Baruch Minke

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. pmc Drosophila photoreceptors and signaling mechanisms
    Ben Katz
    Department of Physiology, , Faculty of Medicine, The Hebrew University Jerusalem, Israel
    Front Cell Neurosci 3:2. 2009
  2. doi request reprint The history of the prolonged depolarizing afterpotential (PDA) and its role in genetic dissection of Drosophila phototransduction
    Baruch Minke
    Department of Medical Neurobiology, The Institute of Medical Research Israel Canada, Faculty of Medicine and the Edmond and Lily Safra Center for Brain Sciences ELSC, The Hebrew University, Jerusalem, Israel
    J Neurogenet 26:106-17. 2012
  3. pmc The history of the Drosophila TRP channel: the birth of a new channel superfamily
    Baruch Minke
    Department of Medical Neurobiology, The Institute of Medical Research Israel Canada, The Edmond and Lily Safra Center for Brain Sciences and the Kühne Minerva Center for Studies of Visual Transduction, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel
    J Neurogenet 24:216-33. 2010
  4. pmc Translocation of Gq alpha mediates long-term adaptation in Drosophila photoreceptors
    Shahar Frechter
    Department of Physiology and Kühne Minerva Center for Studies of Visual Transduction, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Neurosci 27:5571-83. 2007
  5. pmc Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channels
    Moshe Parnas
    Department of Physiology and the Kühne Minerva Center for Studies of Visual Transduction, Faculty of Medicine of the Hebrew University, Jerusalem 91120, Israel
    J Neurosci 29:2371-83. 2009
  6. pmc Phospholipase C-mediated suppression of dark noise enables single-photon detection in Drosophila photoreceptors
    Ben Katz
    Department of Medical Neurobiology, The Institute of Medical Research, Israel
    J Neurosci 32:2722-33. 2012
  7. pmc Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels
    Moshe Parnas
    Department of Physiology, Kühne Minerva Center for Studies of Visual Transduction, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel
    Cell Calcium 45:300-9. 2009
  8. pmc Excess of Gbetae over Gqalphae in vivo prevents dark, spontaneous activity of Drosophila photoreceptors
    Natalie Elia
    Department of Biological Chemistry, Kühne Minerva Center for Studies of Visual Transduction, Institute of Life Sciences, The Hebrew University, Givat Ram, Jerusalem 91904, Israel
    J Cell Biol 171:517-26. 2005
  9. pmc Light-regulated interaction of Dmoesin with TRP and TRPL channels is required for maintenance of photoreceptors
    Irit Chorna-Ornan
    Department of Physiology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Cell Biol 171:143-52. 2005
  10. pmc Drosophila TRP and TRPL are assembled as homomultimeric channels in vivo
    Ben Katz
    Department of Medical Neurobiology, Faculty of Medicine and the Edmond and Lily Safra Center for Brain Sciences, Hebrew University, Jerusalem 91120, Israel
    J Cell Sci 126:3121-33. 2013

Collaborators

  • Zvi Selinger
  • Lutz Birnbaumer
  • François Payre
  • Rami Yaka
  • Esther Shohami
  • Ben Katz
  • Shaya Lev
  • Moshe Parnas
  • Maximilian Peters
  • Daniela Dadon
  • Shahar Frechter
  • Vered Tzarfaty
  • David A Zeevi
  • Natalie Elia
  • Mickey Kosloff
  • Shirley Weiss
  • Gideon Bach
  • Ayala Frumkin
  • Armin Huber
  • Irit Chorna-Ornan
  • Tamar Joel-Almagor
  • Keren Agam
  • Hanan Tzadok
  • David Richter
  • Tina Oberacker
  • Elkana Kohn
  • Nansi Jo Colley
  • Mario Lebendiker
  • Alexander Alexandrovich
  • Victoria Trembovler
  • Vered Offen-Glasner
  • Ariela Gordon-Shaag
  • Inna Slutsky
  • Irena Vertkin
  • Henry Metzner
  • Nina E Meyer
  • Yinon Gedi
  • Galit Ankri-Eliahoo
  • Rina Timberg
  • Troy D Zars
  • David R Hyde

Detail Information

Publications28

  1. pmc Drosophila photoreceptors and signaling mechanisms
    Ben Katz
    Department of Physiology, , Faculty of Medicine, The Hebrew University Jerusalem, Israel
    Front Cell Neurosci 3:2. 2009
    ..The fly eye has thus played a major role in the molecular identification of processes and proteins with prime importance...
