Sagiv Shifman

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. pmc The genetic variation of RELN expression in schizophrenia and bipolar disorder
    Galit Ovadia
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    PLoS ONE 6:e19955. 2011
  2. pmc Networks of neuronal genes affected by common and rare variants in autism spectrum disorders
    Eyal Ben-David
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    PLoS Genet 8:e1002556. 2012
  3. pmc Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women
    Sagiv Shifman
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kindgdom
    PLoS Genet 4:e28. 2008
  4. ncbi request reprint COMT: a common susceptibility gene in bipolar disorder and schizophrenia
    Sagiv Shifman
    Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Am J Med Genet B Neuropsychiatr Genet 128:61-4. 2004
  5. ncbi request reprint A complete genetic association scan of the 22q11 deletion region and functional evidence reveal an association between DGCR2 and schizophrenia
    Sagiv Shifman
    Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford, UK
    Hum Genet 120:160-70. 2006
  6. ncbi request reprint Further tests of the association between schizophrenia and single nucleotide polymorphism markers at the catechol-O-methyltransferase locus in an Askenazi Jewish population using microsatellite markers
    Anat Horowitz
    The Life Science Institute, The Hebrew University of Jerusalem, Israel
    Psychiatr Genet 15:163-9. 2005
  7. doi request reprint Further investigation of the association between rs7341475 and rs17746501 and schizophrenia
    Eyal Ben-David
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    Am J Med Genet B Neuropsychiatr Genet 153:1244-7. 2010
  8. ncbi request reprint A survey of the 22q11 microdeletion in a large cohort of schizophrenia patients
    Anat Horowitz
    The Life Science Institute, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Schizophr Res 73:263-7. 2005
  9. ncbi request reprint Linkage disequilibrium patterns of the human genome across populations
    Sagiv Shifman
    The Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Hum Mol Genet 12:771-6. 2003
  10. pmc A highly significant association between a COMT haplotype and schizophrenia
    Sagiv Shifman
    Institute of Life Sciences, The Hebrew University of Jerusalem, Israel
    Am J Hum Genet 71:1296-302. 2002

