R Mechoulam

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi The endocannabinoid system and the brain
    Raphael Mechoulam
    Institute for Drug Research, Hebrew University, Medical Faculty, Jerusalem 91120, Israel
    Annu Rev Psychol 64:21-47. 2013
  2. ncbi The cannabinoids: an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection
    R Mechoulam
    Hebrew University, Jerusalem, Israel
    Pain Res Manag 6:67-73. 2001
  3. ncbi Plant cannabinoids: a neglected pharmacological treasure trove
    Raphael Mechoulam
    Department of Medicinal Chemistry and Natural Products, Faculty of Medicine, Hebrew University, Ein Kerem Campus, Jerusalem 91120, Israel
    Br J Pharmacol 146:913-5. 2005
  4. ncbi Endocannabinoids and neuroprotection
    R Mechoulam
    Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty, Jerusalem 91120, Israel
    Sci STKE 2002:re5. 2002
  5. ncbi Cannabidiol--recent advances
    Raphael Mechoulam
    Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty, Jerusalem 91120, Israel
    Chem Biodivers 4:1678-92. 2007
  6. ncbi Toward an anandamide transporter
    Raphael Mechoulam
    Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 102:17541-2. 2005
  7. ncbi Cannabidiol: an overview of some chemical and pharmacological aspects. Part I: chemical aspects
    Raphael Mechoulam
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University of Jerusalem, Ein Kerem Campus, 91120, Jerusalem, Israel
    Chem Phys Lipids 121:35-43. 2002
  8. ncbi Neuroscience. Stout guards of the central nervous system
    R Mechoulam
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Jerusalem 91120, Israel
    Science 302:65-7. 2003
  9. ncbi Endocannabinoids and traumatic brain injury
    R Mechoulam
    Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty, Ein Kerem Campus, Jerusalem 91120, Israel
    Mol Neurobiol 36:68-74. 2007
  10. ncbi Cannabis and alcohol--a close friendship
    Raphael Mechoulam
    Hebrew University Medical Faculty, Pharmacy School Department of Medicinal Chemistry and Natural Products, Jerusalem 91120, Israel
    Trends Pharmacol Sci 24:266-8. 2003

Detail Information

Publications91

  1. ncbi The endocannabinoid system and the brain
    Raphael Mechoulam
    Institute for Drug Research, Hebrew University, Medical Faculty, Jerusalem 91120, Israel
    Annu Rev Psychol 64:21-47. 2013
    ..Only a few have been investigated for their CNS activity, and future investigations on their action may throw light on a wide spectrum of brain functions...
  2. ncbi The cannabinoids: an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection
    R Mechoulam
    Hebrew University, Jerusalem, Israel
    Pain Res Manag 6:67-73. 2001
    ..The above clinical approaches may ultimately lead to the realization that cannabinoids are valuable clinical drugs in numerous fields...
  3. ncbi Plant cannabinoids: a neglected pharmacological treasure trove
    Raphael Mechoulam
    Department of Medicinal Chemistry and Natural Products, Faculty of Medicine, Hebrew University, Ein Kerem Campus, Jerusalem 91120, Israel
    Br J Pharmacol 146:913-5. 2005
    ..It seems possible that many of the non-psychoactive constituents of this plant will be of biological interest...
  4. ncbi Endocannabinoids and neuroprotection
    R Mechoulam
    Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty, Jerusalem 91120, Israel
    Sci STKE 2002:re5. 2002
    ..2-AG is also a potent modulator of vascular tone, and counteracts the endothelin (ET-1)-induced vasoconstriction that aggravates brain damage; it may thus help to restore blood supply to the injured brain...
  5. ncbi Cannabidiol--recent advances
    Raphael Mechoulam
    Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty, Jerusalem 91120, Israel
    Chem Biodivers 4:1678-92. 2007
    ..The plethora of positive pharmacological effects observed with CBD make this compound a highly attractive therapeutic entity...
  6. ncbi Toward an anandamide transporter
    Raphael Mechoulam
    Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 102:17541-2. 2005
  7. ncbi Cannabidiol: an overview of some chemical and pharmacological aspects. Part I: chemical aspects
    Raphael Mechoulam
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University of Jerusalem, Ein Kerem Campus, 91120, Jerusalem, Israel
    Chem Phys Lipids 121:35-43. 2002
    ..In Part II we shall also present evidence that it is conceivable that, in part at least, its effects are due to its recently discovered inhibition of anandamide uptake and hydrolysis and to its anti-oxidative effect...
