Marta Weinstock

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi request reprint The potential influence of maternal stress hormones on development and mental health of the offspring
    Marta Weinstock
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Centre Jerusalem, Israel
    Brain Behav Immun 19:296-308. 2005
  2. pmc Subtle ethical dilemmas in geriatric management and clinical research
    A J Rosin
    Department of Geriatrics, Shaare Zedek Medical Center, Jerusalem, Israel
    J Med Ethics 31:355-9. 2005
  3. doi request reprint Dose-dependent effects of ladostigil on microglial activation and cognition in aged rats
    Marta Weinstock
    Department of Pharmacology, Institute of Drug Research, Hebrew University Medical Center, Ein Kerem, Jerusalem 91120, Israel
    J Neuroimmune Pharmacol 8:345-55. 2013
  4. doi request reprint Ladostigil prevents age-related glial activation and spatial memory deficits in rats
    Marta Weinstock
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Center, Ein Kerem, Jerusalem 91120, Israel
    Neurobiol Aging 32:1069-78. 2011
  5. ncbi request reprint Gender differences in the effects of prenatal stress on brain development and behaviour
    Marta Weinstock
    Department of Pharmacology, Hebrew University Medical Centre, Ein Kerem, Jerusalem, 91120, Israel
    Neurochem Res 32:1730-40. 2007
  6. ncbi request reprint Maternal adrenal hormone secretion mediates behavioural alterations induced by prenatal stress in male and female rats
    Gal Zagron
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Centre, Ein Kerem, Jerusalem 92110, Israel
    Behav Brain Res 175:323-8. 2006
  7. ncbi request reprint Effect of varied gestational stress on acquisition of spatial memory, hippocampal LTP and synaptic proteins in juvenile male rats
    Rami Yaka
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Centre Jerusalem, Israel
    Behav Brain Res 179:126-32. 2007
  8. doi request reprint Prenatal stress diminishes gender differences in behavior and in expression of hippocampal synaptic genes and proteins in rats
    Ya arit Nachum Biala
    Department of Pharmacology, School of Pharmacy, Hebrew University, Jerusalem, Israel
    Hippocampus 21:1114-25. 2011
  9. doi request reprint Anti-inflammatory effects of ladostigil and its metabolites in aged rat brain and in microglial cells
    Rony Panarsky
    Institute of Drug Research, Hebrew University Medical Center, Ein Kerem, Jerusalem, Israel
    J Neuroimmune Pharmacol 7:488-98. 2012
  10. ncbi request reprint Effect of chronic treatment with ladostigil (TV-3326) on anxiogenic and depressive-like behaviour and on activity of the hypothalamic-pituitary-adrenal axis in male and female prenatally stressed rats
    Tatyana Poltyrev
    Department of Pharmacology, Hebrew University Hadassah School of Medicine, Ein Kerem, Jerusalem 91120, Israel
    Psychopharmacology (Berl) 181:118-25. 2005

Collaborators

  • Iris Lavon
  • Michal Linial
  • Rami Yaka
  • M B Youdim
  • W Maruyama
  • M Naoi
  • Jörg Bock
  • Tatyana Poltyrev
  • Shai Shoham
  • Corina Bejar
  • Donna Schorer-Apelbaum
  • Helena Shifrin
  • Rony Panarsky
  • Ya arit Nachum Biala
  • Jeffrey Sterling
  • Eran Nizri
  • Efrat Groner
  • Meena Sriti Murmu
  • Gal Zagron
  • A J Rosin
  • Yaacov Herzig
  • Yotam Sagi
  • Merav Yogev-Falach
  • Mirela Nadler-Milbauer
  • Lisandro Luques
  • Yoel Bogoch
  • Ehud Lavi
  • Nabil Faranesh
  • Talma Brenner
  • Michal Irony-Tur-Sinai
  • Eugenia Kovalev
  • Yacov Ashani
  • Shiri Salomon
  • Yaarit Biala
  • Katharina Braun
  • Elena Gorodetsky
  • Y van Dijk
  • Boris Krais
  • Tamar Goren
  • John Finberg
  • Michael Chorev
  • Nina Finkelstein
  • Tamar Amit
  • Rachel Friedman
  • Ferenc Rantal
  • Gila Lavian
  • Orit Bar-Am
  • Aviva Gross
  • Gyorgy Toth
  • Andras Zekany
  • Willy Goldenberg
  • David Lerner
  • Tivadar Tamas
  • Istvan Miskolczi
  • Michal Razin
  • Wei Huang
  • Sandor Molnar
  • Adela Zagyva

Detail Information

Publications27

  1. ncbi request reprint The potential influence of maternal stress hormones on development and mental health of the offspring
    Marta Weinstock
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Centre Jerusalem, Israel
    Brain Behav Immun 19:296-308. 2005
    ..Excess amounts of CRH and cortisol reaching the human fetal brain during periods of chronic maternal stress could alter personality and predispose to attention deficits and depressive illness through changes in neurotransmitter activity...
