Dov Tiosano

Summary

Country: Israel

Publications

  1. ncbi request reprint Hypophosphatemia: the common denominator of all rickets
    Dov Tiosano
    Meyer Children s Hospital, Rambam Medical Center, POB 9602, 31096, Haifa, Israel
    J Bone Miner Metab 27:392-401. 2009
  2. doi request reprint Vitamin D action: lessons learned from hereditary 1,25-dihydroxyvitamin-D-resistant rickets patients
    Dov Tiosano
    Pediatric Endocrinology, Meyer Children s Hospital, Rambam Healthcare Campus, Haifa, Israel
    Curr Opin Endocrinol Diabetes Obes 19:452-9. 2012
  3. doi request reprint The role of vitamin D receptor in innate and adaptive immunity: a study in hereditary vitamin D-resistant rickets patients
    Dov Tiosano
    Division of Pediatric Endocrinology, Meyer Children s Hospital, Rambam Health Care Campus, Haifa, Israel
    J Clin Endocrinol Metab 98:1685-93. 2013
  4. ncbi request reprint The role of the vitamin D receptor in regulating vitamin D metabolism: a study of vitamin D-dependent rickets, type II
    D Tiosano
    Department of Pediatrics, Rambam Medical Center, Haifa 31096, Israel
    J Clin Endocrinol Metab 86:1908-12. 2001
  5. doi request reprint Calcium absorption, kinetics, bone density, and bone structure in patients with hereditary vitamin D-resistant rickets
    Dov Tiosano
    Division of Pediatric Endocrinology, Meyer Children s Hospital, Rambam Health Care Campus, Haifa 31096, Israel
    J Clin Endocrinol Metab 96:3701-9. 2011
  6. doi request reprint Fibroblast growth factor-23 and phosphorus metabolism
    Dov Tiosano
    Pediatric Endocrinology, Meyer Children s Hospital, Rambam Medical Center, Rappaport Family Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Endocr Dev 21:67-77. 2011
  7. doi request reprint The renin-angiotensin system, blood pressure, and heart structure in patients with hereditary vitamin D-resistance rickets (HVDRR)
    Dov Tiosano
    Division of Pediatric Endocrinology, Meyer Children s Hospital, Rambam Health Care Campus, Haifa, Israel
    J Bone Miner Res 26:2252-60. 2011
  8. ncbi request reprint Ovarian adrenal rest tumor in a congenital adrenal hyperplasia patient with adrenocorticotropin hypersecretion following adrenalectomy
    Dov Tiosano
    Meyer Children s Hospital, Rambam Medical Center, Haifa, Israel
    Horm Res Paediatr 74:223-8. 2010
  9. ncbi request reprint Metabolic evidence for impaired 17alpha-hydroxylase activity in a kindred bearing the E305G mutation for isolate 17,20-lyase activity
    Dov Tiosano
    Pediatric Endocrinology, Metabolic Biochemistry Laboratory and Genetics Institute, Rambam Medical Center, Meyer Children s Hospital, Technion Israel Institute of Technology, 9602 Haifa, Israel
    Eur J Endocrinol 158:385-92. 2008
  10. ncbi request reprint Recombinant thyrotropin in the diagnosis of congenital hypothyroidism
    Dov Tiosano
    Division of Endocrinology, Meyer Children s Hospital, POB 6092, and Technion Israel Institute of Technology, Haifa 31096, Israel
    J Clin Endocrinol Metab 92:1434-7. 2007

