H Soreq

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. pmc Post-traumatic anxiety associates with failure of the innate immune receptor TLR9 to evade the pro-inflammatory NFκB pathway
    G Zimmerman
    The Edmond and Lily Safra Center for Brain Sciences, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    Transl Psychiatry 2:e78. 2012
  2. pmc N-acetylcholinesterase-induced apoptosis in Alzheimer's disease
    Debra Toiber
    Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    PLoS ONE 3:e3108. 2008
  3. pmc Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase target
    G Shaltiel
    Edmond and Lily Safra Center of Brain Sciences, The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Brain Struct Funct 218:59-72. 2013
  4. pmc Activation of the alternative NFκB pathway improves disease symptoms in a model of Sjogren's syndrome
    Adi Gilboa-Geffen
    Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    PLoS ONE 6:e28727. 2011
  5. pmc Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice
    Amit Berson
    Department of Biological Chemistry and the Edmond and Lily Safra Center of Brain Science, The Hebrew University of Jerusalem, Jerusalem, Israel
    EMBO Mol Med 4:730-42. 2012
  6. pmc The butyrylcholinesterase K variant confers structurally derived risks for Alzheimer pathology
    Erez Podoly
    The Alexander Silberman Life Sciences Institute, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Biol Chem 284:17170-9. 2009
  7. pmc Stressing hematopoiesis and immunity: an acetylcholinesterase window into nervous and immune system interactions
    Adi Gilboa-Geffen
    The Edmond and Lily Safra Center for Brain Sciences and the Institute of Life Sciences, The Hebrew University of Jerusalem Jerusalem, Israel
    Front Mol Neurosci 5:30. 2012
  8. pmc It all starts at the ends: multifaceted involvement of C- and N-terminally modified cholinesterases in Alzheimer's disease
    Amit Berson
    Department of Biological Chemistry and the Edmond and Lily Safra Center of Neuroscience, The Hebrew University of Jerusalem, Jerusalem, Israel
    Rambam Maimonides Med J 1:e0014. 2010
  9. pmc Cholinesterase-Targeting microRNAs Identified in silico Affect Specific Biological Processes
    Geula Hanin
    The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem Jerusalem, Israel
    Front Mol Neurosci 4:28. 2011
  10. ncbi Overlapping molecular signatures in Parkinson's patient leukocytes before and after treatment and in mouse model brain regions
    Lilach Soreq
    Department of Biological Chemistry, The Institute for Life Sciences and the Edmond and Lily Safra Center for Brain Science ELSC, The Hebrew University of Jerusalem, 91904, Israel
    CNS Neurol Disord Drug Targets 12:1086-93. 2013

Collaborators

Detail Information

Publications111 found, 100 shown here

  1. pmc Post-traumatic anxiety associates with failure of the innate immune receptor TLR9 to evade the pro-inflammatory NFκB pathway
    G Zimmerman
    The Edmond and Lily Safra Center for Brain Sciences, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    Transl Psychiatry 2:e78. 2012
    ....
  2. pmc N-acetylcholinesterase-induced apoptosis in Alzheimer's disease
    Debra Toiber
    Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    PLoS ONE 3:e3108. 2008
    ..Here, we report that overexpression of an N-terminally extended "synaptic" acetylcholinesterase variant, N-AChE-S is causally involved in both these phenomena...
  3. pmc Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase target
    G Shaltiel
    Edmond and Lily Safra Center of Brain Sciences, The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Brain Struct Funct 218:59-72. 2013
    ..Our findings attribute stress-inducible cognitive impairments to cholinergic-mediated induction of miR-132 and consequently suppressed ACHE-S, opening venues for intercepting these miR-132-mediated damages...
  4. pmc Activation of the alternative NFκB pathway improves disease symptoms in a model of Sjogren's syndrome
    Adi Gilboa-Geffen
    Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    PLoS ONE 6:e28727. 2011
    ..We propose that BL-7040 could be beneficial in treating Sjogren's syndrome and may be applicable to additional autoimmune syndromes...
  5. pmc Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice
    Amit Berson
    Department of Biological Chemistry and the Edmond and Lily Safra Center of Brain Science, The Hebrew University of Jerusalem, Jerusalem, Israel
    EMBO Mol Med 4:730-42. 2012
    ..Our findings present cholinergic-mediated hnRNP A/B loss and impaired RNA metabolism as important mechanisms involved in AD...
  6. pmc The butyrylcholinesterase K variant confers structurally derived risks for Alzheimer pathology
    Erez Podoly
    The Alexander Silberman Life Sciences Institute, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Biol Chem 284:17170-9. 2009
    ....
