Research Topics
Genomes and Genes | Baruch MinkeSummaryAffiliation: The Hebrew University Country: Israel Publications
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Publications
The history of the prolonged depolarizing afterpotential (PDA) and its role in genetic dissection of Drosophila phototransductionBaruch Minke
Department of Medical Neurobiology, The Institute of Medical Research Israel Canada, Faculty of Medicine and the Edmond and Lily Safra Center for Brain Sciences ELSC, The Hebrew University, Jerusalem, Israel
J Neurogenet 26:106-17. 2012..Remarkably, to this day, the PDA mutants that Pak and his colleagues isolated are the main source of mutants for analysis of the Drosophila visual system...
The history of the Drosophila TRP channel: the birth of a new channel superfamilyBaruch Minke
Department of Medical Neurobiology, The Institute of Medical Research Israel Canada, The Edmond and Lily Safra Center for Brain Sciences and the Kühne Minerva Center for Studies of Visual Transduction, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel
J Neurogenet 24:216-33. 2010..The native Drosophila photoreceptor cells, where the founding member of the TRP channels superfamily was found, is still a useful preparation to study basic features of this remarkable channel...- Translocation of Gq alpha mediates long-term adaptation in Drosophila photoreceptorsShahar Frechter
Department of Physiology and Kühne Minerva Center for Studies of Visual Transduction, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
J Neurosci 27:5571-83. 2007..The slow time scale of this adaptation fits well with day/night light intensity changes, because there is no need to maintain single photon sensitivity during daytime... - Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channelsMoshe Parnas
Department of Physiology and the Kühne Minerva Center for Studies of Visual Transduction, Faculty of Medicine of the Hebrew University, Jerusalem 91120, Israel
J Neurosci 29:2371-83. 2009..We propose that the profound effect of membrane lipid modulations on open channel block alleviation, allows the productions of a robust current in response to light in the absence of depolarization... - Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channelsMoshe Parnas
Department of Physiology, Kühne Minerva Center for Studies of Visual Transduction, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel
Cell Calcium 45:300-9. 2009..Our finding that the activity of the non-thermoTRPs, TRPL and TRPM7 channels is modulated by the same compound as thermoTRPs, suggests that common mechanisms of channel modulation characterize TRP channels... - Excess of Gbetae over Gqalphae in vivo prevents dark, spontaneous activity of Drosophila photoreceptorsNatalie Elia
Department of Biological Chemistry, Kühne Minerva Center for Studies of Visual Transduction, Institute of Life Sciences, The Hebrew University, Givat Ram, Jerusalem 91904, Israel
J Cell Biol 171:517-26. 2005..This mechanism could be relevant to the regulation of G protein signaling in general... - Light-regulated interaction of Dmoesin with TRP and TRPL channels is required for maintenance of photoreceptorsIrit Chorna-Ornan
Department of Physiology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
J Cell Biol 171:143-52. 2005..Thus, our data strongly suggest that the light- and phosphorylation-dependent dynamic association of Dmoesin to membrane channels is involved in maintenance of the photoreceptor cells... - Compartmentalization and Ca2+ buffering are essential for prevention of light-induced retinal degenerationShirley Weiss
Department of Medical Neurobiology, Institute for Medical Research Israel Canada IMRIC and the Edmond and Lily Safra Center for Brain Sciences ELSC, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel
J Neurosci 32:14696-708. 2012..We propose that calphotin-mediated compartmentalization and Ca(2+) buffering constitute an effective strategy to protect cells from Ca(2+) overload and light-induced degeneration... - The activity of the TRP-like channel depends on its expression systemShaya Lev
Department of Medical Neurobiology, Institute of Medical Research Israel Canada, Hebrew University, Jerusalem, Israel
Channels (Austin) 6:86-93. 2012..However, clues on the gating mechanism may arise from understanding how different expression systems affect TRPC channel activation... - Phospholipase C-mediated suppression of dark noise enables single-photon detection in Drosophila photoreceptorsBen Katz
Department of Medical Neurobiology, The Institute of Medical Research, Israel
J Neurosci 32:2722-33. 2012..We thus demonstrate how a G-protein-mediated transduction system, with PLC as its target, selectively suppresses its intrinsic noise while preserving reliable signaling... - Signal-dependent hydrolysis of phosphatidylinositol 4,5-bisphosphate without activation of phospholipase C: implications on gating of Drosophila TRPL (transient receptor potential-like) channelShaya Lev
Department of Medical Neurobiology, Institute of Medical Research Israel Canada, The Edmond and Lily Safra Center for Brain Sciences, Faculty of Medicine of the Hebrew University, Jerusalem 91120, Israel
J Biol Chem 287:1436-47. 2012..This suggests that PI(4,5)P(2) is a crucial substrate for PLC-mediated activation of the channels, whereas PUFA may function as the channel activator. Together, this study defines a narrow range of possible mechanisms for TRPL gating... - Heteromultimeric TRPML channel assemblies play a crucial role in the regulation of cell viability models and starvation-induced autophagyDavid A Zeevi
Monique and Jacques Roboh Department of Genetic Research, Institute of Medical Research Israel Canada IMRIC, Faculty of Medicine of the Hebrew University and Hadassah Hebrew University Hospital, Jerusalem 91120, Israel
J Cell Sci 123:3112-24. 2010..Collectively, our results indicate that heteromultimerization of TRPML channels plays a role in various TRPML-regulated mechanisms... - Constitutive activity of the human TRPML2 channel induces cell degenerationShaya Lev
Department of Medical Neurobiology and the Kühne Minerva Center for Studies of Visual Transduction, Faculty of Medicine of the Hebrew University, Jerusalem, Israel
J Biol Chem 285:2771-82. 2010..Hence, in addition to overall structure, all three TRPML channels also share common modes of regulation... - Light-regulated translocation of signaling proteins in Drosophila photoreceptorsShahar Frechter
Department of Physiology, The Hebrew University-Hadassah Medical School, P.O. Box 12272, Jerusalem 91120, Israel
J Physiol Paris 99:133-9. 2006..Altogether, signal-dependent movement of signaling proteins plays a major role in the maintenance and function of photoreceptor cells... - Open channel block by Ca2+ underlies the voltage dependence of drosophila TRPL channelMoshe Parnas
Department of Physiology and the Kühne Minerva Center for Studies of Visual Transduction, Faculty of Medicine, Hebrew University, Jerusalem 91120, Israel
J Gen Physiol 129:17-28. 2007.... 
