D Karussis

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi request reprint Hematopoietic stem cell transplantation in multiple sclerosis: experimental evidence to rethink the procedures
    Dimitrios Karussis
    Department of Neurology, Hadassah University Hospital, Jerusalem 91120, Israel
    J Neurol Sci 223:59-64. 2004
  2. ncbi request reprint Neuroprotection in multiple sclerosis
    Dimitrios Karussis
    Department of Neurology and the Agnes Ginges Center for Neurogenetics, Laboratory of Neuroimmunology, Hadassah University Hospital, Jerusalem, Ein Karem IL 91120, Israel
    Clin Neurol Neurosurg 108:250-4. 2006
  3. ncbi request reprint Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein
    Hanna Rosenmann
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel, AHEPA University Hospital, Thessaloniki, Greece
    Arch Neurol 63:1459-67. 2006
  4. ncbi request reprint Immunomodulation and neuroprotection with mesenchymal bone marrow stem cells (MSCs): a proposed treatment for multiple sclerosis and other neuroimmunological/neurodegenerative diseases
    Dimitrios Karussis
    Department of Neurology and Laboratory of Neuroimmunology and the Agnes Ginges Center for Neurogenetics, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem, IL 91120, Israel
    J Neurol Sci 265:131-5. 2008
  5. pmc Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis
    Dimitrios Karussis
    Department of Neurology, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem IL 91120, Israel
    Arch Neurol 67:1187-94. 2010
  6. doi request reprint Hematopoietic stem cell transplantation in multiple sclerosis
    Dimitrios Karussis
    Department of Neurology, Multiple sclerosis Center and Laboratory of Neuroimmunology, The Agnes Ginges Center for Neurogenetics, Hadassah University Hospital, Jerusalem, Ein Kerem, Israel
    Expert Rev Neurother 13:567-78. 2013
  7. doi request reprint Immunotherapy of multiple sclerosis: the state of the art
    Dimitrios Karussis
    Department of Neurology, MS Center and the Agnes Ginges Center for Neurogenetics, Hadassah Hebrew University Hospital, Laboratory of Neuroimmunology, Hadassah, Ein Kerem, Jerusalem, IL 91120, Israel
    BioDrugs 27:113-48. 2013
  8. pmc T cell vaccination benefits relapsing progressive multiple sclerosis patients: a randomized, double-blind clinical trial
    Dimitrios Karussis
    Department of Neurology, MS Center and the Agnes Ginges Center for Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
    PLoS ONE 7:e50478. 2012
  9. doi request reprint Clinical experience with stem cells and other cell therapies in neurological diseases
    Dimitrios Karussis
    Department of Neurology, MS Center and Laboratory of Neuroimmunology, Agnes Ginges Center for Neurogenetics, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel
    J Neurol Sci 324:1-9. 2013
  10. ncbi request reprint Use of stem cells for the treatment of multiple sclerosis
    Dimitrios Karussis
    Department of Neurology, Laboratory of Neuroimmunology, Hadassah Hebrew University Center, Jerusalem, Ein Karem, IL 91120, Israel
    Expert Rev Neurother 7:1189-201. 2007

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Hematopoietic stem cell transplantation in multiple sclerosis: experimental evidence to rethink the procedures
    Dimitrios Karussis
    Department of Neurology, Hadassah University Hospital, Jerusalem 91120, Israel
    J Neurol Sci 223:59-64. 2004
    ..A more radical solution for autoimmunity may involve the use of non-myeloablative allogeneic transplantation...
  2. ncbi request reprint Neuroprotection in multiple sclerosis
    Dimitrios Karussis
    Department of Neurology and the Agnes Ginges Center for Neurogenetics, Laboratory of Neuroimmunology, Hadassah University Hospital, Jerusalem, Ein Karem IL 91120, Israel
    Clin Neurol Neurosurg 108:250-4. 2006
    ..It seems that future treatment strategies for MS should combine immunomodulation with neuroprotective modalities to achieve maximal clinical benefit...
  3. ncbi request reprint Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein
    Hanna Rosenmann
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel, AHEPA University Hospital, Thessaloniki, Greece
    Arch Neurol 63:1459-67. 2006
    ..Vaccination with amyloid-beta peptide was reported to cause marked reduction in amyloid deposition, but it also induced encephalitis. Not much is known regarding neurofibrillary tangle-related autoimmune effects...
