Ronen Robert Leker

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. doi request reprint Growth factors improve neurogenesis and outcome after focal cerebral ischemia
    Ronen Robert Leker
    Stroke Service and the Peritz and Chantal Scheinberg Cerebrovascular Research Laboratory, Department of Neurology, Hebrew University Hadassah Medical Center, Hadassah Ein Kerem, Jerusalem, Israel
    J Neural Transm 116:1397-402. 2009
  2. ncbi request reprint Exacerbation of myasthenia gravis during the menstrual period
    R R Leker
    Department of Neurology, Hadassah University Hospital, Hebrew University and Hadassah Medical School, Jerusalem, Israel
    J Neurol Sci 156:107-11. 1998
  3. doi request reprint Fate and manipulations of endogenous neural stem cells following brain ischemia
    Ronen R Leker
    Hadassah Hebrew University Medical Center, Department of Neurology, Cerebrovascular Service, Hadassah Ein Kerem, Jerusalem 91120, Israel
    Expert Opin Biol Ther 9:1117-25. 2009
  4. pmc Transforming growth factor alpha induces angiogenesis and neurogenesis following stroke
    R R Leker
    Department of Neurology, Peritz and Chantal Scheinberg Cerebrovascular Research Laboratory, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Neuroscience 163:233-43. 2009
  5. doi request reprint Prior use of statins improves outcome in patients with intracerebral hemorrhage: prospective data from the National Acute Stroke Israeli Surveys (NASIS)
    Ronen R Leker
    Department of Neurology, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Stroke 40:2581-4. 2009
  6. ncbi request reprint Novel therapies for acute ischemic stroke
    Ronen R Leker
    Department of Neurology, Ginges Center for Neurogenetics, Scheinberg Cerebrovascular Research Laboratory, Hadassah University Hospital, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Isr Med Assoc J 8:788-92. 2006
  7. ncbi request reprint Long-lasting regeneration after ischemia in the cerebral cortex
    Ronen R Leker
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Stroke 38:153-61. 2007
  8. ncbi request reprint Manipulation of endogenous neural stem cells following ischemic brain injury
    Ronen R Leker
    Department of Neurology, Peritz Scheinberg Cerebrovascular Research Laboratory and the Agnes Ginges Center for Human Neurogenetics
    Pathophysiol Haemost Thromb 35:58-62. 2006
  9. ncbi request reprint Cerebral ischemia and trauma-different etiologies yet similar mechanisms: neuroprotective opportunities
    Ronen R Leker
    Department of Neurology and the Agnes Ginges Center for Human Neurogenetics, Hebrew University Hadassah Medical School and Hadassah University Hospital, Jerusalem, Israel
    Brain Res Brain Res Rev 39:55-73. 2002
  10. ncbi request reprint NAP, a femtomolar-acting peptide, protects the brain against ischemic injury by reducing apoptotic death
    Ronen R Leker
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hebrew University Hadassah Medical School, University Hospital, Jerusalem, Israel
    Stroke 33:1085-92. 2002

Detail Information

Publications25

  1. doi request reprint Growth factors improve neurogenesis and outcome after focal cerebral ischemia
    Ronen Robert Leker
    Stroke Service and the Peritz and Chantal Scheinberg Cerebrovascular Research Laboratory, Department of Neurology, Hebrew University Hadassah Medical Center, Hadassah Ein Kerem, Jerusalem, Israel
    J Neural Transm 116:1397-402. 2009
    ..Importantly, current evidence suggests that such perturbations may lead to better functional outcome after stroke. This article summarizes the progress made in this field...
  2. ncbi request reprint Exacerbation of myasthenia gravis during the menstrual period
    R R Leker
    Department of Neurology, Hadassah University Hospital, Hebrew University and Hadassah Medical School, Jerusalem, Israel
    J Neurol Sci 156:107-11. 1998
    ..Myasthenia gravis (MG) is an autoimmune disorder mediated by antiacetylcholine receptor antibodies. It has long been suspected to exacerbate during the menstrual period but this has never been adequately documented...
  3. doi request reprint Fate and manipulations of endogenous neural stem cells following brain ischemia
    Ronen R Leker
    Hadassah Hebrew University Medical Center, Department of Neurology, Cerebrovascular Service, Hadassah Ein Kerem, Jerusalem 91120, Israel
    Expert Opin Biol Ther 9:1117-25. 2009
    ..Contemporary evidence now suggests that such perturbations may lead to better functional outcome after brain injury...
