Tally Naveh-Many

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. pmc The peptidyl-prolyl isomerase Pin1 determines parathyroid hormone mRNA levels and stability in rat models of secondary hyperparathyroidism
    Morris Nechama
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Invest 119:3102-14. 2009
  2. ncbi Cis and trans acting factors in the regulation of parathyroid hormone (PTH) mRNA stability by calcium and phosphate
    Tally Naveh-Many
    Minerva Center for Calcium and Bone Metabolism, Hadassah University Hospital, P O Box 12000, 91120, Jerusalem, Israel
    FEBS Lett 529:60-4. 2002
  3. ncbi The protein phosphatase calcineurin determines basal parathyroid hormone gene expression
    Osnat Bell
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hospital, PO Box 12000, Jerusalem 91120, Israel
    Mol Endocrinol 19:516-26. 2005
  4. doi The mRNA decay promoting factor K-homology splicing regulator protein post-transcriptionally determines parathyroid hormone mRNA levels
    Morris Nechama
    Minerva Center for Calcium and Bone Metabolism, Hadassah Hebrew University Medical Center, PO Box 12000, Jerusalem, Israel 91120
    FASEB J 22:3458-68. 2008
  5. pmc The parathyroid is a target organ for FGF23 in rats
    Iddo Z Ben-Dov
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Invest 117:4003-8. 2007
  6. ncbi Calcineurin Abeta is central to the expression of the renal type II Na/Pi co-transporter gene and to the regulation of renal phosphate transport
    Yulia Moz
    Nephrology Services, Hadassah Hospital, P O Box 12000, Jerusalem, Israel 91120
    J Am Soc Nephrol 15:2972-80. 2004
  7. ncbi Identification and characterization of cis-acting elements in the human and bovine PTH mRNA 3'-untranslated region
    Osnat Bell
    Hebrew University and Hadassah Medical Center, Jerusalem, Israel
    J Bone Miner Res 20:858-66. 2005
  8. pmc The calcium-sensing receptor regulates parathyroid hormone gene expression in transfected HEK293 cells
    Hillel Galitzer
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    BMC Biol 7:17. 2009
  9. doi Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease
    H Galitzer
    Department of Nephrology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Kidney Int 77:211-8. 2010
  10. doi Regulation of PTH mRNA stability by the calcimimetic R568 and the phosphorus binder lanthanum carbonate in CKD
    Morris Nechama
    Minerva Center for Calcium and Bone Metabolism, Hadassah Hebrew Univ Medical Center, P O Box 12000, Jerusalem, Israel 91120
    Am J Physiol Renal Physiol 296:F795-800. 2009

