Danielle Melloul

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi request reprint Regulation of insulin gene transcription
    D Melloul
    Department of Endocrinology and Metabolism, Hadassah University Hospital, Jerusalem, Israel
    Diabetologia 45:309-26. 2002
  2. pmc Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function
    Bernadette Neve
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8090, Institute Pasteur de Lille, F 59019 Lille, France
    Proc Natl Acad Sci U S A 102:4807-12. 2005
  3. ncbi request reprint Regulation of pdx-1 gene expression
    Danielle Melloul
    Department of Endocrinology and Metabolism, Hadassah University Hospital, Jerusalem, Israel
    Diabetes 51:S320-5. 2002
  4. ncbi request reprint Pancreatic Duodenal Homeobox (PDX-1) in health and disease
    Danielle Melloul
    Department of Endocrinology, Hadassah University Hospital, General Health Services, Jerusalem, Israel
    J Pediatr Endocrinol Metab 15:1461-72. 2002
  5. ncbi request reprint Transcription factors in islet development and physiology: role of PDX-1 in beta-cell function
    Danielle Melloul
    Department of Endocrinology and Metabolism, the Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Ann N Y Acad Sci 1014:28-37. 2004
  6. doi request reprint Evaluation of impaired beta-cell function in nonobese-diabetic (NOD) mouse model using bioluminescence imaging
    Dror Sever
    Department of Endocrinology, Hadassah University Hospital, P O Box 12000, 91120 Jerusalem, Israel
    FASEB J 25:676-84. 2011
  7. doi request reprint Role of NF-kappaB in beta-cell death
    Danielle Melloul
    Department of Endocrinology, Hadassah University Hospital, P O Box 12000, Jerusalem 91120, Israel
    Biochem Soc Trans 36:334-9. 2008
  8. pmc Inhibition of nuclear factor-κB activation in pancreatic β-cells has a protective effect on allogeneic pancreatic islet graft survival
    Roy Eldor
    Department of Endocrinology, Hadassah University Hospital, Jerusalem, Israel
    PLoS ONE 8:e56924. 2013
  9. doi request reprint The ToI-beta transgenic mouse: a model to study the specific role of NF-kappaB in beta-cells
    Roy Eldor
    Department of Endocrinology, Hadassah University Hospital, Jerusalem, Israel
    Diabetes Res Clin Pract 86:S7-14. 2009
  10. ncbi request reprint Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1
    Valerie M Schwitzgebel
    Pediatric Endocrinology and Diabetology, Geneva University Hospital, CH 1211 Geneva, Switzerland
    J Clin Endocrinol Metab 88:4398-406. 2003

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Regulation of insulin gene transcription
    D Melloul
    Department of Endocrinology and Metabolism, Hadassah University Hospital, Jerusalem, Israel
    Diabetologia 45:309-26. 2002
    ..From the overview of the research presented, it is clear that much more study is required to fully comprehend the mechanisms involved in the regulated-expression of the insulin gene in the beta cell to prevent its impairment in diabetes...
  2. pmc Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function
    Bernadette Neve
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8090, Institute Pasteur de Lille, F 59019 Lille, France
    Proc Natl Acad Sci U S A 102:4807-12. 2005
    ..Thus, both functional and genetic analyses reveal that KLF11 plays a role in the regulation of pancreatic beta cell physiology, and its variants may contribute to the development of diabetes...
  3. ncbi request reprint Regulation of pdx-1 gene expression
    Danielle Melloul
    Department of Endocrinology and Metabolism, Hadassah University Hospital, Jerusalem, Israel
    Diabetes 51:S320-5. 2002
    ..We postulate that disruption of pdx-1 cis-acting regulatory sequences and/or mutations or functional impairment of transcription factors controlling the expression of the gene can lead to diabetes...
  4. ncbi request reprint Pancreatic Duodenal Homeobox (PDX-1) in health and disease
    Danielle Melloul
    Department of Endocrinology, Hadassah University Hospital, General Health Services, Jerusalem, Israel
    J Pediatr Endocrinol Metab 15:1461-72. 2002
    ..This review underlines the unique role of PDX-1 in maintaining adult beta-cell-specific functions in normal and disease-related states...
  5. ncbi request reprint Transcription factors in islet development and physiology: role of PDX-1 in beta-cell function
    Danielle Melloul
    Department of Endocrinology and Metabolism, the Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Ann N Y Acad Sci 1014:28-37. 2004
    ..We consider that loss of PDX-1 function or altered pdx-1 gene expression due to mutations or functional impairment of transcription factors controlling its expression can lead to diabetes...
  6. doi request reprint Evaluation of impaired beta-cell function in nonobese-diabetic (NOD) mouse model using bioluminescence imaging
    Dror Sever
    Department of Endocrinology, Hadassah University Hospital, P O Box 12000, 91120 Jerusalem, Israel
    FASEB J 25:676-84. 2011
    ....
  7. doi request reprint Role of NF-kappaB in beta-cell death
    Danielle Melloul
    Department of Endocrinology, Hadassah University Hospital, P O Box 12000, Jerusalem 91120, Israel
    Biochem Soc Trans 36:334-9. 2008
    ..Thus beta-cell-specific activation of NF-kappaB is a key event in the progressive loss of beta-cells in diabetes. Inhibition of this process could be a potential effective strategy for beta-cell protection...
  8. pmc Inhibition of nuclear factor-κB activation in pancreatic β-cells has a protective effect on allogeneic pancreatic islet graft survival
    Roy Eldor
    Department of Endocrinology, Hadassah University Hospital, Jerusalem, Israel
    PLoS ONE 8:e56924. 2013
    ..Furthermore, we suggest a potential, readily available therapeutic agent that may temper this process...
  9. doi request reprint The ToI-beta transgenic mouse: a model to study the specific role of NF-kappaB in beta-cells
    Roy Eldor
    Department of Endocrinology, Hadassah University Hospital, Jerusalem, Israel
    Diabetes Res Clin Pract 86:S7-14. 2009
    ..Together, our results show the ToI-beta mouse model to be a highly controlled and very accurate model for examining pancreatic beta-cell-specific temporal inhibition of NF-kappaB...
  10. ncbi request reprint Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1
    Valerie M Schwitzgebel
    Pediatric Endocrinology and Diabetology, Geneva University Hospital, CH 1211 Geneva, Switzerland
    J Clin Endocrinol Metab 88:4398-406. 2003
    ..We conclude that the IPF1 level is critical for human pancreas formation...