Francesca Levi-Schaffer

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi request reprint Tumor necrosis factors in a murine model of allergic peritonitis: effects on eosinophil accumulation and inflammatory mediators' release
    Vladislav Temkin
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, P O Box 12065, Jerusalem 91120, Israel
    Cytokine 24:74-80. 2003
  2. ncbi request reprint Mast cells enhance eosinophil survival in vitro: role of TNF-alpha and granulocyte-macrophage colony-stimulating factor
    F Levi-Schaffer
    Department of Pharmacology, School of Pharmacy, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Immunol 160:5554-62. 1998
  3. doi request reprint Mast cell stabilizing properties of antihistamines
    Francesca Levi-Schaffer
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    J Invest Dermatol 129:2549-51. 2009
  4. ncbi request reprint Tryptase, a novel link between allergic inflammation and fibrosis
    Francesca Levi-Schaffer
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Trends Immunol 24:158-61. 2003
  5. ncbi request reprint Proteomic analysis of human eosinophil activation mediated by mast cells, granulocyte macrophage colony stimulating factor and tumor necrosis factor alpha
    Francesca Levi-Schaffer
    Department of Pharmacology, The Hebrew University of Jerusalem, Jerusalem, Israel
    Proteomics 2:1616-26. 2002
  6. ncbi request reprint Nerve growth factor and eosinophils in inflamed juvenile conjunctival nevus
    Francesca Levi-Schaffer
    Department of Pharmacology and the David R Bloom Center for Pharmacy School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Invest Ophthalmol Vis Sci 43:1850-6. 2002
  7. pmc Hypoxia modulates human eosinophil function
    Alon H Nissim Ben Efraim
    Department of Pharmacology and Experimental Therapeutics, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Clin Mol Allergy 8:10. 2010
  8. ncbi request reprint Activation and inhibition of mast cells degranulation affect their morphometric parameters
    F Levi-Schaffer
    Department of Pharmacology, School of Pharmacy, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Life Sci 66:PL283-90. 2000
  9. pmc Human eosinophils regulate human lung- and skin-derived fibroblast properties in vitro: a role for transforming growth factor beta (TGF-beta)
    F Levi-Schaffer
    Department of Pharmacology, School of Pharmacy, Hebrew University Hadassah Medical School, POB 12065, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 96:9660-5. 1999
  10. ncbi request reprint Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor
    Adrian M Piliponsky
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Blood 101:1898-904. 2003

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Tumor necrosis factors in a murine model of allergic peritonitis: effects on eosinophil accumulation and inflammatory mediators' release
    Vladislav Temkin
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, P O Box 12065, Jerusalem 91120, Israel
    Cytokine 24:74-80. 2003
    ..On the other hand histamine and IL-6 were higher, while EPO was lower in TNF-KO mice. In conclusion, our findings show that TNF is involved in eosinophil accumulation and inflammatory mediators' release in a murine model of allergy...
  2. ncbi request reprint Mast cells enhance eosinophil survival in vitro: role of TNF-alpha and granulocyte-macrophage colony-stimulating factor
    F Levi-Schaffer
    Department of Pharmacology, School of Pharmacy, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Immunol 160:5554-62. 1998
    ..In conclusion, we have demonstrated that mast cells enhance eosinophil survival in part through their activation to produce and release the autocrine survival cytokine GM-CSF...
  3. doi request reprint Mast cell stabilizing properties of antihistamines
    Francesca Levi-Schaffer
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    J Invest Dermatol 129:2549-51. 2009
    ..Thus, desloratadine provides benefits that are independent of H1 receptor binding and based on mast cell stabilization...
  4. ncbi request reprint Tryptase, a novel link between allergic inflammation and fibrosis
    Francesca Levi-Schaffer
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Trends Immunol 24:158-61. 2003
    ....
