E Shohami

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi request reprint Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant
    E Shohami
    Department of Pharmacology, Hebrew University, School of Pharmacy, Jerusalem, Israel
    J Neuroimmunol 72:169-77. 1997
  2. ncbi request reprint Dexanabinol; a novel neuroprotective drug in experimental focal cerebral ischemia
    R R Leker
    Department of Neurology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Neurol Sci 162:114-9. 1999
  3. ncbi request reprint Long term cerebroprotective effects of dexanabinol in a model of focal cerebral ischemia
    G Lavie
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hebrew University Hadassah Medical School, Hadassah University Hospital, Ein Kerem, P O Box 12000, 91120, Jerusalem, Israel
    Brain Res 901:195-201. 2001
  4. ncbi request reprint Closed head injury in the rat induces whole body oxidative stress: overall reducing antioxidant profile
    E Shohami
    Department of Pharmacology, Hebrew University of Jerusalem, Israel
    J Neurotrauma 16:365-76. 1999
  5. ncbi request reprint An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
    D Panikashvili
    Department of Pharmacology, Medical Faculty, Hebrew University, Jerusalem 91120, Israel
    Nature 413:527-31. 2001
  6. ncbi request reprint Closed head injury increases extracellular levels of antioxidants in rat hippocampus in vivo: an adaptive mechanism?
    E Moor
    Department of Pharmacology, The Hebrew University of Jerusalem, The School of Pharmacy, Hadassah Ein Kerem, Jerusalem 91120, Israel
    Neurosci Lett 316:169-72. 2001
  7. ncbi request reprint Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injury
    I Yatsiv
    Department of Pharmacology, School of Pharmacy, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    FASEB J 19:1701-3. 2005
  8. ncbi request reprint Dual role of tumor necrosis factor alpha in brain injury
    E Shohami
    Department of Pharmacology, Hebrew University School of Pharmacy, Jerusalem, Israel
    Cytokine Growth Factor Rev 10:119-30. 1999
  9. doi request reprint Subacute treatment with vascular endothelial growth factor after traumatic brain injury increases angiogenesis and gliogenesis
    O Thau-Zuchman
    Department of Neurology and the Peritz and Chantal Scheinberg Cerebrovascular Research Laboratory, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Neuroscience 202:334-41. 2012
  10. ncbi request reprint Therapeutic effect of dexamethasone in T-2 toxicosis
    E Shohami
    Department of Pharmacology, Hadassah Medical School, Jerusalem, Israel
    Pharm Res 4:527-30. 1987

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant
    E Shohami
    Department of Pharmacology, Hebrew University, School of Pharmacy, Jerusalem, Israel
    J Neuroimmunol 72:169-77. 1997
    ..TNF-alpha modulating agents, if given within the early time window post-injury, may improve the final neurological outcome in victims of brain trauma...
  2. ncbi request reprint Dexanabinol; a novel neuroprotective drug in experimental focal cerebral ischemia
    R R Leker
    Department of Neurology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Neurol Sci 162:114-9. 1999
    ..No effect could be demonstrated on NOS activity. In conclusion, dexanabinol may be a pluripotent cerebroprotective agent...
  3. ncbi request reprint Long term cerebroprotective effects of dexanabinol in a model of focal cerebral ischemia
    G Lavie
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hebrew University Hadassah Medical School, Hadassah University Hospital, Ein Kerem, P O Box 12000, 91120, Jerusalem, Israel
    Brain Res 901:195-201. 2001
    ..05 for all). In conclusion, the extended therapeutic window and the multi-mechanistic durable neuroprotective effects of dexanabinol make it a promising candidate for future stroke therapy...
  4. ncbi request reprint Closed head injury in the rat induces whole body oxidative stress: overall reducing antioxidant profile
    E Shohami
    Department of Pharmacology, Hebrew University of Jerusalem, Israel
    J Neurotrauma 16:365-76. 1999
    ..01) even up to 24 h. We conclude that although the injury was delivered over the left cerebral hemisphere, the whole body appeared to be under oxidative stress, within 24 h after brain injury...