  4. pmc Transforming growth factor alpha induces angiogenesis and neurogenesis following stroke
    R R Leker
    Department of Neurology, Peritz and Chantal Scheinberg Cerebrovascular Research Laboratory, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Neuroscience 163:233-43. 2009
    ..At least part of the pro-angiogenic effect appears to be secondary to the incorporation of bone marrow-derived endothelial cells into blood vessels in the infarct border zone...
  5. doi request reprint Prior use of statins improves outcome in patients with intracerebral hemorrhage: prospective data from the National Acute Stroke Israeli Surveys (NASIS)
    Ronen R Leker
    Department of Neurology, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Stroke 40:2581-4. 2009
    ..Intracerebral hemorrhage (ICH) is a deadly form of stroke. Pretreatment with statins exerts protective effects in patients with ischemic stroke, but their effects in patients with ICH remains unclear...
  6. ncbi request reprint Novel therapies for acute ischemic stroke
    Ronen R Leker
    Department of Neurology, Ginges Center for Neurogenetics, Scheinberg Cerebrovascular Research Laboratory, Hadassah University Hospital, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Isr Med Assoc J 8:788-92. 2006
    ..The current situation calls for novel therapeutic strategies to be used in acute ischemic stroke. This review surveys some of these novel and promising cutting edge therapies...
  7. ncbi request reprint Long-lasting regeneration after ischemia in the cerebral cortex
    Ronen R Leker
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Stroke 38:153-61. 2007
    ....
  8. ncbi request reprint Manipulation of endogenous neural stem cells following ischemic brain injury
    Ronen R Leker
    Department of Neurology, Peritz Scheinberg Cerebrovascular Research Laboratory and the Agnes Ginges Center for Human Neurogenetics
    Pathophysiol Haemost Thromb 35:58-62. 2006
    ..Endogenous NSCs are capable of self-renewal and differentiation into functional brain cells. This paper summarizes the evidence recently gathered in support of a therapeutic role for endogenous NSCs in acute experimental stroke...
  9. ncbi request reprint Cerebral ischemia and trauma-different etiologies yet similar mechanisms: neuroprotective opportunities
    Ronen R Leker
    Department of Neurology and the Agnes Ginges Center for Human Neurogenetics, Hebrew University Hadassah Medical School and Hadassah University Hospital, Jerusalem, Israel
    Brain Res Brain Res Rev 39:55-73. 2002
    ....
  10. ncbi request reprint NAP, a femtomolar-acting peptide, protects the brain against ischemic injury by reducing apoptotic death
    Ronen R Leker
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hebrew University Hadassah Medical School, University Hospital, Jerusalem, Israel
    Stroke 33:1085-92. 2002
    ..Activity-dependent neuroprotective protein mediates some of the protective effects of vasoactive intestinal peptide. The neuroprotective NAP sequence is derived from activity-dependent neuroprotective protein...
  11. ncbi request reprint Anticardiolipin antibodies are frequently present in patients with idiopathic intracranial hypertension
    R R Leker
    Department of Neurology, Hebrew University, Hadassah University Medical Center, Jerusalem, Israel
    Arch Neurol 55:817-20. 1998
    ..Anticardiolipin antibodies (ACL-Ab) are associated with various neurologic syndromes, but idiopathic intracranial hypertension (IIH) has only rarely been reported in this context...
  12. pmc Unidirectional dyslexia in a polyglot
    R R Leker
    Department of Neurology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Neurol Neurosurg Psychiatry 66:517-9. 1999
    ..The deficit suggests the existence of a separate, language associated, neuronal network within the right hemisphere important to different language reading modes...
  13. ncbi request reprint Dexanabinol; a novel neuroprotective drug in experimental focal cerebral ischemia
    R R Leker
    Department of Neurology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Neurol Sci 162:114-9. 1999
    ..No effect could be demonstrated on NOS activity. In conclusion, dexanabinol may be a pluripotent cerebroprotective agent...
  14. ncbi request reprint Features of dural sinus thrombosis simulating pseudotumor cerebri
    R R Leker
    Department of Neurology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Eur J Neurol 6:601-4. 1999
    ..It may be impossible to differentiate between patients with and without DST if MRI/MRV or angiography are not performed in this scenario...