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Hypophosphatemia: the common denominator of all rickets
    Dov Tiosano
    Meyer Children s Hospital, Rambam Medical Center, POB 9602, 31096, Haifa, Israel
    J Bone Miner Metab 27:392-401. 2009
    ....
  2. doi request reprint Vitamin D action: lessons learned from hereditary 1,25-dihydroxyvitamin-D-resistant rickets patients
    Dov Tiosano
    Pediatric Endocrinology, Meyer Children s Hospital, Rambam Healthcare Campus, Haifa, Israel
    Curr Opin Endocrinol Diabetes Obes 19:452-9. 2012
    ..This article summarizes the role of vitamin D in calcium absorption, rennin-angiotensin system (RAS), and cardiac state in HVDRR patients...
  3. doi request reprint The role of vitamin D receptor in innate and adaptive immunity: a study in hereditary vitamin D-resistant rickets patients
    Dov Tiosano
    Division of Pediatric Endocrinology, Meyer Children s Hospital, Rambam Health Care Campus, Haifa, Israel
    J Clin Endocrinol Metab 98:1685-93. 2013
    ..Vitamin D has regulatory effects on innate and adaptive immunity. Curiously, hereditary vitamin D-resistant rickets (HVDRR) patients show no increased incidence of infectious or autoimmune diseases...
  4. ncbi request reprint The role of the vitamin D receptor in regulating vitamin D metabolism: a study of vitamin D-dependent rickets, type II
    D Tiosano
    Department of Pediatrics, Rambam Medical Center, Haifa 31096, Israel
    J Clin Endocrinol Metab 86:1908-12. 2001
    ..Assessment of the influence of 1,25-(OH)(2)D shows reciprocal control of enzyme activity in man, suppressing 1-OHase and stimulating 24-OHase activity...
  5. doi request reprint Calcium absorption, kinetics, bone density, and bone structure in patients with hereditary vitamin D-resistant rickets
    Dov Tiosano
    Division of Pediatric Endocrinology, Meyer Children s Hospital, Rambam Health Care Campus, Haifa 31096, Israel
    J Clin Endocrinol Metab 96:3701-9. 2011
    ..Surprisingly, spontaneous recovery of calcium metabolism occurs after the end of puberty without the need for further calcium supplementation...
  6. doi request reprint Fibroblast growth factor-23 and phosphorus metabolism
    Dov Tiosano
    Pediatric Endocrinology, Meyer Children s Hospital, Rambam Medical Center, Rappaport Family Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Endocr Dev 21:67-77. 2011
    ..This review summarizes the role of the FGF-23 axis on phosphorus metabolism, and presents the clinical entities that arise from activation or inactivation of the FGF-23 axis...
  7. doi request reprint The renin-angiotensin system, blood pressure, and heart structure in patients with hereditary vitamin D-resistance rickets (HVDRR)
    Dov Tiosano
    Division of Pediatric Endocrinology, Meyer Children s Hospital, Rambam Health Care Campus, Haifa, Israel
    J Bone Miner Res 26:2252-60. 2011
    ..These findings reveal that 6- to 36-year-old humans with HVDRR have normal renin and ACE activity, mild but nonsignificant elevation of AT-II, normal aldosterone levels, and no hypertension or gross heart abnormalities...
  8. ncbi request reprint Ovarian adrenal rest tumor in a congenital adrenal hyperplasia patient with adrenocorticotropin hypersecretion following adrenalectomy
    Dov Tiosano
    Meyer Children s Hospital, Rambam Medical Center, Haifa, Israel
    Horm Res Paediatr 74:223-8. 2010
    ..Ovarian adrenal rest tumors (OARTs) are rare in contrast to testicular adrenal rest tumors. We report a case of OART in a patient with congenital adrenal hyperplasia who developed Nelson's syndrome after bilateral adrenalectomy...
  9. ncbi request reprint Metabolic evidence for impaired 17alpha-hydroxylase activity in a kindred bearing the E305G mutation for isolate 17,20-lyase activity
    Dov Tiosano
    Pediatric Endocrinology, Metabolic Biochemistry Laboratory and Genetics Institute, Rambam Medical Center, Meyer Children s Hospital, Technion Israel Institute of Technology, 9602 Haifa, Israel
    Eur J Endocrinol 158:385-92. 2008
    ..Expression studies suggested intact 17alpha-hydroxylase activity which was at odds with subnormal tetracosactrin stimulated cortisol in the patients...
  10. ncbi request reprint Recombinant thyrotropin in the diagnosis of congenital hypothyroidism
