Justin Silver

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. doi request reprint Fibroblast growth factor 23 acts on the parathyroid to decrease parathyroid hormone secretion
    Hillel Galitzer
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Curr Opin Nephrol Hypertens 17:363-7. 2008
  2. doi request reprint FGF23 and the parathyroid
    Justin Silver
    Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Adv Exp Med Biol 728:92-9. 2012
  3. ncbi request reprint The details bedevil DCOR
    J Silver
    Minerva Center for Calcium and Bone Metabolism, Nephrology and Hypertension Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Kidney Int 72:1041-3. 2007
  4. doi request reprint Phosphate and the parathyroid
    Justin Silver
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Kidney Int 75:898-905. 2009
  5. doi request reprint FGF23 and the parathyroid glands
    Justin Silver
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Ein Karem, Jerusalem, 91120, Israel
    Pediatr Nephrol 25:2241-5. 2010
  6. ncbi request reprint Harnessing the parathyroids to create stronger bones
    Justin Silver
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah University Hospital, Jerusalem, Israel
    Curr Opin Nephrol Hypertens 13:471-6. 2004
  7. ncbi request reprint Mechanisms of secondary hyperparathyroidism
    Justin Silver
    Minerva Center for Calcium and Bone Metabolism, Nephrology and Hypertension Services, Hadassah University Hospital, Jerusalem, Israel 91120
    Am J Physiol Renal Physiol 283:F367-76. 2002
  8. ncbi request reprint Sensing phosphate across the kingdoms
    Justin Silver
    Minerva Center for Calcium and Bone Metabolism, Nephrology and Hypertention Services, Hadassah Hospital, The Hebrew University Medical School, Jerusalem, Israel
    Curr Opin Nephrol Hypertens 12:357-61. 2003
  9. doi request reprint Regulation of PTH mRNA stability by the calcimimetic R568 and the phosphorus binder lanthanum carbonate in CKD
    Morris Nechama
    Minerva Center for Calcium and Bone Metabolism, Hadassah Hebrew Univ Medical Center, P O Box 12000, Jerusalem, Israel 91120
    Am J Physiol Renal Physiol 296:F795-800. 2009
  10. pmc The parathyroid is a target organ for FGF23 in rats
    Iddo Z Ben-Dov
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Invest 117:4003-8. 2007

Collaborators

Detail Information

Publications38

  1. doi request reprint Fibroblast growth factor 23 acts on the parathyroid to decrease parathyroid hormone secretion
    Hillel Galitzer
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Curr Opin Nephrol Hypertens 17:363-7. 2008
    ..The aim of this article is to describe the intriguing action of fibroblast growth factor 23 on the parathyroid...
  2. doi request reprint FGF23 and the parathyroid
    Justin Silver
    Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Adv Exp Med Biol 728:92-9. 2012
    ..There is therefore a negative feedback loop between bone and the parathyroid...
  3. ncbi request reprint The details bedevil DCOR
    J Silver
    Minerva Center for Calcium and Bone Metabolism, Nephrology and Hypertension Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Kidney Int 72:1041-3. 2007
    ..Dialysis Clinical Outcomes Revisited (DCOR) is an outcomes study on the effect of sevelamer compared with calcium-based phosphorus binders in dialysis patients. It does not show a clear superiority of one compound over the other...
  4. doi request reprint Phosphate and the parathyroid
    Justin Silver
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Kidney Int 75:898-905. 2009
    ..The responses of the parathyroid to changes in serum Pi are now being revealed but the sensing mechanisms remain a mystery...
  5. doi request reprint FGF23 and the parathyroid glands
    Justin Silver
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Ein Karem, Jerusalem, 91120, Israel
    Pediatr Nephrol 25:2241-5. 2010
    ..In addition, in advanced experimental CKD, FGF23 has a decreased ability to inhibit PTH expression...
  6. ncbi request reprint Harnessing the parathyroids to create stronger bones
    Justin Silver
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah University Hospital, Jerusalem, Israel
    Curr Opin Nephrol Hypertens 13:471-6. 2004
    ..This may lead to new strategies for the treatment of osteoporosis and the low turnover bone disease of some dialysis patients...
  7. ncbi request reprint Mechanisms of secondary hyperparathyroidism
    Justin Silver
    Minerva Center for Calcium and Bone Metabolism, Nephrology and Hypertension Services, Hadassah University Hospital, Jerusalem, Israel 91120
    Am J Physiol Renal Physiol 283:F367-76. 2002
    ..PT trans factors and cis elements have been defined...