  7. pmc Stressing hematopoiesis and immunity: an acetylcholinesterase window into nervous and immune system interactions
    Adi Gilboa-Geffen
    The Edmond and Lily Safra Center for Brain Sciences and the Institute of Life Sciences, The Hebrew University of Jerusalem Jerusalem, Israel
    Front Mol Neurosci 5:30. 2012
    ..The therapeutic agents can thus be targeted to the enzyme protein, its encoding mRNA transcripts, or the regulator microRNA-132, opening new venues for therapeutic interference with multiple nervous and immune system diseases...
  8. pmc It all starts at the ends: multifaceted involvement of C- and N-terminally modified cholinesterases in Alzheimer's disease
    Amit Berson
    Department of Biological Chemistry and the Edmond and Lily Safra Center of Neuroscience, The Hebrew University of Jerusalem, Jerusalem, Israel
    Rambam Maimonides Med J 1:e0014. 2010
    ..Harnessing the neuroprotective variants while reducing the levels of damaging ones may hence underlie the development of novel therapeutics. ..
  9. pmc Cholinesterase-Targeting microRNAs Identified in silico Affect Specific Biological Processes
    Geula Hanin
    The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem Jerusalem, Israel
    Front Mol Neurosci 4:28. 2011
    ....
  10. ncbi Overlapping molecular signatures in Parkinson's patient leukocytes before and after treatment and in mouse model brain regions
    Lilach Soreq
    Department of Biological Chemistry, The Institute for Life Sciences and the Edmond and Lily Safra Center for Brain Science ELSC, The Hebrew University of Jerusalem, 91904, Israel
    CNS Neurol Disord Drug Targets 12:1086-93. 2013
    ..Finally, we discuss potential future directions of high-throughput RNA research as facilitators of the PD knowledge base through next generation sequencing technologies of both long and short RNA transcripts including microRNAs...
  11. pmc Plasma acetylcholinesterase activity correlates with intracerebral β-amyloid load
    Adi Alkalay
    Helen Wills Neuroscience Institute, University of California Berkeley, CA, USA
    Curr Alzheimer Res 10:48-56. 2013
    ..We examined the relationship between amyloid-beta (Aβ) plaques and plasma cholinesterase activity in a heterogeneous dementia population...
  12. ncbi Threshold-independent meta-analysis of Alzheimer's disease transcriptomes shows progressive changes in hippocampal functions, epigenetics and microRNA regulation
    Shahar Barbash
    Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    Curr Alzheimer Res 9:425-35. 2012
    ..Our findings open new venues for identifying novel targets for intervention with AD progression...
  13. doi Meta-analysis of genetic and environmental Parkinson's disease models reveals a common role of mitochondrial protection pathways
    Lilach Soreq
    Department of Medical Neurobiology Physiology, IMRIC, The Hebrew University Hadassah Medical School, Jerusalem, 91120 Israel
    Neurobiol Dis 45:1018-30. 2012
    ..Together, these findings offer new insights and novel targets for therapeutic interference with the gene-environment interactions underlying sporadic PD...
  14. pmc Pro-apoptotic protein-protein interactions of the extended N-AChE terminus
    Debra Toiber
    Department of Biological Chemistry, The Hebrew University of Jerusalem, The Edmond J Safra Campus, Jerusalem, Israel
    J Neural Transm 116:1435-42. 2009
    ..Each of these could potentially modulate N-AChE-S-induced apoptosis with possible therapeutic value for the treatment of Alzheimer's disease...
  15. pmc Changes in brain MicroRNAs contribute to cholinergic stress reactions
    Ari Meerson
    Department of Biological Chemistry, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel
    J Mol Neurosci 40:47-55. 2010
    ..We show stress-induced changes in miR-183 and miR-134 and suggest that, by regulating splicing factors and their targets, these changes modify both alternative splicing and cholinergic neurotransmission in the stressed brain...
  16. pmc Translational control of recombinant human acetylcholinesterase accumulation in plants
    Brian C Geyer
    The School of Life Sciences and Biodesign Institute, Arizona State University, Tempe, AZ 85287 4501, USA
    BMC Biotechnol 7:27. 2007
    ....
  17. ncbi From brain to blood: alternative splicing evidence for the cholinergic basis of Mammalian stress responses
    Marjorie Pick
    Department of Biological Chemistry, The Hebrew University of Jerusalem Safra Campus Givat Ram, Jerusalem 91904, Israel
    Ann N Y Acad Sci 1018:85-98. 2004
    ..Together, these approaches provide a conceptually unified view of the studied pathways for controlling stress responses in brain and blood...
  18. ncbi Anti-sense approach to anticholinesterase therapeutics
    H Soreq
    Department of Biological Chemistry, Hebrew University, Jerusalem, Israel
    Isr Med Assoc J 2:81-5. 2000
    ....
  19. ncbi It is all about resolution. Meeting report based upon presentations at the 10th International Global BioMillennium 2006 symposium on molecular cell biology (Tbilisi, Georgia)
    Hermona Soreq
    Department of Biological Chemistry, The Hebrew University of Jerusalem, Israel
    FEBS J 274:924-7. 2007
    ....
