U Wormser

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi Involvement of tumor necrosis factor-alpha in sulfur mustard-induced skin lesion; effect of topical iodine
    Uri Wormser
    Department of Pharmacology, School of Pharmacy Faculty of Medicine, Berman Building, Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram, 91904 Jerusalem, Israel
    Arch Toxicol 79:660-70. 2005
  2. ncbi Protective effect of topical iodine preparations upon heat-induced and hydrofluoric acid-induced skin lesions
    Uri Wormser
    Faculty of Sciences, The Hebrew University, Givat Ram, Jerusalem, Israel
    Toxicol Pathol 30:552-8. 2002
  3. ncbi Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice
    Uri Wormser
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    Toxicol Appl Pharmacol 200:40-7. 2004
  4. ncbi Topical iodine preparation as therapy against sulfur mustard-induced skin lesions
    U Wormser
    Berman Building, Institute of Life Sciences, Faculty of Sciences, The Hebrew University, Edmond Safra Campus, Givat Ram, 91904, Jersusalem, Israel
    Toxicol Appl Pharmacol 169:33-9. 2000
  5. ncbi Protective effect of povidone iodine ointment against skin lesions induced by chemical and thermal stimuli
    U Wormser
    Institute of Life Sciences, The Hebrew University of Jerusalem, Israel
    J Appl Toxicol 20:S183-5. 2000
  6. ncbi Topical treatment with povidone iodine reduces nitrogen mustard-induced skin collagenolytic activity
    Uri Wormser
    Faculty of Sciences, Berman Building, The Hebrew University, Edmond Safra Campus, Givat Ram, 91904 Jerusalem, Israel
    Arch Toxicol 76:119-21. 2002
  7. ncbi Skin toxicokinetics of mustard gas in the guinea pig: effect of hypochlorite and safety aspects
    Uri Wormser
    Faculty of Sciences, The Hebrew University, Edmond Safra Campus, Givat Ram, Jerusalem, Israel
    Arch Toxicol 76:517-22. 2002
  8. ncbi Protective effect of topical iodine containing anti-inflammatory drugs against sulfur mustard-induced skin lesions
    Uri Wormser
    Berman Building, Institute of Life Sciences, The Hebrew University, 91904 Jerusalem, Israel
    Arch Toxicol 78:156-66. 2004
  9. ncbi Noninvasive procedure for in situ determination of skin surface aspartic proteinase activity in animals; implications for human skin
    U Wormser
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University, Jerusalem, Israel
    Arch Dermatol Res 289:686-91. 1997
  10. ncbi From topical antidote against skin irritants to a novel counter-irritating and anti-inflammatory peptide
    Berta Brodsky
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Institute of Life Sciences, The Hebrew University, 91120 Jerusalem, Israel
    Toxicol Appl Pharmacol 229:342-50. 2008