  5. ncbi request reprint An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
    D Panikashvili
    Department of Pharmacology, Medical Faculty, Hebrew University, Jerusalem 91120, Israel
    Nature 413:527-31. 2001
    ..The beneficial effect of 2-AG was dose-dependently attenuated by SR-141761A, an antagonist of the CB1 cannabinoid receptor...
  6. ncbi request reprint Closed head injury increases extracellular levels of antioxidants in rat hippocampus in vivo: an adaptive mechanism?
    E Moor
    Department of Pharmacology, The Hebrew University of Jerusalem, The School of Pharmacy, Hadassah Ein Kerem, Jerusalem 91120, Israel
    Neurosci Lett 316:169-72. 2001
    ..Together with previous results, the current findings suggest that ascorbic acid and uric acid are mobilized from brain cells to the extracellular space...
  7. ncbi request reprint Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injury
    I Yatsiv
    Department of Pharmacology, School of Pharmacy, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    FASEB J 19:1701-3. 2005
    ..vehicle-treated animals. We propose that further studies on Epo in TBI should be conducted in order to consider it as a novel therapy for TBI...
  8. ncbi request reprint Dual role of tumor necrosis factor alpha in brain injury
    E Shohami
    Department of Pharmacology, Hebrew University School of Pharmacy, Jerusalem, Israel
    Cytokine Growth Factor Rev 10:119-30. 1999
    ..It is suggested that the appropriate context of mediators, at any given time after brain injury may well determine whether the effect of TNF alpha is protective or toxic...
  9. doi request reprint Subacute treatment with vascular endothelial growth factor after traumatic brain injury increases angiogenesis and gliogenesis
    O Thau-Zuchman
    Department of Neurology and the Peritz and Chantal Scheinberg Cerebrovascular Research Laboratory, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Neuroscience 202:334-41. 2012
    ..However, treated mice had only insignificant motor improvements in this paradigm, suggesting that the bulk of the beneficial effects observed when VEGF is given early after TBI results from the neuroprotective effects...
  10. ncbi request reprint Therapeutic effect of dexamethasone in T-2 toxicosis
    E Shohami
    Department of Pharmacology, Hadassah Medical School, Jerusalem, Israel
    Pharm Res 4:527-30. 1987
    ..BW 755c had no consistent effect on the survival of rats in T-2 toxicosis. It is suggested that dexamethasone might be a useful therapeutic agent in T-2 toxicosis in animals and humans, but its mechanism of action remains obscure...
  11. ncbi request reprint A peptide derived from activity-dependent neuroprotective protein (ADNP) ameliorates injury response in closed head injury in mice
    L Beni-Adani
    Department of Neurosurgery, The Hebrew University Hadassah Medical Center, Jerusalem, Israel
    J Pharmacol Exp Ther 296:57-63. 2001
    ..Thus, NAP provides significant amelioration from the complex array of injuries elicited by head trauma...
  12. doi request reprint Inactivation of PKMĪ¶ in the NAc shell abolished cocaine-conditioned reward
    D Shabashov
    Institute for Drug Research IDR, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    J Mol Neurosci 47:546-53. 2012
    ....
  13. ncbi request reprint Experimental closed head injury in rats: prostaglandin production in a noninjured zone
    E Shohami
    Department of Pharmacology, Hadassah University Hospital, Jerusalem, Israel
    Neurosurgery 22:859-63. 1988
    ..Both PGD2 and PGI2 have protective effects in the brain. We suggest that their endogenous increase may be part of a repair mechanism at the periphery of the injured zone...
  14. ncbi request reprint Experimental models of head trauma
    R R Leker
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hebrew University Hadassah Medical School, Hadassah University Hospital, Jerusalem, Israel
    Acta Neurochir Suppl 83:49-54. 2002
    ..In order to attain these goals adequate animal models for traumatic brain injury are needed. In the following paper the authors will review the various animal models for head trauma and emphasize their potential strengths and weaknesses...
