascular beds, providing much larger combinatorial diversity of integrin activation on rolling leukocytes than previously predicted...
  41. ncbi request reprint Real-time in vitro assay for studying chemoattractant-triggered leukocyte transendothelial migration under physiological flow conditions
    Guy Cinamon
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Methods Mol Biol 239:233-42. 2004
  42. ncbi request reprint L-selectin dimerization enhances tether formation to properly spaced ligand
    Oren Dwir
    Department of Immunology, Weizmann Institute of Science, Rehovot, 76100 Israel
    J Biol Chem 277:21130-9. 2002
    ..This is the first indication that shear stress augments effective selectin ligand density at local contact sites by promoting L-selectin encounter of immobilized ligand...
  43. ncbi request reprint Endothelial chemokines destabilize L-selectin-mediated lymphocyte rolling without inducing selectin shedding
    Valentin Grabovsky
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 277:20640-50. 2002
    ..This negative feedback mechanism may underlie the jerky nature of rolling mediated by L-selectin in vivo...
  44. ncbi request reprint A real time in vitro assay for studying leukocyte transendothelial migration under physiological flow conditions
    Guy Cinamon
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Immunol Methods 273:53-62. 2003
    ..In the present review, we describe this new flow-based migration assay and discuss future applications for investigating TEM processes of different types of leukocytes across distinct endothelial barriers...
  45. pmc TAp63 regulates VLA-4 expression and chronic lymphocytic leukemia cell migration to the bone marrow in a CD74-dependent manner
    Inbal Binsky
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Immunol 184:4761-9. 2010
    ..These results could form the basis of novel therapeutic strategies aimed at blocking homing of CLL cells in their return to the BM and attenuating their survival...
  46. ncbi request reprint LAD-III, a novel group of leukocyte integrin activation deficiencies
    Ronen Alon
    Department of Immunology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Trends Immunol 24:561-6. 2003
    ..Here, the mechanisms by which GPCRs might regulate leukocyte and platelet integrins are outlined with respect to this new family of LAD cases. We propose to term this the LAD-III family...
  47. doi request reprint Suppression of experimental autoimmune myasthenia gravis by inhibiting the signaling between IFN-gamma inducible protein 10 (IP-10) and its receptor CXCR3
    Tali Feferman
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Neuroimmunol 209:87-95. 2009
    ..Treatment by either of these reagents led to suppression of EAMG suggesting that inhibition of CXCR3/IP-10 signaling can be considered as a potential treatment modality for MG...
  48. doi request reprint Tumor suppressor death-associated protein kinase attenuates inflammatory responses in the lung
    Sigal Nakav
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Am J Respir Cell Mol Biol 46:313-22. 2012
    ..The DAPk-mediated suppression of lung inflammation and airway injury may contribute to the tumor-suppressor functions of this kinase in epithelial carcinogenesis...
  49. ncbi request reprint Transendothelial migration of effector T cells across inflamed endothelial barriers does not require heparan sulfate proteoglycans
    Liat Stoler-Barak
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Int Immunol 26:315-24. 2014
    ..In contrast, effector T cells can integrate chemotactic TEM signals directly from intra-endothelial chemokine stores rather than from externally deposited chemokines. ..
  50. ncbi request reprint TGF-beta1 enhances SDF-1alpha-induced chemotaxis and homing of naive T cells by up-regulating CXCR4 expression and downstream cytoskeletal effector molecules
    Susanne Franitza
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Eur J Immunol 32:193-202. 2002
    ..We propose that the effect of TGF-beta1 on the chemotaxis of naive T cells may be important in the locomotion of naive T cells toward SDF-1alpha-rich niches...
  51. pmc ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow
    Lin Yang
    Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB 752P, Boston, MA 02215, USA
    Blood 106:584-92. 2005
    ..In summary, ICAM-1 promotes junctional and nonjunctional TEM across inflamed vascular endothelium via distinct cytoplasmic tail associations...
  52. pmc Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm
    Taylor H Schreiber
    Harvard Skin Disease Research Center and the Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 109:1381-6. 2007
    ....
  53. pmc Measurement of selectin tether bond lifetimes
    Timothy A Springer
    Biophys J 83:2318-20; author reply 2320-3. 2002
  54. ncbi request reprint Integrin modulation and signaling in leukocyte adhesion and migration
    David M Rose
    Department of Medicine, University of California, and VA Healthcare System, San Diego, CA, USA
    Immunol Rev 218:126-34. 2007
    ..We describe mechanisms through which alpha4beta1 integrin signaling regulates appropriate Rac activation to drive leukocyte migration...
