A Zimran

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi request reprint Ethical considerations for enzyme replacement therapy in neuronopathic Gaucher disease
    D Elstein
    Gaucher Clinic, Shaare Zedek Medical Center, Jerusalem, Israel
    Clin Genet 54:179-84. 1998
  2. ncbi request reprint Effect of ozone on red blood cell enzymes and intermediates
    A Zimran
    Department of Medicine, Shaare Zedek Medical Center, Jerusalem, Israel
    Acta Haematol 102:148-51. 2000
  3. ncbi request reprint High prevalence of complement C7 deficiency among healthy blood donors of Moroccan Jewish ancestry
    D Halle
    Shaare Zedek Medical Center, Jerusalem, Israel
    Am J Med Genet 99:325-7. 2001
  4. ncbi request reprint Lung involvement and enzyme replacement therapy in Gaucher's disease
    O Goitein
    Department of Radiology, Shaare Zedek Medical Center, Jerusalem, Israel
    QJM 94:407-15. 2001
  5. ncbi request reprint High prevalence of low serum vitamin B12 in a multi-ethnic Israeli population
    Y Gielchinsky
    Gaucher Clinic, Shaare Zedek Medical Centre, Jerusalem, Israel
    Br J Haematol 115:707-9. 2001
  6. doi request reprint Prevalence of low serum cobalamin in infertile couples
    R Pront
    Gaucher Clinic, Shaare Zedek Medical Center, Jerusalem, Israel
    Andrologia 41:46-50. 2009
  7. ncbi request reprint Are symptoms of peripheral neuropathy more prevalent in patients with Gaucher disease?
    A Halperin
    Gaucher Clinic, Shaare Zedek Medical Center, Jerusalem, Israel
    Acta Neurol Scand 115:275-8. 2007
  8. ncbi request reprint The interleukin-6 promoter polymorphism in Gaucher disease: a new modifier gene?
    G Altarescu
    Genetics Institute, Shaare Zedek Medical Center, Jerusalem, Israel
    QJM 96:575-8. 2003
  9. ncbi request reprint Chitotriosidase deficiency in survivors of Candida sepsis
    M Masoud
    Gaucher Clinic, Shaare Zedek Medical Center, Jerusalem 91031, Israel
    Blood Cells Mol Dis 29:116-8. 2002
  10. ncbi request reprint Plasma chitotriosidase activity in patients with beta-thalassemia
    G Altarescu
    Gaucher Clinic, Shaare Zedek Medical Center, Jerusalem, Israel
    Am J Hematol 71:7-10. 2002

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Ethical considerations for enzyme replacement therapy in neuronopathic Gaucher disease
    D Elstein
    Gaucher Clinic, Shaare Zedek Medical Center, Jerusalem, Israel
    Clin Genet 54:179-84. 1998
    ..In conclusion. we describe recommendations for the ethical treatment and/or withdrawal of treatment, as well as practical guidelines for dosage regimens, in children with neuronopathic Gaucher disease...
  2. ncbi request reprint Effect of ozone on red blood cell enzymes and intermediates
    A Zimran
    Department of Medicine, Shaare Zedek Medical Center, Jerusalem, Israel
    Acta Haematol 102:148-51. 2000
    ..Since these parameters were unaffected by ozone, we suggest that clinical trials for the use of ozone autohemotherapy should be encouraged...
  3. ncbi request reprint High prevalence of complement C7 deficiency among healthy blood donors of Moroccan Jewish ancestry
    D Halle
    Shaare Zedek Medical Center, Jerusalem, Israel
    Am J Med Genet 99:325-7. 2001
    ..Conversely, when a patient of Moroccan ancestry is diagnosed with a Neisserial infection, it is important to determine the complement status...
  4. ncbi request reprint Lung involvement and enzyme replacement therapy in Gaucher's disease
    O Goitein
    Department of Radiology, Shaare Zedek Medical Center, Jerusalem, Israel
    QJM 94:407-15. 2001
    ..Clinically, some benefited significantly from enzyme therapy, but in contrast to the dramatic reduction in organomegaly, there was no normalization in pulmonary function or lung architecture...