  8. ncbi Neuroscience. Stout guards of the central nervous system
    R Mechoulam
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Jerusalem 91120, Israel
    Science 302:65-7. 2003
    ..showing that activation of the cannabinoid receptor CB1 by the endocannabinoid anandamide protects against excitotoxic damage in a mouse model of kainic acid-induced epilepsy...
  9. ncbi Endocannabinoids and traumatic brain injury
    R Mechoulam
    Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty, Ein Kerem Campus, Jerusalem 91120, Israel
    Mol Neurobiol 36:68-74. 2007
    ....
  10. ncbi Cannabis and alcohol--a close friendship
    Raphael Mechoulam
    Hebrew University Medical Faculty, Pharmacy School Department of Medicinal Chemistry and Natural Products, Jerusalem 91120, Israel
    Trends Pharmacol Sci 24:266-8. 2003
    ..Recent research suggests that ethanol preference, which is dependent on CB(1) receptors, is higher in young mice than in old mice, and higher in female mice than in male mice...
  11. ncbi Endocannabinoids, feeding and suckling--from our perspective
    R Mechoulam
    Department of Medicinal Chemistry and Natural Products, Pharmacy School, Medical Faculty, Hebrew University, Jerusalem, Israel
    Int J Obes (Lond) 30:S24-8. 2006
    ..Blocking the endocannabinoid system with a CB1 antagonist on the 1st day after birth leads to inhibition of suckling; later administration also affects suckling, but does not fully block it...
  12. ncbi Cannabinoids and brain injury: therapeutic implications
    Raphael Mechoulam
    Dept of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Jerusalem 91120, Israel
    Trends Mol Med 8:58-61. 2002
    ..Some plant and synthetic cannabinoids, which do not bind to the cannabinoid receptors, have also been shown to be neuroprotective, possibly through their direct effect on the excitatory glutamate system and/or as antioxidants...
  13. ncbi Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice
    Y Avraham
    Department of Human Nutrition and Metabolism, Braun School of Public Health, Hadassah Hebrew University Medical School, Jerusalem, Israel
    Br J Pharmacol 162:1650-8. 2011
    ....
  14. ncbi Critical role of the endogenous cannabinoid system in mouse pup suckling and growth
    E Fride
    Department of Medicinal Chemistry and Natural Products, Faculty of Medicine, Hebrew University, Jerusalem, Israel
    Eur J Pharmacol 419:207-14. 2001
    ..We conclude that the endocannabinoid system plays a vital role in milk suckling, and hence in growth and development during the early stages of mouse life...
  15. ncbi 2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor
    L Hanus
    Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 98:3662-5. 2001
    ..It binds to the CB(1) cannabinoid receptor (K(i) = 21.2 +/- 0.5 nM) and causes sedation, hypothermia, intestinal immobility, and mild antinociception in mice. It binds weakly to the CB(2) receptor (K(i) > 3 microM)...
  16. ncbi Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT1A receptor activation
    I Magen
    Department of Human Nutrition and Metabolism, Braun School of Public Health, Hebrew University Medical Faculty, Jerusalem, Israel
    Br J Pharmacol 159:950-7. 2010
    ..We aimed to demonstrate the involvement of 5-HT(1A) receptors in the therapeutic effect of cannabidiol, a non-psychoactive constituent of Cannabis sativa, in a model of hepatic encephalopathy induced by bile-duct ligation (BDL) in mice...
  17. ncbi An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
    D Panikashvili
    Department of Pharmacology, Medical Faculty, Hebrew University, Jerusalem 91120, Israel
    Nature 413:527-31. 2001
    ..The beneficial effect of 2-AG was dose-dependently attenuated by SR-141761A, an antagonist of the CB1 cannabinoid receptor...
  18. ncbi Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant
    E Shohami
    Department of Pharmacology, Hebrew University, School of Pharmacy, Jerusalem, Israel
    J Neuroimmunol 72:169-77. 1997
    ..TNF-alpha modulating agents, if given within the early time window post-injury, may improve the final neurological outcome in victims of brain trauma...
  19. ncbi Endocannabinoids
    R Mechoulam
    Hebrew University, Medical Faculty, Jerusalem, Israel
    Eur J Pharmacol 359:1-18. 1998
    ....