Collaborators

Detail Information

Publications24

  1. ncbi Involvement of tumor necrosis factor-alpha in sulfur mustard-induced skin lesion; effect of topical iodine
    Uri Wormser
    Department of Pharmacology, School of Pharmacy Faculty of Medicine, Berman Building, Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram, 91904 Jerusalem, Israel
    Arch Toxicol 79:660-70. 2005
    ..The combination of iodine and antiTNF-alpha antibodies might constitute a new approach for treatment of SM-exposed individuals...
  2. ncbi Protective effect of topical iodine preparations upon heat-induced and hydrofluoric acid-induced skin lesions
    Uri Wormser
    Faculty of Sciences, The Hebrew University, Givat Ram, Jerusalem, Israel
    Toxicol Pathol 30:552-8. 2002
    ..Our findings suggest the therapeutic usage of these newly developed iodine preparations for thermally induced and hydrofluoric acid-induced skin burns...
  3. ncbi Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice
    Uri Wormser
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    Toxicol Appl Pharmacol 200:40-7. 2004
    ..These findings may indicate that COX-2 participates in the early stages of sulfur mustard-induced acute skin toxicity and that COX-1 might exert some protective function against this chemical insult...
  4. ncbi Topical iodine preparation as therapy against sulfur mustard-induced skin lesions
    U Wormser
    Berman Building, Institute of Life Sciences, Faculty of Sciences, The Hebrew University, Edmond Safra Campus, Givat Ram, 91904, Jersusalem, Israel
    Toxicol Appl Pharmacol 169:33-9. 2000
    ..SM was not affected chemically by iodine as measured by gas chromatography-mass spectrometry (GC-MS) analysis. These findings suggest that the iodine preparation functions as an antidote against skin lesions induced by SM...
  5. ncbi Protective effect of povidone iodine ointment against skin lesions induced by chemical and thermal stimuli
    U Wormser
    Institute of Life Sciences, The Hebrew University of Jerusalem, Israel
    J Appl Toxicol 20:S183-5. 2000
    ..Apart from being a safe and widely used disinfectant, PI ointment is recommended as an efficient protective agent against skin toxicity caused by hazardous chemicals and by heat stimuli...
  6. ncbi Topical treatment with povidone iodine reduces nitrogen mustard-induced skin collagenolytic activity
    Uri Wormser
    Faculty of Sciences, Berman Building, The Hebrew University, Edmond Safra Campus, Givat Ram, 91904 Jerusalem, Israel
    Arch Toxicol 76:119-21. 2002
    ..Reduced collagenolytic activity may serve as one of the mechanisms by which iodine protects the skin against chemical insult...
  7. ncbi Skin toxicokinetics of mustard gas in the guinea pig: effect of hypochlorite and safety aspects
    Uri Wormser
    Faculty of Sciences, The Hebrew University, Edmond Safra Campus, Givat Ram, Jerusalem, Israel
    Arch Toxicol 76:517-22. 2002
    ..These findings are important for health authorities and regulatory agencies in planning precautionary steps to be taken in case of emergency and in routine laboratory work...
  8. ncbi Protective effect of topical iodine containing anti-inflammatory drugs against sulfur mustard-induced skin lesions
    Uri Wormser
    Berman Building, Institute of Life Sciences, The Hebrew University, 91904 Jerusalem, Israel
    Arch Toxicol 78:156-66. 2004
    ..These findings suggest that the povidone-iodine preparation combined with anti-inflammatory agents functions as a potent antidote against skin lesions induced by SM at relatively long intervals between exposure and treatment...
  9. ncbi Noninvasive procedure for in situ determination of skin surface aspartic proteinase activity in animals; implications for human skin
    U Wormser
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University, Jerusalem, Israel
    Arch Dermatol Res 289:686-91. 1997
    ..Skin surface aspartic proteinase/cathepsin D activity may serve as a marker for skin aging or for certain skin disorders leading to a new approach to their medical treatments...
  10. ncbi From topical antidote against skin irritants to a novel counter-irritating and anti-inflammatory peptide
    Berta Brodsky
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Institute of Life Sciences, The Hebrew University, 91120 Jerusalem, Israel
    Toxicol Appl Pharmacol 229:342-50. 2008
    ....
  11. ncbi In vivo and in vitro toxicity of newly synthesized monofunctional sulfur mustard derivatives
    U Wormser
    Department of Pharmacology, Faculty of Medicine, Jerusalem, Israel
    Toxicology 108:125-8. 1996
    ..CBCS or derivatives may serve as models compounds for investigating the mechanism of action of alkylating agents...
  12. ncbi Early effects of iodine on DNA synthesis in sulfur mustard-induced skin lesions
    Berta Brodsky
    Department of Pharmacology, School of Pharmacy, Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Givat Ram, Jerusalem, Israel
    Arch Toxicol 80:212-6. 2006
    ..Iodine treatment following SM exposure exerted an effect similar to that of SM only, indicating that DNA synthesis is not directly involved in the mechanism of action of iodine-induced protection...