  2. doi request reprint The history of the prolonged depolarizing afterpotential (PDA) and its role in genetic dissection of Drosophila phototransduction
    Baruch Minke
    Department of Medical Neurobiology, The Institute of Medical Research Israel Canada, Faculty of Medicine and the Edmond and Lily Safra Center for Brain Sciences ELSC, The Hebrew University, Jerusalem, Israel
    J Neurogenet 26:106-17. 2012
    ..Remarkably, to this day, the PDA mutants that Pak and his colleagues isolated are the main source of mutants for analysis of the Drosophila visual system...
  3. pmc The history of the Drosophila TRP channel: the birth of a new channel superfamily
    Baruch Minke
    Department of Medical Neurobiology, The Institute of Medical Research Israel Canada, The Edmond and Lily Safra Center for Brain Sciences and the Kühne Minerva Center for Studies of Visual Transduction, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel
    J Neurogenet 24:216-33. 2010
    ..The native Drosophila photoreceptor cells, where the founding member of the TRP channels superfamily was found, is still a useful preparation to study basic features of this remarkable channel...
  4. pmc Translocation of Gq alpha mediates long-term adaptation in Drosophila photoreceptors
    Shahar Frechter
    Department of Physiology and Kühne Minerva Center for Studies of Visual Transduction, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Neurosci 27:5571-83. 2007
    ..The slow time scale of this adaptation fits well with day/night light intensity changes, because there is no need to maintain single photon sensitivity during daytime...
  5. pmc Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channels
    Moshe Parnas
    Department of Physiology and the Kühne Minerva Center for Studies of Visual Transduction, Faculty of Medicine of the Hebrew University, Jerusalem 91120, Israel
    J Neurosci 29:2371-83. 2009
    ..We propose that the profound effect of membrane lipid modulations on open channel block alleviation, allows the productions of a robust current in response to light in the absence of depolarization...
  6. pmc Phospholipase C-mediated suppression of dark noise enables single-photon detection in Drosophila photoreceptors
    Ben Katz
    Department of Medical Neurobiology, The Institute of Medical Research, Israel
    J Neurosci 32:2722-33. 2012
    ..We thus demonstrate how a G-protein-mediated transduction system, with PLC as its target, selectively suppresses its intrinsic noise while preserving reliable signaling...
  7. pmc Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels
    Moshe Parnas
    Department of Physiology, Kühne Minerva Center for Studies of Visual Transduction, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel
    Cell Calcium 45:300-9. 2009
    ..Our finding that the activity of the non-thermoTRPs, TRPL and TRPM7 channels is modulated by the same compound as thermoTRPs, suggests that common mechanisms of channel modulation characterize TRP channels...
  8. pmc Excess of Gbetae over Gqalphae in vivo prevents dark, spontaneous activity of Drosophila photoreceptors
    Natalie Elia
    Department of Biological Chemistry, Kühne Minerva Center for Studies of Visual Transduction, Institute of Life Sciences, The Hebrew University, Givat Ram, Jerusalem 91904, Israel
    J Cell Biol 171:517-26. 2005
    ..This mechanism could be relevant to the regulation of G protein signaling in general...
  9. pmc Light-regulated interaction of Dmoesin with TRP and TRPL channels is required for maintenance of photoreceptors
    Irit Chorna-Ornan
    Department of Physiology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Cell Biol 171:143-52. 2005
    ..Thus, our data strongly suggest that the light- and phosphorylation-dependent dynamic association of Dmoesin to membrane channels is involved in maintenance of the photoreceptor cells...
  10. pmc Drosophila TRP and TRPL are assembled as homomultimeric channels in vivo
    Ben Katz
    Department of Medical Neurobiology, Faculty of Medicine and the Edmond and Lily Safra Center for Brain Sciences, Hebrew University, Jerusalem 91120, Israel
    J Cell Sci 126:3121-33. 2013
    ..However, the C-terminal regions of both TRP and TRPL predominantly specify the assembly of homomeric TRP and TRPL channels...
