Marta Weinstock

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi request reprint Effects of maternal stress on development and behaviour in rat offspring
    M Weinstock
    Department of Pharmacology, School of Pharmacy, Hebrew University Hadassah School of Medicine, Ein Kerem, Jerusalem 91120, Israel
    Stress 4:157-67. 2001
  2. ncbi request reprint Limited potentiation of blood pressure response to oral tyramine by brain-selective monoamine oxidase A-B inhibitor, TV-3326 in conscious rabbits
    M Weinstock
    Department of Pharmacology, Hebrew University, Hadassah Medical Centre, Ein Kerem, Jerusalem, Israel
    Neuropharmacology 43:999-1005. 2002
  3. ncbi request reprint Can the behaviour abnormalities induced by gestational stress in rats be prevented or reversed?
    M Weinstock
    Department of Pharmacology, Hebrew University Hadassah School of Medicine, Ein Kerem, Jarusalem, Israel
    Stress 5:167-76. 2002
  4. ncbi request reprint Effect of prenatal stress on plasma corticosterone and catecholamines in response to footshock in rats
    M Weinstock
    Department of Pharmacology, School of Pharmacy, Hebrew University Hadassah Medical Centre, Ein Kerem, Jerusalem, Israel
    Physiol Behav 64:439-44. 1998
  5. ncbi request reprint Effect of TV3326, a novel monoamine-oxidase cholinesterase inhibitor, in rat models of anxiety and depression
    Marta Weinstock
    Department of Pharmacology, Hebrew University Faculty of Medicine, Jerusalem 91120, Israel
    Psychopharmacology (Berl) 160:318-24. 2002
  6. ncbi request reprint Rat models of dementia based on reductions in regional glucose metabolism, cerebral blood flow and cytochrome oxidase activity
    M Weinstock
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Centre, Jerusalem, Israel
    J Neural Transm 111:347-66. 2004
  7. ncbi request reprint Alterations induced by gestational stress in brain morphology and behaviour of the offspring
    M Weinstock
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Centre, Ein Kerem, 91120, Jerusalem, Israel
    Prog Neurobiol 65:427-51. 2001
  8. ncbi request reprint Neuroprotective effects of novel cholinesterase inhibitors derived from rasagiline as potential anti-Alzheimer drugs
    M Weinstock
    Department of Pharmacology, Hebrew University Faculty of Medicine, Jerusalem, Israel
    Ann N Y Acad Sci 939:148-61. 2001
  9. ncbi request reprint A novel cholinesterase and brain-selective monoamine oxidase inhibitor for the treatment of dementia comorbid with depression and Parkinson's disease
    Marta Weinstock
    Department of Pharmacology, Hebrew University Hadassah School of Medicine, Ein Kerem, 91120, Jerusalem, Israel
    Prog Neuropsychopharmacol Biol Psychiatry 27:555-61. 2003
  10. doi request reprint Ladostigil prevents age-related glial activation and spatial memory deficits in rats
    Marta Weinstock
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Center, Ein Kerem, Jerusalem 91120, Israel
    Neurobiol Aging 32:1069-78. 2011

Collaborators

  • S Shoham
  • A Gross
  • Iris Lavon
  • Rami Yaka
  • M B Youdim
  • Michal Linial
  • W Maruyama
  • M Naoi
  • Jörg Bock
  • Tatyana Poltyrev
  • Helena Shifrin
  • R H Wang
  • Rony Panarsky
  • Ya arit Nachum Biala
  • Jeffrey Sterling
  • Corina Bejar
  • Eran Nizri
  • L Luques
  • Efrat Groner
  • Y Bogoch
  • Gal Zagron
  • Meena Sriti Murmu
  • Donna Schorer-Apelbaum
  • Yaacov Herzig
  • Yotam Sagi
  • Merav Yogev-Falach
  • Mirela Nadler-Milbauer
  • Lisandro Luques
  • Yoel Bogoch
  • T Poltyrev