  13. ncbi Skin surface proteolytic activity. Partial characterization and identification
    U Wormser
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University, Israel
    Adv Exp Med Biol 436:207-12. 1998
    ..The present study demonstrates the presence of proteolytic activity located on skin surface using a unique, non-invasive method for in situ proteinase determination in the living animal...
  14. ncbi Low molecular weight antioxidants released from the skin's epidermal layers: an age dependent phenomenon in the rat
    Ron Kohen
    Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel
    Exp Gerontol 39:67-72. 2004
    ..Differences in the ability to release high levels of uric acid among species were well correlated with their metabolic rates. It is suggested that in rat the released LMWA may serve as a possible marker for aging of the skin...
  15. ncbi Peaceful use of disastrous neurotoxicants
    Yoram Finkelstein
    Service and Unit of Neurology and Toxicology, Shaare Zedek Medical Center, Jerusalem, Israel
    Neurotoxicology 31:608-20. 2010
    ..These reviews highlight different aspects of neurotoxicity, addressing epidemiology and mechanisms of toxicity; and identifying novel potential therapies...
  16. ncbi Phthalate exposure among pregnant women in Jerusalem, Israel: results of a pilot study
    Tamar Berman
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem 91120, Israel
    Environ Int 35:353-7. 2009
    ..Few studies have evaluated exposure to phthalates in pregnant women, despite the potential sensitivity of the developing fetus to adverse effects of phthalates...
  17. ncbi Release of amino acids, fluorescamine-reactive substances and substance P from the epidermis of the living animal
    U Wormser
    Department of Evolution Systematics and Ecology, Institute of Life Sciences, Berman Building, Faculty of Science, Givat Ram, The Hebrew University of Jerusalem, Jerusalem, Israel
    Skin Pharmacol Appl Skin Physiol 12:98-104. 1999
    ..2 times upon heat stimulus as compared to control skin. Amines and other compounds released from the skin may serve as markers for skin aging or for certain skin disorders, leading to a new approach for their treatments...
  18. ncbi Novel peptides as potential treatment of systemic lupus erythematosus
    E Shapira
    Institute of Life Sciences, The Hebrew University, Jerusalem, Israel
    Lupus 20:463-72. 2011
    ..Decreased levels of double negative CD4(-)CD8(-) and B220(+) cells were determined in lymph organs of UBE-treated animals. The beneficial effects of both UBE and IIIM1 suggest these peptides as potential drugs for SLE...
  19. ncbi Effect of different iodine formulations on the expression and activity of Streptococcus mutans glucosyltransferase and fructosyltransferase in biofilm and planktonic environments
    Avshalom Tam
    Institute of Dental Sciences, Faculty of Dentistry, Hebrew University-Hadassah, Jerusalem, Israel
    J Antimicrob Chemother 57:865-71. 2006
    ..CONCLUSIONS: This study indicates that iodine at sub-bactericidal concentrations demonstrates molecular and enzymatic effects that are highly associated with biofilm formation...
  20. ncbi Amelioration of experimental autoimmune encephalitis by novel peptides: involvement of T regulatory cells
    Elena Shapira
    Institute of Drug Research, School of Pharmacy, Faculty of Medicine, Institute of Life Sciences, The Hebrew University, POB 12065, 91120 Jerusalem, Israel
    J Autoimmun 35:98-106. 2010
    ..RA1 might be involved in the relatively low prevalence of MS in Japan and other Japanese rice-eating populations...
  21. ncbi A chick model for the mechanisms of mustard gas neurobehavioral teratogenicity
    Uri Wormser
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Institute of Life Sciences, The Hebrew University, Jerusalem, Israel
    Neurotoxicol Teratol 27:65-71. 2005
    ....
  22. ncbi Protection from toxicants
    Berta Brodsky
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
    Curr Probl Dermatol 34:76-86. 2007
    ..In addition, the ointment should be left on the skin long enough for achieving the therapeutic effect. This simple topical treatment can prevent suffering, skin transplantation and complications associated with skin burns...
  23. ncbi Topical iodine facilitates transdermal delivery of insulin
    Amnon C Sintov
    Department of Clinical Pharmacology and School of Pharmacy, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    J Control Release 118:185-8. 2007
    ..The proposed procedure might be applicable for additional disulfide-containing peptides such as calcitonin, somatostatin, oxytocin/vasopressin and their analogs...
  24. ncbi Vitamin D3-based conjugates for topical treatment of psoriasis: synthesis, antiproliferative activity, and cutaneous penetration studies
    Shimon Ben-Shabat
    The Institutes for Applied Research and the School of Pharmacy, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel
    Pharm Res 22:50-7. 2005
    ..The goals of the experiments reported in this paper were to explore skin bioavailability and cell growth inhibitory activity of new vitamin D3-based conjugates studied as a potential drug complex for psoriasis...