H Rahamimoff

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. doi request reprint Immunosuppressive drugs, immunophilins, and functional expression of NCX isoforms
    Hannah Rahamimoff
    Department of Biochemistry and Molecular Biology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Adv Exp Med Biol 961:275-87. 2013
  2. ncbi request reprint Cyclosporin A-dependent downregulation of the Na+/Ca2+ exchanger expression
    H Rahamimoff
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem, 91120 Israel
    Ann N Y Acad Sci 1099:204-14. 2007
  3. doi request reprint Modulation of Na+-Ca2+ exchanger expression by immunosuppressive drugs is isoform-specific
    Benayahu Elbaz
    Department of Biochemistry, Hebrew University Hadassah Medical School, P O Box 12272, Jerusalem 91120, Israel
    Mol Pharmacol 73:1254-63. 2008
  4. ncbi request reprint Cloning of two isoforms of the rat brain Na(+)-Ca2+ exchanger gene and their functional expression in HeLa cells
    I Furman
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem, Israel
    FEBS Lett 319:105-9. 1993
  5. ncbi request reprint Cloning of the rat heart Na(+)-Ca2+ exchanger and its functional expression in HeLa cells
    W Low
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem, Israel
    FEBS Lett 316:63-7. 1993
  6. ncbi request reprint The putative amino-terminal signal peptide of the cloned rat brain Na(+)-Ca2+ exchanger gene (RBE-1) is not mandatory for functional expression
    I Furman
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Biol Chem 270:19120-7. 1995
  7. ncbi request reprint The transport activity of the Na+-Ca2+ exchanger NCX1 expressed in HEK 293 cells is sensitive to covalent modification of intracellular cysteine residues by sulfhydryl reagents
    X Ren
    Department of Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel
    J Biol Chem 276:9572-9. 2001
  8. ncbi request reprint Transport activity and surface expression of the Na+-Ca2+ exchanger NCX1 are inhibited by the immunosuppressive agent cyclosporin A and by the nonimmunosuppressive agent PSC833
    Chava Kimchi-Sarfaty
    Laboratory of Cell Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    J Biol Chem 277:2505-10. 2002
  9. ncbi request reprint NCX1 surface expression: a tool to identify structural elements of functional importance
    Hannah Rahamimoff
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Ann N Y Acad Sci 976:176-86. 2002

Collaborators

Detail Information

Publications9

  1. doi request reprint Immunosuppressive drugs, immunophilins, and functional expression of NCX isoforms
    Hannah Rahamimoff
    Department of Biochemistry and Molecular Biology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Adv Exp Med Biol 961:275-87. 2013
    ..Exchange of the large cytosolic loop of NCX3 with that of NCX1 renders the mutant protein insensitive to FK506...
  2. ncbi request reprint Cyclosporin A-dependent downregulation of the Na+/Ca2+ exchanger expression
    H Rahamimoff
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem, 91120 Israel
    Ann N Y Acad Sci 1099:204-14. 2007
    ..Deletion of 426 amino acids from the large cytoplasmic loop of the protein retains the CsA-dependent downregulation of the truncated NCX1 suggesting that CsA-Cyp-NCX interaction involves the remaining protein domains...
  3. doi request reprint Modulation of Na+-Ca2+ exchanger expression by immunosuppressive drugs is isoform-specific
    Benayahu Elbaz
    Department of Biochemistry, Hebrew University Hadassah Medical School, P O Box 12272, Jerusalem 91120, Israel
    Mol Pharmacol 73:1254-63. 2008
    ..Expression of NCX genes is tissue-specific. Hence, our results can potentially provide a tool for choosing the immunosuppressive protocol to be used...
  4. ncbi request reprint Cloning of two isoforms of the rat brain Na(+)-Ca2+ exchanger gene and their functional expression in HeLa cells
    I Furman
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem, Israel
    FEBS Lett 319:105-9. 1993
    ....
  5. ncbi request reprint Cloning of the rat heart Na(+)-Ca2+ exchanger and its functional expression in HeLa cells
    W Low
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem, Israel
    FEBS Lett 316:63-7. 1993
    ..The electrogenic properties of the cloned transporter were demonstrated following reconstitution of the expressed exchanger protein into a tightly sealed phospholipid membrane...
  6. ncbi request reprint The putative amino-terminal signal peptide of the cloned rat brain Na(+)-Ca2+ exchanger gene (RBE-1) is not mandatory for functional expression
    I Furman
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Biol Chem 270:19120-7. 1995
    ..Our results suggest that the putative signal peptide of the cloned Na(+)-Ca2+ exchanger gene does not play a mandatory role in functional expression of the protein in HeLa cells...
  7. ncbi request reprint The transport activity of the Na+-Ca2+ exchanger NCX1 expressed in HEK 293 cells is sensitive to covalent modification of intracellular cysteine residues by sulfhydryl reagents
    X Ren
    Department of Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel
    J Biol Chem 276:9572-9. 2001
    ..Our results suggest that Na(+)-Ca(2+) exchange activity is inhibited by covalent modification with sulfhydryl reagents of cysteine residues that are accessible from the cytoplasmic face of the membrane...
  8. ncbi request reprint Transport activity and surface expression of the Na+-Ca2+ exchanger NCX1 are inhibited by the immunosuppressive agent cyclosporin A and by the nonimmunosuppressive agent PSC833
    Chava Kimchi-Sarfaty
    Laboratory of Cell Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    J Biol Chem 277:2505-10. 2002
    ..Furman, I., and Rahamimoff, H. (1999) J. Biol. Chem. 274, 24873-24880) and did not induce its kinesis to the surface membrane, further demonstrating molecular differences between P-glycoprotein and NCX1 mutants for interaction with CsA...
  9. ncbi request reprint NCX1 surface expression: a tool to identify structural elements of functional importance
    Hannah Rahamimoff
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Ann N Y Acad Sci 976:176-86. 2002
    ..FK506 and rapamycin treatment of HEK293 cells expressing rat NCX1 isoforms has no effect on transport activity, surface expression, or the total amount of exchanger protein in the transfected cells...