  20. pmc Identifying alternative hyper-splicing signatures in MG-thymoma by exon arrays
    Lilach Soreq
    Department of Physiology, The Hebrew University, Hadassah Medical School, Jerusalem, Israel
    PLoS ONE 3:e2392. 2008
    ..Here, we report the use of Affymetrix Human Exon Arrays to spot hyper-splicing events characteristic of myasthenia gravis (MG)-thymoma, thymic tumors which develop in patients with MG and discriminate them from colon cancer changes...
  21. doi NeurimmiRs: microRNAs in the neuroimmune interface
    Hermona Soreq
    Institute of Life Sciences and Edmond and Lily Safra Center of Brain Sciences, The Hebrew University of Jerusalem, Edmond J Safra Campus, Jerusalem 91904, Israel
    Trends Mol Med 17:548-55. 2011
    ..Thus, manipulating NeurimmiR control over the immune contributions to cognitive pathways may offer new therapeutic targets...
  22. ncbi Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins
    R Karpel
    Department of Biological Chemistry, Hebrew University, Jerusalem, Israel
    Exp Cell Res 210:268-77. 1994
    ....
  23. pmc Expression of a human acetylcholinesterase promoter-reporter construct in developing neuromuscular junctions of Xenopus embryos
    R Ben Aziz-Aloya
    Department of Biological Chemistry, Hebrew University of Jerusalem, Israel
    Proc Natl Acad Sci U S A 90:2471-5. 1993
    ....
  24. ncbi Neuronal overexpression of "readthrough" acetylcholinesterase is associated with antisense-suppressible behavioral impairments
    O Cohen
    Department of Biological Chemistry, The Hebrew University of Jerusalem, 91905 Jerusalem, Israel
    Mol Psychiatry 7:874-85. 2002
    ....
  25. ncbi Genomic dissection reveals locus response to stress for mammalian acetylcholinesterase
    A D Grant
    Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Israel
    Cell Mol Neurobiol 21:783-97. 2001
    ..Experimental evidence shows coregulation of murine ACHE and ARS following confined swim, indicating coordinated locus response to stress, that is possibly mediated by altered cholinergic neurotransmission...
  26. pmc Coamplification of human acetylcholinesterase and butyrylcholinesterase genes in blood cells: correlation with various leukemias and abnormal megakaryocytopoiesis
    Y Lapidot-Lifson
    Department of Biological Chemistry, Hebrew University of Jerusalem, Israel
    Proc Natl Acad Sci U S A 86:4715-9. 1989
    ....
  27. pmc Excess "read-through" acetylcholinesterase attenuates but the "synaptic" variant intensifies neurodeterioration correlates
    M Sternfeld
    The Eric Roland Center for Neurodegenerative Diseases, Department of Biological Chemistry, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Proc Natl Acad Sci U S A 97:8647-52. 2000
    ..Our findings suggest that AChE-R serves as a modulator that may play a role in preventing the shift from transient, acute stress to progressive neurological disease...
  28. ncbi Transgenic acetylcholinesterase induces enlargement of murine neuromuscular junctions but leaves spinal cord synapses intact
    C Andres
    Department of Biological Chemistry, The Hebrew University of Jerusalem, Israel
    Neurochem Int 32:449-56. 1998
    ....
  29. ncbi Complex host cell responses to antisense suppression of ACHE gene expression
    N Galyam
    Department of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of Jerusalem, Israel
    Antisense Nucleic Acid Drug Dev 11:51-7. 2001
    ..Our findings demonstrate suppressed AChE expression using extremely low concentrations of AS-ODN and attribute reduced efficacy at higher concentrations to complex host cell feedback responses...
  30. pmc Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure
    H Soreq
    Department of Biological Chemistry, Hebrew University, Jerusalem, Israel
    Proc Natl Acad Sci U S A 87:9688-92. 1990
    ..Thus, the human AcChoEase gene includes a putative G + C-rich attenuator domain and is subject to structural alterations in cases of AcChoEase gene amplification...
  31. doi Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility
    I Mor
    The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    J Cell Mol Med 12:479-95. 2008
    ..Interchanging interactions with RACK1 and enolase-alpha may hence enable AChE-R to affect both sperm differentiation and function by participating in independent cellular pathways...
  32. pmc ARP, a peptide derived from the stress-associated acetylcholinesterase variant, has hematopoietic growth promoting activities
    D Grisaru
    Department of Biological Chemistry, Hebrew University of Jerusalem, Israel
    Mol Med 7:93-105. 2001
    ..CONCLUSIONS: Our findings attribute a role to AChE-R and ARP in hematopoietic homeostasis following stress, and suggest the use of ARP in clinical settings where ex vivo expansion of progenitor cells is required...