  11. pmc Signal-dependent hydrolysis of phosphatidylinositol 4,5-bisphosphate without activation of phospholipase C: implications on gating of Drosophila TRPL (transient receptor potential-like) channel
    Shaya Lev
    Department of Medical Neurobiology, Institute of Medical Research Israel Canada, The Edmond and Lily Safra Center for Brain Sciences, Faculty of Medicine of the Hebrew University, Jerusalem 91120, Israel
    J Biol Chem 287:1436-47. 2012
    ..This suggests that PI(4,5)P(2) is a crucial substrate for PLC-mediated activation of the channels, whereas PUFA may function as the channel activator. Together, this study defines a narrow range of possible mechanisms for TRPL gating...
  12. pmc Compartmentalization and Ca2+ buffering are essential for prevention of light-induced retinal degeneration
    Shirley Weiss
    Department of Medical Neurobiology, Institute for Medical Research Israel Canada IMRIC and the Edmond and Lily Safra Center for Brain Sciences ELSC, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel
    J Neurosci 32:14696-708. 2012
    ..We propose that calphotin-mediated compartmentalization and Ca(2+) buffering constitute an effective strategy to protect cells from Ca(2+) overload and light-induced degeneration...
  13. pmc The activity of the TRP-like channel depends on its expression system
    Shaya Lev
    Department of Medical Neurobiology, Institute of Medical Research Israel Canada, Hebrew University, Jerusalem, Israel
    Channels (Austin) 6:86-93. 2012
    ..However, clues on the gating mechanism may arise from understanding how different expression systems affect TRPC channel activation...
  14. pmc Open channel block by Ca2+ underlies the voltage dependence of drosophila TRPL channel
    Moshe Parnas
    Department of Physiology and the Kühne Minerva Center for Studies of Visual Transduction, Faculty of Medicine, Hebrew University, Jerusalem 91120, Israel
    J Gen Physiol 129:17-28. 2007
    ....
  15. pmc Heteromultimeric TRPML channel assemblies play a crucial role in the regulation of cell viability models and starvation-induced autophagy
    David A Zeevi
    Monique and Jacques Roboh Department of Genetic Research, Institute of Medical Research Israel Canada IMRIC, Faculty of Medicine of the Hebrew University and Hadassah Hebrew University Hospital, Jerusalem 91120, Israel
    J Cell Sci 123:3112-24. 2010
    ..Collectively, our results indicate that heteromultimerization of TRPML channels plays a role in various TRPML-regulated mechanisms...
  16. pmc Constitutive activity of the human TRPML2 channel induces cell degeneration
    Shaya Lev
    Department of Medical Neurobiology and the Kühne Minerva Center for Studies of Visual Transduction, Faculty of Medicine of the Hebrew University, Jerusalem, Israel
    J Biol Chem 285:2771-82. 2010
    ..Hence, in addition to overall structure, all three TRPML channels also share common modes of regulation...
  17. pmc Light-regulated translocation of signaling proteins in Drosophila photoreceptors
    Shahar Frechter
    Department of Physiology, The Hebrew University Hadassah Medical School, P O Box 12272, Jerusalem 91120, Israel
    J Physiol Paris 99:133-9. 2006
    ..Altogether, signal-dependent movement of signaling proteins plays a major role in the maintenance and function of photoreceptor cells...
  18. ncbi request reprint TRP gating is linked to the metabolic state and maintenance of the Drosophila photoreceptor cells
    Baruch Minke
    Department of Physiology, Kühne Minerva Center for Studies of Visual Transduction, Hadassah Medical School, The Hebrew University, P O Box 12272, Jerusalem 91120, Israel
    Cell Calcium 33:395-408. 2003
    ..The link of TRP gating to the metabolic state and maintenance of cells makes cells expressing TRP extremely vulnerable to metabolic stress via a mechanism that may underlie retinal degeneration and neuronal cell death upon malfunction...