  20. ncbi Structural features affecting chiral discrimination of terpene derivatives on a carbamated amylose stationary phase
    S Abu-Lafi
    Pharmaceutical Chemistry Department, School of Pharmacy, Hebrew University of Jerusalem, Israel
    J Chromatogr A 664:159-67. 1994
    ..Hence it was concluded that the most important interaction of the terpene derivatives with the carbamated amylose was hydrogen bonding...
  21. ncbi Capsaicin affects brain function in a model of hepatic encephalopathy associated with fulminant hepatic failure in mice
    Y Avraham
    Department of Metabolism and Human Nutrition, Braun School of Public Health, Hadassah Hebrew University Medical School, Jerusalem, Israel
    Br J Pharmacol 158:896-906. 2009
    ....
  22. ncbi Recent advantages in cannabinoid research
    R Mechoulam
    Hebrew University, Medical Faculty, Jerusalem, Israel
    Forsch Komplementarmed 6:16-20. 1999
    ..A synthetic cannabinoid, HU-211, is in advanced clinical tests against brain damage caused by closed head injury. It may prove to be valuable against stroke and other neurological diseases...
  23. ncbi CB1 cannabinoid receptors are involved in neuroprotection via NF-kappa B inhibition
    David Panikashvili
    Department of Pharmacology, Hebrew University, Jerusalem, Israel
    J Cereb Blood Flow Metab 25:477-84. 2005
    ..We thus propose that 2-AG exerts its neuroprotection after CHI, at least in part, via CB1 receptor-mediated mechanisms that involve inhibition of intracellular inflammatory signaling pathways...
  24. ncbi Carbachol, an acetylcholine receptor agonist, enhances production in rat aorta of 2-arachidonoyl glycerol, a hypotensive endocannabinoid
    R Mechoulam
    Hebrew University, School of Pharmacy, Medical Faculty, Jerusalem, Israel
    Eur J Pharmacol 362:R1-3. 1998
    ..2-Arachidonoyl glycerol potently reduces blood pressure in rats and may represent an endothelium-derived hypotensive factor...
  25. ncbi Discovery of endocannabinoids and some random thoughts on their possible roles in neuroprotection and aggression
    R Mechoulam
    Medical Faculty, Hebrew University, Jerusalem, 91120, Israel
    Prostaglandins Leukot Essent Fatty Acids 66:93-9. 2002
    ..The unexpected production of aggression by Cannabis and cannabinoids under stressful conditions, published mainly in the past, is summarized...
  26. ncbi Cannabinoids and capsaicin improve liver function following thioacetamide-induced acute injury in mice
    Yosefa Avraham
    Department of Human Nutrition and Metabolism, Braun School of Public Health, Hadassah Hebrew University Medical School, Jerusalem, Israel
    Am J Gastroenterol 103:3047-56. 2008
    ..We have shown the beneficial effects of cannabinoids in a murine model of hepatic encephalopathy following thioacetamide and now report their effects on the liver injury...
  27. ncbi Drug-induced hypothermia reduces ischemic damage: effects of the cannabinoid HU-210
    Ronen R Leker
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel
    Stroke 34:2000-6. 2003
    ..Therefore, we sought to examine whether the synthetic CB1 agonist HU-210 is capable of reducing ischemic damage and to determine the mechanisms responsible for such protection...
  28. ncbi Endocannabinoids as positive or negative factors in hematopoietic cell migration and differentiation
    Deborah Patinkin
    Department of Pathology, Hebrew University, Medical Faculty, Jerusalem, Israel
    Eur J Pharmacol 595:1-6. 2008
    ..This is suggestive of some cross-talk between two different regulatory systems, one governed by glycoprotein ligands and the other by endocannabinoids...
  29. ncbi Effects of the endocannabinoid noladin ether on body weight, food consumption, locomotor activity, and cognitive index in mice
    Yosefa Avraham
    Department of Human Nutrition and Metabolism and Braun School of Public Health, Hebrew University Hadassah Medical School, Ein Kerem Campus, P O Box 12272, Jerusalem 91120, Israel
    Brain Res Bull 65:117-23. 2005
    ..Noladin seems to signal food consumption and weight through CB1 receptors based on effects observed with the CB1 antagonist, while the cognition and activity are probably mediated by non-cannabinoid receptors...
  30. ncbi The endocannabinoid 2-AG protects the blood-brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines
    David Panikashvili
    Department of Pharmacology, Faculty of Medicine, School of Pharmacy, The Hebrew University School of Jerusalem, Jerusalem 91120, Israel
    Neurobiol Dis 22:257-64. 2006
    ..It also augmented the levels of endogenous antioxidants. We suggest that 2-AG exerts neuroprotection in part by inhibition of the early (1-4 h) inflammatory response and augmentation of the brain reducing power...