  8. ncbi request reprint Sensing phosphate across the kingdoms
    Justin Silver
    Minerva Center for Calcium and Bone Metabolism, Nephrology and Hypertention Services, Hadassah Hospital, The Hebrew University Medical School, Jerusalem, Israel
    Curr Opin Nephrol Hypertens 12:357-61. 2003
    ..The present review summarizes recent findings that may help in understanding how the cell senses changes in serum phosphate...
  9. doi request reprint Regulation of PTH mRNA stability by the calcimimetic R568 and the phosphorus binder lanthanum carbonate in CKD
    Morris Nechama
    Minerva Center for Calcium and Bone Metabolism, Hadassah Hebrew Univ Medical Center, P O Box 12000, Jerusalem, Israel 91120
    Am J Physiol Renal Physiol 296:F795-800. 2009
    ..Therefore, the calcimimetic R568 and correction of serum phosphorus by La determine PTH mRNA stability through KSRP-mediated recruitment of a degradation complex to the PTH mRNA, thereby decreasing PTH expression...
  10. pmc The parathyroid is a target organ for FGF23 in rats
    Iddo Z Ben-Dov
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Invest 117:4003-8. 2007
    ..These data indicate that FGF23 acts directly on the parathyroid through the MAPK pathway to decrease serum PTH. This bone-parathyroid endocrine axis adds a new dimension to the understanding of mineral homeostasis...
  11. pmc The calcium-sensing receptor regulates parathyroid hormone gene expression in transfected HEK293 cells
    Hillel Galitzer
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    BMC Biol 7:17. 2009
    ..There is no parathyroid cell line; therefore, we developed a parathyroid engineered cell using expression vectors for the full-length human parathyroid hormone gene and the human calcium receptor...
  12. ncbi request reprint Identification and characterization of cis-acting elements in the human and bovine PTH mRNA 3'-untranslated region
    Osnat Bell
    Hebrew University and Hadassah Medical Center, Jerusalem, Israel
    J Bone Miner Res 20:858-66. 2005
    ..The function of the elements was shown in vitro...
  13. doi request reprint Human PTH gene regulation in vivo using transgenic mice
    Vardit Lavi-Moshayoff
    Nephrology Services, Hadassah Hebrew University Medical Center, P O Box 12000, Jerusalem, Israel 91120
    Am J Physiol Renal Physiol 297:F713-9. 2009
    ....
  14. ncbi request reprint Calcineurin Abeta is central to the expression of the renal type II Na/Pi co-transporter gene and to the regulation of renal phosphate transport
    Yulia Moz
    Nephrology Services, Hadassah Hospital, P O Box 12000, Jerusalem, Israel 91120
    J Am Soc Nephrol 15:2972-80. 2004
    ..These results suggest that the use of calcineurin inhibitors contributes to the renal Pi wasting seen in renal transplant patients...
  15. doi request reprint PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop
    Vardit Lavi-Moshayoff
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew Univ Medical Center, PO Box 12000, Jerusalem, Israel 91120
    Am J Physiol Renal Physiol 299:F882-9. 2010
    ..The effect of PTH on FGF23 completes a bone-parathyroid endocrine feedback loop. Importantly, secondary hyperparathyroidism is essential for the high-FGF23 levels in early CKD...
  16. ncbi request reprint The protein phosphatase calcineurin determines basal parathyroid hormone gene expression
    Osnat Bell
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hospital, PO Box 12000, Jerusalem 91120, Israel
    Mol Endocrinol 19:516-26. 2005
    ..Therefore, calcineurin regulates AUF1 posttranslationally in vitro and PTH gene expression in vivo but still allows its physiological regulation by calcium and phosphate...
  17. pmc The peptidyl-prolyl isomerase Pin1 determines parathyroid hormone mRNA levels and stability in rat models of secondary hyperparathyroidism
    Morris Nechama
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Invest 119:3102-14. 2009
    ..These results demonstrate that Pin1 is a key mediator of PTH mRNA stability and indicate a role for Pin1 in the pathogenesis of secondary hyperparathyroidism in individuals with CKD...
  18. doi request reprint Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease
    H Galitzer
    Department of Nephrology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Kidney Int 77:211-8. 2010
    ..This in vivo resistance is sustained in parathyroid organ culture in vitro...
