Research Topics
Species | R YirmiyaSummaryAffiliation: The Hebrew University Country: Israel Publications
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Detail Information
Publications
The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signalingJoseph Tam
Bone Laboratory, Hadassah School of Dental Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel
FASEB J 22:285-94. 2008..Elevation of bone 2-AG apparently suppresses NE release from bone sympathetic terminals, thus alleviating the inhibition of bone formation. The involvement of osteoblastic CB2 signaling in this process is minimal, if any...
Major depression is a risk factor for low bone mineral density: a meta-analysisRaz Yirmiya
Department of Psychology, The Hebrew University of Jerusalem, Jerusalem 91905, Israel
Biol Psychiatry 66:423-32. 2009....
Depression induces bone loss through stimulation of the sympathetic nervous systemRaz Yirmiya
Department of Psychology, Faculty of Social Sciences, Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
Proc Natl Acad Sci U S A 103:16876-81. 2006..Together with the common occurrence of depression and bone loss in the aging population, the present data implicate depression as a potential major risk factor for osteoporosis and the associated increase in fracture incidence...- Immune modulation of learning, memory, neural plasticity and neurogenesisRaz Yirmiya
Department of Psychology, The Hebrew University of Jerusalem, Jerusalem 91905, Israel
Brain Behav Immun 25:181-213. 2011.... - Brain interleukin-1 is involved in spatial memory and passive avoidance conditioningR Yirmiya
Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem, 91905, Israel
Neurobiol Learn Mem 78:379-89. 2002..These results suggest that IL-1 signaling within the hippocampus plays a critical role in learning and memory processes... - The role of brain cytokines in mediating the behavioral and neuroendocrine effects of intracerebral mycoplasma fermentansR Yirmiya
Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
Brain Res 829:28-38. 1999..We suggest that cytokines within the brain are involved in mediating at least some of the neurobehavioral and neuroendocrine abnormalities that may be produced by MF in AIDS patients... - Illness, cytokines, and depressionR Yirmiya
Department of Psychology, Hebrew University, Hadassah Hospital, Jerusalem, Israel
Ann N Y Acad Sci 917:478-87. 2000..Taken together, these findings suggest that cytokines are involved in the etiology and symptomatology of illness-associated depression... - Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppressionI Goshen
Department of Psychology, The Hebrew University, Jerusalem, Israel
Mol Psychiatry 13:717-28. 2008..Thus, procedures aimed at reducing brain IL-1 levels may have potent antidepressive actions... - Effects of antidepressant drugs on the behavioral and physiological responses to lipopolysaccharide (LPS) in rodentsR Yirmiya
Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem, Israel
Neuropsychopharmacology 24:531-44. 2001..The effects of antidepressants on the acute phase response may have important clinical implications for the psychiatric and neuroendocrine disturbances that are commonly associated with various medical conditions... - Acute effects of purified and UV-inactivated Herpes simplex virus type 1 on the hypothalamo-pituitary-adrenocortical axisT Ben-Hur
Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University, Jerusalem, Israel
Neuroendocrinology 74:160-6. 2001.... - A novel permissive role for glucocorticoids in induction of febrile and behavioral signs of experimental herpes simplex virus encephalitisT Ben-Hur
Department of Neurology, Hadassah Hebrew University Hospital, Jerusalem, Israel
Neuroscience 108:119-27. 2001..Circulating glucocorticoids play an essential permissive role in the induction of these host brain responses... - Interleukin-1 signaling modulates stress-induced analgesiaG Wolf
Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
Brain Behav Immun 21:652-9. 2007..However, the analgesic response to moderate stress is markedly potentiated in mice with impaired IL-1 signaling, corroborating the anti-analgesic role of IL-1 in several pain modulatory conditions, including SIA... - Effect of Mycoplasma fermentans on brain PGE(2): role of glucocorticoids and their receptorsA Wohlman
Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel
