Fuad Fares

Summary

Affiliation: University of Haifa
Country: Israel

Publications

  1. doi Carrier frequency of autosomal-recessive disorders in the Ashkenazi Jewish population: should the rationale for mutation choice for screening be reevaluated?
    Fuad Fares
    Department of Molecular Genetics, Carmel Medical Center, University of Haifa, Haifa 31905, Israel
    Prenat Diagn 28:236-41. 2008
  2. pmc Benzene-poly-carboxylic acid complex, a novel anti-cancer agent induces apoptosis in human breast cancer cells
    Fuad Fares
    Department of Human Biology, Faculty of Natural Sciences, University of Haifa, and Department of Molecular Genetics, Carmel Medical Center, Haifa, Israel
    PLoS ONE 9:e85156. 2014
  3. pmc Designing a Long Acting Erythropoietin by Fusing Three Carboxyl-Terminal Peptides of Human Chorionic Gonadotropin β Subunit to the N-Terminal and C-Terminal Coding Sequence
    Fuad Fares
    Department of Human Biology, Faculty of Natural Sciences, University of Haifa and Department of Molecular Genetics, Carmel Medical Center, Mount Carmel, 31905 Haifa, Israel
    Int J Cell Biol 2011:275063. 2011
  4. pmc The indolic diet-derivative, 3,3'-diindolylmethane, induced apoptosis in human colon cancer cells through upregulation of NDRG1
    A Lerner
    Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, Haifa 34362, Israel
    J Biomed Biotechnol 2012:256178. 2012
  5. ncbi Patents on enhancing the potency and longevity of highly valuable protein hormones
    Fuad Fares
    Department of Human Biology, Faculty of Natural Sciences, University of Haifa, Mount Carmel, Haifa 31905, Israel
    Recent Pat Endocr Metab Immune Drug Discov 7:148-54. 2013
  6. doi Designing a long-acting human growth hormone (hGH) by fusing the carboxyl-terminal peptide of human chorionic gonadotropin beta-subunit to the coding sequence of hGH
    Fuad Fares
    Department of Human Biology, Faculty of Natural Sciences, University of Haifa, and Carmel Medical Center, Haifa 31905, Israel
    Endocrinology 151:4410-7. 2010
  7. doi The potential efficacy of 3,3'-diindolylmethane in prevention of prostate cancer development
    Fuad Fares
    Department of Biology, University of Haifa, Israel
    Eur J Cancer Prev 19:199-203. 2010
  8. doi Reproductive and metabolic responses of desert adapted common spiny male mice (Acomys cahirinus) to vasopressin treatment
    Elena Bukovetzky
    Department of Evolutionary and Environmental Biology, University of Haifa, Mount Carmel, Haifa 31905, Israel
    Comp Biochem Physiol A Mol Integr Physiol 162:349-56. 2012
  9. ncbi Development of a long-acting erythropoietin by fusing the carboxyl-terminal peptide of human chorionic gonadotropin beta-subunit to the coding sequence of human erythropoietin
    Fuad Fares
    Department of Molecular Genetics, Carmel Medical Center, 7 Michal Street, Haifa 34362, Israel
    Endocrinology 148:5081-7. 2007
  10. doi Absence of the α(2c)-adrenoceptor Del322-325 allele is associated with increased mortality in patients with chronic systolic heart failure
    Offer Amir
    Department of Cardiovascular Medicine, Lady Davis Carmel Medical Center and Ruth and Bruce Rappaport School of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Card Fail 18:925-9. 2012

