R Yirmiya

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi request reprint The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling
    Joseph Tam
    Bone Laboratory, Hadassah School of Dental Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel
    FASEB J 22:285-94. 2008
  2. pmc Depression induces bone loss through stimulation of the sympathetic nervous system
    Raz Yirmiya
    Department of Psychology, Faculty of Social Sciences, Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
    Proc Natl Acad Sci U S A 103:16876-81. 2006
  3. doi request reprint Major depression is a risk factor for low bone mineral density: a meta-analysis
    Raz Yirmiya
    Department of Psychology, The Hebrew University of Jerusalem, Jerusalem 91905, Israel
    Biol Psychiatry 66:423-32. 2009
  4. ncbi request reprint Brain interleukin-1 is involved in spatial memory and passive avoidance conditioning
    R Yirmiya
    Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem, 91905, Israel
    Neurobiol Learn Mem 78:379-89. 2002
  5. doi request reprint Immune modulation of learning, memory, neural plasticity and neurogenesis
    Raz Yirmiya
    Department of Psychology, The Hebrew University of Jerusalem, Jerusalem 91905, Israel
    Brain Behav Immun 25:181-213. 2011
  6. ncbi request reprint The role of brain cytokines in mediating the behavioral and neuroendocrine effects of intracerebral mycoplasma fermentans
    R Yirmiya
    Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
    Brain Res 829:28-38. 1999
  7. ncbi request reprint Illness, cytokines, and depression
    R Yirmiya
    Department of Psychology, Hebrew University, Hadassah Hospital, Jerusalem, Israel
    Ann N Y Acad Sci 917:478-87. 2000
  8. ncbi request reprint Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression
    I Goshen
    Department of Psychology, The Hebrew University, Jerusalem, Israel
    Mol Psychiatry 13:717-28. 2008
  9. ncbi request reprint Effects of antidepressant drugs on the behavioral and physiological responses to lipopolysaccharide (LPS) in rodents
    R Yirmiya
    Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem, Israel
    Neuropsychopharmacology 24:531-44. 2001
  10. ncbi request reprint Acute effects of purified and UV-inactivated Herpes simplex virus type 1 on the hypothalamo-pituitary-adrenocortical axis
    T Ben-Hur
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University, Jerusalem, Israel
    Neuroendocrinology 74:160-6. 2001

Collaborators

Detail Information

Publications51

  1. ncbi request reprint The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling
    Joseph Tam
    Bone Laboratory, Hadassah School of Dental Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel
    FASEB J 22:285-94. 2008
    ..Elevation of bone 2-AG apparently suppresses NE release from bone sympathetic terminals, thus alleviating the inhibition of bone formation. The involvement of osteoblastic CB2 signaling in this process is minimal, if any...
  2. pmc Depression induces bone loss through stimulation of the sympathetic nervous system
    Raz Yirmiya
    Department of Psychology, Faculty of Social Sciences, Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
    Proc Natl Acad Sci U S A 103:16876-81. 2006
    ..Together with the common occurrence of depression and bone loss in the aging population, the present data implicate depression as a potential major risk factor for osteoporosis and the associated increase in fracture incidence...
  3. doi request reprint Major depression is a risk factor for low bone mineral density: a meta-analysis
    Raz Yirmiya
    Department of Psychology, The Hebrew University of Jerusalem, Jerusalem 91905, Israel
    Biol Psychiatry 66:423-32. 2009
    ....
  4. ncbi request reprint Brain interleukin-1 is involved in spatial memory and passive avoidance conditioning
    R Yirmiya
    Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem, 91905, Israel
    Neurobiol Learn Mem 78:379-89. 2002
    ..These results suggest that IL-1 signaling within the hippocampus plays a critical role in learning and memory processes...
  5. doi request reprint Immune modulation of learning, memory, neural plasticity and neurogenesis
    Raz Yirmiya
    Department of Psychology, The Hebrew University of Jerusalem, Jerusalem 91905, Israel
    Brain Behav Immun 25:181-213. 2011
    ....
