Asher Ornoy

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi request reprint Growth and neurodevelopmental outcome of children born to mothers with pregestational and gestational diabetes
    Asher Ornoy
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, and Israeli Ministry of Health, Jerusalem, Israel
    Pediatr Endocrinol Rev 3:104-13. 2005
  2. ncbi request reprint Herpes simplex virus and Epstein-Barr virus infections in pregnancy: consequences of neonatal or intrauterine infection
    Meytal Avgil
    Laboratory of Teratology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Reprod Toxicol 21:436-45. 2006
  3. doi request reprint Hyperglycemia and hypoxia are interrelated in their teratogenic mechanism: studies on cultured rat embryos
    Asher Ornoy
    Department of Medical Neurobiology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Birth Defects Res B Dev Reprod Toxicol 89:106-15. 2010
  4. pmc The role of reactive oxygen species in diabetes-induced anomalies in embryos of Cohen diabetic rats
    Sarah W Zangen
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Int J Exp Diabetes Res 3:247-55. 2002
  5. doi request reprint Lack of severe long-term outcomes of acute, subclinical B1 deficiency in 216 children in Israel exposed in early infancy
    Asher Ornoy
    Department of Child Development and Rehabilitation, Israeli Ministry of Health, Jerusalem, Israel
    Pediatr Res 73:111-9. 2013
  6. doi request reprint Biomarkers of maternal diabetes and its complication in pregnancy
    Asher Ornoy
    Laboratory of Teratology, Canada Israel Institute of Medical Research, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Reprod Toxicol 34:174-9. 2012
  7. doi request reprint The Cohen diabetic rat as a model for fetal growth restriction: vitamins C and E reduce fetal oxidative stress but do not restore normal growth
    Asher Ornoy
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Diabetes Research Unit, Hebrew University Hadassah Medical School and Hospital, Jerusalem, Israel
    Reprod Toxicol 28:521-9. 2009
  8. ncbi request reprint The effects of antiphospholipid antibodies obtained from women with SLE/APS and associated pregnancy loss on rat embryos and placental explants in culture
    A Ornoy
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Lupus 12:573-8. 2003
  9. ncbi request reprint Fetal effects of primary and secondary cytomegalovirus infection in pregnancy
    Asher Ornoy
    Israeli Teratogen Information Service, Israel Ministry of Health, Jerusalem
    Reprod Toxicol 21:399-409. 2006
  10. ncbi request reprint Maternal autoimmune diseases and immunologically induced embryonic and fetoplacental damage
    Asher Ornoy
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Birth Defects Res A Clin Mol Teratol 70:371-81. 2004

Collaborators

Detail Information

Publications87

  1. ncbi request reprint Growth and neurodevelopmental outcome of children born to mothers with pregestational and gestational diabetes
    Asher Ornoy
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, and Israeli Ministry of Health, Jerusalem, Israel
    Pediatr Endocrinol Rev 3:104-13. 2005
    ..These effects are negatively correlated with the degree of maternal glycemic control...
  2. ncbi request reprint Herpes simplex virus and Epstein-Barr virus infections in pregnancy: consequences of neonatal or intrauterine infection
    Meytal Avgil
    Laboratory of Teratology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Reprod Toxicol 21:436-45. 2006
    ..These placental pathological changes may increase fetal damage...
  3. doi request reprint Hyperglycemia and hypoxia are interrelated in their teratogenic mechanism: studies on cultured rat embryos
    Asher Ornoy
    Department of Medical Neurobiology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Birth Defects Res B Dev Reprod Toxicol 89:106-15. 2010
    ..The purpose of this study was to evaluate the hypothesis that in the developing embryo hyperglycemia also leads to hypoxia, both resulting in oxidative damage...
  4. pmc The role of reactive oxygen species in diabetes-induced anomalies in embryos of Cohen diabetic rats
    Sarah W Zangen
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Int J Exp Diabetes Res 3:247-55. 2002
    ..Maternal hyperglycemia seems to result in environmentally induced embryonic oxidative stress, resulting in further embryonic damage...
  5. doi request reprint Lack of severe long-term outcomes of acute, subclinical B1 deficiency in 216 children in Israel exposed in early infancy
    Asher Ornoy
    Department of Child Development and Rehabilitation, Israeli Ministry of Health, Jerusalem, Israel
    Pediatr Res 73:111-9. 2013
    ..We investigated whether subclinical B(1) deficiency in early infancy had medical, neurodevelopmental, or cognitive effects at 3-5 y of age...
  6. doi request reprint Biomarkers of maternal diabetes and its complication in pregnancy
    Asher Ornoy
    Laboratory of Teratology, Canada Israel Institute of Medical Research, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Reprod Toxicol 34:174-9. 2012
    ..Cord plasma biomarkers include IGFs, leptin, adiponectin, resistin, markers of oxidative stress and of hypoxia. Whether these biomarkers can be predictors of long term outcome in infants of diabetic mothers is yet to be determined...