  5. ncbi request reprint Proteomic analysis of human eosinophil activation mediated by mast cells, granulocyte macrophage colony stimulating factor and tumor necrosis factor alpha
    Francesca Levi-Schaffer
    Department of Pharmacology, The Hebrew University of Jerusalem, Jerusalem, Israel
    Proteomics 2:1616-26. 2002
    ..The presented proteomic analysis is the first step in the exploration of molecular mechanisms involved in eosinophil activation...
  6. ncbi request reprint Nerve growth factor and eosinophils in inflamed juvenile conjunctival nevus
    Francesca Levi-Schaffer
    Department of Pharmacology and the David R Bloom Center for Pharmacy School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Invest Ophthalmol Vis Sci 43:1850-6. 2002
    ....
  7. pmc Hypoxia modulates human eosinophil function
    Alon H Nissim Ben Efraim
    Department of Pharmacology and Experimental Therapeutics, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Clin Mol Allergy 8:10. 2010
    ..Eosinophils produce VEGF and are pro-angiogenic. However, to the best of our knowledge no study has been performed to verify the existence of a direct link between eosinophils, hypoxia and angiogenesis in allergic inflammation...
  8. ncbi request reprint Activation and inhibition of mast cells degranulation affect their morphometric parameters
    F Levi-Schaffer
    Department of Pharmacology, School of Pharmacy, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Life Sci 66:PL283-90. 2000
    ....
  9. pmc Human eosinophils regulate human lung- and skin-derived fibroblast properties in vitro: a role for transforming growth factor beta (TGF-beta)
    F Levi-Schaffer
    Department of Pharmacology, School of Pharmacy, Hebrew University Hadassah Medical School, POB 12065, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 96:9660-5. 1999
    ..These data corroborate the importance of eosinophils in skin and lung fibrosis...
  10. ncbi request reprint Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor
    Adrian M Piliponsky
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Blood 101:1898-904. 2003
    ..Mast cell responsiveness to eosinophil mediators is a potentially novel evidence for an alternative pathway of allergen-independent activation able to contribute to the perpetuation of allergy...
  11. ncbi request reprint The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells
    Ido Bachelet
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
    J Immunol 175:7989-95. 2005
    ..These data demonstrate a novel pathway for the regulation of human mast cell function and allergic responses, indicating IRp60 as a candidate target for future treatment of allergic and mast cell-associated diseases...
  12. ncbi request reprint CD48 is an allergen and IL-3-induced activation molecule on eosinophils
    Ariel Munitz
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Immunol 177:77-83. 2006
    ..Additionally, anti-IL-3 reduces CD48 expression and the degree of airway inflammation. Thus, CD48 is an IL-3-induced activating receptor on eosinophils, likely involved in promoting allergic inflammation...
  13. ncbi request reprint Suppression of normal and malignant kit signaling by a bispecific antibody linking kit with CD300a
    Ido Bachelet
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel
    J Immunol 180:6064-9. 2008
    ..Our findings highlight CD300a as a novel regulator of Kit in human MC and suggest roles for this receptor as a suppressor of Kit signaling in MC-related disorders...
  14. ncbi request reprint 2B4 (CD244) is expressed and functional on human eosinophils
    Ariel Munitz
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Immunol 174:110-8. 2005
    ..Furthermore, we showed that eosinophils express slam-associated protein. The demonstration that human eosinophils express a functional 2B4 receptor indicates a broader role for these cells in health and disease...
  15. ncbi request reprint Mast cells induce activation of human lung fibroblasts in vitro
    Ekaterina Garbuzenko
    Department of Pharmacology, Hadassah Hebrew, University Medical Center, Jerusalem, Israel
    Exp Lung Res 30:705-21. 2004
    ..8%, P < .001) and induced synthesis of collagen from these cells (190% +/- 28% increase versus control, P < .05). This study demonstrates that mast cells influence several aspects of lung fibroblast function in vitro...