  2. pmc Subtle ethical dilemmas in geriatric management and clinical research
    A J Rosin
    Department of Geriatrics, Shaare Zedek Medical Center, Jerusalem, Israel
    J Med Ethics 31:355-9. 2005
    ..Because cognitive capacity is not always identical with competency, meaningful tools have recently been developed in which the emphasis is on the specific situation to be investigated...
  3. doi request reprint Dose-dependent effects of ladostigil on microglial activation and cognition in aged rats
    Marta Weinstock
    Department of Pharmacology, Institute of Drug Research, Hebrew University Medical Center, Ein Kerem, Jerusalem 91120, Israel
    J Neuroimmune Pharmacol 8:345-55. 2013
    ..A dose causing 30 % ChE inhibition is necessary in order to reverse existing memory deficits at 20 months of age...
  4. doi request reprint Ladostigil prevents age-related glial activation and spatial memory deficits in rats
    Marta Weinstock
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Center, Ein Kerem, Jerusalem 91120, Israel
    Neurobiol Aging 32:1069-78. 2011
    ..Early treatment with ladostigil could slow disease progression in conditions like Alzheimer's disease in which oxidative stress and inflammatory processes are present...
  5. ncbi request reprint Gender differences in the effects of prenatal stress on brain development and behaviour
    Marta Weinstock
    Department of Pharmacology, Hebrew University Medical Centre, Ein Kerem, Jerusalem, 91120, Israel
    Neurochem Res 32:1730-40. 2007
    ..Genders may differ in the sensitivity of developing brain areas to stress hormones...
  6. ncbi request reprint Maternal adrenal hormone secretion mediates behavioural alterations induced by prenatal stress in male and female rats
    Gal Zagron
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Centre, Ein Kerem, Jerusalem 92110, Israel
    Behav Brain Res 175:323-8. 2006
    ..These data show that excess stress-induced COR can alter the programming of the foetal brain and predispose it to alterations in behaviour that are gender specific...
  7. ncbi request reprint Effect of varied gestational stress on acquisition of spatial memory, hippocampal LTP and synaptic proteins in juvenile male rats
    Rami Yaka
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Centre Jerusalem, Israel
    Behav Brain Res 179:126-32. 2007
    ..The alteration by prenatal stress in the relative amounts of scaffolding proteins and those which compose glutamate receptors could explain the depression of LTP and impairment in the acquisition of spatial learning...
  8. doi request reprint Prenatal stress diminishes gender differences in behavior and in expression of hippocampal synaptic genes and proteins in rats
    Ya arit Nachum Biala
    Department of Pharmacology, School of Pharmacy, Hebrew University, Jerusalem, Israel
    Hippocampus 21:1114-25. 2011
    ..The study provides an unbiased view of key genes and proteins that act as gender dependent molecular sensors. The disruption of their expression by adverse early life stress may explain the alterations that occur in behavior...
  9. doi request reprint Anti-inflammatory effects of ladostigil and its metabolites in aged rat brain and in microglial cells
    Rony Panarsky
    Institute of Drug Research, Hebrew University Medical Center, Ein Kerem, Jerusalem, Israel
    J Neuroimmune Pharmacol 7:488-98. 2012
    ..We propose that the anti-inflammatory activity may contribute towards the neuroprotective action of ladostigil against the development of memory impairments induced by aging or toxin-induced microglial activation...