  7. doi request reprint The Cohen diabetic rat as a model for fetal growth restriction: vitamins C and E reduce fetal oxidative stress but do not restore normal growth
    Asher Ornoy
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Diabetes Research Unit, Hebrew University Hadassah Medical School and Hospital, Jerusalem, Israel
    Reprod Toxicol 28:521-9. 2009
    ..In addition, we treated the pregnant rats with antioxidants (vitamins C and E added to their food) to evaluate the effects of antioxidants in the prevention of FGR and in changing the redox state of the fetuses...
  8. ncbi request reprint The effects of antiphospholipid antibodies obtained from women with SLE/APS and associated pregnancy loss on rat embryos and placental explants in culture
    A Ornoy
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Lupus 12:573-8. 2003
    ..Successful treatment of the women resulted in a correction of the damage induced in the cultured rat embryos and in the cultured placental explants...
  9. ncbi request reprint Fetal effects of primary and secondary cytomegalovirus infection in pregnancy
    Asher Ornoy
    Israeli Teratogen Information Service, Israel Ministry of Health, Jerusalem
    Reprod Toxicol 21:399-409. 2006
    ..This also brings in an additional problem, when considering the need for proper immunization against CMV, as immunization is primarily aimed for women without immunity...
  10. ncbi request reprint Maternal autoimmune diseases and immunologically induced embryonic and fetoplacental damage
    Asher Ornoy
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Birth Defects Res A Clin Mol Teratol 70:371-81. 2004
    ..We also describe experimental models that help to understand the etiology and pathogenesis of the effects of this maternal disease on the developing embryo, fetus and placenta...
  11. doi request reprint Hyperglycemia, hypoxia and their combination exert oxidative stress and changes in antioxidant gene expression: studies on cultured rat embryos
    Asher Ornoy
    Laboratory of Teratology, Department of Medical Neurobiology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Birth Defects Res B Dev Reprod Toxicol 92:231-9. 2011
    ..We investigated the interrelationship between hyperglycemia and hypoxia and their effects on genes involved in the balance of embryonic redox status...
  12. doi request reprint Prenatal origin of obesity and their complications: Gestational diabetes, maternal overweight and the paradoxical effects of fetal growth restriction and macrosomia
    Asher Ornoy
    Laboratory of Teratology, Department of Medical Neurobiology, Israel Canada Institute of Medical Sciences, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Reprod Toxicol 32:205-12. 2011
    ....
  13. ncbi request reprint Pregnancy outcome following infections by coxsackie, echo, measles, mumps, hepatitis, polio and encephalitis viruses
    Asher Ornoy
    The Hebrew University Hadassah Medical School and Jerusalem Institute of Child Development, Israeli Ministry of Health, Jerusalem
    Reprod Toxicol 21:446-57. 2006
    ..There is no evidence that immunization in pregnancy against these diseases (with attenuated viruses) may adversely affect pregnancy outcome...
  14. ncbi request reprint Neuroteratogens in man: an overview with special emphasis on the teratogenicity of antiepileptic drugs in pregnancy
    Asher Ornoy
    Laboratory of Teratology, Hebrew University Hadassah Medical School and Israeli Ministry of Health, Jerusalem, Israel
    Reprod Toxicol 22:214-26. 2006
    ..Lamotrigine monotherapy in pregnancy seems to be relatively safe. In general, polytherapy is more dangerous to the fetus than monotherapy and, at least for VPA and lamotrigine, there seems to be a "threshold effect"...
  15. ncbi request reprint The outcome of pregnancy following pre-pregnancy or early pregnancy alendronate treatment
    Asher Ornoy
    The Israeli Teratogen Information Service, Laboratory of Teratology, Hebrew University Hadassah Medical School, Israeli Ministry of Health, Jerusalem, Israel
    Reprod Toxicol 22:578-9. 2006
    ..We describe the outcome of 24 pregnancies after pre-pregnancy or early pregnancy alendronate therapy. Based on the pregnancy outcome it seems that alendronate does not impose a major teratogenic risk...
  16. ncbi request reprint Decreased response of osteoblasts obtained from aged Cohen diabetic sensitive rats to sex steroid hormones and 1,25OH2D3 in culture
    Asher Ornoy
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, P O B 12272, 91120 Jerusalem, Israel
    Odontology 94:38-43. 2006
    ..This decreased response, especially to estradiol, may be a major cause of the osteopenia observed in diabetes...
  17. ncbi request reprint Embryonic oxidative stress as a mechanism of teratogenesis with special emphasis on diabetic embryopathy
    Asher Ornoy
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Reprod Toxicol 24:31-41. 2007
    ....
  18. ncbi request reprint Fetal effects of primary and non-primary cytomegalovirus infection in pregnancy: are we close to prevention?