Neuroimmunomodulation 9:141-7. 2001..These hormones have an attenuating effect on PGE(2 )production, probably through an MF-induced increase in GC binding by brain tissue. This mechanism may be important in the pathological effect of MF within the brain of AIDS patients... - The role of endogenous interleukin-1 in stress-induced adrenal activation and adrenalectomy-induced adrenocorticotropic hormone hypersecretionI Goshen
Department of Psychology, The Hebrew University of Jerusalem, Jerusalem 91905, Israel
Endocrinology 144:4453-8. 2003..In conclusion, our results suggest that endogenous IL-1 plays a critical role in HPA axis activation after stress and ADX... - The EAE-associated behavioral syndrome: II. Modulation by anti-inflammatory treatmentsY Pollak
Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
J Neuroimmunol 137:100-8. 2003.... - The EAE-associated behavioral syndrome: I. Temporal correlation with inflammatory mediatorsY Pollak
Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
J Neuroimmunol 137:94-9. 2003..These results suggest that inflammatory processes in general, and the production of pro-inflammatory cytokines in particular, are involved in mediating EAE-associated sickness behavior... - The effects of perioperative pain management techniques on food consumption and body weight after laparotomy in ratsYehuda Shavit
Department of Psychology, The Hebrew University, Mount Scopus, Jerusalem 91905, Israel
Anesth Analg 101:1112-6, table of contents. 2005..Both analgesic treatments resulted in a faster recovery, especially preoperative analgesics combined with interleukin-1 receptor antagonist... - Depression and bone massItai A Bab
Bone Laboratory, The Hebrew University of Jerusalem, Jerusalem, Israel
Ann N Y Acad Sci 1192:170-5. 2010..Bone loss, but not the depressive behavior, could be prevented by a beta-blocker. Hence, depression appears as a significant risk factor for low BMD, causing bone loss through stimulation of the sympathetic nervous system... - Depression, selective serotonin reuptake inhibitors, and osteoporosisItai Bab
The Hebrew University of Jerusalem, Israel
Curr Osteoporos Rep 8:185-91. 2010..Patients with depressive disorders should undergo a routine skeletal evaluation and receive timely antiosteoporotic therapy, especially when SSRI treatment is prescribed... - Cytokine-associated emotional and cognitive disturbances in humansA Reichenberg
Department of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel
Arch Gen Psychiatry 58:445-52. 2001..Hence, cytokines represent a novel target for neuropsychopharmacological research... - Experimental autoimmune encephalomyelitis-associated behavioral syndrome as a model of 'depression due to multiple sclerosis'Y Pollak
Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
Brain Behav Immun 16:533-43. 2002..Similarly, anti-depressant drugs have been used effectively in treating MSD. These findings suggest that the EBS may serve as an animal model for MSD... - Central IL-1 receptor signaling regulates bone growth and massAlon Bajayo
Bone Laboratory, Hebrew University of Jerusalem, Jerusalem 91120, Israel
Proc Natl Acad Sci U S A 102:12956-61. 2005.... - Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activityS Ben-Eliyahu
Department of Psychology, Tel Aviv University, Israel
Int J Cancer 80:880-8. 1999..Clinical circumstances in which surgical stress may induce enhanced metastatic growth are discussed... - Transcriptional regulation of the murine Presenilin-2 gene reveals similarities and differences to its human orthologueHadile Ounallah-Saad
Medical Genetics Institute, Shaare Zedek Medical Center, Hebrew University Medical School, Jerusalem, Israel
Gene 446:81-9. 2009..Differential Psen2 regulation in human and mouse has implications for Alzheimer disease mouse models... - Interleukin-1 antagonizes morphine analgesia and underlies morphine toleranceYehuda Shavit
Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
Pain 115:50-9. 2005..These findings suggest that morphine produces an IL-1-mediated homeostatic response, which serves to limit the duration and extent of morphine analgesia and which underlies the development of tolerance... - Interleukin-1 signaling is required for induction and maintenance of postoperative incisional pain: genetic and pharmacological studies in miceGilly Wolf
Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
Brain Behav Immun 22:1072-7. 2008..This treatment reversed the allodynic response throughout the observation period. Together, these findings suggest that IL-1 plays a critical role in the development and maintenance of postoperative incisional pain... - Involvement of brain cytokines in the neurobehavioral disturbances induced by HIV-1 glycoprotein120Ohr Barak
Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem, 91905, Israel
Brain Res 933:98-108. 2002.... - Impairment of interleukin-1 (IL-1) signaling reduces basal pain sensitivity in mice: genetic, pharmacological and developmental aspectsGilly Wolf
Department of Psychology, The Hebrew University, Mount Scopus, Jerusalem 91905, Israel
Pain 104:471-80. 2003..These findings suggest that basal pain sensitivity is genetically, developmentally and tonically influenced by IL-1 signaling... - Neuronal overexpression of "readthrough" acetylcholinesterase is associated with antisense-suppressible behavioral impairmentsO Cohen
Department of Biological Chemistry, The Hebrew University of Jerusalem, 91905 Jerusalem, Israel
Mol Psychiatry 7:874-85. 2002.... - Endotoxin-induced changes in food consumption in healthy volunteers are associated with TNF-alpha and IL-6 secretionA Reichenberg
Department of Psychology, The Hebrew University, Mount Scopus, Jerusalem 91905, Israel
Psychoneuroendocrinology 27:945-56. 2002..53 and -0.45). Neither the febrile response, nor the secretion of cortisol was associated with the changes in food consumption. These results suggest that TNF-alpha and IL-6 are involved in endotoxin-induced anorexia in humans... - Intrahippocampal transplantation of transgenic neural precursor cells overexpressing interleukin-1 receptor antagonist blocks chronic isolation-induced impairment in memory and neurogenesisOfra Ben Menachem-Zidon
Department of Psychology, The Hebrew University of Jerusalem, Department of Neurology, Hadassah Hebrew University Hospital, Jerusalem, Israel
Neuropsychopharmacology 33:2251-62. 2008.... - A dual role for interleukin-1 in hippocampal-dependent memory processesInbal Goshen
Department of Psychology, The Hebrew University, Jerusalem 91905, Israel
Psychoneuroendocrinology 32:1106-15. 2007..e., a slight increase in brain IL-1 levels can improve memory, whereas any deviation from the physiological range, either by excess elevation in IL-1 levels or by blockade of IL-1 signaling, results in impaired memory... - Environmental enrichment restores memory functioning in mice with impaired IL-1 signaling via reinstatement of long-term potentiation and spine size enlargementInbal Goshen
Department of Psychology, The Hebrew University, Jerusalem 91905, Israel
J Neurosci 29:3395-403. 2009.... - Cholinergic status modulations in human volunteers under acute inflammationKeren Ofek
The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
J Mol Med (Berl) 85:1239-51. 2007..Our findings establish Cholinergic Status modulations as early facilitators and predictors of individual variabilities in the peripheral response to infection... - Cytokine-induced changes in mood and behaviour: implications for 'depression due to a general medical condition', immunotherapy and antidepressive treatmentYehuda Pollak
Department of Psychology, The Hebrew University of Jerusalem, Israel
Int J Neuropsychopharmacol 5:389-99. 2002..Therefore, illness-associated depression should not be underestimated (in terms of prevalence and severity), and should be treated with antidepressant drugs, which may act on the specific physiological mechanisms of this disorder... - Intracerebral HIV-1 glycoprotein 120 produces sickness behavior and pituitary-adrenal activation in rats: role of prostaglandinsOhr Barak
Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
Brain Behav Immun 16:720-35. 2002..Prostaglandins are important mediators of the physiological, but not the behavioral effects of brain gp120... - Involvement of Na(+), K(+)-ATPase and endogenous digitalis-like compounds in depressive disordersInbal Goldstein
Department of Physiology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
Biol Psychiatry 60:491-9. 2006..CONCLUSIONS: The results support the possibility that Na(+), K(+)-ATPase and endogenous DLC participate in the pathogenesis of depressive disorders... - Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta productionYehuda Pollak
Department of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel
Ann Neurol 57:741-5. 2005..These findings demonstrate that cholinergic enhancement produces central and peripheral antiinflammatory effects and suggest a novel therapeutic mechanism for acetylcholinesterase inhibitors... - Effects of antidepressants on cytokine production and actionsNathalie Castanon