  10. ncbi request reprint Effect of chronic treatment with ladostigil (TV-3326) on anxiogenic and depressive-like behaviour and on activity of the hypothalamic-pituitary-adrenal axis in male and female prenatally stressed rats
    Tatyana Poltyrev
    Department of Pharmacology, Hebrew University Hadassah School of Medicine, Ein Kerem, Jerusalem 91120, Israel
    Psychopharmacology (Berl) 181:118-25. 2005
    ....
  11. ncbi request reprint Ladostigil prevents gliosis, oxidative-nitrative stress and memory deficits induced by intracerebroventricular injection of streptozotocin in rats
    Shai Shoham
    Research Department, Herzog Hospital, Jerusalem, Israel
    Neuropharmacology 52:836-43. 2007
    ..Taken together the data support the role of glial activation and oxidative-nitrative stress in discrete brain areas in the aetiology of memory deficits and indicate a potential mechanism for their prevention by drug treatment...
  12. ncbi request reprint The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates
    Efrat Groner
    Department of Pharmacology, Hebrew University, Ein Kerem, Jerusalem 91120, Israel
    Mol Pharmacol 71:1610-7. 2007
    ..The data show how the degree of enzyme inhibition can be manipulated by structural changes in the N-methyl, N-alkyl carbamates and the corresponding leaving group to achieve therapeutic levels of brain AChE, BChE, and MAO-B inhibition...
  13. ncbi request reprint A novel cholinesterase and brain-selective monoamine oxidase inhibitor for the treatment of dementia comorbid with depression and Parkinson's disease
    Marta Weinstock
    Department of Pharmacology, Hebrew University Hadassah School of Medicine, Ein Kerem, 91120, Jerusalem, Israel
    Prog Neuropsychopharmacol Biol Psychiatry 27:555-61. 2003
    ..These unique multiple actions of TV-3326 make it a potentially useful drug for the treatment of dementia with Parkinsonian-like symptoms and depression...
  14. ncbi request reprint Effect of TV3326, a novel monoamine-oxidase cholinesterase inhibitor, in rat models of anxiety and depression
    Marta Weinstock
    Department of Pharmacology, Hebrew University Faculty of Medicine, Jerusalem 91120, Israel
    Psychopharmacology (Berl) 160:318-24. 2002
    ....
  15. pmc Rivastigmine alleviates experimentally induced colitis in mice and rats by acting at central and peripheral sites to modulate immune responses
    Helena Shifrin
    Department of Pharmacology, Institute of Drug Research, Hebrew University Medical Center, Jerusalem, Israel
    PLoS ONE 8:e57668. 2013
    ..These include ACh released from vagal nerve endings that activates alpha7 nicotinic receptors on circulating macrophages and in brainstem neurons...
  16. ncbi request reprint Intrauterine factors as determinants of depressive disorder
    Marta Weinstock
    Department of Pharmacology, The Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Isr J Psychiatry Relat Sci 47:36-45. 2010
    ..Clinical improvement of MDD by antidepressants is accompanied by normalization of the regulation of the HPA axis and of serotoninergic transmission...
  17. doi request reprint Suppression of neuroinflammation and immunomodulation by the acetylcholinesterase inhibitor rivastigmine
    Eran Nizri
    Laboratory of Neuroimmunology, Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Jerusalem, Israel
    J Neuroimmunol 203:12-22. 2008
    ..These effects were abolished by alpha7 nicotinic acetylcholine receptor antagonists. Antigen presentation was also affected by this treatment. Thus, rivastigmine treatment had immunomodulatory activity in EAE...
  18. doi request reprint The long-term behavioural consequences of prenatal stress
    Marta Weinstock
    Department of Pharmacology, Hebrew University, Medical Centre, Ein Kerem, Jerusalem 91120, Israel
    Neurosci Biobehav Rev 32:1073-86. 2008
    ..Conclusion: Excess circulating maternal stress hormones alter the programming of foetal neurons, and together with genetic factors, the postnatal environment and quality of maternal attention, determine the behaviour of the offspring...
  19. ncbi request reprint Gender difference in the prevention of hyperanxiety in adult prenatally stressed rats by chronic treatment with amitriptyline
    Tatyana Poltyrev
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Centre, Ein Kerem, 91120 Jerusalem, Israel
    Psychopharmacology (Berl) 171:270-6. 2004
    ..The study determined whether oral administration of amitriptyline for 6 weeks from before puberty to prenatally stressed (PS) male and female rats could prevent hyperanxiety in adulthood...