  16. doi request reprint Ultrastructural evidence for human mast cell-eosinophil interactions in vitro
    Yael Minai-Fleminger
    Pharmacology and Experimental Therapeutics Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem 91120, Israel
    Cell Tissue Res 341:405-15. 2010
    ..This is the first in vitro evidence of functional physical interactions between human MC and Eos, interactions that might also occur in vivo during allergic diseases...
  17. doi request reprint Eotaxin-2/CCL24 and eotaxin-3/CCL26 exert differential profibrogenic effects on human lung fibroblasts
    Martin Kohan
    Lung Cellular and Molecular Biology Laboratory, Institute of Pulmonology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Ann Allergy Asthma Immunol 104:66-72. 2010
    ..We previously demonstrated that eotaxin/CCL11 is profibrogenic for human lung fibroblasts. The effect of eotaxin-2/ CCL24 and eotaxin-3/CCL26 on lung fibroblasts has not yet been investigated...
  18. ncbi request reprint The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils
    Ariel Munitz
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, POB 12065, Jerusalem 91120, Israel
    Blood 107:1996-2003. 2006
    ..These findings demonstrate a novel pathway for suppressing the activity of human eosinophils, thus indicating IRp60 as a future potential target for the treatment of allergic and eosinophil-associated diseases...
  19. pmc Role of mast cells and myofibroblasts in human peritoneal adhesion formation
    Xiang Xu
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Ann Surg 236:593-601. 2002
    ..To study fibroblasts and mast cells in human peritoneal adhesions and to evaluate whether their interaction plays a role in adhesion development...
  20. ncbi request reprint Effects of eosinophils on mast cells: a new pathway for the perpetuation of allergic inflammation
    Adrian M Piliponsky
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University Hadassah Medical School, P O Box 12065, 91120, Jerusalem, Israel
    Mol Immunol 38:1369. 2002
    ....
  21. pmc CD48 is critically involved in allergic eosinophilic airway inflammation
    Ariel Munitz
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
    Am J Respir Crit Care Med 175:911-8. 2007
    ..Although CD48 is widely expressed on hematopoietic cells and commonly studied in the context of natural killer and cytotoxic T cell functions, its role in helper T cell type 2 settings has not been examined...
  22. ncbi request reprint Mast cells and eosinophils: a novel link between inflammation and angiogenesis in allergic diseases
    Ilaria Puxeddu
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    J Allergy Clin Immunol 116:531-6. 2005
    ..We discuss the multifaceted roles of mast cells and eosinophils in tissue remodeling and angiogenesis during allergic diseases and whether these cells can be both source and target cells for pro-angiogenic mediators...
  23. ncbi request reprint The CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung fibroblasts
    Ilaria Puxeddu
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Allergy Clin Immunol 117:103-10. 2006
    ..Eotaxin/CCL11 plays an important role in asthma. It acts through the chemokine receptor CCR3 expressed on hematopoietic and nonhematopoietic cells in the lung...
  24. doi request reprint Expression and function of CD300 in NK cells
    Dikla Lankry
    Lautenberg Center for General and Tumor Immunology, Biomedical Research Institute, Hadassah Medical School, Hebrew University, Jerusalem, Israel
    J Immunol 185:2877-86. 2010
    ..Using mutational-analysis survey, we show that tyrosine 267 located in the third ITIM motif of the CD300a protein is important for the inhibitory function of CD300a...
  25. ncbi request reprint Human mast cells undergo TRAIL-induced apoptosis
    Beata Berent-Maoz
    Department of Pharmacology, School of Pharmacy, The Hebrew University of Jerusalem, Israel
    J Immunol 176:2272-8. 2006
    ..Results suggest that TRAIL-mediated apoptosis may be a mechanism of regulating MC survival in vivo and, potentially, for down-regulating MC hyperplasia in pathologic conditions...