  4. ncbi request reprint Immunomodulation and neuroprotection with mesenchymal bone marrow stem cells (MSCs): a proposed treatment for multiple sclerosis and other neuroimmunological/neurodegenerative diseases
    Dimitrios Karussis
    Department of Neurology and Laboratory of Neuroimmunology and the Agnes Ginges Center for Neurogenetics, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem, IL 91120, Israel
    J Neurol Sci 265:131-5. 2008
    ..We therefore developed a explorative protocol for the evaluation of this therapeutic approach in a small group of patients with MS and other neurodegenerative diseases...
  5. pmc Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis
    Dimitrios Karussis
    Department of Neurology, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem IL 91120, Israel
    Arch Neurol 67:1187-94. 2010
    ....
  6. doi request reprint Hematopoietic stem cell transplantation in multiple sclerosis
    Dimitrios Karussis
    Department of Neurology, Multiple sclerosis Center and Laboratory of Neuroimmunology, The Agnes Ginges Center for Neurogenetics, Hadassah University Hospital, Jerusalem, Ein Kerem, Israel
    Expert Rev Neurother 13:567-78. 2013
    ....
  7. doi request reprint Immunotherapy of multiple sclerosis: the state of the art
    Dimitrios Karussis
    Department of Neurology, MS Center and the Agnes Ginges Center for Neurogenetics, Hadassah Hebrew University Hospital, Laboratory of Neuroimmunology, Hadassah, Ein Kerem, Jerusalem, IL 91120, Israel
    BioDrugs 27:113-48. 2013
    ....
  8. pmc T cell vaccination benefits relapsing progressive multiple sclerosis patients: a randomized, double-blind clinical trial
    Dimitrios Karussis
    Department of Neurology, MS Center and the Agnes Ginges Center for Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
    PLoS ONE 7:e50478. 2012
    ..T-cell vaccination (TCV) for multiple sclerosis (MS) refers to treatment with autologous anti-myelin T-cells, attenuated by irradiation. Previously published clinical trials have been all open-labeled...
  9. doi request reprint Clinical experience with stem cells and other cell therapies in neurological diseases
    Dimitrios Karussis
    Department of Neurology, MS Center and Laboratory of Neuroimmunology, Agnes Ginges Center for Neurogenetics, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel
    J Neurol Sci 324:1-9. 2013
    ..This review summarizes the state-of-the-art and the clinical worldwide experience with the use of various types of stem cells in neurological diseases...
  10. ncbi request reprint Use of stem cells for the treatment of multiple sclerosis
    Dimitrios Karussis
    Department of Neurology, Laboratory of Neuroimmunology, Hadassah Hebrew University Center, Jerusalem, Ein Karem, IL 91120, Israel
    Expert Rev Neurother 7:1189-201. 2007
    ....
  11. doi request reprint The potential use of stem cells in multiple sclerosis: an overview of the preclinical experience
    Dimitrios Karussis
    Department of Neurology, Laboratory of Neuroimmunology, Agnes Ginges Center for Neurogenetics, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem, Israel
    Clin Neurol Neurosurg 110:889-96. 2008
    ..In this review, we summarize the experience with the use of different types of stem cells in the animal models of MS (EAE) and we describe the advantages and disadvantages of each stem cell type for future clinical applications in MS...
  12. doi request reprint Hematopoietic stem cell transplantation in multiple sclerosis: a review of the clinical experience and a report of an international meeting
    Dimitrios Karussis
    Department of Neurology, MS Center and Laboratory of Neuroimmunology, Hadassah Hebrew University Hospital, Jerusalem, IL 91120 Israel
    Expert Rev Clin Immunol 6:347-52. 2010
    ....
  13. ncbi request reprint Lack of apolipoprotein-E exacerbates experimental allergic encephalomyelitis
    D Karussis
    Department of Neurology, Laboratory of Neuroimmunology and the Agnes Ginges Center for Neurogenetics, Hadassah Medical Center, Hebrew University, Jerusalem, Israel
    Mult Scler 9:476-80. 2003
    ..Defective neuronal repair mechanisms and enhanced immune reactivity in apoE deficient mice may explain our findings. Clinical implications for MS are discussed...
  14. ncbi request reprint The Ras-pathway inhibitor, S-trans-trans-farnesylthiosalicylic acid, suppresses experimental allergic encephalomyelitis
    D Karussis
    Department of Neurology and Laboratory of Neuroimmunology, Agnes Ginges Center for Human Neurogenetics, Hadassah Medical Center, Hebrew University, IL 91120, Jerusalem, Israel
    J Neuroimmunol 120:1-9. 2001
    ..To evaluate the effects of the synthetic Ras-pathway inhibitor, S-trans-trans-farnesylthiosalicylic acid (FTS) on acute and chronic experimental autoimmune encephalomyelitis (EAE and CR-EAE)...