Collaborators

Detail Information

Publications30

  1. pmc The peptidyl-prolyl isomerase Pin1 determines parathyroid hormone mRNA levels and stability in rat models of secondary hyperparathyroidism
    Morris Nechama
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Invest 119:3102-14. 2009
    ..These results demonstrate that Pin1 is a key mediator of PTH mRNA stability and indicate a role for Pin1 in the pathogenesis of secondary hyperparathyroidism in individuals with CKD...
  2. ncbi Cis and trans acting factors in the regulation of parathyroid hormone (PTH) mRNA stability by calcium and phosphate
    Tally Naveh-Many
    Minerva Center for Calcium and Bone Metabolism, Hadassah University Hospital, P O Box 12000, 91120, Jerusalem, Israel
    FEBS Lett 529:60-4. 2002
    ..Our results identified a functional cis element in PTH mRNA. Differences in protein binding to this element determine PTH mRNA stability and its regulation by calcium and phosphate...
  3. ncbi The protein phosphatase calcineurin determines basal parathyroid hormone gene expression
    Osnat Bell
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hospital, PO Box 12000, Jerusalem 91120, Israel
    Mol Endocrinol 19:516-26. 2005
    ..Therefore, calcineurin regulates AUF1 posttranslationally in vitro and PTH gene expression in vivo but still allows its physiological regulation by calcium and phosphate...
  4. doi The mRNA decay promoting factor K-homology splicing regulator protein post-transcriptionally determines parathyroid hormone mRNA levels
    Morris Nechama
    Minerva Center for Calcium and Bone Metabolism, Hadassah Hebrew University Medical Center, PO Box 12000, Jerusalem, Israel 91120
    FASEB J 22:3458-68. 2008
    ..Therefore, calcium or phosphorus depletion, as well as chronic kidney failure, regulate the interaction of KSRP and AUF1 with PTH mRNA and its half-life. Our data indicate a novel role for KSRP in PTH gene expression...
  5. pmc The parathyroid is a target organ for FGF23 in rats
    Iddo Z Ben-Dov
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Invest 117:4003-8. 2007
    ..These data indicate that FGF23 acts directly on the parathyroid through the MAPK pathway to decrease serum PTH. This bone-parathyroid endocrine axis adds a new dimension to the understanding of mineral homeostasis...
  6. ncbi Calcineurin Abeta is central to the expression of the renal type II Na/Pi co-transporter gene and to the regulation of renal phosphate transport
    Yulia Moz
    Nephrology Services, Hadassah Hospital, P O Box 12000, Jerusalem, Israel 91120
    J Am Soc Nephrol 15:2972-80. 2004
    ..These results suggest that the use of calcineurin inhibitors contributes to the renal Pi wasting seen in renal transplant patients...
  7. ncbi Identification and characterization of cis-acting elements in the human and bovine PTH mRNA 3'-untranslated region
    Osnat Bell
    Hebrew University and Hadassah Medical Center, Jerusalem, Israel
    J Bone Miner Res 20:858-66. 2005
    ..The function of the elements was shown in vitro...
  8. pmc The calcium-sensing receptor regulates parathyroid hormone gene expression in transfected HEK293 cells
    Hillel Galitzer
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    BMC Biol 7:17. 2009
    ..There is no parathyroid cell line; therefore, we developed a parathyroid engineered cell using expression vectors for the full-length human parathyroid hormone gene and the human calcium receptor...
  9. doi Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease
    H Galitzer
    Department of Nephrology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Kidney Int 77:211-8. 2010
    ..This in vivo resistance is sustained in parathyroid organ culture in vitro...
  10. doi Regulation of PTH mRNA stability by the calcimimetic R568 and the phosphorus binder lanthanum carbonate in CKD
    Morris Nechama
    Minerva Center for Calcium and Bone Metabolism, Hadassah Hebrew Univ Medical Center, P O Box 12000, Jerusalem, Israel 91120
    Am J Physiol Renal Physiol 296:F795-800. 2009
    ..Therefore, the calcimimetic R568 and correction of serum phosphorus by La determine PTH mRNA stability through KSRP-mediated recruitment of a degradation complex to the PTH mRNA, thereby decreasing PTH expression...
  11. pmc KSRP-PMR1-exosome association determines parathyroid hormone mRNA levels and stability in transfected cells
    Morris Nechama
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    BMC Cell Biol 10:70. 2009
    ..AUF1 and Unr stabilize PTH mRNA while KSRP, recruiting the exoribonucleolytic complex exosome, promotes PTH mRNA decay...
  12. doi PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop
    Vardit Lavi-Moshayoff
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew Univ Medical Center, PO Box 12000, Jerusalem, Israel 91120
    Am J Physiol Renal Physiol 299:F882-9. 2010
    ..The effect of PTH on FGF23 completes a bone-parathyroid endocrine feedback loop. Importantly, secondary hyperparathyroidism is essential for the high-FGF23 levels in early CKD...
  13. ncbi Mechanisms of secondary hyperparathyroidism
    Justin Silver
    Minerva Center for Calcium and Bone Metabolism, Nephrology and Hypertension Services, Hadassah University Hospital, Jerusalem, Israel 91120
    Am J Physiol Renal Physiol 283:F367-76. 2002
    ..PT trans factors and cis elements have been defined...
  14. doi Fibroblast growth factor 23 acts on the parathyroid to decrease parathyroid hormone secretion
    Hillel Galitzer
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Curr Opin Nephrol Hypertens 17:363-7. 2008
    ..The aim of this article is to describe the intriguing action of fibroblast growth factor 23 on the parathyroid...
  15. ncbi In vitro evidence that upstream of N-ras participates in the regulation of parathyroid hormone messenger ribonucleic acid stability
    Maya Dinur
    Minerva Center for Calcium and Bone Metabolism, Hebrew University Hadassah Medical Center, Jerusalem 91120, Israel
    Mol Endocrinol 20:1652-60. 2006