  19. doi request reprint Deletion of the vitamin D receptor specifically in the parathyroid demonstrates a limited role for the receptor in parathyroid physiology
    Tomer Meir
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hospital, Jerusalem, Israel
    Am J Physiol Renal Physiol 297:F1192-8. 2009
    ..Therefore, deletion of the VDR specifically in the parathyroid decreases parathyroid CaR expression and only moderately increases basal PTH levels, suggesting that the VDR has a limited role in parathyroid physiology...
  20. ncbi request reprint Increased parathyroid hormone gene expression in secondary hyperparathyroidism of experimental uremia is reversed by calcimimetics: correlation with posttranslational modification of the trans acting factor AUF1
    Ronen Levi
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hebrew University Hadassah Hospital, P O Box 12000, Jerusalem, Israel 91120
    J Am Soc Nephrol 17:107-12. 2006
    ..Therefore, uremia and activation of the CaR mediated by calcimimetics modify AUF1 posttranslationally. These modifications in AUF1 correlate with changes in protein-PTH mRNA binding and PTH mRNA levels...
  21. ncbi request reprint Lanthanum carbonate decreases PTH gene expression with no hepatotoxicity in uraemic rats
    Iddo Z Ben-Dov
    Minerva Center for Calcium and Bone Metabolism, Nephrology and Hypertension Services, Hadassah Hebrew University Medical Center, Ein Karem, PO Box 12000, Jerusalem, Israel 91120
    Nephrol Dial Transplant 22:362-8. 2007
    ..Some recent studies in rodents have cast safety uncertainties. The aims of this study were to examine the effects of La on parathyroid hormone (PTH) gene expression and hepatic toxicity...
  22. ncbi request reprint Cis and trans acting factors in the regulation of parathyroid hormone (PTH) mRNA stability by calcium and phosphate
    Tally Naveh-Many
    Minerva Center for Calcium and Bone Metabolism, Hadassah University Hospital, P O Box 12000, 91120, Jerusalem, Israel
    FEBS Lett 529:60-4. 2002
    ..Our results identified a functional cis element in PTH mRNA. Differences in protein binding to this element determine PTH mRNA stability and its regulation by calcium and phosphate...
  23. ncbi request reprint Pathogenesis of parathyroid dysfunction in end-stage kidney disease
    Ronen Levi
    Nephrology and Hypertension Services, Minerva Center for Calcium and Bone Metabolism, Hebrew University Hadassah Medical Center, 91120, Jerusalem, Israel
    Pediatr Nephrol 20:342-5. 2005
    ..The PT trans factors and cis elements have been defined...
  24. ncbi request reprint The parathyroid hormone mRNA 3'-untranslated region AU-rich element is an unstructured functional element
    Rachel Kilav
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hospital, The Hebrew University Medical School, P O Box 12000, Jerusalem, Israel 91120
    J Biol Chem 279:2109-16. 2004
    ..The PTH mRNA 3'-UTR cis-acting element is an open region that utilizes the distinct sequence pattern to determine mRNA stability by its interaction with trans-acting factors...
  25. ncbi request reprint Cellular and molecular mechanisms of secondary hyperparathyroidism
    J Silver
    Department of Nephrology and Hypertension Services, Hadassah University Hospital, Jerusalem, Israel
    Clin Nephrol 63:119-26. 2005
    ..These findings may help guide the development of novel therapies for secondary hyperparathyroidism...
  26. ncbi request reprint Molecular mechanisms of secondary hyperparathyroidism
    J Silver
    Minerva Center for Calcium and Bone Metabolism, Hadassah Hospital and Hebrew University, Hadassah Medical School, Jerusalem, Israel
    Pediatr Nephrol 14:626-8. 2000
    ..The understanding of the molecular mechanisms involved in the genesis of secondary hyperparathyroidism will allow the design of new effective strategies in the management of this troubling condition...
  27. ncbi request reprint Regulation of the parathyroid hormone gene by vitamin D, calcium and phosphate
    J Silver
    Minerva Center for Calcium, Hadassah University Hospital, Hebrew University School of Medicine, Jerusalem, Israel
    Kidney Int Suppl 73:S2-7. 1999
    ..The characterization of the parathyroid cytosolic proteins that interact with the PTH mRNA 3'-UTR may lead to a clearer understanding of how changes in serum calcium and phosphate result in secondary hyperparathyroidism...
