Affiliation: The Hebrew University
- Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in womenSagiv Shifman
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kindgdom
PLoS Genet 4:e28. 2008..58 (p = 8.8 x 10(-7); p = 1.6 x 10(-5) for gene-sex interaction). The female-specific association between RELN and schizophrenia is one of the few examples of a replicated sex-specific genetic association in any disease...
- A complete genetic association scan of the 22q11 deletion region and functional evidence reveal an association between DGCR2 and schizophreniaSagiv Shifman
Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford, UK
Hum Genet 120:160-70. 2006..The genetic and functional evidences here reported suggest a possible role of the DGCR2 gene in the pathology of schizophrenia and also in the therapeutic effects of antipsychotic drugs...
- Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locusJanice M Fullerton
Wellcome Trust Centre for Human Genetics, Headington, Oxford, United Kingdom
Biol Psychiatry 63:874-83. 2008..This locus is syntenic with a human region that has been consistently implicated in the genetic aetiology of neuroticism...
- Genetic variants in major depressionJonathan Flint
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
Novartis Found Symp 289:23-32; discussion 33-42, 87-93. 2008..Larger sample sizes and more sophisticated analytical approaches will be needed than have hitherto been applied...
- Animal models of psychiatric diseaseJonathan Flint
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Curr Opin Genet Dev 18:235-40. 2008....
- A high-resolution single nucleotide polymorphism genetic map of the mouse genomeSagiv Shifman
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
PLoS Biol 4:e395. 2006..Genetic maps are available from http://gscan.well.ox.ac.uk/#genetic_map and as supporting information to this publication...
- Linkage disequilibrium patterns of the human genome across populationsSagiv Shifman
The Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Hum Mol Genet 12:771-6. 2003..This has significant consequences when using LD mapping for the genetic dissection of complex traits, as higher density SNP maps will be required to scan the genome...
- COMT: a common susceptibility gene in bipolar disorder and schizophreniaSagiv Shifman
Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Am J Med Genet B Neuropsychiatr Genet 128:61-4. 2004..We suggest that polymorphisms in the COMT gene may influence susceptibility to both diseases--and probably also a wider range of behavioral traits...
- Quantitative technologies for allele frequency estimation of SNPs in DNA poolsSagiv Shifman
Department of Evolution, Systematics and Ecology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Mol Cell Probes 16:429-34. 2002..We found that the influence of the error variance attributed to pool construction on quantification accuracy is insignificant and is SNP dependent...
- A highly significant association between a COMT haplotype and schizophreniaSagiv Shifman
Institute of Life Sciences, The Hebrew University of Jerusalem, Israel
Am J Hum Genet 71:1296-302. 2002..We found a highly significant association between schizophrenia and a COMT haplotype (P=9.5x10-8). The approach presented can be widely implemented for the genetic dissection of other common diseases...
- Genetic dissection of common diseasesNaomi B Zak
IDgene Pharmaceutical Ltd Jerusalem, Israel
Isr Med Assoc J 4:438-43. 2002..The properties of single nucleotide polymorphisms, which are presently the markers of choice, are discussed, and the technologies that are currently available for SNP genotyping are briefly presented...
- Further tests of the association between schizophrenia and single nucleotide polymorphism markers at the catechol-O-methyltransferase locus in an Askenazi Jewish population using microsatellite markersAnat Horowitz
The Life Science Institute, The Hebrew University of Jerusalem, Israel
Psychiatr Genet 15:163-9. 2005..Although significant, the extent of linkage disequilibrium in terms of r2 was small (in the order of 0.01)...
- The beauty of admixtureAriel Darvasi
Nat Genet 37:118-9. 2005
- A survey of the 22q11 microdeletion in a large cohort of schizophrenia patientsAnat Horowitz
The Life Science Institute, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Schizophr Res 73:263-7. 2005..Moreover, the rate of false positives is very low (P-value in the range of 10(-4) to 10(-3)). Approximately 1% of the patient cohort was found to carry 22q11 deletions...
- Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's diseaseLiat BenMoyal-Segal
The Life Sciences Institute, The Hebrew University of Jerusalem, Israel
FASEB J 19:452-4. 2005..Our findings suggest that inherited interactive weakness of AChE and PON1 expression increases the insecticide-induced occurrence of Parkinson's disease...
- Mouse inbred strain sequence information and yin-yang crosses for quantitative trait locus fine mappingSagiv Shifman
The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Genetics 169:849-54. 2005..This suggests that with a large number of strains in hand, selecting a small number of strains may provide a significant contribution to the fine mapping of QTL...
- Power and efficiency of the TDT and case-control design for association scansRalph McGinnis
GlaxoSmithKline Pharmaceuticals, Harlow, Essex, United Kingdom
Behav Genet 32:135-44. 2002..Nevertheless, possible population stratification needs to be addressed when the case-control design is applied...