  31. ncbi Endocannabinoids affect neurological and cognitive function in thioacetamide-induced hepatic encephalopathy in mice
    Yosefa Avraham
    Department of Metabolism and Human Nutrition, Braun School of Public Health, Hadassah Hebrew University Medical School, Jerusalem, Israel 91120
    Neurobiol Dis 21:237-45. 2006
    ..Modulation of this system either by exogenous agonists specific for the CB2 receptors or possibly also by antagonists to the CB1 receptors may have therapeutic potential...
  32. ncbi A cannabinoid anticancer quinone, HU-331, is more potent and less cardiotoxic than doxorubicin: a comparative in vivo study
    Natalya M Kogan
    Department of Medicinal Chemistry and Natural Products, Pharmacy School, Ein Kerem Medical Campus, The Hebrew University, Jerusalem 91120, Israel
    J Pharmacol Exp Ther 322:646-53. 2007
    ..In vivo, HU-331 was more active and less toxic than doxorubicin and thus it has a high potential for development as a new anticancer drug...
  33. ncbi Peripheral cannabinoid receptor, CB2, regulates bone mass
    Orr Ofek
    Bone Laboratory, Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 103:696-701. 2006
    ..Hence, CB2 offers a molecular target for the diagnosis and treatment of osteoporosis, the most prevalent degenerative disease in developed countries...
  34. ncbi A cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cells
    Natalya M Kogan
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, The Hebrew University, Jerusalem 91120, Israel
    Mol Pharmacol 70:51-9. 2006
    ..A significant decrease in the total area occupied by vessels in HU-331-treated tumors was also observed. These data lead us to consider HU-331 to have high potential as a new antiangiogenic and anticancer drug...
  35. ncbi HU-331, a novel cannabinoid-based anticancer topoisomerase II inhibitor
    Natalya M Kogan
    Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University, Jerusalem 91120, Israel
    Mol Cancer Ther 6:173-83. 2007
    ..The cannabinoid quinone HU-331 is a highly specific inhibitor of topoisomerase II, compared with most known anticancer quinones. It might represent a new potent anticancer drug...
  36. ncbi Enantiomeric cannabidiol derivatives: synthesis and binding to cannabinoid receptors
    Lumir O Hanus
    Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Medical Faculty, The Hebrew University of Jerusalem, Ein Kerem 91120, Jerusalem, Israel
    Org Biomol Chem 3:1116-23. 2005
    ..Some of these compounds also bind weakly to the CB(2) receptor...
  37. ncbi Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappa B activation
    Arieh Moussaieff
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Jerusalem 91120, Israel
    Mol Pharmacol 72:1657-64. 2007
    ..Cembrenoid diterpenoids, specifically IA and its derivatives, may thus constitute a potential novel group of NF-kappaB inhibitors, originating from an ancient anti-inflammatory herbal remedy...
  38. ncbi Short-term fasting and prolonged semistarvation have opposite effects on 2-AG levels in mouse brain
    Lumir Hanus
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Ein Kerem Campus, Jerusalem 91120, Israel
    Brain Res 983:144-51. 2003
    ..We confirmed the elevation of 2-AG levels. It seems possible that these time-dependent variations of 2-AG levels may be of importance as a general coping strategy by animals during periods of starvation...
  39. ncbi Endocannabinoids in liver disease and hepatic encephalopathy
    Iddo Magen
    Department of Nutrition and Metabolism, Hebrew University Medical Faculty, Ein Kerem Campus, Jerusalem 91120, Isreal
    Curr Pharm Des 14:2362-9. 2008
    ..The present review summarizes the literature on the association between ECs and liver disease, as well as the therapeutic potential of ECs and exogenous cannabinoids in liver disease with emphasis on hepatic encephalopathy...
  40. ncbi Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells
    Ruth Gallily
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University Medical Faculty, Ein Kerem Campus, Jerusalem 1120, Israel
    Leuk Lymphoma 44:1767-73. 2003
    ..Caspase-3 activation was observed after the cannabinoid treatment, and may represent a mechanism for the apoptosis. Our data suggest a possible new approach to treatment of AML...
