Research Topics
| D KarussisSummaryAffiliation: The Hebrew University Country: Israel Publications
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Detail Information
Publications
Cognitive dysfunction following thalamic stroke: a study of 16 cases and review of the literatureD Karussis
Department of Neurology, Hadassah University Hospital, P O Box 12000, Jerusalem, Israel
J Neurol Sci 172:25-9. 2000..These findings reconfirm those found in previous studies and suggest that the thalamus is part of an integral neuronal network concerned with cognitive functions...- Hematopoietic stem cell transplantation in multiple sclerosis: experimental evidence to rethink the proceduresDimitrios Karussis
Department of Neurology, Hadassah University Hospital, Jerusalem 91120, Israel
J Neurol Sci 223:59-64. 2004..A more radical solution for autoimmunity may involve the use of non-myeloablative allogeneic transplantation... - Neuroprotection in multiple sclerosisDimitrios Karussis
Department of Neurology and the Agnes Ginges Center for Neurogenetics, Laboratory of Neuroimmunology, Hadassah University Hospital, Jerusalem, Ein Karem IL 91120, Israel
Clin Neurol Neurosurg 108:250-4. 2006..It seems that future treatment strategies for MS should combine immunomodulation with neuroprotective modalities to achieve maximal clinical benefit... - Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau proteinHanna Rosenmann
Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel, AHEPA University Hospital, Thessaloniki, Greece
Arch Neurol 63:1459-67. 2006..Vaccination with amyloid-beta peptide was reported to cause marked reduction in amyloid deposition, but it also induced encephalitis. Not much is known regarding neurofibrillary tangle-related autoimmune effects... - Immunomodulation and neuroprotection with mesenchymal bone marrow stem cells (MSCs): a proposed treatment for multiple sclerosis and other neuroimmunological/neurodegenerative diseasesDimitrios Karussis
Department of Neurology and Laboratory of Neuroimmunology and the Agnes Ginges Center for Neurogenetics, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem, IL 91120, Israel
J Neurol Sci 265:131-5. 2008..We therefore developed a explorative protocol for the evaluation of this therapeutic approach in a small group of patients with MS and other neurodegenerative diseases... 
Immunotherapy of multiple sclerosis: the state of the artDimitrios Karussis
Department of Neurology, MS Center and the Agnes Ginges Center for Neurogenetics, Hadassah Hebrew University Hospital, Laboratory of Neuroimmunology, Hadassah, Ein Kerem, Jerusalem, IL 91120, Israel
BioDrugs 27:113-48. 2013....
T cell vaccination benefits relapsing progressive multiple sclerosis patients: a randomized, double-blind clinical trialDimitrios Karussis
Department of Neurology, MS Center and the Agnes Ginges Center for Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
PLoS ONE 7:e50478. 2012..T-cell vaccination (TCV) for multiple sclerosis (MS) refers to treatment with autologous anti-myelin T-cells, attenuated by irradiation. Previously published clinical trials have been all open-labeled...- Clinical experience with stem cells and other cell therapies in neurological diseasesDimitrios Karussis
Department of Neurology, MS Center and Laboratory of Neuroimmunology, Agnes Ginges Center for Neurogenetics, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel
J Neurol Sci 324:1-9. 2013..This review summarizes the state-of-the-art and the clinical worldwide experience with the use of various types of stem cells in neurological diseases... - Use of stem cells for the treatment of multiple sclerosisDimitrios Karussis
Department of Neurology, Laboratory of Neuroimmunology, Hadassah Hebrew University Center, Jerusalem, Ein Karem, IL 91120, Israel
Expert Rev Neurother 7:1189-201. 2007.... - The potential use of stem cells in multiple sclerosis: an overview of the preclinical experienceDimitrios Karussis
Department of Neurology, Laboratory of Neuroimmunology, Agnes Ginges Center for Neurogenetics, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem, Israel
Clin Neurol Neurosurg 110:889-96. 2008..In this review, we summarize the experience with the use of different types of stem cells in the animal models of MS (EAE) and we describe the advantages and disadvantages of each stem cell type for future clinical applications in MS... - Lack of apolipoprotein-E exacerbates experimental allergic encephalomyelitisD Karussis
Department of Neurology, Laboratory of Neuroimmunology and the Agnes Ginges Center for Neurogenetics, Hadassah Medical Center, Hebrew University, Jerusalem, Israel