  6. ncbi request reprint The role of brain cytokines in mediating the behavioral and neuroendocrine effects of intracerebral mycoplasma fermentans
    R Yirmiya
    Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
    Brain Res 829:28-38. 1999
    ..We suggest that cytokines within the brain are involved in mediating at least some of the neurobehavioral and neuroendocrine abnormalities that may be produced by MF in AIDS patients...
  7. ncbi request reprint Illness, cytokines, and depression
    R Yirmiya
    Department of Psychology, Hebrew University, Hadassah Hospital, Jerusalem, Israel
    Ann N Y Acad Sci 917:478-87. 2000
    ..Taken together, these findings suggest that cytokines are involved in the etiology and symptomatology of illness-associated depression...
  8. ncbi request reprint Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression
    I Goshen
    Department of Psychology, The Hebrew University, Jerusalem, Israel
    Mol Psychiatry 13:717-28. 2008
    ..Thus, procedures aimed at reducing brain IL-1 levels may have potent antidepressive actions...
  9. ncbi request reprint Effects of antidepressant drugs on the behavioral and physiological responses to lipopolysaccharide (LPS) in rodents
    R Yirmiya
    Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem, Israel
    Neuropsychopharmacology 24:531-44. 2001
    ..The effects of antidepressants on the acute phase response may have important clinical implications for the psychiatric and neuroendocrine disturbances that are commonly associated with various medical conditions...
  10. ncbi request reprint Acute effects of purified and UV-inactivated Herpes simplex virus type 1 on the hypothalamo-pituitary-adrenocortical axis
    T Ben-Hur
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University, Jerusalem, Israel
    Neuroendocrinology 74:160-6. 2001
    ..Adrenalectomized rats failed to respond to ICV inoculation of purified HSV-1 by increase in ACTH. In contrast, these rats responded to ICV injection of LPS...
  11. ncbi request reprint A novel permissive role for glucocorticoids in induction of febrile and behavioral signs of experimental herpes simplex virus encephalitis
    T Ben-Hur
    Department of Neurology, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Neuroscience 108:119-27. 2001
    ..Circulating glucocorticoids play an essential permissive role in the induction of these host brain responses...
  12. ncbi request reprint Interleukin-1 signaling modulates stress-induced analgesia
    G Wolf
    Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
    Brain Behav Immun 21:652-9. 2007
    ..However, the analgesic response to moderate stress is markedly potentiated in mice with impaired IL-1 signaling, corroborating the anti-analgesic role of IL-1 in several pain modulatory conditions, including SIA...
  13. ncbi request reprint Effect of Mycoplasma fermentans on brain PGE(2): role of glucocorticoids and their receptors
    A Wohlman
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel
    Neuroimmunomodulation 9:141-7. 2001
    ..These hormones have an attenuating effect on PGE(2 )production, probably through an MF-induced increase in GC binding by brain tissue. This mechanism may be important in the pathological effect of MF within the brain of AIDS patients...
  14. ncbi request reprint The role of endogenous interleukin-1 in stress-induced adrenal activation and adrenalectomy-induced adrenocorticotropic hormone hypersecretion
    I Goshen
    Department of Psychology, The Hebrew University of Jerusalem, Jerusalem 91905, Israel
    Endocrinology 144:4453-8. 2003
    ..In conclusion, our results suggest that endogenous IL-1 plays a critical role in HPA axis activation after stress and ADX...
  15. ncbi request reprint The EAE-associated behavioral syndrome: II. Modulation by anti-inflammatory treatments
    Y Pollak
    Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
    J Neuroimmunol 137:100-8. 2003
    ....
  16. ncbi request reprint The EAE-associated behavioral syndrome: I. Temporal correlation with inflammatory mediators
    Y Pollak
    Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
    J Neuroimmunol 137:94-9. 2003
    ..These results suggest that inflammatory processes in general, and the production of pro-inflammatory cytokines in particular, are involved in mediating EAE-associated sickness behavior...
  17. doi request reprint Depression, selective serotonin reuptake inhibitors, and osteoporosis
    Itai Bab
    The Hebrew University of Jerusalem, Israel
    Curr Osteoporos Rep 8:185-91. 2010
    ..Patients with depressive disorders should undergo a routine skeletal evaluation and receive timely antiosteoporotic therapy, especially when SSRI treatment is prescribed...