  • Talma Brenner
  • Ehud Lavi
  • Nabil Faranesh
  • Michal Irony-Tur-Sinai
  • Y N Biala
  • Yacov Ashani
  • Shiri Salomon
  • Katharina Braun
  • Yaarit Biala
  • Elena Gorodetsky
  • Boris Krais
  • Michael Chorev
  • Nina Finkelstein
  • Tamar Amit
  • Ferenc Rantal
  • Gila Lavian
  • Willy Goldenberg
  • Tivadar Tamas
  • Michal Razin
  • Tamar Goren
  • John Finberg
  • Rachel Friedman
  • Orit Bar-Am
  • Gyorgy Toth
  • Andras Zekany
  • David Lerner
  • Istvan Miskolczi
  • Wei Huang
  • Sandor Molnar
  • Adela Zagyva
  • D Schorer-Apelbaum

Detail Information

Publications41

  1. ncbi request reprint Effects of maternal stress on development and behaviour in rat offspring
    M Weinstock
    Department of Pharmacology, School of Pharmacy, Hebrew University Hadassah School of Medicine, Ein Kerem, Jerusalem 91120, Israel
    Stress 4:157-67. 2001
    ....
  2. ncbi request reprint Limited potentiation of blood pressure response to oral tyramine by brain-selective monoamine oxidase A-B inhibitor, TV-3326 in conscious rabbits
    M Weinstock
    Department of Pharmacology, Hebrew University, Hadassah Medical Centre, Ein Kerem, Jerusalem, Israel
    Neuropharmacology 43:999-1005. 2002
    ..If TV-3326 is found to produce as little potentiation of the tyramine response in human subjects, it may be a potentially useful therapeutic agent for the treatment of Alzheimer's disease with depression...
  3. ncbi request reprint Can the behaviour abnormalities induced by gestational stress in rats be prevented or reversed?
    M Weinstock
    Department of Pharmacology, Hebrew University Hadassah School of Medicine, Ein Kerem, Jarusalem, Israel
    Stress 5:167-76. 2002
    ..This suggests that the new non-peptide CRH1 receptor antagonists that enter the brain might provide an effective treatment for the behaviour abnormalities in the offspring arising as a result of gestational stress...
  4. ncbi request reprint Effect of prenatal stress on plasma corticosterone and catecholamines in response to footshock in rats
    M Weinstock
    Department of Pharmacology, School of Pharmacy, Hebrew University Hadassah Medical Centre, Ein Kerem, Jerusalem, Israel
    Physiol Behav 64:439-44. 1998
    ..The findings demonstrate for the first time that prenatal stress can induce long term changes in the sensitivity of the sympathoadrenal system to stress...
  5. ncbi request reprint Effect of TV3326, a novel monoamine-oxidase cholinesterase inhibitor, in rat models of anxiety and depression
    Marta Weinstock
    Department of Pharmacology, Hebrew University Faculty of Medicine, Jerusalem 91120, Israel
    Psychopharmacology (Berl) 160:318-24. 2002
    ....
  6. ncbi request reprint Rat models of dementia based on reductions in regional glucose metabolism, cerebral blood flow and cytochrome oxidase activity
    M Weinstock
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Centre, Jerusalem, Israel
    J Neural Transm 111:347-66. 2004
    ..Antioxidants and neuroprotective agents may also decrease memory deficits by preventing inflammation and neurodegeneration...
  7. ncbi request reprint Alterations induced by gestational stress in brain morphology and behaviour of the offspring
    M Weinstock
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Centre, Ein Kerem, 91120, Jerusalem, Israel
    Prog Neurobiol 65:427-51. 2001
    ..The character of the behavioural abnormalities probably depends on the timing of the maternal stress in relation to development of the particular neuronal systems...