Mult Scler 9:476-80. 2003..Defective neuronal repair mechanisms and enhanced immune reactivity in apoE deficient mice may explain our findings. Clinical implications for MS are discussed... - Hematopoietic stem cell transplantation in multiple sclerosis: a review of the clinical experience and a report of an international meetingDimitrios Karussis
Department of Neurology, MS Center and Laboratory of Neuroimmunology, Hadassah Hebrew University Hospital, Jerusalem, IL 91120 Israel
Expert Rev Clin Immunol 6:347-52. 2010.... - Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosisDimitrios Karussis
Department of Neurology, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem IL 91120, Israel
Arch Neurol 67:1187-94. 2010.... - The Ras-pathway inhibitor, S-trans-trans-farnesylthiosalicylic acid, suppresses experimental allergic encephalomyelitisD Karussis
Department of Neurology and Laboratory of Neuroimmunology, Agnes Ginges Center for Human Neurogenetics, Hadassah Medical Center, Hebrew University, IL 91120, Jerusalem, Israel
J Neuroimmunol 120:1-9. 2001..To evaluate the effects of the synthetic Ras-pathway inhibitor, S-trans-trans-farnesylthiosalicylic acid (FTS) on acute and chronic experimental autoimmune encephalomyelitis (EAE and CR-EAE)... - Linomide downregulates autoimmunity through induction of TH2 cytokine production by lymphocytesD Karussis
Department of Neurology, Hadassah Hebrew University Hospital, Jerusalem, Israel
Immunol Lett 67:203-8. 1999..These data may contribute to the design of new immunomodulating treatments for a group of autoimmune diseases... - Inhibition of experimental autoimmune neuritis by the immunomodulator linomideT Karpati
Department of Neurology, Hadassah University Hospital, Hebrew University Hadassah, Medical School, Jerusalem, Israel
Immunol Lett 63:141-5. 1998..Furthermore, a downregulation of the endothelial expression of the adhesion molecules ICAM-1 at the target site and LFA-1 on lymphocytes could also contribute to the absence of inflammatory cells in the neuraxis... - Polyneuropathy associated with interferon beta treatment in patients with multiple sclerosisDana Ekstein
Department of Neurology, The Agnes Ginges Center for Neurogenetics, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem, Israel
Neurology 65:456-8. 2005..In five patients the neuropathy improved after discontinuation of treatment and in two patients it relapsed upon rechallenge... - CD44 involvement in autoimmune inflammations: the lesson to be learned from CD44-targeting by antibody or from knockout miceDavid Naor
The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Ann N Y Acad Sci 1110:233-47. 2007..The mechanisms that stand behind these findings are discussed... - Pseudo-quadriceps sparing in multiple sclerosisN Levin
Department of Neurology and the Agnes Ginges Center for Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
Eur J Neurol 18:1184-6. 2011..Sparing of the quadriceps muscle has been reported in various myopathies. In multiple sclerosis (MS) and pyramidal syndromes, in general, such a differential involvement of distinct muscle groups has not been described... - Familial Mediterranean fever (FMF) and multiple sclerosis: an association study in one of the world's largest FMF cohortsG Yahalom
Department of Neurology, The Chaim Sheba Medical Center, Tel Hashomer, Israel
Eur J Neurol 18:1146-50. 2011..To describe and characterize the association between familial Mediterranean fever (FMF) and multiple sclerosis (MS)... - Extrathymic malignancies in patients with myasthenia gravisNetta Levin
Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah-Hebrew University Hospital, Jerusalem 91120, Israel
J Neurol Sci 237:39-43. 2005..Although MG is not a paraneoplastic phenomenon of extrathymic malignancy, the association between MG and malignancy may be due to a common background of immune dysregulation... - Transplanted multipotential neural precursor cells migrate into the inflamed white matter in response to experimental autoimmune encephalomyelitisTamir Ben-Hur
Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
Glia 41:73-80. 2003..Thus, the inflammatory process may attract targeted migration of transplanted precursor cells into the brain parenchyma... - Amelioration of experimental colitis by Copaxone is associated with class-II-restricted CD4 immune blockingChamutal Gur
Liver Unit, Hadassah University Hospital, Jerusalem, Israel
Clin Immunol 118:307-16. 2006..CONCLUSIONS: Copaxone had class-II-restricted anti-inflammatory effect in our animal colitis model associated with CD4/NK/NKT/TH1/TH2 suppression... - Neuroprotection and immunomodulation with mesenchymal stem cells in chronic experimental autoimmune encephalomyelitisIbrahim Kassis
Department of Neurology and Agnes Ginges Center for Neurogenetics, Jerusalem, Israel