  26. ncbi request reprint Eosinophil major basic protein: first identified natural heparanase-inhibiting protein
    Vladislav Temkin
    Department of Pharmacology, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Allergy Clin Immunol 113:703-9. 2004
    ..Heparanase and eosinophils are involved in several diseases, including inflammation, cancer, and angiogenesis...
  27. doi request reprint Human mast cells express intracellular TRAIL
    Beata Berent-Maoz
    Department of Pharmacology and Experimental Therapeutics, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
    Cell Immunol 262:80-3. 2010
    ..These in vitro data show that human MC can produce and express intracellular TRAIL whose location could not be altered by different stimuli...
  28. ncbi request reprint Nerve growth factor and tissue repair remodeling: trkA(NGFR) and p75(NTR), two receptors one fate
    Alessandra Micera
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel
    Cytokine Growth Factor Rev 18:245-56. 2007
    ..In summary, these novel findings on the potential pro-healing capacity of NGF might open new possibilities for this growth factor in modulating the healing processes in several pathological conditions...
  29. ncbi request reprint Reversal of airway inflammation and remodeling in asthma by a bispecific antibody fragment linking CCR3 to CD300a
    Ariel Munitz
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Israel
    J Allergy Clin Immunol 118:1082-9. 2006
    ..However, molecular pathways that inhibit their functions in this process have been scarcely characterized. Recently we established that cross-linking of CD300a inhibits MC and eosinophil activation...
  30. ncbi request reprint New insights on the involvement of Nerve Growth Factor in allergic inflammation and fibrosis
    Alessandra Micera
    Department of Pharmacology, Faculty of Medicine, School of Pharmacy, The Hebrew University of Jerusalem, PO Box 12065, Jerusalem 91120, Israel
    Cytokine Growth Factor Rev 14:369-74. 2003
    ..Recent evidences link NGF and these two processes. While NGF is clearly a new tool in the management of untreatable ulcers, its role in allergic inflammation, although appearing to be pro-inflammatory, is still not clearly defined...
  31. ncbi request reprint Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process
    Ido Bachelet
    Deparment of Pharmacology, The School of Pharmacy, The Faculty of Medicine, The Hebrew University of Jerusalem, and Department of Obstetrics and Gynecology, Hadassah University Hospital, Israel
    J Biol Chem 281:27190-6. 2006
    ..Moreover, costimulatory responses might be a critical component in allergic reactions and may therefore become novel targets for anti-allergic therapy...
  32. ncbi request reprint Tryptase activates the mitogen-activated protein kinase/activator protein-1 pathway in human peripheral blood eosinophils, causing cytokine production and release
    Vladislav Temkin
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Israel
    J Immunol 169:2662-9. 2002
    ..In summary, we have demonstrated that the preformed mast cell mediator tryptase induces cytokine production and release in human peripheral blood eosinophils by the mitogen-activated protein kinase/AP-1 pathway...
  33. ncbi request reprint Abrogation of allergic reactions by a bispecific antibody fragment linking IgE to CD300a
    Ido Bachelet
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel
    J Allergy Clin Immunol 117:1314-20. 2006
    ..We have recently shown that the inhibitory receptor CD300a is expressed on human mast cells and modulates a large array of their functions...
  34. doi request reprint Influence of FAS on murine mast cell maturation
    Beata Berent-Maoz
    Department of Pharmacology and Experimental Therapeutics, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Ann Allergy Asthma Immunol 106:239-44. 2011
    ..However, accumulated evidence shows that FAS signaling also exhibits nonapoptotic functions, such as induction of cell proliferation and differentiation. FAS is the only death receptor known to be expressed on murine mast cells (MCs)...
  35. ncbi request reprint Fibrosis in ocular allergic inflammation: recent concepts in the pathogenesis of ocular allergy
    Abraham Solomon
    Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel
    Curr Opin Allergy Clin Immunol 3:389-93. 2003
    ..As a main example of allergic ocular diseases associated with fibrosis, vernal keratoconjunctivitis is discussed in the light of recent findings...