INRA INSERM U394, Neurobiologie Integrative, Institut Francois Magendie, rue Camille Saint Saens, Bordeaux Cedex 33077, France
Brain Behav Immun 16:569-74. 2002..Whether their demonstrated immune effects are a side effect or a significant part of their clinical activity still remains to be elucidated... - Maternal adrenalectomy abrogates the effect of fetal alcohol exposure on the interleukin-1beta-induced febrile response: gender differencesAnna N Taylor
Department of Neurobiology and Brain Research Institute, School of Medicine, University of California, Los Angeles, Calif 90095 1763, USA
Neuroendocrinology 76:185-92. 2002..In females, early prenatal surgical stress is sufficient to reverse the effects of FAE, possibly via adrenal-independent mechanisms that affect the thermoregulatory system... - Immunization with a nonpathogenic HSV-1 strain prevents clinical and neuroendocrine changes of experimental HSV-1 encephalitisTamir Ben-Hur
Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, P O Box 12, 000, Jerusalem 91120, Israel
J Neuroimmunol 152:5-10. 2004..Mortality was completely prevented. These results indicate that immunization with HSV-1 strain R-15 protects rats from lethal HSV-1 encephalitis and prevents its clinical and neurochemical manifestations... - Endotoxin-induced changes in human working and declarative memory associate with cleavage of plasma "readthrough" acetylcholinesteraseOsnat Cohen
Department of Biological Chemistry and The Eric Roland Center for Neurodegenerative Diseases, The Hebrew University of Jerusalem, Israel 91904
J Mol Neurosci 21:199-212. 2003.... - Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult ratsStaci D Bilbo
Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA
Psychoneuroendocrinology 33:261-9. 2008.... - Cytokines and cholinergic signals co-modulate surgical stress-induced changes in mood and memoryIrit Shapira-Lichter
Department of Psychology, The Hebrew University, Jerusalem 91905, Israel
Brain Behav Immun 22:388-98. 2008..Taken together, these findings suggest that exposure to a surgical stressor induces a reciprocal up-regulation of AChE-R and pro-inflammatory cytokines, which are involved in regulating the surgery-induced mood and memory disturbances... - IL-1 beta signaling is required for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal GRK2Wendy Kleibeuker
University Medical Centre Utrecht, Laboratory of Psychoneuroimmunology, Lundlaan 6, 3584 EA Utrecht, The Netherlands
Brain Behav Immun 22:200-8. 2008..These results suggest a functional relation between the L5 SNT-induced IL-1 beta-mediated decrease in GRK2 and development of mechanical allodynia... - Cytokines and depression: an updateRobert Dantzer
INRA-INSERM U394, Institut Francois Magendie Integrative Neurobiology, Rue Camille Saint-Saens, 33077 Bordeaux Cedex, France
Brain Behav Immun 16:501-2. 2002 - Genetic impairment of interleukin-1 signaling attenuates neuropathic pain, autotomy, and spontaneous ectopic neuronal activity, following nerve injury in miceGilly Wolf
Department of Psychology, Hebrew University, Mount Scopus, Jerusalem 91905, Israel
Pain 120:315-24. 2006..Taken together, these results suggest that IL-1 signaling plays an important role in neuropathic pain and in the altered neuronal activity that underlies its development... - Impaired interleukin-1 signaling is associated with deficits in hippocampal memory processes and neural plasticityAvi Avital
Department of Psychology, Haifa University, Haifa, Israel
Hippocampus 13:826-34. 2003.... - Low-dose endotoxemia and human neuropsychological functionsKaren Suarez Krabbe
Centre of Inflammation and Metabolism, Department of Infectious Diseases, University of Copenhagen, Denmark
Brain Behav Immun 19:453-60. 2005..In conclusion, our findings demonstrate a negative association between circulating IL-6 and memory functions during very low-dose endotoxemia independently of physical stress symptoms, and the hypothalamo-pituitary-adrenal axis... - Alcohol consumption attenuates febrile responses to lipopolysaccharide and interleukin-1 beta in male ratsAnna N Taylor
Department of Neurobiology and Brain Research Institute, University of California Los Angeles School of Medicine, Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, 90095 1763, USA
Alcohol Clin Exp Res 26:44-52. 2002..This study investigated the effects of 14 days of alcohol exposure on cytokine-mediated neuroimmune interactions that affect the febrile component of the host-defense response...