  41. ncbi A historical overview of chemical research on cannabinoids
    R Mechoulam
    Department of Medicinal Chemistry and Natural Products, Hebrew University of Jerusalem, Medical Faculty, Ein Kerem Campus, 91120, Jerusalem, Israel
    Chem Phys Lipids 108:1-13. 2000
    ..The tortuous path leading to the discovery of the endogenous cannabinoids is described. Future directions, which will probably be followed are delineated...
  42. ncbi The Jerusalem Balsam: from the Franciscan Monastery in the old city of Jerusalem to Martindale 33
    A Moussaieff
    Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Hebrew University, Jerusalem 91120, Israel
    J Ethnopharmacol 101:16-26. 2005
    ..myrrh (Commiphora spp.), aloe (Aloe sp.) and mastic (Pistacia lentiscus L.). We conducted pharmacological assays on this four-plant formula. It showed anti-inflammatory, as well as anti-oxidative, and anti-septic properties...
  43. ncbi The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling
    Joseph Tam
    Bone Laboratory, Hadassah School of Dental Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel
    FASEB J 22:285-94. 2008
    ..Elevation of bone 2-AG apparently suppresses NE release from bone sympathetic terminals, thus alleviating the inhibition of bone formation. The involvement of osteoblastic CB2 signaling in this process is minimal, if any...
  44. ncbi Cannabinoids ameliorate cerebral dysfunction following liver failure via AMP-activated protein kinase
    Yossi Dagon
    Department of Human Nutrition and Metabolism, Braun School of Public Health, Faculty of Medicine Hebrew University Hadassah Medical School, Jerusalem, Israel
    FASEB J 21:2431-41. 2007
    ..These results suggest that HE is a disease of energy flux. CB-2 signaling is a cerebral stress response mechanism and makes AMPK a promising target for its treatment by modulating the cannabinoid system...
  45. ncbi Synthesis and antitumor activity of quinonoid derivatives of cannabinoids
    Natalya M Kogan
    Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University, Jerusalem 91120, Israel
    J Med Chem 47:3800-6. 2004
    ..All three compounds displayed antiproliferative activity in several human cancer cell lines in vitro, and quinone 2 significantly reduced cancer growth of HT-29 cancer in nude mice...
  46. ncbi Cannabinoids in health and disease
    Natalya M Kogan
    Medicinal Chemistry and Natural Products Dept, Pharmacy School, Ein Kerem Medical Campus, The Hebrew University of Jerusalem, Israel
    Dialogues Clin Neurosci 9:413-30. 2007
    ....
  47. ncbi Tetrahydrocannabinol and endocannabinoids in feeding and appetite
    Elliot M Berry
    Department of Human Nutrition and Metabolism, Hebrew University, School of Public Health and Faculty of Medicine, Jerusalem 91120, Israel
    Pharmacol Ther 95:185-90. 2002
    ..In obese humans, it causes weight reduction. Very little is known about the physiological and biochemical mechanisms involved in the effects of Delta(9)-tetrahydrocannabinol and the cannabinoids in feeding and appetite...
  48. ncbi N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties
    Garry Milman
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, and Laboratory of Environmental Physiology, Faculty of Dental Medicine, Hebrew University, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 103:2428-33. 2006
    ..Many of these effects parallel those reported for abnormal cannabidiol (Abn-CBD), a synthetic agonist of a putative novel cannabinoid-type receptor. Hence, ARA-S may represent an endogenous agonist for this receptor...
  49. ncbi Looking back at Cannabis research
    R Mechoulam
    Hebrew University, Medical Faculty, Department of Medicinal Chemistry and Natural Products, Jerusalem, 91120, Israel
    Curr Pharm Des 6:1313-22. 2000
    ..Investigations on two non-psychotropic, synthetic cannabinoids, HU-211, a neuroprotective agent and HU-308, a specific CB2 agonist are presented...
  50. ncbi Cannabidiol lowers incidence of diabetes in non-obese diabetic mice
    L Weiss
    Hadassah University Hospital, Department of Bone Marrow Transplantation and Cancer Immunotherapy, POB 12000, Jerusalem, 91120, Israel
    Autoimmunity 39:143-51. 2006
    ....
  51. ncbi Novel natural and synthetic ligands of the endocannabinoid system
    Lumir O Hanus
    Institute for Drug Research, Hebrew University, Jerusalem, Israel
    Curr Med Chem 17:1341-59. 2010
    ....
  52. ncbi Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain
    Arieh Moussaieff
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University of Jerusalem, 91120, Jerusalem, Israel
    FASEB J 22:3024-34. 2008
    ..Furthermore, the biochemical and pharmacological effects of IA may provide a biological basis for deeply rooted cultural and religious traditions...