    Asher Ornoy
    Dept of Anatomy and Cell Biology, Laboratory of Teratology, Hadassah Hebrew University Medical School, Israel
    Isr Med Assoc J 9:398-401. 2007
    ..This may justify the use of invasive methods for the detection of possible fetal infection even in cases of non-primary CMV infection. This should also be a consideration when deciding upon population screening or immunization for CMV...
  19. doi request reprint The outcome of pregnancy following topiramate treatment: a study on 52 pregnancies
    Asher Ornoy
    The Israeli Teratogen Information Service, Laboratory of Teratology, Hebrew University, Hadassah Medical School and Israeli Ministry of Health, Jerusalem, Israel
    Reprod Toxicol 25:388-9. 2008
    ..There was an increased rate of spontaneous abortions not related to the drug effects...
  20. doi request reprint Valproic acid in pregnancy: how much are we endangering the embryo and fetus?
    Asher Ornoy
    Laboratory of Teratology, Hebrew University Hadassah Medical School and Israeli Ministry of Health, Jerusalem, Israel
    Reprod Toxicol 28:1-10. 2009
    ..Other possible explanations are: increased fetal oxidative stress induced by VPA, with the brain being more susceptible to oxidative stress in comparison to other fetal organs, or the folic acid inhibitory action of this drug...
  21. ncbi request reprint The impact of intrauterine exposure versus postnatal environment in neurodevelopmental toxicity: long-term neurobehavioral studies in children at risk for developmental disorders
    A Ornoy
    Laboratory of Teratology, Hebrew University Hadassah Medical School and Israeli Ministry of Health, Jerusalem, Israel
    Toxicol Lett 140:171-81. 2003
    ..A good environment (high parental SES) may significantly improve the outcome...
  22. ncbi request reprint The effects of alcohol and illicit drugs on the human embryo and fetus
    Asher Ornoy
    Laboratory of Teratology, Hebrew University Hadassah Medical School, Israeli Ministry of Health, Jerusalem, Israel
    Isr J Psychiatry Relat Sci 39:120-32. 2002
    ..We should therefore address our efforts in improving the environment of these children and in treating the early symptoms of inattention and hyperactivity, even before the child reaches school...
  23. ncbi request reprint Is benzodiazepine use during pregnancy really teratogenic?
    A Ornoy
    Israeli Teratogen Information Service, Israeli Ministry of Health and Hebrew University, Hadassah Medical School, Jerusalem
    Reprod Toxicol 12:511-5. 1998
    ..It is unknown whether BD could be responsible for developmental or behavioral problems, which are observed only at a later stage...
  24. ncbi request reprint Role of reactive oxygen species (ROS) in the diabetes-induced anomalies in rat embryos in vitro: reduction in antioxidant enzymes and low-molecular-weight antioxidants (LMWA) may be the causative factor for increased anomalies
    A Ornoy
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, Jerusalem, Israel 91120
    Teratology 60:376-86. 1999
    ..This, in turn, may be embryotoxic...
  25. ncbi request reprint Pregnancy outcome after in utero exposure to colchicine
    Orna Diav-Citrin
    Israeli Teratology Information Service and Israel Ministry of Health, Jerusalem, Israel
    Am J Obstet Gynecol 203:144.e1-6. 2010
    ..We sought to examine the fetal safety of colchicine...
  26. doi request reprint Oxidative stress in Cohen diabetic rat model by high-sucrose, low-copper diet: inducing pancreatic damage and diabetes
    Seonghun Ryu
    Department of Anatomy and Cell Biology, Laboratory of Teratology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Metabolism 57:1253-61. 2008
    ..In the CD rats that develop DM when fed HSD, the pancreas showed susceptibility to oxidative stress-induced injuries. Thus, enhanced oxidative stress seems to play a role in the pathogenesis of DM in this strain...
  27. ncbi request reprint Reduced SOD activity and increased neural tube defects in embryos of the sensitive but not of the resistant Cohen diabetic rats cultured under diabetic conditions
    Sarah Weksler-Zangen
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Birth Defects Res A Clin Mol Teratol 67:429-37. 2003
    ..In our study we investigated the role of the antioxidant defense mechanism, genetic predisposition or environmental factors in embryos cultured under diabetic conditions...
  28. doi request reprint Pregnancy outcome after in utero exposure to angiotensin converting enzyme inhibitors or angiotensin receptor blockers
    Orna Diav-Citrin
    The Israeli Teratology Information Service, Jerusalem, Israel Ministry of Health, Jerusalem, Israel
    Reprod Toxicol 31:540-5. 2011
    ..To examine first trimester safety of angiotensin-converting-enzyme-inhibitors (ACEIs) or angiotensin-receptor-blockers (ARBs)...