  19. ncbi request reprint Activation of the Drosophila TRP and TRPL channels requires both Ca2+ and protein dephosphorylation
    Keren Agam
    Department of Physiology, the Kuhne Minerva Center for studies of visual transduction, The Hebrew University, Hadassah Medical School, Jerusalem 91120, Israel
    Cell Calcium 35:87-105. 2004
    ..The results suggest that the combined action of Ca2+ and protein dephosphorylation activate the TRP and TRPL channels, while protein phosphorylation by PKC antagonized channels openings...
  20. pmc Linoleic acid inhibits TRP channels with intrinsic voltage sensitivity: Implications on the mechanism of linoleic acid action
    Moshe Parnas
    Departments of Physiology and the Kühne Minerva Center for Studies of Visual Transduction, Faculty of Medicine of the Hebrew University, Jerusalem, Israel
    Channels (Austin) 3:164-6. 2009
    ..Together, our findings further support the notion that lipids do not act as second messengers by direct binding to a specific site of the channels but rather act indirectly by affecting the channel-plasma membrane interface...
  21. ncbi request reprint The TRP calcium channel and retinal degeneration
    Baruch Minke
    Department of Physiology and the Kühne Minerva Center for Studies of Visual Transduction, The Hebrew University Hadassah Medical School Jerusalem 91120, Israel
    Adv Exp Med Biol 514:601-22. 2002
    ....
  22. pmc Carvacrol together with TRPC1 elimination improve functional recovery after traumatic brain injury in mice
    Maximilian Peters
    Department of Medical Neurobiology, Institute of Medical Research Israel Canada, Jerusalem, Israel
    J Neurotrauma 29:2831-4. 2012
    ..We conclude that TRPC1-sensitive mechanisms are involved in TBI pathology, and that inhibition of this channel by carvacrol enhances recovery and should be considered for further studies in animal models and humans...
  23. pmc Regulation of light-dependent Gqalpha translocation and morphological changes in fly photoreceptors
    Mickey Kosloff
    Department of Biological Chemistry and the Kuhne Minerva Center for Studies of Visual Transduction, Institute of Life Sciences, The Hebrew University, Givat Ram, Jerusalem, 91904, Israel
    EMBO J 22:459-68. 2003
    ....
  24. ncbi request reprint TRP channel proteins and signal transduction
    Baruch Minke
    Department of Physiology and the Kühne Minerva Center for Studies of Visual Transduction, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Physiol Rev 82:429-72. 2002
    ..The channels' roles and characteristics such as gating mechanism, regulation, and permeability are determined by evolution according to the specific functional requirements...
  25. pmc Cellular functions of transient receptor potential channels
    Daniela Dadon
    Department of Medical Neurobiology, The Institute of Medical Research Israel Canada and the Kühne Minerva Center, for Studies of Visual Transduction, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel
    Int J Biochem Cell Biol 42:1430-45. 2010
    ..All the above features of Transient Receptor Potential channels make them crucial components in important, sometimes conflicting, cellular processes that still need to be explored...
  26. pmc Insights on TRP channels from in vivo studies in Drosophila
    Baruch Minke
    Department of Physiology and Kühne Minerva Center for Studies of Visual Transduction, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Annu Rev Physiol 68:649-84. 2006
    ..Thus, PLC and its downstream second messengers, Ca2+ and DAG, constitute critical mediators of TRP/TRPL gating in vivo...
  27. pmc Constitutive activity of TRP channels methods for measuring the activity and its outcome
    Shaya Lev
    Department of Medical Neurobiology and the Kühne Minerva Center for Studies of Visual Transduction, Institute of Medical Research Israel Canada IMRIC, The Edmond and Lily Safra Center for Brain Sciences ELSC, The Hebrew University, Jerusalem, Israel
    Methods Enzymol 484:591-612. 2010
    ..Finally, it describes methods for qualitatively and quantitatively measuring the accompanied cellular degeneration...
  28. pmc TRP channels and Ca2+ signaling
    Baruch Minke
    Department of Physiology and the Kühne Minerva Center for Studies of Visual Transduction, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Cell Calcium 40:261-75. 2006
    ..The beautiful location of the symposium, together with informal intensive discussions among the participants, contributed to the success of this meeting...