  53. ncbi Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury
    Ronen Durst
    Cardiology Department, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Am J Physiol Heart Circ Physiol 293:H3602-7. 2007
    ..Inasmuch as CBD has previously been administered to humans without causing side effects, it may represent a promising novel treatment for myocardial ischemia...
  54. ncbi Incensole acetate: a novel neuroprotective agent isolated from Boswellia carterii
    Arieh Moussaieff
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Jerusalem, Israel
    J Cereb Blood Flow Metab 28:1341-52. 2008
    ..This study attributes the anti-inflammatory activity of Boswellia resin to IA and related cembranoid diterpenes and suggests that they may serve as novel neuroprotective agents...
  55. ncbi Resolution of chiral cannabinoids on amylose tris(3,5-dimethylphenylcarbamate) chiral stationary phase: effects of structural features and mobile phase additives
    S Levin
    Pharmaceutical Chemistry Department, School of Pharmacy, Hebrew University of Jerusalem, Israel
    J Chromatogr A 654:53-64. 1993
    ....
  56. ncbi Suppressors of cancer cell proliferation from fig (Ficus carica) resin: isolation and structure elucidation
    S Rubnov
    Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University, Jerusalem 91120, Israel
    J Nat Prod 64:993-6. 2001
    ..Identity was established by spectroscopic methods (NMR, MS) and confirmed by chemical synthesis. Both the natural and the synthetic compounds showed in vitro inhibitory effects on proliferation of various cancer cell lines...
  57. ncbi Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model
    M Lodzki
    Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, 91120, Israel
    J Control Release 93:377-87. 2003
    ..In conclusion, ethosomes enable CBD's skin permeation and its accumulation in a depot at levels that demonstrate the potential of transdermal CBD to be used as an anti-inflammatory treatment...
  58. ncbi The chemistry of endocannabinoids
    N M Kogan
    Department of Medicinal Chemistry and Natural Products, Pharmacy School, Medical Faculty, Hebrew University, 91120 Jerusalem, Israel
    J Endocrinol Invest 29:3-14. 2006
    ..In the present review, we shall try to give an overview of the chemistry of the endocannabinoids as well as of some synthetic molecules that affect the endocannabinoid system...
  59. ncbi Cannabidiol arrests onset of autoimmune diabetes in NOD mice
    Lola Weiss
    Department of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel
    Neuropharmacology 54:244-9. 2008
    ..Our data strengthen our previous assumption that CBD, known to be safe in man, can possibly be used as a therapeutic agent for treatment of type 1 diabetes...
  60. ncbi Multiple sclerosis may disrupt endocannabinoid brain protection mechanism
    Esther Shohami
    Department of Pharmacology and Medicinal Chemistry, Hebrew University, Medical Faculty, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 103:6087-8. 2006
  61. ncbi Involvement of neuronal cannabinoid receptor CB1 in regulation of bone mass and bone remodeling
    Joseph Tam
    Bone Laboratory, Hebrew University of Jerusalem, PO Box 12272, Jerusalem 91120, Israel
    Mol Pharmacol 70:786-92. 2006
    ..Unraveling these differences can provide useful information on the physiologic functional milieu of CB1 in bone...
  62. ncbi Oleoyl serine, an endogenous N-acyl amide, modulates bone remodeling and mass
    Reem Smoum
    Bone Laboratory and Institute of Drug Research, Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 107:17710-5. 2010
    ..It represents a lead to antiosteoporotic drug discovery, advantageous to currently available therapies, which are essentially either proformative or antiresorptive...
  63. ncbi Cannabidiol: an overview of some pharmacological aspects
    Raphael Mechoulam
    Deportment of Medicinal Chemistry and Natural Products, Hebrew University of Jerusalem, Israel
    J Clin Pharmacol 42:11S-19S. 2002
    ..It is possible that, in part at least, its effects are due to its recently discovered inhibition of anandamide uptake and hydrolysis and to its antioxidative effect...
  64. ncbi Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: evidence for a site distinct from CB1 and CB2
    Douglas McHugh
    Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK
    Mol Pharmacol 73:441-50. 2008
    ..Furthermore, our findings have implications for the potential pharmacological manipulation of elements of the endocannabinoid system for the treatment of various inflammatory conditions...