  29. pmc Pregnancy outcome, thyroid dysfunction and fetal goitre after in utero exposure to propylthiouracil: a controlled cohort study
    Hila Rosenfeld
    The Israeli Teratology Information Service, Israel Ministry of Health, Jerusalem 91120, Israel
    Br J Clin Pharmacol 68:609-17. 2009
    ..The major aims of this study were to evaluate the rate of major anomalies and to report the rate of fetal goitre, accompanied by hypothyroidism, in fetuses/ newborns of mothers after in utero exposure to PTU...
  30. ncbi request reprint Placental oxidative stress and decreased global DNA methylation are corrected by copper in the Cohen diabetic rat
    Zivanit Ergaz
    Hebrew University Hadassah Medical School, Jerusalem, Israel Electronic address
    Toxicol Appl Pharmacol 276:220-30. 2014
    ..DNA hypomethylation makes our model a unique method for investigating genes associated with growth, oxidative stress, hypoxia and copper...
  31. pmc Paroxetine and fluoxetine in pregnancy: a prospective, multicentre, controlled, observational study
    Orna Diav-Citrin
    The Israeli Teratogen Information Service, Israel Ministry of Health, Jerusalem, Israel
    Br J Clin Pharmacol 66:695-705. 2008
    ..The aim of the present study was to evaluate the teratogenic risk of paroxetine and fluoxetine...
  32. ncbi request reprint Safety of haloperidol and penfluridol in pregnancy: a multicenter, prospective, controlled study
    Orna Diav-Citrin
    Israeli Teratogen Information Service, Jerusalem 91120, Israel
    J Clin Psychiatry 66:317-22. 2005
    ..To assess the safety of the butyrophenone neuroleptics haloperidol and penfluridol in pregnancy...
  33. doi request reprint The effect of copper deficiency on fetal growth and liver anti-oxidant capacity in the Cohen diabetic rat model
    Zivanit Ergaz
    Hebrew University Hadassah Medical School, Jerusalem, Israel
    Toxicol Appl Pharmacol 265:209-20. 2012
    ..We conclude that in our model of dietary-induced fetal growth restriction, copper deficiency plays a major etiologic role in the decrease of fetal growth and anti-oxidant capacity...
  34. doi request reprint Pregnancy outcome after gestational exposure to the new macrolides: a prospective multi-center observational study
    Benjamin Bar-Oz
    Department of Neonatology, Hadassah and Hebrew University Medical Center, Jerusalem, Israel
    Eur J Obstet Gynecol Reprod Biol 141:31-4. 2008
    ..To determine whether the use of the new macrolides (azithromycin, clarithromycin, roxithromycin) during the first trimester of pregnancy is associated with an increased risk of major malformations...
  35. ncbi request reprint Pregnancy outcome after gestational exposure to mebendazole: a prospective controlled cohort study
    Orna Diav-Citrin
    Israeli Teratogen Information Service, Israel Ministry of Health, Jerusalem, Israel
    Am J Obstet Gynecol 188:282-5. 2003
    ..Its use in pregnancy is a reason for concern for women and their health care providers. The purpose of this study was to examine the fetal safety of mebendazole...
  36. doi request reprint Are the cognitive functions of children with Down syndrome related to their participation?
    Tanya Rihtman
    School of Occupational Therapy, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Dev Med Child Neurol 52:72-8. 2010
    ..On the basis of current international health paradigms, the purpose of this study was to assess the developmental profile of these children...
  37. ncbi request reprint Nitroxide radicals protect cultured rat embryos and yolk sacs from diabetic-induced damage
    Seonghun Ryu
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, Jerusalem, Israel 91120
    Birth Defects Res A Clin Mol Teratol 79:604-11. 2007
    ..We investigated the effects of superoxide dismutase-mimics nitroxides, 2,2,6,6-tetramethyl piperidine-N-oxyl (TPL) as an effective antioxidant, on diabetes-induced embryopathy...
  38. pmc Primary versus nonprimary cytomegalovirus infection during pregnancy, Israel
    Galia Rahav
    Hadassah Medical Center Hebrew University School of Medicine, Jerusalem, Israel
    Emerg Infect Dis 13:1791-3. 2007
    ..The risk for vertical transmission was 1.83x higher for primary infection than for nonprimary infection. Nonetheless, congenital CMV disease was diagnosed in both infection groups at similar rates...
  39. ncbi request reprint Preliminary findings of the developmental effects of in utero exposure to topiramate
    Tanya Rihtman
    School of Occupational Therapy, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Reprod Toxicol 34:308-11. 2012
    ..While the study group is small, and only preliminary conclusions may be inferred, it appears that TX exposure may have subtle effects on the development of children in a range of areas including motor function, cognition, and behavior...