  28. ncbi request reprint Characterization of cis-acting element in renal NaPi-2 cotransporter mRNA that determines mRNA stability
    Yulia Moz
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah University Hospital, Jerusalem, Israel 91120
    Am J Physiol Renal Physiol 284:F663-70. 2003
    ..Our results suggest that the protein-binding region of the NaPi-2 mRNA functions as a cis-acting instability element. In hypophosphatemia there is increased binding to the cis-acting element and subsequent stabilization of NaPi-2 mRNA...
  29. ncbi request reprint Pathogenesis of parathyroid dysfunction in end-stage renal disease
    Justin Silver
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah University Hospital, Jerusalem, Israel
    Adv Ren Replace Ther 9:159-67. 2002
    ..The mechanisms of these effects are discussed in this review...
  30. doi request reprint Vitamin D supplementation after renal transplantation: how much vitamin D should we prescribe?
    Ronen Levi
    Nephrology Services, Minerva Center for Calcium and Bone Metabolism, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Kidney Int 75:576-8. 2009
    ..Supplementation with oral parental vitamin D could correct this problem. Courbebaisse et al. define how much oral vitamin D to prescribe to renal allograft recipients...
  31. ncbi request reprint Calcitonin gene regulation in vivo
    J Silver
    Minerva Center for Calcium and Bone Metabolism, Hadassah University Hospital, Jerusalem, Israel
    Horm Metab Res 25:470-2. 1993
    ..Estrogens given to ovariectomized rats led to increases in calcitonin mRNA. The estrogen receptor was present in the thyroid C-cells. Therefore the calcitonin gene is regulated by vitamin D and estrogens, but not by calcium...
  32. ncbi request reprint A conserved cis-acting element in the parathyroid hormone 3'-untranslated region is sufficient for regulation of RNA stability by calcium and phosphate
    R Kilav
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah University Hospital, Jerusalem il-91120, Israel
    J Biol Chem 276:8727-33. 2001
    ..This defined element in the PTH mRNA 3'-UTR is necessary and sufficient for the regulation of PTH mRNA stability by calcium and phosphate...
  33. ncbi request reprint Parathyroid hormone gene expression in Hyp mice fed a low-phosphate diet
    K H Marks
    Minerva Center for Calcium and Bone Metabolism, Hadassah University Hospital, Jerusalem, Israel
    Nephrol Dial Transplant 12:1581-5. 1997
    ..Phosphate directly regulates the parathyroid (PT) in normal rats and it is of interest whether this regulation is intact in Hyp mice...
  34. pmc Dynein light chain binding to a 3'-untranslated sequence mediates parathyroid hormone mRNA association with microtubules
    E Epstein
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah University Hospital, Jerusalem, Israel 91120
    J Clin Invest 105:505-12. 2000
    ..The dynein complex may be the motor that is responsible for transporting mRNAs to specific locations in the cytoplasm and for the consequent is asymmetric distribution of translated proteins in the cell...
  35. ncbi request reprint A form of Jansen's metaphyseal chondrodysplasia with limited metabolic and skeletal abnormalities is caused by a novel activating parathyroid hormone (PTH)/PTH-related peptide receptor mutation
    Murat Bastepe
    Endocrine Unit, Massachusetts General Hospital for Children, MGH Harvard Medical School, Wellman 5, Boston, MA 02114, USA
    J Clin Endocrinol Metab 89:3595-600. 2004
    ..Our findings indicate that a mild form of JMC has been identified that is characterized by less pronounced skeletal and laboratory abnormalities...
  36. doi request reprint Nutritional vitamin D: the benefits of supplementation
    David A Bushinsky
    Curr Opin Nephrol Hypertens 17:345-7. 2008
  37. ncbi request reprint Mutational analysis of the PTH 3'-untranslated region in parathyroid disorders
    Jessica Costa-Guda
    Center for Molecular Medicine, University of Connecticut School of Medicine, Farmington, CT 06030 3101, USA
    Clin Endocrinol (Oxf) 65:806-9. 2006
    ....
  38. ncbi request reprint A novel mutation in fibroblast growth factor 23 gene as a cause of tumoral calcinosis
    Kaori Araya
    Department of Pediatrics, University of Tokyo Hospital, 3 28 6, Bunkyo ku, Tokyo 113 8655, Japan
    J Clin Endocrinol Metab 90:5523-7. 2005
    ..Fibroblast growth factor (FGF)23 was identified as a responsible factor in hypophosphatemic diseases caused by renal phosphate leak...