  15. ncbi request reprint Cognitive dysfunction following thalamic stroke: a study of 16 cases and review of the literature
    D Karussis
    Department of Neurology, Hadassah University Hospital, P O Box 12000, Jerusalem, Israel
    J Neurol Sci 172:25-9. 2000
    ..These findings reconfirm those found in previous studies and suggest that the thalamus is part of an integral neuronal network concerned with cognitive functions...
  16. ncbi request reprint Linomide downregulates autoimmunity through induction of TH2 cytokine production by lymphocytes
    D Karussis
    Department of Neurology, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Immunol Lett 67:203-8. 1999
    ..These data may contribute to the design of new immunomodulating treatments for a group of autoimmune diseases...
  17. ncbi request reprint Inhibition of experimental autoimmune neuritis by the immunomodulator linomide
    T Karpati
    Department of Neurology, Hadassah University Hospital, Hebrew University Hadassah, Medical School, Jerusalem, Israel
    Immunol Lett 63:141-5. 1998
    ..Furthermore, a downregulation of the endothelial expression of the adhesion molecules ICAM-1 at the target site and LFA-1 on lymphocytes could also contribute to the absence of inflammatory cells in the neuraxis...
  18. ncbi request reprint Polyneuropathy associated with interferon beta treatment in patients with multiple sclerosis
    Dana Ekstein
    Department of Neurology, The Agnes Ginges Center for Neurogenetics, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem, Israel
    Neurology 65:456-8. 2005
    ..In five patients the neuropathy improved after discontinuation of treatment and in two patients it relapsed upon rechallenge...
  19. ncbi request reprint CD44 involvement in autoimmune inflammations: the lesson to be learned from CD44-targeting by antibody or from knockout mice
    David Naor
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Ann N Y Acad Sci 1110:233-47. 2007
    ..The mechanisms that stand behind these findings are discussed...
  20. doi request reprint Pseudo-quadriceps sparing in multiple sclerosis
    N Levin
    Department of Neurology and the Agnes Ginges Center for Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Eur J Neurol 18:1184-6. 2011
    ..Sparing of the quadriceps muscle has been reported in various myopathies. In multiple sclerosis (MS) and pyramidal syndromes, in general, such a differential involvement of distinct muscle groups has not been described...
  21. doi request reprint Familial Mediterranean fever (FMF) and multiple sclerosis: an association study in one of the world's largest FMF cohorts
    G Yahalom
    Department of Neurology, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Eur J Neurol 18:1146-50. 2011
    ..To describe and characterize the association between familial Mediterranean fever (FMF) and multiple sclerosis (MS)...
  22. ncbi request reprint Amelioration of experimental colitis by Copaxone is associated with class-II-restricted CD4 immune blocking
    Chamutal Gur
    Liver Unit, Hadassah University Hospital, Jerusalem, Israel
    Clin Immunol 118:307-16. 2006
    ..Copaxone modifies TH1 immune response in multiple sclerosis. As Crohn's disease shares TH1 predominance, this study came to investigate the anti-inflammatory response of Copaxone in animal model of colitis...
  23. ncbi request reprint Transplanted multipotential neural precursor cells migrate into the inflamed white matter in response to experimental autoimmune encephalomyelitis
    Tamir Ben-Hur
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Glia 41:73-80. 2003
    ..Thus, the inflammatory process may attract targeted migration of transplanted precursor cells into the brain parenchyma...
  24. ncbi request reprint Extrathymic malignancies in patients with myasthenia gravis
    Netta Levin
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel
    J Neurol Sci 237:39-43. 2005
    ..Data on clinical characteristics of MG patients with extrathymic malignancies and the role of concomitant diseases and their treatment are lacking...
  25. doi request reprint Neuroprotection and immunomodulation with mesenchymal stem cells in chronic experimental autoimmune encephalomyelitis
    Ibrahim Kassis
    Department of Neurology and Agnes Ginges Center for Neurogenetics, Jerusalem, Israel
    Arch Neurol 65:753-61. 2008
    ..To investigate the therapeutic potential of mesenchymal stromal cells (MSCs) in the chronic model of experimental autoimmune encephalomyelitis (EAE)...
  26. ncbi request reprint Transplanted neural precursor cells reduce brain inflammation to attenuate chronic experimental autoimmune encephalomyelitis
    Ofira Einstein
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Exp Neurol 198:275-84. 2006
    ..We suggest that the beneficial effect of transplanted NPCs in chronic EAE is mediated, in part, by decreasing brain inflammation and reducing tissue injury...