  40. doi request reprint Epstein-Barr virus infection in pregnancy--a prospective controlled study
    Meytal Avgil
    The Israeli Teratogen Information Service, Israel Ministry of Health Jerusalem, Israel
    Reprod Toxicol 25:468-71. 2008
    ..Epstein-Barr virus (EBV) is one of the most common human viruses. To date, there is limited information regarding the influence of maternal EBV infection on pregnancy outcome...
  41. ncbi request reprint Pregnancy outcome after gestational exposure to loratadine or antihistamines: a prospective controlled cohort study
    Orna Diav-Citrin
    Israeli Teratogen Information Service, Israel Ministry of Health, Laboratory of Teratology, The Hebrew University Hadassah Medical School, PO Box 12272, Jerusalem 91120, Israel
    J Allergy Clin Immunol 111:1239-43. 2003
    ..Loratadine is a second-generation histamine H(1)-receptor antagonist, used in the treatment of allergic conditions. No prospective controlled trials on loratadine in human pregnancy have been published to date...
  42. ncbi request reprint Pregnancy outcome after first trimester exposure to corticosteroids: a prospective controlled study
    Chamutal Gur
    The Israeli Teratogen Information Service, The Israeli Ministry of Health, Hadassah Medical School and The Israeli Ministry of Health, The Hebrew University, P O Box 12272, Jerusalem 91120, Israel
    Reprod Toxicol 18:93-101. 2004
    ..To evaluate the safety of glucocorticosteroids (GCS) in pregnancy...
  43. ncbi request reprint The response to sex steroid hormones and vitamin D of cultured osteoblasts derived from ovariectomized mice with and without 17beta-estradiol pretreatment
    Natan Patlas
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, P O B 12272, 91120 Jerusalem, Israel
    Odontology 93:16-23. 2005
    ..These results imply that the animal's estrogen status prior to culture can influence the response to estrogens; this finding may have important implications for hormone replacement therapy (HRT) in postmenopausal women...
  44. ncbi request reprint Pregnancy outcome after in utero exposure to valproate : evidence of dose relationship in teratogenic effect
    Orna Diav-Citrin
    The Israeli Teratology Information Service, Israel Ministry of Health, Jerusalem, Israel
    CNS Drugs 22:325-34. 2008
    ..Valproate is a first-line antiepileptic agent and is also used in the treatment of bipolar disorder and migraine. It is a known human teratogen. The objective of the study was to evaluate the teratogenic risk of valproate...
  45. ncbi request reprint Antiphosphatidylserine antibodies affect rat yolk sacs in culture: a mechanism for fetal loss in antiphospholipid syndrome
    Shelly Tartakover Matalon
    Department of Anatomy and Cell Biology, Laboratory of Teratology, Hebrew University Hadassah Medical School, Jerusalem
    Am J Reprod Immunol 51:144-51. 2004
    ..A variety of reproductive impairments have been reported in the context of the antiphospholipid syndrome (APS). APS is associated with the presence of antibodies to negatively charged phospholipids that may affect the outcome of pregnancy...
  46. ncbi request reprint Pregnancy outcome in the Psammomys obesus gerbil on low- and high-energy diets
    Natan Patlas
    Department of Anatomy and Cell Biology The Hebrew University, Laboratory of Teratology, Hadassah Medical School, Jerusalem, Israel
    Biol Neonate 90:58-65. 2006
    ..The gerbil Psammomys obesus is a unique model for nutritionally induced Type 2 DM (T2DM) that enabled us to study the outcome of uncontrolled T2DM during pregnancy...
  47. ncbi request reprint Effect of sera from women with systemic lupus erythematosus or antiphospholipid syndrome and recurrent abortions on human placental explants in culture
    Sarah Yacobi
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Teratology 66:300-8. 2002
    ..To test this hypothesis, we studied the effects of sera obtained from women with SLE with or without treatment on human placental explants in culture...
  48. ncbi request reprint The functional profile of young adults with suspected Developmental Coordination Disorder (DCD)
    Miri Tal-Saban
    School of Occupational Therapy, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Res Dev Disabil 33:2193-202. 2012
    ..44; p=.047). Deficits in motor coordination continue into adulthood and have an effect on academic and non-academic function, as well as on the emotional state of the individual...
  49. doi request reprint Pregnancy outcome following in utero exposure to hydroxychloroquine: a prospective comparative observational study
    Orna Diav-Citrin
    The Israeli Teratology Information Service, Israel Ministry of Health, Jerusalem, Israel
    Reprod Toxicol 39:58-62. 2013
    ..To evaluate pregnancy safety of hydroxychloroquine (HCQ) for rheumatologic diseases...
  50. ncbi request reprint The effect of sera from women with systemic lupus erythematosus and/or antiphospholipid syndrome on rat embryos in culture
    A Ornoy
    Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Reprod Toxicol 12:185-91. 1998
    ....