Arch Neurol 65:753-61. 2008..To investigate the therapeutic potential of mesenchymal stromal cells (MSCs) in the chronic model of experimental autoimmune encephalomyelitis (EAE)... - Transplanted neural precursor cells reduce brain inflammation to attenuate chronic experimental autoimmune encephalomyelitisOfira Einstein
Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah--Hebrew University Hospital, Jerusalem, Israel
Exp Neurol 198:275-84. 2006..We suggest that the beneficial effect of transplanted NPCs in chronic EAE is mediated, in part, by decreasing brain inflammation and reducing tissue injury... - CD44 variant DNA vaccination with virtual lymph node ameliorates experimental autoimmune encephalomyelitis through the induction of apoptosisTali Garin
Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
J Neurol Sci 258:17-26. 2007..Such methods of cDNA vaccination with CD44 could be applicable in inflammatory CNS diseases, like multiple sclerosis... - Bone marrow mesenchymal stem cells: agents of immunomodulation and neuroprotectionIbrahim Kassis
Department of Neurology, Laboratory of Neuroimmunology, Agnes Ginges Center for Neurogenetics, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem, Israel
Curr Stem Cell Res Ther 6:63-8. 2011..These immunomodulatory and neuroprotective features could make MSCs potential candidates for future therapeutic modalities in immune-mediated and neurodegenerative diseases... - Neuroimmunology in Israel--2002: proceedings of the 2nd annual meeting of the Israel society of neuroimmunologyDimitrios Karussis
Department of Neurology, Hadassah Medical Center, Jerusalem, Israel
J Neuroimmunol 131:1-4. 2002 - Influence of progesterone and clomiphene on Tolosa-Hunt syndromeNetta Levin
Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital and the Hebrew University-Hadassah Medical School, Jerusalem, Israel
Neurology 59:1661-2. 2002 - Opposing effects of the HLA-DRB1*0301-DQB1*0201 haplotype on the risk for multiple sclerosis in diverse Arab populations in IsraelG Benedek
The Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
Genes Immun 11:423-31. 2010.... - The frequency of multiple sclerosis in jewish and arab populations in greater jerusalemArnon Karni
Department of Neurology, Barzilai Medical Center, Ashkelon, Israel
Neuroepidemiology 22:82-6. 2003..The IR of I-E/A was higher than that of I-A/A and Arabs, although this difference did not reach statistical significance... - Intraventricular transplantation of neural precursor cell spheres attenuates acute experimental allergic encephalomyelitisOfira Einstein
Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah-Hebrew University Hospital, Jerusalem, Israel
Mol Cell Neurosci 24:1074-82. 2003..Thus, transplanted NPCs attenuate acute EAE via an anti-inflammatory mechanism which depends on cell ability to migrate into inflamed brain tissue... - [Autoimmune mechanisms in paraneoplastic neurological diseases: the paradigm of opsoclonus myoclonus ataxia syndrome]Haim Ovadia
Department of Neurology, The Agnes Ginges Center of Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel
Harefuah 145:298-303, 317. 2006..The availability of onconeural antigens to the immune effectors mechanisms is probably the main reason why there are few animal models for PND... - Severe skin reaction related to mycophenolate mofetil for myasthenia gravisNetta Levin
Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Jerusalem, Israel
Clin Neuropharmacol 28:152-3. 2005.... - Integrating an evidence-based assessment of benefit and risk in disease-modifying treatment of multiple sclerosisDouglas S Goodin
Department of Neurology, University of California, San Francisco, CA 94121, USA Email
Curr Med Res Opin 23:2823-32. 2007.... - Axonal damage in multiple sclerosis: a complex issue in a complex diseaseNikolaos Grigoriadis
Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, 1 Stilp Kyriakidi Str, 54636 Thessaloniki, Greece
Clin Neurol Neurosurg 106:211-7. 2004..Experimental data suggest that therapeutic interventions such as the induction of rapid remyelination may lead to the protection of axons. In addition to immunomodulation, future strategies for neuroprotection may be of great importance... - Hematopoietic stem cell transplantation for multiple sclerosisRichard K Burt
Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
Arch Neurol 62:860-4. 2005 - Neuroinflammation in multiple sclerosis: evidence for autoimmune dysregulation, not simple autoimmune reactionNikolaos Grigoriadis
Department of Neurology, Laboratory of Experimental Neurology and Neuroimmunology, AHEPA University Hospital, Aristotle University of Thessaloniki, 1 Stilp Kyriakidi str 54636, Thessaloniki, Greece
Clin Neurol Neurosurg 108:241-4. 2006....