  33. ncbi SC35 promotes sustainable stress-induced alternative splicing of neuronal acetylcholinesterase mRNA
    E Meshorer
    Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    Mol Psychiatry 10:985-97. 2005
    ..Together, these findings point to an interactive relationship of SC35 with cholinergic signals in the long-lasting consequences of stress on nervous system plasticity and development...
  34. ncbi Adaptive acetylcholinesterase splicing patterns attenuate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice
    Y Ben-Shaul
    The Eric Roland Center for Neurodegenerative Diseases and the Center for Computational Neuroscience, The Hebrew University of Jersalem, Institute of Life Sciences, Edmond J Safra Campus, Givat Ram Jerusalem, 91904, Israel
    Eur J Neurosci 23:2915-22. 2006
    ..We propose that inherited or acquired alternative splicing deficits could accelerate Parkinsonism and that, correspondingly, adaptive alternative splicing events may attenuate disease progression...
  35. ncbi Murine and human mast cell express acetylcholinesterase
    H Nechushtan
    Department of Biochemistry, Hebrew University Hadassah Medical School, Hebrew University of Jerusalem, Israel
    FEBS Lett 379:1-6. 1996
    ..Our findings predict the involvement of mast cell AChE in neuronal-mast cell interactions...
  36. pmc Functional redundancy of acetylcholinesterase and neuroligin in mammalian neuritogenesis
    M Grifman
    Department of Biological Chemistry, Institute of Life Sciences, Hebrew University of Jerusalem, 91904, Jerusalem, Israel
    Proc Natl Acad Sci U S A 95:13935-40. 1998
    ..Our findings demonstrate redundant neurite growth-promoting activities for AChE and neuroligin and implicate interactions of AChE-like proteins and neurexins as potential mediators of cytoarchitectural changes supporting neuritogenesis...
  37. ncbi Modified testicular expression of stress-associated "readthrough" acetylcholinesterase predicts male infertility
    I Mor
    Department of, Biological Chemistry, The Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem, Israel
    FASEB J 15:2039-41. 2001
    ..These findings indicate AChE-R involvement in impaired sperm quality, which suggests that it is a molecular marker for stress-related infertility...
  38. ncbi Muscarinic modulations of neuronal anticholinesterase responses
    A Salmon
    Department of Biological Chemistry and The Eric Roland Center for Neurodegenerative Diseases, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Chem Biol Interact 157:105-13. 2005
    ....
  39. doi Human recombinant butyrylcholinesterase purified from the milk of transgenic goats interacts with beta-amyloid fibrils and suppresses their formation in vitro
    E Podoly
    Alexander Silberman Life Sciences Institute, Hebrew University of Jerusalem, Givat Ram, Jerusalem, Israel
    Neurodegener Dis 5:232-6. 2008
    ..In Alzheimer's disease (AD), brain butyrylcholinesterase (BChE) co-localizes with beta-amyloid (Abeta) fibrils...
  40. ncbi Position effect variegations and brain-specific silencing in transgenic mice overexpressing human acetylcholinesterase variants
    M Sternfeld
    Department of Biological Chemistry, Hebrew University of Jerusalem, Israel
    J Physiol Paris 92:249-55. 1998
    ..In contrast, brain AChE levels remained within a range of 1.5-fold over control, suggesting an upper limit of brain AChE which is compatible with life...
  41. ncbi Promoter elements and alternative splicing in the human ACHE gene
    R Ben Aziz-Aloya
    Department of Biological Chemistry, Hebrew University of Jerusalem, Israel
    Prog Brain Res 98:147-53. 1993
  42. pmc Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration
    C Andres
    Department of Biological Chemistry, The Hebrew University of Jerusalem, 91904 Israel
    Proc Natl Acad Sci U S A 94:8173-8. 1997
    ....
  43. ncbi Genetic predisposition to adverse consequences of anti-cholinesterases in 'atypical' BCHE carriers
    Y Loewenstein-Lichtenstein
    Department of Biological Chemistry, Hebrew University of Jerusalem, Israel
    Nat Med 1:1082-5. 1995
    ..Genetic differences among BuChE variants may thus explain at least some of the adverse responses to anti-ChE therapies...
  44. ncbi Changes in neuronal acetylcholinesterase gene expression and division of labor in honey bee colonies
    M Shapira
    Department of Biological Chemistry, The Life Sciences Institute, The Hebrew University of Jerusalem, Givat Ram
    J Mol Neurosci 17:1-12. 2001
    ....
  45. pmc Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis
    Y Lapidot-Lifson
    Department of Biological Chemistry, Hebrew University of Jerusalem, Israel
    Proc Natl Acad Sci U S A 89:579-83. 1992
    ..Therefore, these findings strengthen the link between cholinergic signaling and cell division control in hematopoiesis and implicate both CHED and cholinesterases in this differentiation process...