  51. ncbi request reprint Vitamins C and E improve rat embryonic antioxidant defense mechanism in diabetic culture medium
    V Zaken
    Department of Anatomy and Cell Biology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Teratology 64:33-44. 2001
    ..This in turn may cause a depletion of the LMWA, such as vitamins C and E. The addition of these vitamins normalizes the embryonic antioxidant defense mechanism, reducing the damage caused by the diabetic environment...
  52. ncbi request reprint Is lithium a real teratogen? What can we conclude from the prospective versus retrospective studies? A review
    Sarah Yacobi
    Department of Anatomy and Cell Biology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Isr J Psychiatry Relat Sci 45:95-106. 2008
    ..Lithium is a drug used mainly for the treatment of Bipolar Disorder (BD). Case reports and several retrospective studies have demonstrated possible teratogenicity, but the data in the different studies was inconclusive...
  53. pmc Alcohol abuse in pregnant women: effects on the fetus and newborn, mode of action and maternal treatment
    Asher Ornoy
    Laboratory of Teratology, The Institute of Medical Research Israel Canada, Hadassah Medical School and Hospital, The Hebrew University of Jerusalem, Ein Kerem, P O Box 12271, Jerusalem, 91120, Israel
    Int J Environ Res Public Health 7:364-79. 2010
    ..The long term intellectual outcome of children born to ethanol dependent mothers is influenced to a large extent by the environment in which the exposed child is raised...
  54. ncbi request reprint Intrauterine growth restriction-etiology and consequences: what do we know about the human situation and experimental animal models?
    Zivanit Ergaz
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Reprod Toxicol 20:301-22. 2005
    ..As the ultimate goal is prevention, we seem still to be distant from achieving this goal...
  55. ncbi request reprint [The effects of Cytomegalic virus (CMV) infection during pregnancy on the developing human fetus]
    Asher Ornoy
    Israeli Teratogen Information Service, Laboratory of Teratology, Hebrew University Hadassah Medical School, Israeli Ministry of Health, Jerusalem, Israel
    Harefuah 141:565-8, 577. 2002
    ..The best preventive measure is appropriate immunization against CMV, but no effective immunization seems to exist as of today...
  56. ncbi request reprint Co-occurrence of developmental delays among preschool children with attention-deficit-hyperactivity disorder
    Aviva Yochman
    School of Occupational Therapy, Faculty of Medicine of Hadassah and the Hebrew University, Mt Scopus, Jerusalem, Israel
    Dev Med Child Neurol 48:483-8. 2006
    ....
  57. ncbi request reprint Repair behavior in children with intellectual impairments: evidence for metalinguistic competence
    Y Levy
    Psychology Department, Hebrew University Medical School, Jerusalem, Israel
    J Speech Lang Hear Res 46:368-81. 2003
    ....
  58. pmc A simple method of culture of 11.5-day-old rat embryos in DMEM/F12 and 20% fetal bovine serum
    A Ornoy
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University, Hadassah Medical School, Jerusalem, Israel
    J Anat 203:419-23. 2003
    ..This method is not appropriate for younger embryos; in E10.5 embryos cultured for 28 h we found increased embryonic death and anomalies...
  59. ncbi request reprint The effects of IgG purified from women with SLE and associated pregnancy loss on rat embryos in culture
    S T Matalon
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Am J Reprod Immunol 48:296-304. 2002
    ....
  60. ncbi request reprint Spontaneous language of children with specific neurological syndromes
    Y Levy
    Psychology Department, Hadassah Hebrew University Medical School, Jerusalem, Israel
    J Speech Lang Hear Res 43:351-65. 2000
    ..These findings suggest the possibility of a mechanism that is functionally akin to brain plasticity. Such a mechanism will guarantee the preservation of basic linguistic skills in children with NS...
  61. doi request reprint Neurodevelopmental and psychological assessment of adolescents born to drug-addicted parents: effects of SES and adoption
    Asher Ornoy
    Department of Medical Neurobiology, Hebrew University Hadassah Medical School and Israeli Ministry of Health, Jerusalem, Israel
    Child Abuse Negl 34:354-68. 2010
    ....
  62. ncbi request reprint Reduced placental growth and hCG secretion in vitro induced by antiphospholipid antibodies but not by anti-Ro or anti-La: studies on sera from women with SLE/PAPS
    N Schwartz
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University, Hadassah Medical School, Jerusalem, Israel
    Lupus 16:110-20. 2007
    ..In conclusion, aPL, but not anti-Ro or anti-La, may cause placental damage in vitro. Thus betahCG levels might constitute a predictive marker for the risk of placental damage and pregnancy loss in women with SLE/PAPS...
  63. ncbi request reprint Young adults with developmental coordination disorder: a longitudinal study
    Miri Tal-Saban
    Miri Tal Saban, MSc, is Doctoral Student and Director, Kesher Outreach Program, School of Occupational Therapy, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Am J Occup Ther 68:307-16. 2014
    ..Linear regression found the Psychological Health domain of the WHOQOL-BREF to be a significant predictor of life satisfaction (B = 0.533; p = .001). ..
