Affiliation: University of Haifa
Bramasole L, Sinha A, Gurevich S, Radzinski M, Klein Y, Panat N, et al
. Proteasome lid bridges mitochondrial stress with Cdc53/Cullin1 NEDDylation status. Redox Biol. 2018;20:533-543 pubmed publisher
..Thus, the study adds the rubylation cascade to the list of cellular pathways regulated by redox homeostasis. ..
Mahon C, Krogan N, Craik C, Pick E. Cullin E3 ligases and their rewiring by viral factors. Biomolecules. 2014;4:897-930 pubmed publisher
..This review is focused on the many methods used by viruses to perturb host CRLs, focusing on substrate sequestration and viral regulation of E3 activity. ..
Pick E, Hofmann K, Glickman M. PCI complexes: Beyond the proteasome, CSN, and eIF3 Troika. Mol Cell. 2009;35:260-4 pubmed publisher
..The breadth of functions associated with the extended PCI family is a factor of shared subunits, among them a common factor Sem1/DSS1 that facilitates complex assembly. ..
Pick E, Berman T. Formation of alternative proteasomes: same lady, different cap?. FEBS Lett. 2013;587:389-93 pubmed publisher
..Herein, we present supporting data and hypothesize that in eukaryotes, p97 and CSN form a promiscuous, hence hard-to-detect, "alternative cap", enabling the prompt and precise elimination of particular substrates. ..
Golan A, Wei N, Pick E. Immunodepletion and Immunopurification as Approaches for CSN Research. Methods Mol Biol. 2016;1449:103-16 pubmed publisher
..Immunopurification of the CSN from various human tissues or experimental conditions is advantageous for the generation of numerous CSN-interaction maps. ..
Pick E, Golan A, Zimbler J, Guo L, Sharaby Y, Tsuge T, et al
. The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain. PLoS ONE. 2012;7:e43980 pubmed publisher
..We propose that the budding yeast Csi1 is a functional equivalent of the canonical Csn6, and thus the composition of the CSN across phyla is more conserved than hitherto appreciated. ..