  46. ncbi Treatment of human myasthenia gravis with oral antisense suppression of acetylcholinesterase
    Z Argov
    Department of Neurology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Neurology 69:699-700. 2007
  47. ncbi Excavations into the active-site gorge of cholinesterases
    H Soreq
    Department of Biological Chemistry, Hebrew University, Jerusalem, Israel
    Trends Biochem Sci 17:353-8. 1992
    ..The picture that emerges deepens the insight into the biochemical basis for choline ester catalysis and the complex mechanism of interaction between cholinesterases and their numerous ligands...
  48. doi Atherosclerosis and arteriosclerosis parameters in stroke patients associate with paraoxonase polymorphism and esterase activities
    S Shenhar-Tsarfaty
    The Institute of Life Sciences and the Edmond and Lily Safra Center of Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    Eur J Neurol 20:891-8. 2013
    ..We addressed this issue by profiling PON1 polymorphisms and enzymatic activities, and assessing atherosclerosis and cerebral arteriosclerosis severity in post-stroke patients...
  49. doi Cholinergic involvement and manipulation approaches in multiple system disorders
    K Ofek
    The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Chem Biol Interact 203:113-9. 2013
    ....
  50. ncbi Tracking cholinergic pathways from psychological and chemical stressors to variable neurodeterioration paradigms
    D Kaufer
    Department of Biological Chemistry, The Institute of Life Sciences, Hebrew University, Jerusalem, Israel
    Curr Opin Neurol 12:739-43. 1999
    ..Recent publications on the involvement of cholinergic pathways in these and other neurodeterioration syndromes are reviewed...
  51. ncbi Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity
    Eran Meshorer
    Department of Biological Chemistry, The Institute of Life Sciences and The Eric Roland Center for Neurodegenerative Diseases, The Hebrew University of Jerusalem, Israel 91904
    Science 295:508-12. 2002
    ..Our findings suggest that neuronal hypersensitivity under stress involves neuritic replacement of AChE-S with AChE-R...
  52. ncbi Combinatorial complexity of 5' alternative acetylcholinesterase transcripts and protein products
    Eran Meshorer
    Department of Biological Chemistry and the Israel Center of Neuronal Computation, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Biol Chem 279:29740-51. 2004
    ..Alternative promoter usage combined with alternative splicing may thus lead to stress-dependent combinatorial complexity of AChE mRNA transcripts and their protein products...
  53. ncbi Modulated splicing-associated gene expression in P19 cells expressing distinct acetylcholinesterase splice variants
    Shani Ben-Ari
    Department of Biological Chemistry and Israel Center for Neuronal Computation, The Hebrew University of Jerusalem, Jerusalem, Israel
    J Neurochem 97:24-34. 2006
    ....
  54. doi Sustained Alzheimer's amyloid pathology in myeloid differentiation protein-88-deficient APPswe/PS1 mice
    Y Goll
    Department of Biological Chemistry and the Edmond and Lily Safra Center of Brain Science, The Hebrew University of Jerusalem, Jerusalem, Israel
    Neurodegener Dis 13:58-60. 2014
    ..Most Alzheimer's disease (AD) cases arise sporadically and may involve innate immune activation of microglial expressed Toll-like receptors regulated through the myeloid differentiation protein 88 (MyD88) pathway...
  55. ncbi Peripheral site acetylcholinesterase blockade induces RACK1-associated neuronal remodeling
    Noa Farchi
    Department of Neurobiology, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    Neurodegener Dis 4:171-84. 2007
    ..Peripheral anionic site (PAS) blockade of acetylcholinesterase (AChE) notably affects neuronal activity and cyto-architecture, however, the mechanism(s) involved are incompletely understood...
  56. ncbi RNA-targeted suppression of stress-induced allostasis in primate spinal cord neurons
    Tama Evron
    Department of Biological Chemistry, Institute of Life Sciences, and the Israel Center of Neuronal Computation, The Hebrew University of Jerusalem, Jerusalem, Israel
    Neurodegener Dis 2:16-27. 2005
    ....
  57. ncbi Acetylcholinesterase modulates stress-induced motor responses through catalytic and noncatalytic properties
    Ella H Sklan
    Department of Biological Chemistry, Institute of Life Sciences, Hebrew University of Jerusalem, Givat Ram, Jerusalem, Israel
    Biol Psychiatry 60:741-51. 2006
    ....
  58. ncbi Mapping the human acetylcholinesterase gene to chromosome 7q22 by fluorescent in situ hybridization coupled with selective PCR amplification from a somatic hybrid cell panel and chromosome-sorted DNA libraries
    G Ehrlich
    Department of Biological Chemistry, Hebrew University of Jerusalem, Israel
    Genomics 13:1192-7. 1992
    ..abstract truncated at 250 words)..
  59. ncbi Chronic cholinergic imbalances promote brain diffusion and transport abnormalities
    Eran Meshorer
    Department of Biological Chemistry and Israel Center for Neuronal Computation, The Hebrew University of Jerusalem, Jerusalem, Israel
    FASEB J 19:910-22. 2005
    ....