  64. doi request reprint Pregnancy outcome following gestational exposure to TNF-alpha-inhibitors: a prospective, comparative, observational study
    Orna Diav-Citrin
    The Israeli Teratology Information Service, Israel Ministry of Health, Jerusalem, Israel The Hebrew University Hadassah Medical School, Jerusalem, Israel Electronic address
    Reprod Toxicol 43:78-84. 2014
    ..To evaluate pregnancy safety of anti-TNF-α medications...
  65. doi request reprint Adolescents and adults coordination questionnaire: development and psychometric properties
    Miri Tal Saban
    Kesher Outreach Program, School of Occupational Therapy, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Am J Occup Ther 66:406-13. 2012
    ....
  66. ncbi request reprint Responses of preschool children with and without ADHD to sensory events in daily life
    Aviva Yochman
    School of Occupational Therapy, Hebrew University Hadassah Medical School, PO Box 24026, Mount Scopus, Jerusalem, Israel
    Am J Occup Ther 58:294-302. 2004
    ..In addition, the relationship between levels of hyperactivity and sensory deficits was examined...
  67. ncbi request reprint Perinatal and early postnatal factors underlying developmental delay and disabilities
    Zivanit Ergaz
    Department of Neonatology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Dev Disabil Res Rev 17:59-70. 2011
    ..Studies that concern neuroprotective therapies and prediction of long-term neurologic outcome by clinical examination, neuroimaging techniques, and electroencephalographic studies are reviewed as well...
  68. ncbi request reprint Teratogen update: antithyroid drugs-methimazole, carbimazole, and propylthiouracil
    Orna Diav-Citrin
    The Israeli Teratogen Information Service, Israeli Ministry of Health, Jerusalem, Israel
    Teratology 65:38-44. 2002
  69. ncbi request reprint Parvovirus B19 in pregnancy
    Zivanit Ergaz
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Reprod Toxicol 21:421-35. 2006
    ..Risk assessment for maternal infection during pregnancy is especially important during epidemics when sero-conversion rates are high...
  70. pmc Selective serotonin reuptake inhibitors in human pregnancy: to treat or not to treat?
    Orna Diav-Citrin
    The Israeli Teratology Information Service, Israel Ministry of Health, P O Box 1176, Jerusalem 91010, Israel
    Obstet Gynecol Int 2012:698947. 2012
    ..The risk associated with treatment discontinuation, for example, higher frequency of relapse and increased risk of preterm delivery, should also be considered. The overall benefit of treatment seems to outweigh the potential risks...
  71. ncbi request reprint Pregnancy outcome after gestational exposure to metronidazole: a prospective controlled cohort study
    O Diav-Citrin
    Israeli Teratogen Information Service, Israeli Ministry of Health, Jerusalem 91120, Israel
    Teratology 63:186-92. 2001
    ..CONCLUSIONS: This study confirms that metronidazole does not represent a major teratogenic risk in humans when used in the recommended doses...
  72. ncbi request reprint The teratogenic effect of carbamazepine: a meta-analysis of 1255 exposures
    S Matalon
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Reprod Toxicol 16:9-17. 2002
    ..In light of these results, we recommend performing a level 2 ultrasound and fetal echocardiography in women treated with CBZ during pregnancy...
  73. ncbi request reprint Developmental outcome of school-age children born to mothers with heroin dependency: importance of environmental factors
    A Ornoy
    Laboratory of Teratology, The Hebrew University Hadassah Medical School Jerusalem, Israel
    Dev Med Child Neurol 43:668-75. 2001
    ..The highest rate of ADHD was in children born to mothers with heroin dependency raised at home, being twice that observed in the other groups. Mothers of these groups of children also had a high rate of ADHD...
  74. ncbi request reprint Genetic and teratogenic effects of cancer treatments on gametes and embryos
    J Arnon
    Israel Ministry of Health and Laboratory of Teratology, Hebrew University Hadassah Medical School, Jerusalem
    Hum Reprod Update 7:394-403. 2001
    ..High doses of radiation during pregnancy induce anomalies, impaired growth and mental retardation, and there may be an increased risk of childhood leukaemia and other tumours in the offspring...
  75. ncbi request reprint School-age children born to diabetic mothers and to mothers with gestational diabetes exhibit a high rate of inattention and fine and gross motor impairment
    A Ornoy
    Department of Anatomy and Cell Biology, Hebrew University, Jerusalem, Israel
    J Pediatr Endocrinol Metab 14:681-9. 2001
    ..These effects were negatively correlated with the degree of maternal glycemic control, and were more pronounced in younger children...