    ..Therefore, Unr binds to the PTH cis element and increases PTH mRNA levels, as does AU-rich binding factor 1. Our results suggest that Unr, together with the other proteins in the RNA binding complex, determines PTH mRNA stability...
  16. ncbi Lanthanum carbonate decreases PTH gene expression with no hepatotoxicity in uraemic rats
    Iddo Z Ben-Dov
    Minerva Center for Calcium and Bone Metabolism, Nephrology and Hypertension Services, Hadassah Hebrew University Medical Center, Ein Karem, PO Box 12000, Jerusalem, Israel 91120
    Nephrol Dial Transplant 22:362-8. 2007
    ..Some recent studies in rodents have cast safety uncertainties. The aims of this study were to examine the effects of La on parathyroid hormone (PTH) gene expression and hepatic toxicity...
  17. ncbi Regulation of parathyroid hormone mRNA stability by calcium, phosphate and uremia
    Tally Naveh-Many
    Minerva Center for Calcium and Bone Metabolism, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Curr Opin Nephrol Hypertens 16:305-10. 2007
    ..Understanding the mechanism by which calcium and phosphate regulate parathyroid hormone gene expression is important for both normal physiology and in pathological states, especially chronic kidney disease...
  18. doi FGF23 and the parathyroid glands
    Justin Silver
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Ein Karem, Jerusalem, 91120, Israel
    Pediatr Nephrol 25:2241-5. 2010
    ..In addition, in advanced experimental CKD, FGF23 has a decreased ability to inhibit PTH expression...
  19. doi Human PTH gene regulation in vivo using transgenic mice
    Vardit Lavi-Moshayoff
    Nephrology Services, Hadassah Hebrew University Medical Center, P O Box 12000, Jerusalem, Israel 91120
    Am J Physiol Renal Physiol 297:F713-9. 2009
    ....
  20. doi Deletion of the vitamin D receptor specifically in the parathyroid demonstrates a limited role for the receptor in parathyroid physiology
    Tomer Meir
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hospital, Jerusalem, Israel
    Am J Physiol Renal Physiol 297:F1192-8. 2009
    ..Therefore, deletion of the VDR specifically in the parathyroid decreases parathyroid CaR expression and only moderately increases basal PTH levels, suggesting that the VDR has a limited role in parathyroid physiology...
  21. doi FGF23 and the parathyroid
    Justin Silver
    Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Adv Exp Med Biol 728:92-9. 2012
    ..There is therefore a negative feedback loop between bone and the parathyroid...
  22. doi Phosphate and the parathyroid
    Justin Silver
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Kidney Int 75:898-905. 2009
    ..The responses of the parathyroid to changes in serum Pi are now being revealed but the sensing mechanisms remain a mystery...
  23. doi Minireview: the play of proteins on the parathyroid hormone messenger ribonucleic Acid regulates its expression
    Tally Naveh-Many
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, POB 12000, Jerusalem 91120, Israel
    Endocrinology 151:1398-402. 2010
    ..These protein-PTH mRNA interactions are orchestrated by the peptidyl-prolyl isomerase Pin1. This review discusses the mechanisms of regulation of PTH mRNA stability determining serum PTH levels and mineral metabolism...
  24. ncbi The parathyroid hormone mRNA 3'-untranslated region AU-rich element is an unstructured functional element
    Rachel Kilav
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hospital, The Hebrew University Medical School, P O Box 12000, Jerusalem, Israel 91120
    J Biol Chem 279:2109-16. 2004
    ..The PTH mRNA 3'-UTR cis-acting element is an open region that utilizes the distinct sequence pattern to determine mRNA stability by its interaction with trans-acting factors...
  25. ncbi Increased parathyroid hormone gene expression in secondary hyperparathyroidism of experimental uremia is reversed by calcimimetics: correlation with posttranslational modification of the trans acting factor AUF1
    Ronen Levi
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hebrew University Hadassah Hospital, P O Box 12000, Jerusalem, Israel 91120
    J Am Soc Nephrol 17:107-12. 2006
    ..Therefore, uremia and activation of the CaR mediated by calcimimetics modify AUF1 posttranslationally. These modifications in AUF1 correlate with changes in protein-PTH mRNA binding and PTH mRNA levels...
  26. doi FGF-23 and secondary hyperparathyroidism in chronic kidney disease
    Justin Silver
    Hadassah Hebrew University Medical Center, Minerva Center for Calcium and Bone Metabolism, Nephrology, Ein Karem, Jerusalem 91120, Israel
    Nat Rev Nephrol 9:641-9. 2013
    ..This Review discusses the mechanisms by which secondary hyperparathyroidism associated with CKD stimulates bone cells to overexpress FGF-23 levels. ..
  27. pmc The complex regulation of HIC (Human I-mfa domain containing protein) expression
    Ella Reiss-Sklan
    Department of Biological Chemistry, Institute of Life Science, The Hebrew University, Jerusalem, Israel
    PLoS ONE 4:e6152. 2009
    ....
  28. ncbi Characterization of cis-acting element in renal NaPi-2 cotransporter mRNA that determines mRNA stability
    Yulia Moz
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah University Hospital, Jerusalem, Israel 91120
    Am J Physiol Renal Physiol 284:F663-70. 2003
    ..Our results suggest that the protein-binding region of the NaPi-2 mRNA functions as a cis-acting instability element. In hypophosphatemia there is increased binding to the cis-acting element and subsequent stabilization of NaPi-2 mRNA...
  29. ncbi Calreticulin destabilizes glucose transporter-1 mRNA in vascular endothelial and smooth muscle cells under high-glucose conditions
    Hana Totary-Jain
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel
    Circ Res 97:1001-8. 2005
    ..This interaction underlies the process of downregulation of glucose transport in vascular cells under high-glucose conditions...
  30. ncbi Mutational analysis of the PTH 3'-untranslated region in parathyroid disorders
    Jessica Costa-Guda
    Center for Molecular Medicine, University of Connecticut School of Medicine, Farmington, CT 06030 3101, USA
    Clin Endocrinol (Oxf) 65:806-9. 2006
    ....