TRP gating is linked to the metabolic state and maintenance of the Drosophila photoreceptor cellsBaruch Minke
Department of Physiology, Kühne Minerva Center for Studies of Visual Transduction, Hadassah Medical School, The Hebrew University, P O Box 12272, Jerusalem 91120, Israel
Cell Calcium 33:395-408. 2003..The link of TRP gating to the metabolic state and maintenance of cells makes cells expressing TRP extremely vulnerable to metabolic stress via a mechanism that may underlie retinal degeneration and neuronal cell death upon malfunction...- Activation of the Drosophila TRP and TRPL channels requires both Ca2+ and protein dephosphorylationKeren Agam
Department of Physiology, , The Hebrew University, Hadassah Medical School, Jerusalem 91120, Israel
Cell Calcium 35:87-105. 2004..The results suggest that the combined action of Ca2+ and protein dephosphorylation activate the TRP and TRPL channels, while protein phosphorylation by PKC antagonized channels openings... - Linoleic acid inhibits TRP channels with intrinsic voltage sensitivity: Implications on the mechanism of linoleic acid actionMoshe Parnas
Departments of Physiology and the Kühne Minerva Center for Studies of Visual Transduction, Faculty of Medicine of the Hebrew University, Jerusalem, Israel
Channels (Austin) 3:164-6. 2009..Together, our findings further support the notion that lipids do not act as second messengers by direct binding to a specific site of the channels but rather act indirectly by affecting the channel-plasma membrane interface... - The TRP calcium channel and retinal degenerationBaruch Minke
Department of Physiology and the Kühne Minerva Center for Studies of Visual Transduction, The Hebrew University Hadassah Medical School Jerusalem 91120, Israel
Adv Exp Med Biol 514:601-22. 2002.... - Regulation of light-dependent Gqalpha translocation and morphological changes in fly photoreceptorsMickey Kosloff
Department of Biological Chemistry and the Kuhne Minerva Center for Studies of Visual Transduction, Institute of Life Sciences, The Hebrew University, Givat Ram, Jerusalem, 91904, Israel
EMBO J 22:459-68. 2003.... - Carvacrol together with TRPC1 elimination improve functional recovery after traumatic brain injury in miceMaximilian Peters
Department of Medical Neurobiology, Institute of Medical Research Israel Canada, Jerusalem, Israel
J Neurotrauma 29:2831-4. 2012..We conclude that TRPC1-sensitive mechanisms are involved in TBI pathology, and that inhibition of this channel by carvacrol enhances recovery and should be considered for further studies in animal models and humans... - TRP channel proteins and signal transductionBaruch Minke
Department of Physiology and the Kühne Minerva Center for Studies of Visual Transduction, The Hebrew University Hadassah Medical School, Jerusalem, Israel
Physiol Rev 82:429-72. 2002..The channels' roles and characteristics such as gating mechanism, regulation, and permeability are determined by evolution according to the specific functional requirements... - Cellular functions of transient receptor potential channelsDaniela Dadon
Department of Medical Neurobiology, The Institute of Medical Research Israel Canada and the Kühne Minerva Center, for Studies of Visual Transduction, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel
Int J Biochem Cell Biol 42:1430-45. 2010..All the above features of Transient Receptor Potential channels make them crucial components in important, sometimes conflicting, cellular processes that still need to be explored... - Insights on TRP channels from in vivo studies in DrosophilaBaruch Minke
Department of Physiology and Kühne Minerva Center for Studies of Visual Transduction, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Annu Rev Physiol 68:649-84. 2006..Thus, PLC and its downstream second messengers, Ca2+ and DAG, constitute critical mediators of TRP/TRPL gating in vivo... - Constitutive activity of TRP channels methods for measuring the activity and its outcomeShaya Lev
Department of Medical Neurobiology and the Kühne Minerva Center for Studies of Visual Transduction, Institute of Medical Research Israel Canada IMRIC, The Edmond and Lily Safra Center for Brain Sciences ELSC, The Hebrew University, Jerusalem, Israel
Methods Enzymol 484:591-612. 2010..Finally, it describes methods for qualitatively and quantitatively measuring the accompanied cellular degeneration... - Drosophila photoreceptors and signaling mechanismsBen Katz
Department of Physiology, , Faculty of Medicine, The Hebrew University Jerusalem, Israel
Front Cell Neurosci 3:2. 2009..The fly eye has thus played a major role in the molecular identification of processes and proteins with prime importance... - TRP channels and Ca2+ signalingBaruch Minke
Department of Physiology and the Kühne Minerva Center for Studies of Visual Transduction, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
Cell Calcium 40:261-75. 2006..The beautiful location of the symposium, together with informal intensive discussions among the participants, contributed to the success of this meeting...