  5. ncbi request reprint High prevalence of low serum vitamin B12 in a multi-ethnic Israeli population
    Y Gielchinsky
    Gaucher Clinic, Shaare Zedek Medical Centre, Jerusalem, Israel
    Br J Haematol 115:707-9. 2001
    ..These findings raise questions on the individual and community levels of serum B12. We recommend evaluation of B12 levels among geographically contingent peoples...
  6. doi request reprint Prevalence of low serum cobalamin in infertile couples
    R Pront
    Gaucher Clinic, Shaare Zedek Medical Center, Jerusalem, Israel
    Andrologia 41:46-50. 2009
    ..Recommendation for supplementation in both males and females to achieve high-normal levels of cobalamin would be prudent...
  7. ncbi request reprint Are symptoms of peripheral neuropathy more prevalent in patients with Gaucher disease?
    A Halperin
    Gaucher Clinic, Shaare Zedek Medical Center, Jerusalem, Israel
    Acta Neurol Scand 115:275-8. 2007
    ..A previous epidemiological survey from an American referral clinic noted a high incidence of neurological symptoms among patients with type I (non-neuronopathic) Gaucher disease all of whom were treated with specific enzyme replacement...
  8. ncbi request reprint The interleukin-6 promoter polymorphism in Gaucher disease: a new modifier gene?
    G Altarescu
    Genetics Institute, Shaare Zedek Medical Center, Jerusalem, Israel
    QJM 96:575-8. 2003
    ..Individuals with Gaucher disease vary significantly with regard to degree of bone disease, but there are no predictive markers for severity of skeletal involvement...
  9. ncbi request reprint Chitotriosidase deficiency in survivors of Candida sepsis
    M Masoud
    Gaucher Clinic, Shaare Zedek Medical Center, Jerusalem 91031, Israel
    Blood Cells Mol Dis 29:116-8. 2002
    ..Several theories are considered to explain the results...
  10. ncbi request reprint Plasma chitotriosidase activity in patients with beta-thalassemia
    G Altarescu
    Gaucher Clinic, Shaare Zedek Medical Center, Jerusalem, Israel
    Am J Hematol 71:7-10. 2002
    ..Our results confirm results of the Italian cohort; however, in the latter, a more universal correlation was noted and chitotriosidase levels were much higher...
  11. ncbi request reprint Platelet function abnormalities in Gaucher disease patients
    S Gillis
    Department of Hematology, Hadassah University Medical Center, Jerusalem, Israel
    Am J Hematol 61:103-6. 1999
    ..Platelet dysfunction is a hitherto unrecognised, relatively common cause of excessive bleeding in Gaucher patients...
  12. doi request reprint Neurocognitive testing in late-onset Tay-Sachs disease: a pilot study
    D Elstein
    Gaucher Clinic, Shaare Zedek Medical Center, P O Box 3235, Jerusalem, 91031, Israel
    J Inherit Metab Dis 31:518-23. 2008
    ..To test neurocognitive function in patients with late-onset Tay-Sachs disease (LOTS) using a computerized system to assess whether cognition is a clinically relevant outcome measure of possible therapeutic intervention in LOTS...
  13. ncbi request reprint Fibromyalgia and Gaucher's disease
    A Brautbar
    Gaucher Clinic, Shaare Zedek Medical Center, PO Box 3235, Jerusalem 91031, Israel
    QJM 99:103-7. 2006
    ..These may indicate fibromyalgia syndrome; if so, other therapeutic options might be more appropriate...
  14. ncbi request reprint Effect of ozone on neutrophil function in vitro
    M Margalit
    Gaucher Clinic and the Department of Medicine and Surgery A, Shaare-Zedek Medical Center, Hadassah University Hospital (Mount Scopus, Jerusalem, Israel
    Clin Lab Haematol 23:243-7. 2001
    ..Combined with previous data, it seems that well-designed clinical trials to assess the efficacy of major autohemotherapy would pose no danger to blood cell populations, and should be encouraged...
  15. doi request reprint Early achievement and maintenance of the therapeutic goals using velaglucerase alfa in type 1 Gaucher disease
    D Elstein
    Gaucher Clinic, Shaare Zedek Medical Center, Jerusalem, Israel
    Blood Cells Mol Dis 46:119-23. 2011
    ..Therapeutic goals have been described to monitor achievement, maintenance and continuity of therapeutic response in patients with type 1 Gaucher disease receiving enzyme replacement therapy...