  8. ncbi request reprint Neuroprotective effects of novel cholinesterase inhibitors derived from rasagiline as potential anti-Alzheimer drugs
    M Weinstock
    Department of Pharmacology, Hebrew University Faculty of Medicine, Jerusalem, Israel
    Ann N Y Acad Sci 939:148-61. 2001
    ..The latter does not result from ChE inhibition. It is associated with the presence of the propargyl group, since it occurs with other propargylamines that do not inhibit MAO, but not with drugs that inhibit only ChE...
  9. ncbi request reprint A novel cholinesterase and brain-selective monoamine oxidase inhibitor for the treatment of dementia comorbid with depression and Parkinson's disease
    Marta Weinstock
    Department of Pharmacology, Hebrew University Hadassah School of Medicine, Ein Kerem, 91120, Jerusalem, Israel
    Prog Neuropsychopharmacol Biol Psychiatry 27:555-61. 2003
    ..These unique multiple actions of TV-3326 make it a potentially useful drug for the treatment of dementia with Parkinsonian-like symptoms and depression...
  10. doi request reprint Ladostigil prevents age-related glial activation and spatial memory deficits in rats
    Marta Weinstock
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Center, Ein Kerem, Jerusalem 91120, Israel
    Neurobiol Aging 32:1069-78. 2011
    ..Early treatment with ladostigil could slow disease progression in conditions like Alzheimer's disease in which oxidative stress and inflammatory processes are present...
  11. doi request reprint Dose-dependent effects of ladostigil on microglial activation and cognition in aged rats
    Marta Weinstock
    Department of Pharmacology, Institute of Drug Research, Hebrew University Medical Center, Ein Kerem, Jerusalem 91120, Israel
    J Neuroimmune Pharmacol 8:345-55. 2013
    ..A dose causing 30 % ChE inhibition is necessary in order to reverse existing memory deficits at 20 months of age...
  12. ncbi request reprint Effect of chronic treatment with ladostigil (TV-3326) on anxiogenic and depressive-like behaviour and on activity of the hypothalamic-pituitary-adrenal axis in male and female prenatally stressed rats
    Tatyana Poltyrev
    Department of Pharmacology, Hebrew University Hadassah School of Medicine, Ein Kerem, Jerusalem 91120, Israel
    Psychopharmacology (Berl) 181:118-25. 2005
    ....
  13. ncbi request reprint Maternal adrenal hormone secretion mediates behavioural alterations induced by prenatal stress in male and female rats
    Gal Zagron
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Centre, Ein Kerem, Jerusalem 92110, Israel
    Behav Brain Res 175:323-8. 2006
    ..These data show that excess stress-induced COR can alter the programming of the foetal brain and predispose it to alterations in behaviour that are gender specific...
  14. ncbi request reprint Gender differences in the effects of prenatal stress on brain development and behaviour
    Marta Weinstock
    Department of Pharmacology, Hebrew University Medical Centre, Ein Kerem, Jerusalem, 91120, Israel
    Neurochem Res 32:1730-40. 2007
    ..Genders may differ in the sensitivity of developing brain areas to stress hormones...
  15. ncbi request reprint Effect of varied gestational stress on acquisition of spatial memory, hippocampal LTP and synaptic proteins in juvenile male rats
    Rami Yaka
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Centre Jerusalem, Israel
    Behav Brain Res 179:126-32. 2007
    ..The alteration by prenatal stress in the relative amounts of scaffolding proteins and those which compose glutamate receptors could explain the depression of LTP and impairment in the acquisition of spatial learning...
  16. ncbi request reprint The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates
    Efrat Groner
    Department of Pharmacology, Hebrew University, Ein Kerem, Jerusalem 91120, Israel
    Mol Pharmacol 71:1610-7. 2007
    ..The data show how the degree of enzyme inhibition can be manipulated by structural changes in the N-methyl, N-alkyl carbamates and the corresponding leaving group to achieve therapeutic levels of brain AChE, BChE, and MAO-B inhibition...