    Dov Tiosano
    Division of Endocrinology, Meyer Children s Hospital, POB 6092, and Technion Israel Institute of Technology, Haifa 31096, Israel
    J Clin Endocrinol Metab 92:1434-7. 2007
    ..When uncertainty persists, treatment is commenced, and the definitive diagnosis of congenital hypothyroidism is deferred to the age of 3 yr...
  11. ncbi request reprint Endocrine complications of thalassemia
    D Tiosano
    Department of Pediatrics, Rambam Medical Center, Haifa, Israel
    J Endocrinol Invest 24:716-23. 2001
    ..Endocrine abnormalities should be monitored carefully and a thorough endocrine evaluation should be carried out yearly in every patients to detect subclinical endocrinopaties...
  12. doi request reprint Postzygotic HRAS mutation causing both keratinocytic epidermal nevus and thymoma and associated with bone dysplasia and hypophosphatemia due to elevated FGF23
    Emily Avitan-Hersh
    Division of Pediatric Endocrinology V G, D T, Department of Pediatrics B S T, R Br, Department of Dermatology E A H, R Be, Laboratory of Molecular Dermatology M I, R Be, Department of Radiology R S, and Department of Pathology D H, Meyer Children s Hospital, Rambam Health Care Campus, Haifa 33705, Israel and Bruce Rappaport Faculty of Medicine R Br, R Be, D T, Institute of Technology, Haifa 32000, Israel
    J Clin Endocrinol Metab 99:E132-6. 2014
    ..We report a case of keratinocytic epidermal nevus syndrome that includes a thymoma, bone dysplasia, and hypophosphatemia with elevated fibroblast growth factor 23 (FGF23) levels associated with postzygotic HRAS mutation...
  13. ncbi request reprint Hypothalamic regulation of adiposity: the role of 11beta-hydroxysteroid dehydrogenase type 1
    Z Hochberg
    Division of Endocrinology, Meyer Children s Hospital, PO Box 9602, Rambam Medical Center, Haifa 31096, Israel
    Horm Metab Res 36:365-9. 2004
    ..Inhibition of 11beta-HSD-1 suppresses preadipocyte differentiation into mature adipocytes, and may provide a therapeutic tool...
  14. pmc SERKAL syndrome: an autosomal-recessive disorder caused by a loss-of-function mutation in WNT4
    Hannah Mandel
    Metabolic Disease Unit, Meyer Children s Hospital, Haifa 31096, Israel
    Am J Hum Genet 82:39-47. 2008
    ..Taken together with previous observations in animal models, the present data attribute a pivotal role to WNT4 signaling during organogenesis in humans...
  15. doi request reprint Update on vitamin D during childhood
    Steven A Abrams
    aUnited States Department of Agriculture Agricultural Research Service, Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA bPediatric Endocrinology, Rambam Healthcare Campus, Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Curr Opin Endocrinol Diabetes Obes 21:51-5. 2014
    ..We propose to review several recent key clinically oriented topics related to vitamin D and health in children...
  16. ncbi request reprint 11 beta-Hydroxysteroid dehydrogenase activity in hypothalamic obesity
    Dov Tiosano
    Departments of Pediatrics, Meyer Children s Hospital, Haifa 31096, Israel
    J Clin Endocrinol Metab 88:379-84. 2003
    ..We propose that deficiency of hypothalamic messengers after surgical injury induces a paracrine/autocrine effect of enhanced glucocorticoid activity due to up-regulated 11 beta-HSD1 activity...
  17. pmc Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3
    Bettina Lorenz-Depiereux
    Institute of Human Genetics, GSF National Research Center for Environment and Health, Munich Neuherberg, Germany
    Am J Hum Genet 78:193-201. 2006
    ..Identification of the gene mutated in a further form of hypophosphatemia adds to the understanding of phosphate homeostasis and may help to elucidate the interaction of the proteins involved in this pathway...
  18. ncbi request reprint CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding
    Daniel P Sherbet
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
    J Biol Chem 278:48563-9. 2003
    ..Mutation E305G provides genetic evidence that androstenedione formation from 17alpha-hydroxyprogesterone via the minor delta4-steroid pathway alone is not sufficient for complete formation of the male phenotype in humans...