  16. ncbi request reprint Viral infections and phenotypic heterogeneity in Gaucher disease
    G Pines
    Gaucher Clinic, Shaare Zedek Medical Center, Jerusalem, Israel
    Blood Cells Mol Dis 27:358-61. 2001
    ..In conclusion, other than a small subset of patients who showed a pattern comparable to immunosuppression, there was no association between severity of Gaucher disease and prior EBV or CMV infection...
  17. ncbi request reprint Outcome of total hip arthroplasty in patients with Gaucher disease
    E Lebel
    Department of Orthopedics, Shaare Zedek Medical Center, Jerusalem, Israel
    J Arthroplasty 16:7-12. 2001
    ..In revisions, the results were not as good. THA is recommended in this population using criteria comparable to those in other patients, with equally good results...
  18. doi request reprint Attitudes of couples identified through screening as carriers of Gaucher disease type 1
    S Zuckerman
    Genetic Counseling Program, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Clin Genet 74:566-70. 2008
    ..We offer explanations for these findings and suggest extensive genetic and medical counseling for any future carrier screening for low penetrance, treatable disease...
  19. doi request reprint Velaglucerase alfa: a new option for Gaucher disease treatment
    A Zimran
    Shaare Zedek Medical Center, Jerusalem, Israel
    Drugs Today (Barc) 47:515-29. 2011
    ..In vitro data suggest velaglucerase alfa may be internalized into cells more efficiently and have a lower rate of seroconversion. However, these results do not necessarily correlate with clinical efficacy...
  20. ncbi request reprint Sustained therapeutic effects of oral miglustat (Zavesca, N-butyldeoxynojirimycin, OGT 918) in type I Gaucher disease
    D Elstein
    Shaare Zedek Medical Centre, Jerusalem, Israel
    J Inherit Metab Dis 27:757-66. 2004
    ..In conclusion, miglustat was increasingly effective over time and showed acceptable tolerability in patients who continued with treatment for 3 years...
  21. ncbi request reprint Decreased salivary output in patients with Gaucher disease
    B Dayan
    Gaucher Clinic, Shaare Zedek Medical Center, Jerusalem 91031, Israel
    QJM 96:53-6. 2003
    ..In a preliminary screening of 109 patients with type I disease, when asked specifically about dry mouth, approximately one quarter claimed to suffer from this symptom...
  22. pmc Enzyme replacement therapy in the management of longstanding skeletal and soft tissue salmonella infection in a patient with Gaucher's disease
    M Margalit
    Gaucher Clinic, Shaare Zedek Medical, Jerusalem, Israel
    Postgrad Med J 78:564-5. 2002
    ..Complete resolution of the infection was seen after 15 months. The possible role of ERT in healing bacterial infections in Gaucher's disease is discussed...
  23. ncbi request reprint Incidence of thrombophilia in patients with Gaucher disease
    D Elstein
    Gaucher Clinic, Shaare Zedek Medical Center, Jerusalem, Israel
    Am J Med Genet 95:429-31. 2000
    ..Studies in larger cohorts and possibly inclusion of additional factors may be needed to ascertain whether a correlation exists...
  24. ncbi request reprint The effect of hormone replacement therapy on cognitive function in post-menopausal women
    R Lavi
    Gaucher Clinic, Shaare Zedek Medical Center, One Bazak Road, Jerusalem 91031, Israel
    QJM 100:567-73. 2007
    ..Despite interest in causes of dementia in older persons, particularly in post-menopausal women, it is unclear whether hormone replacement therapy (HRT) is a risk factor...
  25. doi request reprint Thrombocytopenia and bleeding in dental procedures of patients with Gaucher disease
    N Givol
    Department of Oral and Maxilo Facial Surgery, Sheba Medical Center, Tel Hashomer, Israel
    Haemophilia 18:117-21. 2012
    ..Platelet transfusions are not mandatory and should be applied considering the procedure-related risk and the patient's calculated haematological risk for bleeding...
  26. ncbi request reprint Ozone enema: a model of microscopic colitis in rats
    R Eliakim
    Department of Medicine, Hadassah University Hospital, Jerusalem, Israel
    Dig Dis Sci 46:2515-20. 2001
    ..In conclusion, ozone water therapy had a deleterious effect on normal colonic mucosa, suggesting intrarectal administration be reevaluated. Ozone water enema may serve as a model of microscopic colitis...