  76. ncbi request reprint The safety of proton pump inhibitors in pregnancy: a multicentre prospective controlled study
    O Diav-Citrin
    The Israeli Teratogen Information Service, Israel Ministry of Health, Jerusalem, Israel
    Aliment Pharmacol Ther 21:269-75. 2005
    ..Gastro-oesophageal reflux is a common condition in pregnancy. Human pregnancy experience with lansoprazole or pantoprazole is very limited. More data exist on the safety of omeprazole in pregnancy...
  77. ncbi request reprint Is carbamazepine teratogenic? A prospective controlled study of 210 pregnancies
    O Diav-Citrin
    Israeli Teratogen Information Service, Laboratory of Teratology, Jerusalem, Israel
    Neurology 57:321-4. 2001
    ..24; 95% CI 1.1-4.56) and a birth weight reduction of approximately 250 g after in utero exposure to carbamazepine...
  78. ncbi request reprint Metoclopramide for nausea and vomiting of pregnancy: a prospective multicenter international study
    Matitiahu Berkovitch
    Clinical Pharmacology and Toxicology Unit, Assaf Harofeh Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Perinatol 19:311-6. 2002
    ....
  79. ncbi request reprint The pathogenic role of anti-thyroglobulin antibody on pregnancy: evidence from an active immunization model in mice
    Shelly Tartakover Matalon
    Center for Autoimmune Diseases, Department of Medicine B, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv, Israel
    Hum Reprod 18:1094-9. 2003
    ..The aim of this study was to examine whether active immunization with Tg could elicit anti-Tg autoantibodies and reproductive failure without interfering with thyroid function...
  80. ncbi request reprint Review of the potential effects of three commonly used antineoplastic and immunosuppressive drugs (cyclophosphamide, azathioprine, doxorubicin on the embryo and placenta)
    Shelly Tartakover Matalon
    Oncogenetic Laboratory, Department of Medicine A, Sapir Medical Center, Kfar Saba, Israel
    Reprod Toxicol 18:219-30. 2004
  81. ncbi request reprint Metamizol (dipyrone, optalgin) in pregnancy, is it safe? A prospective comparative study
    Benjamin Bar-Oz
    Department of Neonatology, Hadassa University Hospital, Mount Scopus, Jerusalem
    Eur J Obstet Gynecol Reprod Biol 119:176-9. 2005
    ..To assess the teratogenic effect of metamizol when used during the first trimester of pregnancy...
  82. pmc First-trimester exposure to amoxycillin/clavulanic acid: a prospective, controlled study
    Matitiahu Berkovitch
    Clinical Pharmacology and Toxicology Unit, Drug Consultation Centre, Assaf Harofeh Medical Centre, Zerifin, Israel
    Br J Clin Pharmacol 58:298-302. 2004
    ..In this study we wished to investigate prospectively the safety of intrauterine exposure to amoxycillin/clavulanic acid in a relatively large cohort of women...
  83. ncbi request reprint Immunization of naïve mice with mouse laminin-1 affected pregnancy outcome in a mouse model
    Shelly Tartakover Matalon
    Research Center for Autoimmune Diseases, Department of Medicine B Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Reprod Immunol 50:159-65. 2003
    ..Laminins have important roles during placental and embryonic development. The aim of our study was to determine if active immunization of mice with laminin-1 could elicit an autoimmune response, and induce features of reproductive failure...
  84. ncbi request reprint Developmental evaluation of children born to mothers occupationally exposed to waste anesthetic gases
    Navah Z Ratzon
    Occupational Therapy, Tel Aviv University, Tel Aviv, Israel
    Birth Defects Res A Clin Mol Teratol 70:476-82. 2004
    ..This study focuses on the development of children born to mothers who were exposed during their pregnancy to waste anesthetic gases...
  85. ncbi request reprint Perceptuomotor functioning in preschool children with symptoms of attention deficit hyperactivity disorder
    Aviva Yochman
    School of Occupational Therapy, Faculty of Medicine, The Hebrew University of Jerusalem, Mount Scopus, P O Box 24026, Jerusalem 91240, Israel
    Percept Mot Skills 102:175-86. 2006
    ....
  86. ncbi request reprint Pregnancy outcome of women exposed to azathioprine during pregnancy
    Lee Hilary Goldstein
    Clinical Pharmacology Unit, Teratogen Information Service, Assaf Harofeh Medical Center, Sackler School of Medicine, Tel Aviv University, Israel
    Birth Defects Res A Clin Mol Teratol 79:696-701. 2007
    ..Our objective was too determine whether exposure to AZP during pregnancy increases the risk for major malformations and to determine the effect on pregnancy outcome...
  87. doi request reprint Using observational cohort data for studying drug effects on pregnancy outcome--methodological considerations
    Christof Schaefer
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie BBGes, Berlin Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Spandauer Damm 130, Haus 10, 14050 Berlin, Germany
    Reprod Toxicol 26:36-41. 2008
    ....