  20. ncbi request reprint Amyloid processing and signal transduction properties of antiparkinson-antialzheimer neuroprotective drugs rasagiline and TV3326
    Moussa B H Youdim
    Department of Pharmacology, Technion Faculty of Medicine, Haifa, Israel
    Ann N Y Acad Sci 993:378-86; discussion 387-93. 2003
    ..These data suggest a novel pharmacological mechanism, whereby these ChE inhibitors regulate the secretary processes of APP via activation of the MAP kinase pathway...
  21. ncbi request reprint Therapeutic applications of selective and non-selective inhibitors of monoamine oxidase A and B that do not cause significant tyramine potentiation
    Moussa B H Youdim
    Department of Pharmacology, Bruce Rappaport Faculty of Medicine Technion, Eve Topf and National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Efron St, PO Box 9697, Haifa 31096, Israel
    Neurotoxicology 25:243-50. 2004
    ..Pharmacologically it has limited tyramine potentiation, very similar to moclobemide and being a MAO-AB inhibitor it has the antidepressant, anti-Parkinson and anti-Alzheimer activities in the respective models used to develop such drugs...
  22. ncbi request reprint Attenuation of MPTP-induced dopaminergic neurotoxicity by TV3326, a cholinesterase-monoamine oxidase inhibitor
    Yotam Sagi
    Eve Topf and USA National Parkinson Foundation, Centers of Excellence for Neurodegenerative Diseases Research, Technion Faculty of Medicine, Haifa, Israel
    J Neurochem 86:290-7. 2003
    ..This may explain its antidepressant-like activity, resembling that of moclobemide in the forced-swim test in rats...
  23. ncbi request reprint Novel neuroprotective anti-Alzheimer drugs with anti-depressant activity derived from the anti-Parkinson drug, rasagiline
    Moussa B H Youdim
    Technion Faculty of Medicine, Eve Topf and NPF Centers, 31096, Haifa, Israel
    Mech Ageing Dev 123:1081-6. 2002
    ..Thus MAO inhibition by propargylamines is not a pre-requisite for neuroprotection. Rather, propargylamines have some intrinsic neuroprotective property whose mechanism of action requires further elucidation...
  24. ncbi request reprint Involvement of MAP kinase in the regulation of amyloid precursor protein processing by novel cholinesterase inhibitors derived from rasagiline
    Merav Yogev-Falach
    Technion Faculty of Medicine, Eve Topf and NPF Centers for Neurodegenerative Diseases Department of Pharmacology Haifa, Israel
    FASEB J 16:1674-6. 2002
    ..These data suggest a novel pharmacological mechanism whereby these ChE inhibitors regulate the secretory processes of APP via activation of the MAP kinase pathway...
  25. ncbi request reprint Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease
    Jeffrey Sterling
    Research and Development Division, Teva Pharmaceutical Industries, ABIC, P O Box 8077, Netanya 42504, Israel
    J Med Chem 45:5260-79. 2002
    ..Thus, the apparent enzyme inhibition will be a result of the combined inhibition of all of these individual metabolites. The results of our ongoing in vivo screening programs will be published elsewhere...
  26. ncbi request reprint Anti-apoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)-aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor
    Wakako Maruyama
    Laboratory of Biochemistry and Metabolism, Department of Basic Gerontology, National Institute for Longevity Sciences, Obu, Aichi, Japan
    Neurosci Lett 341:233-6. 2003
    ..This resulted in stabilization of the mitochondrial membrane potential, the collapse of which initiates the apoptotic cascade...
  27. ncbi request reprint Changes of spine density and dendritic complexity in the prefrontal cortex in offspring of mothers exposed to stress during pregnancy
    Meena Sriti Murmu
    Institute of Biology, Department of Zoology and Developmental Neurobiology, Otto von Guericke University, Brenneckestr 6, 39118 Magdeburg Germany
    Eur J Neurosci 24:1477-87. 2006
    ..These findings demonstrate that gestational stress leads to significant alterations of prefrontal neuronal structure in the offspring of the stressed mothers in a sex-specific manner...