Natalya M Kogan

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi request reprint Synthesis and antitumor activity of quinonoid derivatives of cannabinoids
    Natalya M Kogan
    Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University, Jerusalem 91120, Israel
    J Med Chem 47:3800-6. 2004
  2. ncbi request reprint HU-331, a novel cannabinoid-based anticancer topoisomerase II inhibitor
    Natalya M Kogan
    Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University, Jerusalem 91120, Israel
    Mol Cancer Ther 6:173-83. 2007
  3. ncbi request reprint Cannabinoids and cancer
    Natalya M Kogan
    Hebrew University, Pharmacy School, Department of Medicinal Chemistry and Natural Products, Israel
    Mini Rev Med Chem 5:941-52. 2005
  4. ncbi request reprint A cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cells
    Natalya M Kogan
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, The Hebrew University, Jerusalem 91120, Israel
    Mol Pharmacol 70:51-9. 2006
  5. ncbi request reprint A cannabinoid anticancer quinone, HU-331, is more potent and less cardiotoxic than doxorubicin: a comparative in vivo study
    Natalya M Kogan
    Department of Medicinal Chemistry and Natural Products, Pharmacy School, Ein Kerem Medical Campus, The Hebrew University, Jerusalem 91120, Israel
    J Pharmacol Exp Ther 322:646-53. 2007
  6. ncbi request reprint HU-331: a cannabinoid quinone, with uncommon cytotoxic properties and low toxicity
    Maximilian Peters
    The Hebrew University, Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Jerusalem, Israel
    Expert Opin Investig Drugs 16:1405-13. 2007
  7. pmc Cannabinoids in health and disease
    Natalya M Kogan
    Medicinal Chemistry and Natural Products Dept, Pharmacy School, Ein Kerem Medical Campus, The Hebrew University of Jerusalem, Israel
    Dialogues Clin Neurosci 9:413-30. 2007

Detail Information

Publications7

  1. ncbi request reprint Synthesis and antitumor activity of quinonoid derivatives of cannabinoids
    Natalya M Kogan
    Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University, Jerusalem 91120, Israel
    J Med Chem 47:3800-6. 2004
    ..All three compounds displayed antiproliferative activity in several human cancer cell lines in vitro, and quinone 2 significantly reduced cancer growth of HT-29 cancer in nude mice...
  2. ncbi request reprint HU-331, a novel cannabinoid-based anticancer topoisomerase II inhibitor
    Natalya M Kogan
    Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University, Jerusalem 91120, Israel
    Mol Cancer Ther 6:173-83. 2007
    ..The cannabinoid quinone HU-331 is a highly specific inhibitor of topoisomerase II, compared with most known anticancer quinones. It might represent a new potent anticancer drug...
  3. ncbi request reprint Cannabinoids and cancer
    Natalya M Kogan
    Hebrew University, Pharmacy School, Department of Medicinal Chemistry and Natural Products, Israel
    Mini Rev Med Chem 5:941-52. 2005
    ..Other groups also started work in this field, and today, a wide array of cancer cell lines that are affected is known, and some mechanisms involved have been elucidated...
  4. ncbi request reprint A cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cells
    Natalya M Kogan
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, The Hebrew University, Jerusalem 91120, Israel
    Mol Pharmacol 70:51-9. 2006
    ..A significant decrease in the total area occupied by vessels in HU-331-treated tumors was also observed. These data lead us to consider HU-331 to have high potential as a new antiangiogenic and anticancer drug...
  5. ncbi request reprint A cannabinoid anticancer quinone, HU-331, is more potent and less cardiotoxic than doxorubicin: a comparative in vivo study
    Natalya M Kogan
    Department of Medicinal Chemistry and Natural Products, Pharmacy School, Ein Kerem Medical Campus, The Hebrew University, Jerusalem 91120, Israel
    J Pharmacol Exp Ther 322:646-53. 2007
    ..In vivo, HU-331 was more active and less toxic than doxorubicin and thus it has a high potential for development as a new anticancer drug...
  6. ncbi request reprint HU-331: a cannabinoid quinone, with uncommon cytotoxic properties and low toxicity
    Maximilian Peters
    The Hebrew University, Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Jerusalem, Israel
    Expert Opin Investig Drugs 16:1405-13. 2007
    ..This review summarises the properties of HU-331 and compares it with doxorubicin and other topoisomerase II inhibitors...
  7. pmc Cannabinoids in health and disease
    Natalya M Kogan
    Medicinal Chemistry and Natural Products Dept, Pharmacy School, Ein Kerem Medical Campus, The Hebrew University of Jerusalem, Israel
    Dialogues Clin Neurosci 9:413-30. 2007
    ....