  55. ncbi request reprint Immature leukemic CD34+CXCR4+ cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1
    Amnon Peled
    Hadassah University Hospital, Gene Therapy Institutem, Jerusalem, Israel
    Stem Cells 20:259-66. 2002
    ..These findings suggest a major role for SDF-1-mediated, integrin-dependent BM retention of Ph+CD34+ cells...
  56. ncbi request reprint Role of CXCR3 carboxyl terminus and third intracellular loop in receptor-mediated migration, adhesion and internalization in response to CXCL11
    Michal Dagan-Berger
    Gene Therapy Institute, Hadassah University Hospital, PO Box 12000, Jerusalem, Israel
    Blood 107:3821-31. 2006
    ..Thus, distinct conformational changes induced by a given CXCR3 ligand trigger different downstream effectors of adhesion, motility, and CXCR3 desensitization...
  57. ncbi request reprint Differential usage of VLA-4 and CXCR4 by CD3+CD56+ NKT cells and CD56+CD16+ NK cells regulates their interaction with endothelial cells
    Suzanna Franitza
    Hadassah University Hospital, Goldyne Savad Gene Therapy Institute, Jerusalem, Israel
    Eur J Immunol 34:1333-41. 2004
    ..This study therefore suggests an important role for CXCR4 levels of expression and for VLA-4 in regulating the accumulation of NKT cells in the BM...
  58. pmc Elastase release by transmigrating neutrophils deactivates endothelial-bound SDF-1alpha and attenuates subsequent T lymphocyte transendothelial migration
    Ravi M Rao
    Department of Pathology, Center for Excellence in Vascular Biology, Brigham and Women s Hospital, Harvard Medical School, 77 Ave Louis Pasteur NRB 752P, Boston, MA 02115, USA
    J Exp Med 200:713-24. 2004
    ..In summary, transmigrating neutrophils secrete localized elastase that is protected from plasma inhibitors, and thereby modulate trafficking of other leukocyte subsets by altering the endothelial-associated chemotactic activities...
  59. ncbi request reprint Leukocyte adhesion deficiency III: a group of integrin activation defects in hematopoietic lineage cells
    Amos Etzioni
    Meyer Children s Hospital, B Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel
    Curr Opin Allergy Clin Immunol 4:485-90. 2004
    ..The clinical manifestations and molecular basis of this syndrome and related cases will be reviewed...
  60. doi request reprint Kindlin-3: a new gene involved in the pathogenesis of LAD-III
    Adi Mory
    Blood 112:2591. 2008
  61. ncbi request reprint Sialylation of ICAM-2 on platelets impairs adhesion of leukocytes via LFA-1 and DC-SIGN
    Kim S C Weber
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Harvard Medical School, Boston, Massachusetts, USA
    Inflammation 28:177-88. 2004
    ..These findings demonstrated that physiologic sialylation of platelet ICAM-2 renders it less able than endothelial ICAM-2 to support adherence of leukocytes...
  62. ncbi request reprint LAD III versus LAD I variant
    Amos Etzioni
    Blood 110:4129; author reply 4129-30. 2007
  63. ncbi request reprint Immune cell migration in inflammation: present and future therapeutic targets
    Andrew D Luster
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Immunol 6:1182-90. 2005
    ....
  64. ncbi request reprint Crawling and INTEGRating apical cues
    Ronen Alon
    Nat Immunol 5:351-3. 2004
  65. pmc L-selectin-mediated leukocyte tethering in shear flow is controlled by multiple contacts and cytoskeletal anchorage facilitating fast rebinding events
    Ulrich S Schwarz
    Theory Division, Max Planck Institute of Colloids and Interfaces, 14424 Potsdam, Germany
    Proc Natl Acad Sci U S A 101:6940-5. 2004
    ....
  66. ncbi request reprint Synthetic glycoprotein mimics inhibit L-selectin-mediated rolling and promote L-selectin shedding
    Patricia Mowery
    Department of Biochemistry, 433 Babcock Drive, University of Wisconsin Madison, Madison, WI 53706 USA
    Chem Biol 11:725-32. 2004
    ..Thus, their inhibitory potency may arise from their ability to induce shedding. Our data indicate that screening for compounds that promote L-selectin release can identify ligands that inhibit rolling...
  67. ncbi request reprint Rolling on N-linked glycans: a new way to present L-selectin binding sites
    Ronen Alon
    Nat Immunol 8:339-41. 2007