  36. ncbi request reprint Mast cells and eosinophils: the hallmark of asthma
    Ilaria Puxeddu
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Paediatr Respir Rev 5:S31-4. 2004
  37. doi request reprint Airway eosinophil accumulation and eotaxin-2/CCL24 expression following allergen challenge in BALB/c mice
    Chana Ben-Yehuda
    Lung Cellular and Molecular Biology Laboratory, Institute of Pulmonology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Exp Lung Res 34:467-79. 2008
    ..In contrast, only CCL24 seems important for recruitment of eosinophils into BAL. Specific inhibition of CCL11 alone is therefore unlikely to inhibit eosinophil recruitment to the airways...
  38. ncbi request reprint CD48 as a novel target in asthma therapy
    Ariel Munitz
    Department of Pharmacology and Experimental Therapeutics, The School of Pharmacy, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Recent Pat Inflamm Allergy Drug Discov 1:9-12. 2007
    ..Moreover, we shall review inventions making use of CD48, and discuss recent patents and the potential of CD48 as a future target for the therapy of allergic and other diseases...
  39. doi request reprint Mast cells and histamine enhance the proliferation of non-small cell lung cancer cells
    Evgeniy Stoyanov
    Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Lung Cancer 75:38-44. 2012
    ..In conclusion, mast cell/anti-histamine targeted therapies should carefully consider this dual effect...
  40. doi request reprint The effect of hypoxia and cycloxygenase inhibitors on nasal polyp derived fibroblasts
    Smadar Cohen
    Hebrew University School of Medicine Hadassah Medical Center, Jerusalem, Israel
    Am J Otolaryngol 32:564-73. 2011
    ....
  41. doi request reprint Mycophenolic acid suppresses human pterygium and normal tenon fibroblast proliferation in vitro
    Radgonde Amer
    Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel
    Br J Ophthalmol 94:1373-7. 2010
    ....
  42. ncbi request reprint Immune effector cells: mast cells and eosinophils?
    Shira Fraenkel
    Department of Pharmacology, Hebrew University of Jerusalem, Jerusalem, Israel
    Pediatr Pulmonol Suppl 26:42-4. 2004
  43. doi request reprint Mast cells and eosinophils: the two key effector cells in allergic inflammation
    Yael Minai-Fleminger
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, POB 12065, Jerusalem, 91120, Israel
    Inflamm Res 58:631-8. 2009
    ..Such interactions, that we have termed "the allergic effector unit", may modulate the severity and/or duration of the allergic inflammatory reaction...
  44. ncbi request reprint The role of the eosinophil in nasal diseases
    Ron Eliashar
    Department of Otolaryngology Head and Neck Surgery, The Hebrew University School of Medicine, Hadassah Medical Center, Jerusalem, Israel
    Curr Opin Otolaryngol Head Neck Surg 13:171-5. 2005
    ..The eosinophil is involved in physiologic and pathologic processes, such as asthma, parasitic diseases, granulomatous disorders, fibrosis, malignant tumors and several sino-nasal diseases...
  45. ncbi request reprint Co-culture of mast cells with fibroblasts: a tool to study their crosstalk
    Ido Bachelet
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Methods Mol Biol 315:295-317. 2006
    ..Therefore, the co-culture system can be viewed as a suitable tool to investigate mast cell-fibroblast crosstalk...
  46. ncbi request reprint Human peripheral blood eosinophils induce angiogenesis
    Ilaria Puxeddu
    Department of Pharmacology, Faculty of Medicine, School of Pharmacy, The Hebrew University of Jerusalem, POB 12065, Jerusalem 91120, Israel
    Int J Biochem Cell Biol 37:628-36. 2005
    ..This strongly suggests an important role of eosinophils in angiogenesis-associated diseases such as asthma...