Collaborators

Detail Information

Publications22

  1. doi Carrier frequency of autosomal-recessive disorders in the Ashkenazi Jewish population: should the rationale for mutation choice for screening be reevaluated?
    Fuad Fares
    Department of Molecular Genetics, Carmel Medical Center, University of Haifa, Haifa 31905, Israel
    Prenat Diagn 28:236-41. 2008
    ..Therefore, carrier testing of AJ members is important in order to identify couples at risk of having offspring with an autosomal recessive disorder...
  2. pmc Benzene-poly-carboxylic acid complex, a novel anti-cancer agent induces apoptosis in human breast cancer cells
    Fuad Fares
    Department of Human Biology, Faculty of Natural Sciences, University of Haifa, and Department of Molecular Genetics, Carmel Medical Center, Haifa, Israel
    PLoS ONE 9:e85156. 2014
    ..These findings may lead to the development of new therapeutic strategies for treatment of human cancer using BP-C1 analog. ..
  3. pmc Designing a Long Acting Erythropoietin by Fusing Three Carboxyl-Terminal Peptides of Human Chorionic Gonadotropin β Subunit to the N-Terminal and C-Terminal Coding Sequence
    Fuad Fares
    Department of Human Biology, Faculty of Natural Sciences, University of Haifa and Department of Molecular Genetics, Carmel Medical Center, Mount Carmel, 31905 Haifa, Israel
    Int J Cell Biol 2011:275063. 2011
    ..1 h, respectively. These data established the rational for using this chimera as a long-acting EPO analog in clinics. The therapeutic efficacy of EPO-CTP analog needs to be established in higher animals and in human clinical trials...
  4. pmc The indolic diet-derivative, 3,3'-diindolylmethane, induced apoptosis in human colon cancer cells through upregulation of NDRG1
    A Lerner
    Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, Haifa 34362, Israel
    J Biomed Biotechnol 2012:256178. 2012
    ..3,3'-diindolylmethane induced apoptosis may represent a new regulator of N-myc downstream regulated gene-1 in poorly differentiated colonic cancer cells...
  5. ncbi Patents on enhancing the potency and longevity of highly valuable protein hormones
    Fuad Fares
    Department of Human Biology, Faculty of Natural Sciences, University of Haifa, Mount Carmel, Haifa 31905, Israel
    Recent Pat Endocr Metab Immune Drug Discov 7:148-54. 2013
    ..Development of long acting peptides will diminish the cost of these drugs and perhaps reduce the number of injections in the clinical protocols. The article also summarizes some relevant patents...
  6. doi Designing a long-acting human growth hormone (hGH) by fusing the carboxyl-terminal peptide of human chorionic gonadotropin beta-subunit to the coding sequence of hGH
    Fuad Fares
    Department of Human Biology, Faculty of Natural Sciences, University of Haifa, and Carmel Medical Center, Haifa 31905, Israel
    Endocrinology 151:4410-7. 2010
    ..This may suggest that the mechanism of GH metabolic clearance is affected by the presence of CTP. These data establish a rationale for using this chimera as a long-acting GH analog...
  7. doi The potential efficacy of 3,3'-diindolylmethane in prevention of prostate cancer development
    Fuad Fares
    Department of Biology, University of Haifa, Israel
    Eur J Cancer Prev 19:199-203. 2010
    ..These results indicated that the DIM agent is not toxic and has an in-vivo preventive effect against the development of prostate cancer in a mouse model...
  8. doi Reproductive and metabolic responses of desert adapted common spiny male mice (Acomys cahirinus) to vasopressin treatment
    Elena Bukovetzky
    Department of Evolutionary and Environmental Biology, University of Haifa, Mount Carmel, Haifa 31905, Israel
    Comp Biochem Physiol A Mol Integr Physiol 162:349-56. 2012
    ....
  9. ncbi Development of a long-acting erythropoietin by fusing the carboxyl-terminal peptide of human chorionic gonadotropin beta-subunit to the coding sequence of human erythropoietin
    Fuad Fares
    Department of Molecular Genetics, Carmel Medical Center, 7 Michal Street, Haifa 34362, Israel
    Endocrinology 148:5081-7. 2007
    ..These data established the rationale for using this chimera as a long-acting EPO analog. The therapeutic efficacy of EPO-CTP analog needs to be established in higher animals and human clinical trials...
  10. doi Absence of the α(2c)-adrenoceptor Del322-325 allele is associated with increased mortality in patients with chronic systolic heart failure
    Offer Amir
    Department of Cardiovascular Medicine, Lady Davis Carmel Medical Center and Ruth and Bruce Rappaport School of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Card Fail 18:925-9. 2012
    ..We investigated the possible clinical association between the presence or absence of the deletion allele and mortality...
  11. doi A differential response in the reproductive system and energy balance of spiny mice Acomys populations to vasopressin treatment
    Tilaye Wube
    Department of Evolutionary and Environmental Biology, University of Haifa, Mount Carmel 31905, Israel
    Comp Biochem Physiol A Mol Integr Physiol 151:499-504. 2008
    ..russatus. The results also reinforce previous knowledge that different physiological systems could be integrated by a single biochemical signal...