  65. ncbi A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew)
    Magdalena Kwiatkowska
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, N2L 3C5, Canada
    Psychopharmacology (Berl) 174:254-9. 2004
    ..CONCLUSIONS: A low dose of the non-intoxicating cannabinoid CBD may be an effective anti-emetic treatment and combined doses of OND and delta9-THC that are ineffective alone suppresses cisplatin-induced emetic reactions in shrews...
  66. ncbi The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis
    Javier Palazuelos
    Department of Biochemistry and Molecular Biology I, Complutense University, 28040 Madrid, Spain
    J Biol Chem 283:13320-9. 2008
    ....
  67. ncbi Cannabinoid agonists and antagonists modulate lithium-induced conditioned gaping in rats
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario
    Integr Physiol Behav Sci 38:133-45. 2003
    ..Finally, SR-141716 potentiated lithium-induced conditioned gaping, suggesting that the endogenous cannabinoid system plays a role in the control of nausea...
  68. ncbi Effect of cannabinoids on lithium-induced vomiting in the Suncus murinus (house musk shrew)
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5
    Psychopharmacology (Berl) 171:156-61. 2004
    ..The effects of THC and CBD on vomiting were dose dependent; with THC the effect was linear, but with CBD the effect was biphasic...
  69. ncbi The CB1 cannabinoid receptor agonist, HU-210, reduces levodopa-induced rotations in 6-hydroxydopamine-lesioned rats
    Yossi Gilgun-Sherki
    Department of Neurology, Rabin Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva 49100, Israel
    Pharmacol Toxicol 93:66-70. 2003
    ..Our results indicate that activation of the CB1 stimulates the dopaminergic system ipsilaterally to the lesion, and may have implications in the treatment of Parkinson's disease...
  70. ncbi Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a "CB3" receptor
    Ester Fride
    Department of Behavioral Sciences, College of Judea and Samaria, Ariel 44837, Israel
    Eur J Pharmacol 461:27-34. 2003
    ..Our data also suggest that the CB(1)(-/-) neonates possess a compensatory mechanism which helps them overcome the lack of cannabinoid CB(1) receptors...
  71. ncbi Effects of cannabinoids on lithium-induced conditioned rejection reactions in a rat model of nausea
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5
    Psychopharmacology (Berl) 166:156-62. 2003
    ..5 mg/kg, i.p.), and HU-210 (0.001 mg/kg and 0.01 mg/kg, i.p.), and the CB(1) antagonist SR-141716A in modulating the establishment and the expression of lithium-induced conditioned rejection reactions in rats...
  72. ncbi Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid
    Krista Laine
    Departments of Pharmaceutical Chemistry, University of Kuopio, Finland
    Invest Ophthalmol Vis Sci 43:3216-22. 2002
    ..In the present study, both the degradation of endogenous cannabinoids in ocular tissues and the effect on IOP of 2-AG and noladin ether were compared...
  73. ncbi Cannabidiol, a non-psychoactive component of cannabis and its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario N2L 3C5, Canada
    Neuroreport 13:567-70. 2002
    ..These results suggest that cannabinoids without psychoactive side-effects may have therapeutic value in the treatment of chemotherapy-induced nausea...
  74. ncbi Noladin ether, a putative novel endocannabinoid: inactivation mechanisms and a sensitive method for its quantification in rat tissues
    Filomena Fezza
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, Fabbricato 70, 80078, Pozzuoli, Naples, Italy
    FEBS Lett 513:294-8. 2002
    ..Further data suggested that 2-AGE is taken up by cells via the anandamide/2-arachidonoyl glycerol (2-AG) membrane transporter(s), and biosynthesized in a different way as compared to 2-AG...
  75. ncbi Effect of low doses of delta9-tetrahydrocannabinol and cannabidiol on the extinction of cocaine-induced and amphetamine-induced conditioned place preference learning in rats
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, ON, Canada
    Psychopharmacology (Berl) 175:360-6. 2004
    ....
  76. ncbi Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells
    Gil Galanti
    The Mina and Everard Goodman Faculty of Life Science, Bar Ilan University, Ramat Gan, Israel
    Acta Oncol 47:1062-70. 2008
    ..Here we used several experimental approaches, which identified delta-9-tetrahydrocannabinol (Delta(9)-THC) as an essential mediator of cannabinoid antitumoral action...