  18. doi request reprint Depression and bone mass
    Itai A Bab
    Bone Laboratory, The Hebrew University of Jerusalem, Jerusalem, Israel
    Ann N Y Acad Sci 1192:170-5. 2010
    ..Bone loss, but not the depressive behavior, could be prevented by a beta-blocker. Hence, depression appears as a significant risk factor for low BMD, causing bone loss through stimulation of the sympathetic nervous system...
  19. ncbi request reprint The effects of perioperative pain management techniques on food consumption and body weight after laparotomy in rats
    Yehuda Shavit
    Department of Psychology, The Hebrew University, Mount Scopus, Jerusalem 91905, Israel
    Anesth Analg 101:1112-6, table of contents. 2005
    ..Laparotomy significantly decreased FC and BW. Both analgesic treatments resulted in a faster recovery of FC and BW. This beneficial effect was more pronounced in the group receiving preoperative analgesics combined with IL-1ra...
  20. ncbi request reprint Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis
    T Kreisel
    Department of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel
    Mol Psychiatry 19:699-709. 2014
    ....
  21. ncbi request reprint Cytokine-associated emotional and cognitive disturbances in humans
    A Reichenberg
    Department of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel
    Arch Gen Psychiatry 58:445-52. 2001
    ..Hence, cytokines represent a novel target for neuropsychopharmacological research...
  22. ncbi request reprint Experimental autoimmune encephalomyelitis-associated behavioral syndrome as a model of 'depression due to multiple sclerosis'
    Y Pollak
    Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
    Brain Behav Immun 16:533-43. 2002
    ..Similarly, anti-depressant drugs have been used effectively in treating MSD. These findings suggest that the EBS may serve as an animal model for MSD...
  23. pmc Central IL-1 receptor signaling regulates bone growth and mass
    Alon Bajayo
    Bone Laboratory, Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 102:12956-61. 2005
    ....
  24. ncbi request reprint Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activity
    S Ben-Eliyahu
    Department of Psychology, Tel Aviv University, Israel
    Int J Cancer 80:880-8. 1999
    ..Clinical circumstances in which surgical stress may induce enhanced metastatic growth are discussed...
  25. ncbi request reprint Involvement of brain cytokines in the neurobehavioral disturbances induced by HIV-1 glycoprotein120
    Ohr Barak
    Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem, 91905, Israel
    Brain Res 933:98-108. 2002
    ....
  26. ncbi request reprint Interleukin-1 antagonizes morphine analgesia and underlies morphine tolerance
    Yehuda Shavit
    Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
    Pain 115:50-9. 2005
    ..These findings suggest that morphine produces an IL-1-mediated homeostatic response, which serves to limit the duration and extent of morphine analgesia and which underlies the development of tolerance...
  27. ncbi request reprint Transcriptional regulation of the murine Presenilin-2 gene reveals similarities and differences to its human orthologue
    Hadile Ounallah-Saad
    Medical Genetics Institute, Shaare Zedek Medical Center, Hebrew University Medical School, Jerusalem, Israel
    Gene 446:81-9. 2009
    ..Differential Psen2 regulation in human and mouse has implications for Alzheimer disease mouse models...
  28. ncbi request reprint Impairment of interleukin-1 (IL-1) signaling reduces basal pain sensitivity in mice: genetic, pharmacological and developmental aspects
    Gilly Wolf
    Department of Psychology, The Hebrew University, Mount Scopus, Jerusalem 91905, Israel
    Pain 104:471-80. 2003
    ..These findings suggest that basal pain sensitivity is genetically, developmentally and tonically influenced by IL-1 signaling...
  29. ncbi request reprint Interleukin-1 signaling is required for induction and maintenance of postoperative incisional pain: genetic and pharmacological studies in mice
    Gilly Wolf
    Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
    Brain Behav Immun 22:1072-7. 2008
    ..This treatment reversed the allodynic response throughout the observation period. Together, these findings suggest that IL-1 plays a critical role in the development and maintenance of postoperative incisional pain...
  30. ncbi request reprint Neuronal overexpression of "readthrough" acetylcholinesterase is associated with antisense-suppressible behavioral impairments
    O Cohen
    Department of Biological Chemistry, The Hebrew University of Jerusalem, 91905 Jerusalem, Israel
    Mol Psychiatry 7:874-85. 2002
    ....