  15. ncbi request reprint Effects of sex hormones on experimental autoimmune myasthenia gravis
    R R Leker
    Department of Neurology, Hadassah University Hospital, Hebrew University and Hadassah Medical School, Jerusalem, Israel
    Eur J Neurol 7:203-6. 2000
    ..Lymphocyte reactivity was similar for rats with and without ovariectomy. In conclusion, sex hormones do not appear to have an influence on the susceptibility to and the severity of MG...
  16. ncbi request reprint Prognostic factors in artificially ventilated stroke patients
    R R Leker
    Department of Neurology, Hebrew University Hadassah Medical School and Hadassah Medical Center, Ein Kerem, P O Box 12000, 91120, Jerusalem, Israel
    J Neurol Sci 176:83-7. 2000
    ..To evaluate the reasons for implementing artificial ventilation (AV) in patients with acute ischemic stroke (AIS), determine their outcome and characterize prognostic variables in these patients...
  17. ncbi request reprint Expression of endothelial nitric oxide synthase in the ischemic penumbra: relationship to expression of neuronal nitric oxide synthase and vascular endothelial growth factor
    R R Leker
    Department of Neurology and the Agnes Ginges Center for Human Neurogenetics, Hebrew University Hadassah Medical School, Hadassah University Hospital, P O Box 12000, 91120, Jerusalem, Israel
    Brain Res 909:1-7. 2001
    ..The anatomical and temporal pattern of VEGF and eNOS induction in the brain after permanent ischemia suggest that these mediators may play a role in protecting penumbral tissue from additional ischemic damage...
  18. ncbi request reprint Using endogenous neural stem cells to enhance recovery from ischemic brain injury
    Ronen R Leker
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke National Institutes of Health, NIH NINDS Building 36, Room 3c12, 36 Convent Drive, MSC 4092, Bethesda, MD 20892, USA
    Curr Neurovasc Res 1:421-7. 2004
    ..This review summarizes the evidence recently gathered in support of a therapeutic role for endogenous NSCs in acute experimental stroke...
  19. ncbi request reprint The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha
    Ronen R Leker
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hebrew University Hadassah Medical School, Hadassah University Hospital, Ein Kerem, Jerusalem 91120, Israel
    Exp Neurol 187:478-86. 2004
    ....
  20. pmc The combination of granulocyte colony-stimulating factor and stem cell factor significantly increases the number of bone marrow-derived endothelial cells in brains of mice following cerebral ischemia
    Zsuzsanna E Toth
    National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    Blood 111:5544-52. 2008
    ..These findings suggest that G-CSF/SCF treatment might help recovery through induction of bone marrow-derived angiogenesis, thus improving neuronal survival and functional outcome...
  21. ncbi request reprint Drug-induced hypothermia reduces ischemic damage: effects of the cannabinoid HU-210
    Ronen R Leker
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel
    Stroke 34:2000-6. 2003
    ..Therefore, we sought to examine whether the synthetic CB1 agonist HU-210 is capable of reducing ischemic damage and to determine the mechanisms responsible for such protection...
  22. ncbi request reprint Nicaraven Chugai
    Ronen R Leker
    Laboratory of Molecular Biology, NIH NINDS Building 36, Room 3c12, 36 Convent Drive, MSC 4092, Bethesda, MD 20892, USA
    Curr Opin Investig Drugs 4:83-90. 2003
    ..A registration application was filed in April 1995, and in April 2002, nicaraven was still awaiting registration in Japan. By August 2002, Chugai had filed an NDA in Japan for the additional indication of subarachnoidal bleeding...
  23. ncbi request reprint Notch signalling regulates stem cell numbers in vitro and in vivo
    Andreas Androutsellis-Theotokis
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 442:823-6. 2006
    ..These data indicate that stem cell expansion in vitro and in vivo, two central goals of regenerative medicine, may be achieved by Notch ligands through a pathway that is fundamental to development and cancer...
  24. ncbi request reprint Tissue plasminogen activator for stroke in Israel: the time has finally come
    Ronen R Leker
    Isr Med Assoc J 6:95-6. 2004
  25. ncbi request reprint Emergent stenting to treat patients with carotid artery dissection: clinically and radiologically directed therapeutic decision making
    Jose E Cohen
    Department of Neuroradiology, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Stroke 34:e254-7. 2003
    ..Endovascular treatment of CAD may be an attractive alternative to anticoagulation, and methods of identifying patients who stand to benefit from such therapy need to be established...