  47. ncbi request reprint Mast cells as effector cells: a co-stimulating question
    Ido Bachelet
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel
    Trends Immunol 28:360-5. 2007
    ..These molecules might therefore contribute to the outcome of mast cell-associated pathologies, and constitute new therapeutic targets in such diseases...
  48. ncbi request reprint Inhibitory receptors on eosinophils: a direct hit to a possible Achilles heel?
    Ariel Munitz
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
    J Allergy Clin Immunol 119:1382-7. 2007
    ..In conclusion, we assume that targeting inhibitory receptors on eosinophils may provide opportunities for immunoregulatory therapy in the near future...
  49. doi request reprint CD48: A co-stimulatory receptor of immunity
    Moran Elishmereni
    Department of Pharmacology and Experimental Therapeutics, Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Int J Biochem Cell Biol 43:25-8. 2011
    ..Possible CD48-based applications for immune-impaired and inflammatory disorders are discussed as well...
  50. doi request reprint Are we ready to downregulate mast cells?
    Laila Karra
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, POB 12065, Jerusalem 91120, Israel
    Curr Opin Immunol 21:708-14. 2009
    ..Therefore a selective targeting of TRAIL and of IRs on MC could be a novel immunopharmacological way to downregulate MC-associated diseases...
  51. ncbi request reprint Mast cell dynamics and involvement in the development of peritoneal adhesions in the rat
    Xiang Xu
    Department of Pharmacology, School of Pharmacy, The Hebrew Universiry Hadassah Medical School, Jerusalem, Israel
    Life Sci 70:951-67. 2002
    ..In vitro mast cell induced fibroplasia. Therefore, mast cells have a profibrogenic role in this model of peritoneal adhesions...
  52. ncbi request reprint Reduced eosinophil pro-fibrogenic effect in severe childhood asthma compared to mild disease: an effect of corticosteroids?
    Ilaria Puxeddu
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Pediatr Pulmonol 38:222-8. 2004
    ..Our data suggest that the pro-fibrogenic effect of eosinophils might be influenced by treatment with ICS in childhood asthma...
  53. pmc Human mast cell activation by Staphylococcus aureus: interleukin-8 and tumor necrosis factor alpha release and the role of Toll-like receptor 2 and CD48 molecules
    Claudio M Rocha-de-Souza
    Department of Pharmacology and Experimental Therapeutics, Faculty of Medicine, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel
    Infect Immun 76:4489-97. 2008
    ..Cumulatively, these findings suggest that S. aureus internalizes and survives in mast cells. This may play an important role in infections and in atopic diseases associated with S. aureus...
  54. ncbi request reprint Mast cells: not only in allergy
    Ido Bachelet
    Department of Pharmacology, School of Pharmacy, The Faculty of Medicine, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem 91120, Israel
    Immunol Allergy Clin North Am 26:407-25. 2006
    ..Conceivably, mast cells should be refocused on so as to obtain new insights about diverse pathologic conditions, ultimately leading to novel therapeutic approaches targeting these fascinating cells...
  55. doi request reprint Down-regulation of mast cell responses through ITIM containing inhibitory receptors
    Laila Karra
    Department of Pharmacology and Experimental Therapeutics, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Adv Exp Med Biol 716:143-59. 2011
    ..In this chapter, we will discuss down-regulating mechanisms of mast cells focusing on immunoreceptor tyrosine-based inhibition motifs (ITIM)-containing inhibitory receptors (IR)...
  56. ncbi request reprint DNAM-1: an amplifier of immune responses as a therapeutic target in various disorders
    Moran Elishmereni
    The Hebrew University of Jerusalem, Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, POB 12065, Jerusalem 91120, Israel
    Curr Opin Investig Drugs 9:491-6. 2008
    ..The structure of DNAM-1, its mechanism of action and its effects in pathological scenarios are discussed...