  60. ncbi Changes in readthrough acetylcholinesterase expression modulate amyloid-beta pathology
    Amit Berson
    The Eric Roland Center for Neurodegenerative Diseases, Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
    Brain 131:109-19. 2008
    ....
  61. ncbi Inherited and acquired interactions between ACHE and PON1 polymorphisms modulate plasma acetylcholinesterase and paraoxonase activities
    Boris Bryk
    Department of Biological Chemistry, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
    J Neurochem 92:1216-27. 2005
    ..Our findings demonstrate that polymorphism(s) in the adjacent PON1 and ACHE genes affect each other's expression, predicting for carriers of biochemically debilitating ACHE/PON1 polymorphisms adverse genome-environment interactions...
  62. ncbi The thymic theme of acetylcholinesterase splice variants in myasthenia gravis
    Adi Gilboa-Geffen
    Hebrew University of Jerusalem, Jerusalem, Israel
    Blood 109:4383-91. 2007
    ..Together, these findings show that modified AChE gene expression and properties are causally involved in thymic function and development...
  63. ncbi Identifying subtle interrelated changes in functional gene categories using continuous measures of gene expression
    Yoram Ben-Shaul
    Department of Biological Chemistry, The Life Sciences Institute Jerusalem, 91904, Israel
    Bioinformatics 21:1129-37. 2005
    ....
  64. doi Stress-induced alternative splicing modulations in brain and periphery: acetylcholinesterase as a case study
    Iftach Shaked
    The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    Ann N Y Acad Sci 1148:269-81. 2008
    ..Herein we discuss the newly gained understanding achieved by using genomic manipulations of AChE gene expression as tools for approaching the alternative splicing features of mammalian stress responses...
  65. ncbi Readthrough acetylcholinesterase: a multifaceted inducer of stress reactions
    Gabriel Zimmerman
    Interdisciplinary Center of Neural Computation, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Mol Neurosci 30:197-200. 2006
    ....
  66. doi MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase
    Iftach Shaked
    Department of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
    Immunity 31:965-73. 2009
    ..Our findings identify the AChE mRNA-targeting miR-132 as a functional regulator of the brain-to-body resolution of inflammation, opening avenues for study and therapeutic manipulations of the neuro-immune dialog...
  67. ncbi MicroRNA modulation of megakaryoblast fate involves cholinergic signaling
    Cinthya Guimaraes-Sternberg
    Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Edmond Safra Campus, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Leuk Res 30:583-95. 2006
    ..The stress-induced modulation of hematopoietic miR-181a levels through AChE, PKC and PKA cascade(s) suggests using miRNA mimics for diverting the fate of hematopoietic tumor cells towards differentiation and/or apoptosis...
  68. ncbi Complex regulation of acetylcholinesterase gene expression in human brain tumors
    Chava Perry
    Department of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of Jerusalem, Israel 91904
    Oncogene 21:8428-41. 2002
    ..Together, these findings reveal brain tumor-specific regulation of both expression and cellular retention of variant ACHE gene products...
  69. ncbi Pre-mRNA splicing modulations in senescence
    Eran Meshorer
    Department of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Aging Cell 1:10-6. 2002
    ..Here, we review the potential genomic and environmental origins of such changes and discuss the research implications of these findings...
  70. pmc Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behavior
    Klara R Birikh
    Department of Biological Chemistry, Institute of Life Sciences, Hebrew University of Jerusalem, Israel
    Proc Natl Acad Sci U S A 100:283-8. 2003
    ..These findings are consistent with the hypothesis that stress-associated changes in cholinergic gene expression regulate neuronal PKCbetaII functioning, promoting fear-induced conflict behavior after stress...
  71. ncbi Acetylcholinesterase variants in Alzheimer's disease: from neuroprotection to programmed cell death
    David S Greenberg
    Department of Biological Chemistry, The Hebrew University of Jerusalem, Safra Campus, Givat Ram, Jerusalem, Israel
    Neurodegener Dis 7:60-3. 2010
    ....
  72. ncbi Transcriptional regulation of erythropoiesis. Fine tuning of combinatorial multi-domain elements
    Chava Perry
    Department of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of Jerusalem, Israel
    Eur J Biochem 269:3607-18. 2002
    ..Finally, transfections and genomic studies show that the timing of each factor's expression during the hematopoietic process, the cell lineages affected and the existing combination of other factors determine the erythroid cell fate...
  73. ncbi Cytokines and cholinergic signals co-modulate surgical stress-induced changes in mood and memory
    Irit Shapira-Lichter
    Department of Psychology, The Hebrew University, Jerusalem 91905, Israel
    Brain Behav Immun 22:388-98. 2008
    ..Taken together, these findings suggest that exposure to a surgical stressor induces a reciprocal up-regulation of AChE-R and pro-inflammatory cytokines, which are involved in regulating the surgery-induced mood and memory disturbances...