  77. ncbi The promise of advances in the field of endocannabinoids
    Raphael Mechoulam
    Neuro Endocrinol Lett 25:11-2. 2004
  78. ncbi Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation
    Javier Palazuelos
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    FASEB J 20:2405-7. 2006
    ..These findings provide a novel physiological role for the CB2 cannabinoid receptor and open a novel therapeutic avenue for manipulating neural progenitor cell fate...
  79. ncbi Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties
    Moises Garcia Arencibia
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    Brain Res 1134:162-70. 2007
    ..In addition, the activation of CB2 (but not CB1) receptors, or other additional mechanisms, might also contribute to some extent to the potential of cannabinoids in this disease...
  80. ncbi Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis
    Tania Aguado
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    J Biol Chem 282:6854-62. 2007
    ..Overall, our results demonstrate that cannabinoids target glioma stem-like cells, promote their differentiation, and inhibit gliomagenesis, thus giving further support to their potential use in the management of malignant gliomas...
  81. ncbi A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis
    Percy F Sumariwalla
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 50:985-98. 2004
    ..The profound suppressive effects on cellular immune responses and on the production of proinflammatory mediators all indicate its usefulness as a novel nonpsychoactive, synthetic antiinflammatory product...
  82. ncbi Hippocampal cannabinoid-1 receptor upregulation upon endothelin-B receptor deficiency: a neuroprotective substitution effect?
    Christian Unzicker
    Division of Clinical Neuroscience, Max Planck Institute for Experimental Medicine, Gottingen, Germany
    Neurochem Res 30:1305-9. 2005
    ..We suggest that CB1-receptor upregulation in the ETB-mutant hippocampus reflects an attempt to compensate for the lack of ETB-receptors...
  83. ncbi Delta-9-tetrahydrocannabinol and cannabidiol, but not ondansetron, interfere with conditioned retching reactions elicited by a lithium-paired context in Suncus murinus: An animal model of anticipatory nausea and vomiting
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5
    Physiol Behav 87:66-71. 2006
    ..These results support anecdotal claims that marijuana, but not ondansetron, may suppress the expression of anticipatory nausea...
  84. ncbi Conversation with Raphael Mechoulam
    Raphael Mechoulam
    Addiction 102:887-93. 2007
  85. ncbi Attenuation of allergic contact dermatitis through the endocannabinoid system
    Meliha Karsak
    Department of Molecular Psychiatry, University of Bonn, Germany
    Science 316:1494-7. 2007
    ..These results demonstrate a protective role of the endocannabinoid system in contact allergy in the skin and suggest a target for therapeutic intervention...
  86. ncbi Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptors
    Onintza Sagredo
    Departamento de Bioquimica y Biologia Molecular III, Universidad Complutense, 28040 Madrid, Spain
    Eur J Neurosci 26:843-51. 2007
    ..This capability seems to be based exclusively on the antioxidant properties of CBD...
  87. ncbi PADMA-28, a traditional Tibetan herbal preparation, blocks cellular responses to bFGF and IGF-I
    Roya Navab
    Department of Surgery and Medicine, McGill University Health Centre, Montreal, Quebec H3A 1A1, Canada
    Inflammopharmacology 12:373-89. 2004
    ....
  88. ncbi Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease
    Isabel Lastres-Becker
    , Facultad de Medicina, Universidad Complutense, 28040-Madrid, Spain
    Neurobiol Dis 19:96-107. 2005
    ....
  89. ncbi (+)-Cannabidiol analogues which bind cannabinoid receptors but exert peripheral activity only
    Ester Fride
    Department of Behavioral Sciences, College of Judea and Samaria, Ariel 44837, Israel
    Eur J Pharmacol 506:179-88. 2004
    ..We conclude that centrally inactive (+)-cannabidiol analogues should be further developed as antidiarrheal, antiinflammatory and analgesic drugs for gastrointestinal and other peripheral conditions...
  90. ncbi Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors
    Susanne Andrea Golech
    Resuscitative Medicine Department, Naval Medical Research Center, Bethesda, MD, USA
    Brain Res Mol Brain Res 132:87-92. 2004
    ..These studies clearly indicate that 2-AG and other related compounds may function as agonists on VR1 receptors, as well as CB1 and CB2 receptors, and implicated these factors in various HBEC functions...
  91. ncbi The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells
    Yossi Dagon
    Department of Human Nutrition and Metabolism, Braun School of Public Health, Faculty of Medicine Hebrew University, Hadassah Medical School, Israel
    Neurobiol Dis 27:174-81. 2007
    ..These results suggest cannabinoids might have a therapeutic role in the management of the neurological complications of diabetes...