Collaborators

Detail Information

Publications23

  1. pmc The genetic variation of RELN expression in schizophrenia and bipolar disorder
    Galit Ovadia
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    PLoS ONE 6:e19955. 2011
    ..Nevertheless, the positive associations observed in this study needs further replication as it may have implications for understanding the biological causes of schizophrenia and bipolar disorder...
  2. pmc Networks of neuronal genes affected by common and rare variants in autism spectrum disorders
    Eyal Ben-David
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    PLoS Genet 8:e1002556. 2012
    ..The results of this study point toward contribution of minor and major perturbations in the two sub-networks of neuronal genes to ASD risk...
  3. pmc Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women
    Sagiv Shifman
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kindgdom
    PLoS Genet 4:e28. 2008
    ..58 (p = 8.8 x 10(-7); p = 1.6 x 10(-5) for gene-sex interaction). The female-specific association between RELN and schizophrenia is one of the few examples of a replicated sex-specific genetic association in any disease...
  4. ncbi request reprint COMT: a common susceptibility gene in bipolar disorder and schizophrenia
    Sagiv Shifman
    Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Am J Med Genet B Neuropsychiatr Genet 128:61-4. 2004
    ..We suggest that polymorphisms in the COMT gene may influence susceptibility to both diseases--and probably also a wider range of behavioral traits...
  5. ncbi request reprint A complete genetic association scan of the 22q11 deletion region and functional evidence reveal an association between DGCR2 and schizophrenia
    Sagiv Shifman
    Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford, UK
    Hum Genet 120:160-70. 2006
    ..The genetic and functional evidences here reported suggest a possible role of the DGCR2 gene in the pathology of schizophrenia and also in the therapeutic effects of antipsychotic drugs...
  6. ncbi request reprint Further tests of the association between schizophrenia and single nucleotide polymorphism markers at the catechol-O-methyltransferase locus in an Askenazi Jewish population using microsatellite markers
    Anat Horowitz
    The Life Science Institute, The Hebrew University of Jerusalem, Israel
    Psychiatr Genet 15:163-9. 2005
    ..Although significant, the extent of linkage disequilibrium in terms of r2 was small (in the order of 0.01)...
  7. doi request reprint Further investigation of the association between rs7341475 and rs17746501 and schizophrenia
    Eyal Ben-David
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    Am J Med Genet B Neuropsychiatr Genet 153:1244-7. 2010
    ....
  8. ncbi request reprint A survey of the 22q11 microdeletion in a large cohort of schizophrenia patients
    Anat Horowitz
    The Life Science Institute, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Schizophr Res 73:263-7. 2005
    ..Moreover, the rate of false positives is very low (P-value in the range of 10(-4) to 10(-3)). Approximately 1% of the patient cohort was found to carry 22q11 deletions...
  9. ncbi request reprint Linkage disequilibrium patterns of the human genome across populations
    Sagiv Shifman
    The Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Hum Mol Genet 12:771-6. 2003
    ..This has significant consequences when using LD mapping for the genetic dissection of complex traits, as higher density SNP maps will be required to scan the genome...
  10. pmc A highly significant association between a COMT haplotype and schizophrenia
    Sagiv Shifman
    Institute of Life Sciences, The Hebrew University of Jerusalem, Israel
    Am J Hum Genet 71:1296-302. 2002
    ..We found a highly significant association between schizophrenia and a COMT haplotype (P=9.5x10-8). The approach presented can be widely implemented for the genetic dissection of other common diseases...
  11. ncbi request reprint Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus
    Janice M Fullerton
    Wellcome Trust Centre for Human Genetics, Headington, Oxford, United Kingdom
    Biol Psychiatry 63:874-83. 2008
    ..This locus is syntenic with a human region that has been consistently implicated in the genetic aetiology of neuroticism...
  12. pmc Mouse inbred strain sequence information and yin-yang crosses for quantitative trait locus fine mapping
    Sagiv Shifman
    The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Genetics 169:849-54. 2005
    ..This suggests that with a large number of strains in hand, selecting a small number of strains may provide a significant contribution to the fine mapping of QTL...
  13. pmc Fine-scale maps of recombination rates and hotspots in the mouse genome
    Hadassa Brunschwig
    Department of Statistics, The Hebrew University of Jerusalem, Jerusalem 91905, Israel
    Genetics 191:757-64. 2012
    ..They also strengthen previous findings on mouse recombination hotspots, and specifically the impact of sequence variants in Prdm9...
  14. ncbi request reprint Genetic variants in major depression
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Novartis Found Symp 289:23-32; discussion 33-42, 87-93. 2008
    ..Larger sample sizes and more sophisticated analytical approaches will be needed than have hitherto been applied...
  15. ncbi request reprint Quantitative technologies for allele frequency estimation of SNPs in DNA pools
    Sagiv Shifman
    Department of Evolution, Systematics and Ecology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Mol Cell Probes 16:429-34. 2002
    ..We found that the influence of the error variance attributed to pool construction on quantification accuracy is insignificant and is SNP dependent...
  16. ncbi request reprint Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's disease
    Liat BenMoyal-Segal
    The Life Sciences Institute, The Hebrew University of Jerusalem, Israel
    FASEB J 19:452-4. 2005
    ..Our findings suggest that inherited interactive weakness of AChE and PON1 expression increases the insecticide-induced occurrence of Parkinson's disease...
  17. pmc A high-resolution single nucleotide polymorphism genetic map of the mouse genome
    Sagiv Shifman
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Biol 4:e395. 2006
    ..Genetic maps are available from http://gscan.well.ox.ac.uk/#genetic_map and as supporting information to this publication...
  18. doi request reprint Identification of a functional rare variant in autism using genome-wide screen for monoallelic expression
    Eyal Ben-David
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J Safra Campus, Jerusalem 91904, Israel
    Hum Mol Genet 20:3632-41. 2011
    ....
  19. doi request reprint Animal models of psychiatric disease
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Curr Opin Genet Dev 18:235-40. 2008
    ....
  20. ncbi request reprint Allelic expression analysis in the brain suggests a role for heterogeneous insults affecting epigenetic processes in autism spectrum disorders
    Eyal Ben-David
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    Hum Mol Genet 23:4111-24. 2014
    ..We also identified pathways perturbed in specific individuals. These results underline the heterogeneity in gene regulation in ASD, at the level of both allelic and total expression. ..
  21. ncbi request reprint Genetic dissection of common diseases
    Naomi B Zak
    IDgene Pharmaceutical Ltd Jerusalem, Israel
    Isr Med Assoc J 4:438-43. 2002
    ..The properties of single nucleotide polymorphisms, which are presently the markers of choice, are discussed, and the technologies that are currently available for SNP genotyping are briefly presented...
  22. ncbi request reprint The beauty of admixture
    Ariel Darvasi
    Nat Genet 37:118-9. 2005
  23. ncbi request reprint Power and efficiency of the TDT and case-control design for association scans
    Ralph McGinnis
    GlaxoSmithKline Pharmaceuticals, Harlow, Essex, United Kingdom
    Behav Genet 32:135-44. 2002
    ..Nevertheless, possible population stratification needs to be addressed when the case-control design is applied...