  12. doi Effect of increased dietary salinity on the reproductive status and energy intake of xeric and mesic populations of the spiny mouse, Acomys
    Tilaye Wube
    Department of Evolutionary and Environmental Biology, University of Haifa, Mount Carmel, Israel
    Physiol Behav 96:122-7. 2009
    ..russatus by halting it in males, as the dry season progresses while such role in the mesic population of A. cahirinus is unlikely...
  13. ncbi The role of O-linked and N-linked oligosaccharides on the structure-function of glycoprotein hormones: development of agonists and antagonists
    Fuad Fares
    Department of Molecular Genetics, Carmel Medical Center and the Faculty of Medicine, Technion Israel Institute of Technology, Haifa
    Biochim Biophys Acta 1760:560-7. 2006
    ..In the case of hTSH, development of an antagonist may offer a novel therapeutic strategy in the treatment of thyrotoxicosis caused by Graves' disease and TSH secreting pituitary adenoma...
  14. doi Conversion of TSH heterodimer to a single polypeptide chain increases bioactivity and longevity
    Naiel Azzam
    Department of Human Biology, Faculty of Natural Sciences, University of Haifa, Mount Carmel, Haifa 31095, Israel
    Endocrinology 153:954-60. 2012
    ..Other prominent potential clinical use of these variants is in a diagnostic test for metastasis and recurrence of thyroid cancer...
  15. ncbi Paternal isodisomy of chromosome 7 with cystic fibrosis and overgrowth
    Fuad Fares
    Department of Molecular Genetics, Technion Israel Institute of Technology, Haifa, Israel
    Am J Med Genet A 140:1785-8. 2006
    ..The discrepancy between the phenotype of this boy and the other two patients raises the question of imprinted genes or homozygotization of a disease-causing gene in paternal UPD7...
  16. ncbi Inhibitory effect of ethyl acetate extract of the shaggy inc cap medicinal mushroom, Coprinus comatus (Higher Basidiomycetes) fruit bodies on cell growth of human ovarian cancer
    Amal Rouhana-Toubi
    Department of Evolutionary and Environmental Biology and Institute of Evolution, Faculty of Science and Science Education, University of Haifa, Mount Carmel, Haifa 31905, Israel Department of Biotechnology Engineering, Ort Braude College, Karmiel, Israel
    Int J Med Mushrooms 15:457-70. 2013
    ..comatus reduced viability of three lines of human ovarian cancer. Fractionation of this extract by a silica gel column enabled the selection of a fraction significantly more active than the original extract. ..
  17. ncbi Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation
    Hagit Schwimmer
    The Israeli Center for Interdisciplinary Research in Chronobiology, University of Haifa, Mount Carmel, Haifa, Israel
    Chronobiol Int 31:144-50. 2014
    ..Growth rates were followed under various light exposures and global DNA methylations were measured. Results demonstrated the positive effect of LAN on tumors growth-rate, reversed by MLT through global DNA methylation. ..
  18. ncbi Human thyrotropin (TSH) variants designed by site-directed mutagenesis block TSH activity in vitro and in vivo
    Naiel Azzam
    Department of Molecular Genetics, Carmel Medical Center, Michal 7 Street, Haifa 34362, Israel
    Endocrinology 146:2845-50. 2005
    ..Moreover, the variants significantly inhibited (about 50%) TSH activity with respect to thyroid hormone secretion in vivo in mice. These variants may offer a novel therapeutic strategy in treating hyperthyroidism...
  19. ncbi Does COLIA1 SP1-binding site polymorphism predispose women to pelvic organ prolapse?
    Benjamin Feiner
    Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Carmel Medical Center, Technion University Medical School, Haifa, Israel
    Int Urogynecol J Pelvic Floor Dysfunct 20:1061-5. 2009
    ..COLIA1 polymorphism is associated with increased risk for stress urinary incontinence. We hypothesize that a similar association exists with pelvic organ prolapse (POP)...
  20. ncbi Arsenic Trioxide inhibits the growth of human ovarian carcinoma cell line
    Jacob Bornstein
    Department of Obstetrics and Gynecology, Western Galilee Hospital, PO Box 21, Nahariya 22100, and Molecular Genetics Laboratory, Technion Israel Institute of Technology, Haifa, Israel
    Gynecol Oncol 99:726-9. 2005
    ..To determine whether Arsenic Trioxide may be an effective treatment of human ovarian carcinoma, we examined if it induced apoptosis in human ovarian cancer cell line...
  21. doi Photoperiodicity and increasing salinity as environmental cues for reproduction in desert adapted rodents
    Elena Bukovetzky
    Department of Evolutionary and Environmental Biology, University of Haifa, Mount Carmel, Haifa 31905, Israel
    Horm Behav 61:84-90. 2012
    ..The existence of VP and aldosterone receptors in the gonads and WAT suggests the involvement of osmoregulatory hormones in reproductive control of desert adapted rodents...
  22. ncbi Identification of two mutations for ataxia telangiectasia among the Druze community
    Fuad Fares
    Department of Biochemistry and Molecular Genetics, Carmel Medical Center, Haifa, Israel
    Prenat Diagn 24:358-62. 2004
    ..The ability to identify AT carriers routinely provides a unique opportunity for prenatal diagnosis, genetic counseling as well as marriage guidance in the Druze community...