  57. pmc Dexamethasone and salbutamol stimulate human lung fibroblast proliferation
    Eran Pickholtz
    Department of Pharmacology, Institute for Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel
    World Allergy Organ J 4:249-56. 2011
    ..Mast cells are important in the development of asthma and its fibrotic changes...
  58. pmc Novel identified receptors on mast cells
    Helena Migalovich-Sheikhet
    Department of Pharmacology and Experimental Therapeutics, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem Jerusalem, Israel
    Front Immunol 3:238. 2012
    ..Suggested strategies to modulate these receptors' activity for the purpose of therapeutic intervention are also discussed...
  59. pmc Inflamed juvenile conjunctival naevus: clinicopathological characterisation
    Ehud Zamir
    Br J Ophthalmol 86:28-30. 2002
    ..Their clinical and histopathological features have not been characterised in series of patients. The aim of the study is to characterise IJCN clinically and histopathologically...
  60. ncbi request reprint Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome
    Hans Uwe Simon
    Department of Pharmacology, University of Bern, Bern, Switzerland
    Eur J Immunol 33:834-9. 2003
    ..These data suggest that patients with increased eosinophil surface CD25 expression are at higher risk of eosinophil degranulation and subsequent tissue damage when IL-2 is present at inflammatory sites...
  61. ncbi request reprint Human intestinal fibroblasts prevent apoptosis in human intestinal mast cells by a mechanism independent of stem cell factor, IL-3, IL-4, and nerve growth factor
    Gernot Sellge
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Hannover, Germany
    J Immunol 172:260-7. 2004
    ..Such interactions between MCs and FBs may explain why MCs accumulate at sites of inflammatory bowel disease and intestinal fibrosis...
  62. ncbi request reprint Nerve growth factor involvement in the visual system: implications in allergic and neurodegenerative diseases
    Alessandra Micera
    CIR Laboratorio di Oftalmologia, Campus Bio Medico and Fondazione GB Bietti, Rome, Italy
    Cytokine Growth Factor Rev 15:411-7. 2004
    ..The present review of experimental and clinical studies will highlight old and recent strategies for treating ocular surface and tear disorders with NGF...
  63. ncbi request reprint Nerve growth factor effect on human primary fibroblastic-keratocytes: possible mechanism during corneal healing
    Alessandra Micera
    CIR Laboratory of Ophthalmology, University Campus Bio Medico and G B Bietti, Foundation, Via Emilio Longoni 83, 00155 Rome, Italy
    Exp Eye Res 83:747-57. 2006
    ..To sum up, the findings of this study indicate that NGF can modulate some functional activities of fibroblastic-keratocytes, thus substantiating the healing effects of NGF on corneal wound-healing...
  64. ncbi request reprint A single-cell matrix-assisted laser desorption/ionization time-of-flight mass-spectroscopic assay of the cell-maturation process
    Masakazu Shimizu
    Department of Analytical Life Science, Institute of Pharmaceutical Sciences, Hiroshima University, Japan
    Anal Sci 18:107-8. 2002
  65. ncbi request reprint The relationship between allergen-induced tissue eosinophilia and markers of repair and remodeling in human atopic skin
    Simon Phipps
    Department of Allergy and Clinical Immunology, Faculty of Medicine, Imperial College, National Heart and Lung Institute, Dovehouse Street, London, UK, SW3 6LY
    J Immunol 169:4604-12. 2002
    ..TGF-beta1 and IL-13 also induced tenascin expression. We conclude that TGF-beta1 and IL-13, provided partially by eosinophils, contribute to repair and remodeling events in allergic inflammation in human atopic skin...
  66. ncbi request reprint Human mast cells release oncostatin M on contact with activated T cells: possible biologic relevance
    Pazit Salamon
    Allergy and Clinical Immunology Laboratory, Meir General Hospital, Kfar Saba, Israel
    J Allergy Clin Immunol 121:448-455.e5. 2008
    ..We have recently demonstrated that mast cells can be activated by heterotypic adhesion to activated T cells...