  17. ncbi request reprint The potential influence of maternal stress hormones on development and mental health of the offspring
    Marta Weinstock
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Centre Jerusalem, Israel
    Brain Behav Immun 19:296-308. 2005
    ..Excess amounts of CRH and cortisol reaching the human fetal brain during periods of chronic maternal stress could alter personality and predispose to attention deficits and depressive illness through changes in neurotransmitter activity...
  18. doi request reprint Anti-inflammatory effects of ladostigil and its metabolites in aged rat brain and in microglial cells
    Rony Panarsky
    Institute of Drug Research, Hebrew University Medical Center, Ein Kerem, Jerusalem, Israel
    J Neuroimmune Pharmacol 7:488-98. 2012
    ..We propose that the anti-inflammatory activity may contribute towards the neuroprotective action of ladostigil against the development of memory impairments induced by aging or toxin-induced microglial activation...
  19. doi request reprint Prenatal stress diminishes gender differences in behavior and in expression of hippocampal synaptic genes and proteins in rats
    Ya arit Nachum Biala
    Department of Pharmacology, School of Pharmacy, Hebrew University, Jerusalem, Israel
    Hippocampus 21:1114-25. 2011
    ..The study provides an unbiased view of key genes and proteins that act as gender dependent molecular sensors. The disruption of their expression by adverse early life stress may explain the alterations that occur in behavior...
  20. ncbi request reprint Ladostigil prevents gliosis, oxidative-nitrative stress and memory deficits induced by intracerebroventricular injection of streptozotocin in rats
    Shai Shoham
    Research Department, Herzog Hospital, Jerusalem, Israel
    Neuropharmacology 52:836-43. 2007
    ..Taken together the data support the role of glial activation and oxidative-nitrative stress in discrete brain areas in the aetiology of memory deficits and indicate a potential mechanism for their prevention by drug treatment...
  21. ncbi request reprint Therapeutic applications of selective and non-selective inhibitors of monoamine oxidase A and B that do not cause significant tyramine potentiation
    Moussa B H Youdim
    Department of Pharmacology, Bruce Rappaport Faculty of Medicine Technion, Eve Topf and National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Efron St, PO Box 9697, Haifa 31096, Israel
    Neurotoxicology 25:243-50. 2004
    ..Pharmacologically it has limited tyramine potentiation, very similar to moclobemide and being a MAO-AB inhibitor it has the antidepressant, anti-Parkinson and anti-Alzheimer activities in the respective models used to develop such drugs...
  22. ncbi request reprint Amyloid processing and signal transduction properties of antiparkinson-antialzheimer neuroprotective drugs rasagiline and TV3326
    Moussa B H Youdim
    Department of Pharmacology, Technion Faculty of Medicine, Haifa, Israel
    Ann N Y Acad Sci 993:378-86; discussion 387-93. 2003
    ..These data suggest a novel pharmacological mechanism, whereby these ChE inhibitors regulate the secretary processes of APP via activation of the MAP kinase pathway...
  23. doi request reprint Suppression of neuroinflammation and immunomodulation by the acetylcholinesterase inhibitor rivastigmine
    Eran Nizri
    Laboratory of Neuroimmunology, Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Jerusalem, Israel
    J Neuroimmunol 203:12-22. 2008
    ..These effects were abolished by alpha7 nicotinic acetylcholine receptor antagonists. Antigen presentation was also affected by this treatment. Thus, rivastigmine treatment had immunomodulatory activity in EAE...
  24. ncbi request reprint Chronic brain cytochrome oxidase inhibition selectively alters hippocampal cholinergic innervation and impairs memory: prevention by ladostigil
    L Luques
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Center, Ein Kerem, Jerusalem 91120, Israel
    Exp Neurol 206:209-19. 2007
    ..Ladostigil may have a beneficial effect on cognitive deficits in AD patients that have a reduction in cortical COx activity and cholinergic hypofunction...