  31. ncbi request reprint Endotoxin-induced changes in food consumption in healthy volunteers are associated with TNF-alpha and IL-6 secretion
    A Reichenberg
    Department of Psychology, The Hebrew University, Mount Scopus, Jerusalem 91905, Israel
    Psychoneuroendocrinology 27:945-56. 2002
    ..53 and -0.45). Neither the febrile response, nor the secretion of cortisol was associated with the changes in food consumption. These results suggest that TNF-alpha and IL-6 are involved in endotoxin-induced anorexia in humans...
  32. ncbi request reprint Intrahippocampal transplantation of transgenic neural precursor cells overexpressing interleukin-1 receptor antagonist blocks chronic isolation-induced impairment in memory and neurogenesis
    Ofra Ben Menachem-Zidon
    Department of Psychology, The Hebrew University of Jerusalem, Department of Neurology, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Neuropsychopharmacology 33:2251-62. 2008
    ....
  33. ncbi request reprint Cholinergic status modulations in human volunteers under acute inflammation
    Keren Ofek
    The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Mol Med (Berl) 85:1239-51. 2007
    ..Our findings establish Cholinergic Status modulations as early facilitators and predictors of individual variabilities in the peripheral response to infection...
  34. ncbi request reprint A dual role for interleukin-1 in hippocampal-dependent memory processes
    Inbal Goshen
    Department of Psychology, The Hebrew University, Jerusalem 91905, Israel
    Psychoneuroendocrinology 32:1106-15. 2007
    ..e., a slight increase in brain IL-1 levels can improve memory, whereas any deviation from the physiological range, either by excess elevation in IL-1 levels or by blockade of IL-1 signaling, results in impaired memory...
  35. ncbi request reprint Involvement of Na(+), K(+)-ATPase and endogenous digitalis-like compounds in depressive disorders
    Inbal Goldstein
    Department of Physiology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Biol Psychiatry 60:491-9. 2006
    ..This hypothesis was examined by the determination of Na(+), K(+)-ATPase/DLC system in parietal cortex of patients with different mood disorders and two animal models of depression...
  36. ncbi request reprint Cytokine-induced changes in mood and behaviour: implications for 'depression due to a general medical condition', immunotherapy and antidepressive treatment
    Yehuda Pollak
    Department of Psychology, The Hebrew University of Jerusalem, Israel
    Int J Neuropsychopharmacol 5:389-99. 2002
    ..Therefore, illness-associated depression should not be underestimated (in terms of prevalence and severity), and should be treated with antidepressant drugs, which may act on the specific physiological mechanisms of this disorder...
  37. ncbi request reprint Intracerebral HIV-1 glycoprotein 120 produces sickness behavior and pituitary-adrenal activation in rats: role of prostaglandins
    Ohr Barak
    Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
    Brain Behav Immun 16:720-35. 2002
    ..Prostaglandins are important mediators of the physiological, but not the behavioral effects of brain gp120...
  38. doi request reprint Environmental enrichment restores memory functioning in mice with impaired IL-1 signaling via reinstatement of long-term potentiation and spine size enlargement
    Inbal Goshen
    Department of Psychology, The Hebrew University, Jerusalem 91905, Israel
    J Neurosci 29:3395-403. 2009
    ....
  39. ncbi request reprint Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production
    Yehuda Pollak
    Department of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel
    Ann Neurol 57:741-5. 2005
    ..These findings demonstrate that cholinergic enhancement produces central and peripheral antiinflammatory effects and suggest a novel therapeutic mechanism for acetylcholinesterase inhibitors...
  40. ncbi request reprint Effects of antidepressants on cytokine production and actions
    Nathalie Castanon
    INRA INSERM U394, Neurobiologie Integrative, Institut Francois Magendie, rue Camille Saint Saens, Bordeaux Cedex 33077, France
    Brain Behav Immun 16:569-74. 2002
    ..Whether their demonstrated immune effects are a side effect or a significant part of their clinical activity still remains to be elucidated...