  74. ncbi Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's disease
    Liat BenMoyal-Segal
    The Life Sciences Institute, The Hebrew University of Jerusalem, Israel
    FASEB J 19:452-4. 2005
    ..Our findings suggest that inherited interactive weakness of AChE and PON1 expression increases the insecticide-induced occurrence of Parkinson's disease...
  75. ncbi Alternate AChE-R variants facilitate cellular metabolic activity and resistance to genotoxic stress through enolase and RACK1 interactions
    Inbal Mor
    The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    Chem Biol Interact 175:11-21. 2008
    ....
  76. doi Advanced microarray analysis highlights modified neuro-immune signaling in nucleated blood cells from Parkinson's disease patients
    Lilach Soreq
    Department of Physiology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Neuroimmunol 201:227-36. 2008
    ..Combined with gene ontology tests, our findings point at neuro-immune signaling-related transcripts as distinctly expressed early in PD progress and call for exploiting microarray tests also for follow-up of PD treatment efficacy...
  77. pmc Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study
    Ella H Sklan
    Department of Biological Chemistry, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Proc Natl Acad Sci U S A 101:5512-7. 2004
    ....
  78. pmc CREB regulates AChE-R-induced proliferation of human glioblastoma cells
    Chava Perry
    Department of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Neoplasia 6:279-86. 2004
    ....
  79. ncbi Blood-cell-specific acetylcholinesterase splice variations under changing stimuli
    Marjorie Pick
    Department of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Tel Aviv, Israel
    Int J Dev Neurosci 22:523-31. 2004
    ..Peripheral stimuli-induced modulations in acetylcholine regulation may hence reflect blood cell lineage-dependent acetylcholinesterase splice variations...
  80. ncbi Cholinergic status modulations in human volunteers under acute inflammation
    Keren Ofek
    The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Mol Med (Berl) 85:1239-51. 2007
    ..Our findings establish Cholinergic Status modulations as early facilitators and predictors of individual variabilities in the peripheral response to infection...
  81. ncbi Coding region paraoxonase polymorphisms dictate accentuated neuronal reactions in chronic, sub-threshold pesticide exposure
    R Orie Browne
    Department of Physiology, Soroka University Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel
    FASEB J 20:1733-5. 2006
    ..Thus, gene-environment interactions involving the ACHE/PON1 locus may be causally involved in determining the physiological response to OP exposure...
  82. ncbi Termination and beyond: acetylcholinesterase as a modulator of synaptic transmission
    Gabriel Zimmerman
    The Institute of Life Sciences and the Interdisciplinary Center for Neural Computation ICNC, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Cell Tissue Res 326:655-69. 2006
    ..The structural homology between AChE and cell adhesion proteins, together with the recently discovered protein partners of AChE, predict the future unraveling of the molecular pathways underlying these multileveled functions...
  83. pmc Butyrylcholinesterase attenuates amyloid fibril formation in vitro
    Sophia Diamant
    Department of Biological Chemistry, Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel
    Proc Natl Acad Sci U S A 103:8628-33. 2006
    ..In Alzheimer's disease, BChE may have thus acquired an inverse role to that of AChE by adopting imperfect amphipathic characteristics of its C terminus...
  84. ncbi Cellular stress reactions as putative cholinergic links in Alzheimer's disease
    Debra Toiber
    Department of Biological Chemistry, The Institute of Life Sciences and The Eric Roland Center for Neurodegenerative Diseases, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel
    Neurochem Res 30:909-19. 2005
    ..Under chronic cellular stress, aberrant AChE regulation may thus facilitate apoptotic pathways, promoting plaque formation, cognitive impairments and degeneration of cholinergic nerve cells...
  85. ncbi ARP, the cleavable C-terminal peptide of "readthrough" acetylcholinesterase, promotes neuronal development and plasticity
    Amir Dori
    Department of Neurology, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Mol Neurosci 28:247-55. 2006
    ..Together, our findings point at the cleavable ARP peptide as a key regulator of neuronal development and plasticity and suggest its use as a drug target and/or research and therapeutic tool...
  86. doi Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats
    Gabriel Zimmerman
    Interdisciplinary Center for Neural Computation, The Hebrew University of Jerusalem, 91904 Israel
    Eur J Neurosci 27:965-75. 2008
    ..Our findings suggest that altered cholinergic modulation may initiate seizure events in the epileptic temporal cortex...
  87. ncbi Hydrolytic and nonenzymatic functions of acetylcholinesterase comodulate hemopoietic stress responses
    Dan Grisaru
    Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Israel
    J Immunol 176:27-35. 2006
    ..1 and maintained a stable granulocytic state following bacterial LPS exposure. AChE-R accumulation and the consequent inflammatory consequences can thus modulate immune responses to stress stimuli...