  25. doi request reprint Rational design of a drug for Alzheimer's disease with cholinesterase inhibitory and neuroprotective activity
    M Weinstock
    Department of Pharmacology, Hebrew University Medical Centre, Ein Kerem, Jerusalem, Israel
    Chem Biol Interact 175:216-21. 2008
    ..Only the N-ethyl and N-propyl derivatives showed AChE and BuChE inhibitory activity in vivo of a suitably slow onset and long duration, together with MAO-B inhibition...
  26. pmc Rivastigmine alleviates experimentally induced colitis in mice and rats by acting at central and peripheral sites to modulate immune responses
    Helena Shifrin
    Department of Pharmacology, Institute of Drug Research, Hebrew University Medical Center, Jerusalem, Israel
    PLoS ONE 8:e57668. 2013
    ..These include ACh released from vagal nerve endings that activates alpha7 nicotinic receptors on circulating macrophages and in brainstem neurons...
  27. doi request reprint The long-term behavioural consequences of prenatal stress
    Marta Weinstock
    Department of Pharmacology, Hebrew University, Medical Centre, Ein Kerem, Jerusalem 91120, Israel
    Neurosci Biobehav Rev 32:1073-86. 2008
    ..Conclusion: Excess circulating maternal stress hormones alter the programming of foetal neurons, and together with genetic factors, the postnatal environment and quality of maternal attention, determine the behaviour of the offspring...
  28. ncbi request reprint Gender difference in the prevention of hyperanxiety in adult prenatally stressed rats by chronic treatment with amitriptyline
    Tatyana Poltyrev
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Centre, Ein Kerem, 91120 Jerusalem, Israel
    Psychopharmacology (Berl) 171:270-6. 2004
    ..The study determined whether oral administration of amitriptyline for 6 weeks from before puberty to prenatally stressed (PS) male and female rats could prevent hyperanxiety in adulthood...
  29. ncbi request reprint Intrauterine factors as determinants of depressive disorder
    Marta Weinstock
    Department of Pharmacology, The Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Isr J Psychiatry Relat Sci 47:36-45. 2010
    ..Clinical improvement of MDD by antidepressants is accompanied by normalization of the regulation of the HPA axis and of serotoninergic transmission...
  30. ncbi request reprint Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]
    M B Youdim
    Eve Topf and National Parkinson Foundation Centers for Neurodegenerative Diseases Research, Department of Pharmacology, Technion Faculty of Medicine, Haifa, Israel
    Cell Mol Neurobiol 21:555-73. 2001
    ..It is quite likely that the induction of Bcl-2 and activation of PKC by rasagiline and TV3326 is closely linked to the anti-apoptotic action of these drugs and their ability to process APP by activation of alpha-secretase...
  31. ncbi request reprint Steroid hormones mediate sex difference in brain levels of tacrine and its hypothermic effect in the rat
    R H Wang
    Department of Pharmacology, Hebrew University, Hadassah Medical Centre, Ein Kerem, 91120, Jerusalem, Israel
    Neuropharmacology 41:887-94. 2001
    ..It is concluded that steroids can reduce the pharmacological effects of tacrine by interfering with its entry into the brain...
  32. ncbi request reprint Anxiety induced by prenatal stress is associated with suppression of hippocampal genes involved in synaptic function
    Y Bogoch
    Department of Biological Chemistry, Life Science Institute, The Hebrew University, Jerusalem, Israel
    J Neurochem 101:1018-30. 2007
    ..These include genes that play a role in pre-synaptic organization and function. Our results provide a possible relationship between hippocampal gene expression and changes in behaviour resulting from prenatal stress...