  15. ncbi request reprint Endocannabinoids and traumatic brain injury
    R Mechoulam
    Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty, Ein Kerem Campus, Jerusalem 91120, Israel
    Mol Neurobiol 36:68-74. 2007
    ....
  16. ncbi request reprint Rapamycin is a neuroprotective treatment for traumatic brain injury
    S Erlich
    Department of Neurobiochemistry, Tel Aviv University, Ramat Aviv 69978, Israel
    Neurobiol Dis 26:86-93. 2007
    ....
  17. ncbi request reprint Endocannabinoids and neuroprotection
    R Mechoulam
    Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty, Jerusalem 91120, Israel
    Sci STKE 2002:re5. 2002
    ..2-AG is also a potent modulator of vascular tone, and counteracts the endothelin (ET-1)-induced vasoconstriction that aggravates brain damage; it may thus help to restore blood supply to the injured brain...
  18. ncbi request reprint Antioxidant properties of the vasoactive endocannabinoid, 2-arachidonoyl glycerol (2-AG)
    R M McCarron
    Resuscitative Medicine Department, Naval Medical Research Center, Forest Glen, MD, USA
    Acta Neurochir Suppl 86:271-5. 2003
    ..These findings provide evidence of 2-AG antioxidant activity and are consistent with the involvement of ROS in the pathomechanism of CHI-induced BBB injury and brain edema...
  19. ncbi request reprint Immunohistochemical characterization of Fas (CD95) and Fas Ligand (FasL/CD95L) expression in the injured brain: relationship with neuronal cell death and inflammatory mediators
    M B Grosjean
    Center for Dental and Oral Medicine and Cranio maxillofacial Surgery, University of Zurich, Zurich, Switzerland
    Histol Histopathol 22:235-50. 2007
    ..Furthermore, Fas and FasL upregulation seems to be independent of neuroinflammation since no differences were found between cytokine-/- and wild-type mice...
  20. ncbi request reprint Endothelial-mediated regulation of cerebral microcirculation
    R M McCarron
    Trauma and Resuscitative Medicine Department, Naval Medical Research Center, Bethesda, MD, USA
    J Physiol Pharmacol 57:133-44. 2006
    ....
  21. ncbi request reprint Apolipoprotein E4 decreases whereas apolipoprotein E3 increases the level of secreted amyloid precursor protein after closed head injury
    Y Ezra
    Department of Neurobiochemistry, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Neuroscience 121:315-25. 2003
    ..Similar isoform-specific interactions between apoE and APP may play a role in the acute, short-term effects of head trauma in humans...
  22. ncbi request reprint The nitroxide antioxidant tempol is cerebroprotective against focal cerebral ischemia in spontaneously hypertensive rats
    R R Leker
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hebrew University Hadassah Medical School, Hadassah University Hospital, Jerusalem 91120, Israel
    Exp Neurol 176:355-63. 2002
    ..4 +/- 2.38% hemispheric volume, P = 0.02, respectively). In conclusion, treatment with tempol led to significant motor and behavioral improvement and reduced injured tissue volumes both in the short and in the long term after stroke...
  23. ncbi request reprint Experimental closed head injury: analysis of neurological outcome, blood-brain barrier dysfunction, intracranial neutrophil infiltration, and neuronal cell death in mice deficient in genes for pro-inflammatory cytokines
    P F Stahel
    Department of Surgery, University Hospital, Zurich, Switzerland
    J Cereb Blood Flow Metab 20:369-80. 2000
    ..Nevertheless, the increased posttraumatic mortality in TNF/LT-alpha-deficient mice suggests a protective effect of these cytokines by mechanisms that have not been elucidated yet...
  24. ncbi request reprint Changes in regional energy metabolism after closed head injury in the rat
    A E Mautes
    Neurosurgical Research Laboratory, Saarland University Medical School, Homburg Saar, Germany
    J Mol Neurosci 16:33-9. 2001
    ..Cortical glucose and lactate contents could not be discerned over time. Following CHI there is an acute and progressive, yet transient, ischemic cortical profile, which is not reflected in subcortical areas...