  88. ncbi Virtues and woes of AChE alternative splicing in stress-related neuropathologies
    Eran Meshorer
    National Cancer Institute, National Institutes of Health, Building 41, 41 Library Drive, Bethesda, MD 20892, USA
    Trends Neurosci 29:216-24. 2006
    ..g. Alzheimer's and Parkinson's diseases) and neuromuscular syndromes (e.g. myasthenia gravis) raises the possibility that future therapeutic drugs might target specific AChE variant(s) or the corresponding RNA transcripts...
  89. ncbi Stress-induced cholinergic signaling promotes inflammation-associated thrombopoiesis
    Marjorie Pick
    Department of Hematology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Blood 107:3397-406. 2006
    ..Our findings implicate AChE-R in thrombopoietic recovery, suggesting new therapeutic modalities for supporting platelet production...
  90. ncbi Upregulation of neuronal nicotinic receptor subunits alpha4, beta2, and alpha7 in transgenic mice overexpressing human acetylcholinesterase
    Marie M Svedberg
    Karolinska Institutet, Neurotec, Division of Molecular Neuropharmacology, Huddinge University Hospital, Stockholm, Sweden
    J Mol Neurosci 18:211-22. 2002
    ....
  91. ncbi Endotoxin-induced changes in human working and declarative memory associate with cleavage of plasma "readthrough" acetylcholinesterase
    Osnat Cohen
    Department of Biological Chemistry and The Eric Roland Center for Neurodegenerative Diseases, The Hebrew University of Jerusalem, Israel 91904
    J Mol Neurosci 21:199-212. 2003
    ....
  92. ncbi Characterizing pea acetylcholinesterase
    Mrinalini Muralidharan
    School of Life Sciences and The Biodesign Institute, P O Box 874501, Arizona State University, Tempe, AZ 85287 4501, USA
    Chem Biol Interact 157:406-7. 2005
    ..Here, we describe the presence of cholinesterase and its initial characterization in pea roots...
  93. ncbi The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis
    Talma Brenner
    Department of Neurology, Hadassah University Hospital and Hebrew University Hadassah Medical School, Jerusalem, Israel 91120
    FASEB J 17:214-22. 2003
    ..The efficacy of targeting only one AChE splicing variant highlights potential advantages of mRNA-targeted therapeutics for chronic cholinergic malfunctioning...
  94. ncbi The stress-associated acetylcholinesterase variant AChE-R is expressed in human CD34(+) hematopoietic progenitors and its C-terminal peptide ARP promotes their proliferation
    Varda R Deutsch
    Department of Hematology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Exp Hematol 30:1153-61. 2002
    ..This led us to explore the hematopoietic involvement of AChE-R and its cleavable C-terminal peptide ARP...
  95. ncbi Defects in pre-mRNA processing as causes of and predisposition to diseases
    Peter Stoilov
    University of Erlangen Nurenberg, Institute of Biochemistry, 91054 Erlangen, Germany
    DNA Cell Biol 21:803-18. 2002
    ..The elucidation of genetic mechanisms regulating pre-mRNA processing, combined with the development of drugs targeted at consensus RNA sequences and/or corresponding proteins, can lead to novel diagnostic and therapeutic approaches...
  96. ncbi Organophosphate risk of leukemogenesis
    Chava Perry
    Leuk Res 28:905-6. 2004
  97. ncbi Purification of transgenic plant-derived recombinant human acetylcholinesterase-R
    Brian C Geyer
    School of Life Sciences and The Biodesign Institute, P O Box 874501, Arizona State University, Tempe, AZ 85287 4501, USA
    Chem Biol Interact 157:331-4. 2005
    ....
  98. ncbi Acetylcholinesterase activity in veterans of the first Gulf War
    John Concato
    VA Connecticut Healthcare System, Clinical Epidemiology Research Center, West Haven, CT 06516, USA
    J Investig Med 55:360-7. 2007
    ..This study was designed to examine relationships of deployment to the Gulf, as well as symptoms after military service, with postdeployment activity of acetylcholinesterase (AChE) and related enzymes...
  99. ncbi Functional manipulations of acetylcholinesterase splice variants highlight alternative splicing contributions to murine neocortical development
    Amir Dori
    Department of Neurosurgery, Soroka University Medical Center, Beer Sheva, Israel
    Cereb Cortex 15:419-30. 2005
    ..Our findings attribute to alternative splicing events an interactive major role in neocortical development...
  100. doi The role of the read through variant of acetylcholinesterase in anxiogenic effects of predator stress in mice
    Robert Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, NF, A1B 3X9 Canada
    Behav Brain Res 189:180-90. 2008
    ....
  101. ncbi Memory deficits correlating with acetylcholinesterase splice shift and amyloid burden in doubly transgenic mice
    Tina M Rees
    Department of Molecular Pharmacology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Curr Alzheimer Res 2:291-300. 2005
    ..These new findings support the notion of cholinergic-amyloid interrelationships and highlight the double transgenic mice as a promising alternative for testing Alzheimer's therapies...