  41. ncbi request reprint Maternal adrenalectomy abrogates the effect of fetal alcohol exposure on the interleukin-1beta-induced febrile response: gender differences
    Anna N Taylor
    Department of Neurobiology and Brain Research Institute, School of Medicine, University of California, Los Angeles, Calif 90095 1763, USA
    Neuroendocrinology 76:185-92. 2002
    ..In females, early prenatal surgical stress is sufficient to reverse the effects of FAE, possibly via adrenal-independent mechanisms that affect the thermoregulatory system...
  42. ncbi request reprint Alcohol consumption attenuates febrile responses to lipopolysaccharide and interleukin-1 beta in male rats
    Anna N Taylor
    Department of Neurobiology and Brain Research Institute, University of California Los Angeles School of Medicine, Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, 90095 1763, USA
    Alcohol Clin Exp Res 26:44-52. 2002
    ..This study investigated the effects of 14 days of alcohol exposure on cytokine-mediated neuroimmune interactions that affect the febrile component of the host-defense response...
  43. ncbi request reprint Immunization with a nonpathogenic HSV-1 strain prevents clinical and neuroendocrine changes of experimental HSV-1 encephalitis
    Tamir Ben-Hur
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, P O Box 12, 000, Jerusalem 91120, Israel
    J Neuroimmunol 152:5-10. 2004
    ..Mortality was completely prevented. These results indicate that immunization with HSV-1 strain R-15 protects rats from lethal HSV-1 encephalitis and prevents its clinical and neurochemical manifestations...
  44. ncbi request reprint Cytokines and depression: an update
    Robert Dantzer
    INRA INSERM U394, Institut Francois Magendie Integrative Neurobiology, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Brain Behav Immun 16:501-2. 2002
  45. pmc Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats
    Staci D Bilbo
    Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA
    Psychoneuroendocrinology 33:261-9. 2008
    ....
  46. ncbi request reprint Impaired interleukin-1 signaling is associated with deficits in hippocampal memory processes and neural plasticity
    Avi Avital
    Department of Psychology, Haifa University, Haifa, Israel
    Hippocampus 13:826-34. 2003
    ....
  47. ncbi request reprint Endotoxin-induced changes in human working and declarative memory associate with cleavage of plasma "readthrough" acetylcholinesterase
    Osnat Cohen
    Department of Biological Chemistry and The Eric Roland Center for Neurodegenerative Diseases, The Hebrew University of Jerusalem, Israel 91904
    J Mol Neurosci 21:199-212. 2003
    ....
  48. ncbi request reprint Cytokines and cholinergic signals co-modulate surgical stress-induced changes in mood and memory
    Irit Shapira-Lichter
    Department of Psychology, The Hebrew University, Jerusalem 91905, Israel
    Brain Behav Immun 22:388-98. 2008
    ..Taken together, these findings suggest that exposure to a surgical stressor induces a reciprocal up-regulation of AChE-R and pro-inflammatory cytokines, which are involved in regulating the surgery-induced mood and memory disturbances...
  49. ncbi request reprint Low-dose endotoxemia and human neuropsychological functions
    Karen Suarez Krabbe
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, University of Copenhagen, Denmark
    Brain Behav Immun 19:453-60. 2005
    ..In conclusion, our findings demonstrate a negative association between circulating IL-6 and memory functions during very low-dose endotoxemia independently of physical stress symptoms, and the hypothalamo-pituitary-adrenal axis...
  50. ncbi request reprint Genetic impairment of interleukin-1 signaling attenuates neuropathic pain, autotomy, and spontaneous ectopic neuronal activity, following nerve injury in mice
    Gilly Wolf
    Department of Psychology, Hebrew University, Mount Scopus, Jerusalem 91905, Israel
    Pain 120:315-24. 2006
    ..Taken together, these results suggest that IL-1 signaling plays an important role in neuropathic pain and in the altered neuronal activity that underlies its development...
  51. ncbi request reprint IL-1 beta signaling is required for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal GRK2
    Wendy Kleibeuker
    University Medical Centre Utrecht, Laboratory of Psychoneuroimmunology, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Brain Behav Immun 22:200-8. 2008
    ..These results suggest a functional relation between the L5 SNT-induced IL-1 beta-mediated decrease in GRK2 and development of mechanical allodynia...