  33. ncbi request reprint Intracerebroventricular injection of streptozotocin causes neurotoxicity to myelin that contributes to spatial memory deficits in rats
    S Shoham
    Research Department, Herzog Hospital, School of Pharmacy, Hebrew University Medical Centre, Jerusalem, Israel
    Exp Neurol 184:1043-52. 2003
    ..The selective damage to myelin may well result from oxidative stress...
  34. ncbi request reprint Testosterone mediates sex difference in hypothermia and cholinesterase inhibition by rivastigmine
    R H Wang
    Department of Pharmacology, School of Pharmacy, Hebrew University, Hadassah Medical Centre, Ein Kerem, Jerusalem 91120, Israel
    Eur J Pharmacol 433:73-9. 2001
    ..Testosterone may further decrease the temperature-lowering effect of rivastigmine and acetylcholine receptor agonists in males by an action at a receptor level...
  35. ncbi request reprint Effect of gestational stress on maternal behavior in response to cage transfer and handling of pups in two strains of rat
    T Poltyrev
    Department of Pharmacology, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel
    Stress 3:85-95. 1999
    ....
  36. ncbi request reprint Novel neuroprotective anti-Alzheimer drugs with anti-depressant activity derived from the anti-Parkinson drug, rasagiline
    Moussa B H Youdim
    Technion Faculty of Medicine, Eve Topf and NPF Centers, 31096, Haifa, Israel
    Mech Ageing Dev 123:1081-6. 2002
    ..Thus MAO inhibition by propargylamines is not a pre-requisite for neuroprotection. Rather, propargylamines have some intrinsic neuroprotective property whose mechanism of action requires further elucidation...
  37. ncbi request reprint Involvement of MAP kinase in the regulation of amyloid precursor protein processing by novel cholinesterase inhibitors derived from rasagiline
    Merav Yogev-Falach
    Technion Faculty of Medicine, Eve Topf and NPF Centers for Neurodegenerative Diseases Department of Pharmacology Haifa, Israel
    FASEB J 16:1674-6. 2002
    ..These data suggest a novel pharmacological mechanism whereby these ChE inhibitors regulate the secretory processes of APP via activation of the MAP kinase pathway...
  38. ncbi request reprint Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease
    Jeffrey Sterling
    Research and Development Division, Teva Pharmaceutical Industries, ABIC, P O Box 8077, Netanya 42504, Israel
    J Med Chem 45:5260-79. 2002
    ..Thus, the apparent enzyme inhibition will be a result of the combined inhibition of all of these individual metabolites. The results of our ongoing in vivo screening programs will be published elsewhere...
  39. ncbi request reprint Anti-apoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)-aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor
    Wakako Maruyama
    Laboratory of Biochemistry and Metabolism, Department of Basic Gerontology, National Institute for Longevity Sciences, Obu, Aichi, Japan
    Neurosci Lett 341:233-6. 2003
    ..This resulted in stabilization of the mitochondrial membrane potential, the collapse of which initiates the apoptotic cascade...
  40. ncbi request reprint Changes of spine density and dendritic complexity in the prefrontal cortex in offspring of mothers exposed to stress during pregnancy
    Meena Sriti Murmu
    Institute of Biology, Department of Zoology and Developmental Neurobiology, Otto von Guericke University, Brenneckestr 6, 39118 Magdeburg Germany
    Eur J Neurosci 24:1477-87. 2006
    ..These findings demonstrate that gestational stress leads to significant alterations of prefrontal neuronal structure in the offspring of the stressed mothers in a sex-specific manner...
  41. ncbi request reprint Attenuation of MPTP-induced dopaminergic neurotoxicity by TV3326, a cholinesterase-monoamine oxidase inhibitor
    Yotam Sagi
    Eve Topf and USA National Parkinson Foundation, Centers of Excellence for Neurodegenerative Diseases Research, Technion Faculty of Medicine, Haifa, Israel
    J Neurochem 86:290-7. 2003
    ..This may explain its antidepressant-like activity, resembling that of moclobemide in the forced-swim test in rats...