Genomes and Genes
Affiliation: University of Haifa
- Formation of alternative proteasomes: Same lady, different cap?Elah Pick
Department of Biology and Environment, University of Haifa at Oranim, Tivon 36006, Israel Electronic address
FEBS Lett 587:389-93. 2013..Herein, we present supporting data and hypothesize that in eukaryotes, p97 and CSN form a promiscuous, hence hard-to-detect, "alternative cap", enabling the prompt and precise elimination of particular substrates...
- The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domainElah Pick
Department of Biology, University of Haifa at Oranim, Tivon, Israel
PLoS ONE 7:e43980. 2012..We propose that the budding yeast Csi1 is a functional equivalent of the canonical Csn6, and thus the composition of the CSN across phyla is more conserved than hitherto appreciated...
- PCI complexes: Beyond the proteasome, CSN, and eIF3 TroikaElah Pick
Department of Biology, Haifa University at Oranim, Tivon, Israel
Mol Cell 35:260-4. 2009..The breadth of functions associated with the extended PCI family is a factor of shared subunits, among them a common factor Sem1/DSS1 that facilitates complex assembly...
- Dual function of Rpn5 in two PCI complexes, the 26S proteasome and COP9 signalosomeZanlin Yu
Department of Biology, Technion Israel Institute of Technology, 32000 Haifa, Israel
Mol Biol Cell 22:911-20. 2011..These observations demonstrate that functional substitution of subunits by paralogues is feasible, implying that the canonical composition of the three PCI complexes in S. cerevisiae is more robust than hitherto appreciated...