  27. ncbi request reprint CD44 variant DNA vaccination with virtual lymph node ameliorates experimental autoimmune encephalomyelitis through the induction of apoptosis
    Tali Garin
    Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Neurol Sci 258:17-26. 2007
    ..Such methods of cDNA vaccination with CD44 could be applicable in inflammatory CNS diseases, like multiple sclerosis...
  28. ncbi request reprint Bone marrow mesenchymal stem cells: agents of immunomodulation and neuroprotection
    Ibrahim Kassis
    Department of Neurology, Laboratory of Neuroimmunology, Agnes Ginges Center for Neurogenetics, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem, Israel
    Curr Stem Cell Res Ther 6:63-8. 2011
    ..These immunomodulatory and neuroprotective features could make MSCs potential candidates for future therapeutic modalities in immune-mediated and neurodegenerative diseases...
  29. ncbi request reprint Neuroimmunology in Israel--2002: proceedings of the 2nd annual meeting of the Israel society of neuroimmunology
    Dimitrios Karussis
    Department of Neurology, Hadassah Medical Center, Jerusalem, Israel
    J Neuroimmunol 131:1-4. 2002
  30. ncbi request reprint The frequency of multiple sclerosis in jewish and arab populations in greater jerusalem
    Arnon Karni
    Department of Neurology, Barzilai Medical Center, Ashkelon, Israel
    Neuroepidemiology 22:82-6. 2003
    ..The IR of I-E/A was higher than that of I-A/A and Arabs, although this difference did not reach statistical significance...
  31. doi request reprint Opposing effects of the HLA-DRB1*0301-DQB1*0201 haplotype on the risk for multiple sclerosis in diverse Arab populations in Israel
    G Benedek
    The Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Genes Immun 11:423-31. 2010
    ....
  32. ncbi request reprint Intraventricular transplantation of neural precursor cell spheres attenuates acute experimental allergic encephalomyelitis
    Ofira Einstein
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Mol Cell Neurosci 24:1074-82. 2003
    ..Thus, transplanted NPCs attenuate acute EAE via an anti-inflammatory mechanism which depends on cell ability to migrate into inflamed brain tissue...
  33. ncbi request reprint Severe skin reaction related to mycophenolate mofetil for myasthenia gravis
    Netta Levin
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Jerusalem, Israel
    Clin Neuropharmacol 28:152-3. 2005
    ....
  34. ncbi request reprint Influence of progesterone and clomiphene on Tolosa-Hunt syndrome
    Netta Levin
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital and the Hebrew University Hadassah Medical School, Jerusalem, Israel
    Neurology 59:1661-2. 2002
  35. ncbi request reprint [Autoimmune mechanisms in paraneoplastic neurological diseases: the paradigm of opsoclonus myoclonus ataxia syndrome]
    Haim Ovadia
    Department of Neurology, The Agnes Ginges Center of Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel
    Harefuah 145:298-303, 317. 2006
    ..The availability of onconeural antigens to the immune effectors mechanisms is probably the main reason why there are few animal models for PND...
  36. ncbi request reprint Neuroinflammation in multiple sclerosis: evidence for autoimmune dysregulation, not simple autoimmune reaction
    Nikolaos Grigoriadis
    Department of Neurology, Laboratory of Experimental Neurology and Neuroimmunology, AHEPA University Hospital, Aristotle University of Thessaloniki, 1 Stilp Kyriakidi str 54636, Thessaloniki, Greece
    Clin Neurol Neurosurg 108:241-4. 2006
    ....
  37. ncbi request reprint Integrating an evidence-based assessment of benefit and risk in disease-modifying treatment of multiple sclerosis
    Douglas S Goodin
    Department of Neurology, University of California, San Francisco, CA 94121, USA Email
    Curr Med Res Opin 23:2823-32. 2007
    ....
  38. ncbi request reprint Hematopoietic stem cell transplantation for multiple sclerosis
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    Arch Neurol 62:860-4. 2005
  39. ncbi request reprint Axonal damage in multiple sclerosis: a complex issue in a complex disease
    Nikolaos Grigoriadis
    Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, 1 Stilp Kyriakidi Str, 54636 Thessaloniki, Greece
    Clin Neurol Neurosurg 106:211-7. 2004
    ..Experimental data suggest that therapeutic interventions such as the induction of rapid remyelination may lead to the protection of axons. In addition to immunomodulation, future strategies for neuroprotection may be of great importance...