Uriel Heresco-Levy

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi request reprint D-serine efficacy as add-on pharmacotherapy to risperidone and olanzapine for treatment-refractory schizophrenia
    Uriel Heresco-Levy
    Ezrath Nashim Herzog Memorial Hospital, Jerusalem, Israel Department of Psychiatry, Hadassah Medical School, Hebrew University, Jerusalem, Israel
    Biol Psychiatry 57:577-85. 2005
  2. ncbi request reprint Controlled trial of D-cycloserine adjuvant therapy for treatment-resistant major depressive disorder
    Uriel Heresco-Levy
    Ezrath Nashim Herzog Memorial Hospital and Department of Psychiatry, Hadassah Medical School, Hebrew University, Jerusalem, Israel
    J Affect Disord 93:239-43. 2006
  3. doi request reprint Glycine site agonists of the N-methyl-D-aspartate receptor and Parkinson's disease: a hypothesis
    Uriel Heresco-Levy
    Psychiatry Department, Ezrath Nashim Herzog Memorial Hospital and Hebrew University Hadassah Medical School, Jerusalem, Israel
    Mov Disord 28:419-24. 2013
  4. doi request reprint A randomized add-on trial of high-dose D-cycloserine for treatment-resistant depression
    Uriel Heresco-Levy
    Psychiatry Department, Ezrath Nashim Herzog Memorial Hospital, Jerusalem, Israel
    Int J Neuropsychopharmacol 16:501-6. 2013
  5. ncbi request reprint Glutamatergic neurotransmission modulators as emerging new drugs for schizophrenia
    Uriel Heresco-Levy
    Ezrath Nashim Sarah Herzog Memorial Hospital, Psychiatry Department, Hadassah Medical School, Hebrew University, PO Box 3900, Jerusalem 91035, Israel
    Expert Opin Emerg Drugs 10:827-44. 2005
  6. ncbi request reprint Comparative effects of glycine and D-cycloserine on persistent negative symptoms in schizophrenia: a retrospective analysis
    Uriel Heresco-Levy
    Ezrath Nashim Sarah Herzog Memorial Hospital, P O Box 35300, Givat Shaul, Jerusalem, Israel
    Schizophr Res 66:89-96. 2004
  7. ncbi request reprint High glycine levels are associated with prepulse inhibition deficits in chronic schizophrenia patients
    Uriel Heresco-Levy
    Psychiatry and Research Department, Ezrath Nashim Herzog Memorial Hospital, P O Box 3900, Givat Shaul 91351, Jerusalem, Israel
    Schizophr Res 91:14-21. 2007
  8. doi request reprint Pilot controlled trial of D-serine for the treatment of post-traumatic stress disorder
    Uriel Heresco-Levy
    Psychiatry and Research Departments, Ezrath Nashim Herzog Memorial Hospital, Jerusalem, Israel
    Int J Neuropsychopharmacol 12:1275-82. 2009
  9. ncbi request reprint Placebo-controlled trial of D-cycloserine added to conventional neuroleptics, olanzapine, or risperidone in schizophrenia
    Uriel Heresco-Levy
    Ezrath Nashim Herzog Memorial Hospital, Jerusalem, Israel
    Am J Psychiatry 159:480-2. 2002
  10. ncbi request reprint Relation of plasma glycine, serine, and homocysteine levels to schizophrenia symptoms and medication type
    Guy Neeman
    Ezrath Nashim Herzog Memorial Hospital, P O Box 3900, Jerusalem 91035, Israel
    Am J Psychiatry 162:1738-40. 2005

Collaborators

Detail Information

Publications38

  1. ncbi request reprint D-serine efficacy as add-on pharmacotherapy to risperidone and olanzapine for treatment-refractory schizophrenia
    Uriel Heresco-Levy
    Ezrath Nashim Herzog Memorial Hospital, Jerusalem, Israel Department of Psychiatry, Hadassah Medical School, Hebrew University, Jerusalem, Israel
    Biol Psychiatry 57:577-85. 2005
    ..We assessed the efficacy and safety of D-serine adjuvant treatment for Occidental schizophrenia patients treated with newer atypical antipsychotics...
  2. ncbi request reprint Controlled trial of D-cycloserine adjuvant therapy for treatment-resistant major depressive disorder
    Uriel Heresco-Levy
    Ezrath Nashim Herzog Memorial Hospital and Department of Psychiatry, Hadassah Medical School, Hebrew University, Jerusalem, Israel
    J Affect Disord 93:239-43. 2006
    ..The antibiotic drug d-cycloserine (DCS) acts as a partial agonist at the NMDAR-GLY site. Preclinical and clinical data suggest that at dosages >or=100 mg/day DCS acts as a functional NMDAR antagonist and may have antidepressant effects...
  3. doi request reprint Glycine site agonists of the N-methyl-D-aspartate receptor and Parkinson's disease: a hypothesis
    Uriel Heresco-Levy
    Psychiatry Department, Ezrath Nashim Herzog Memorial Hospital and Hebrew University Hadassah Medical School, Jerusalem, Israel
    Mov Disord 28:419-24. 2013
    ..This hypothesis is discussed in the context of glycine site agonist effects on intrasynaptic NMDAR subunits and striatal synaptic plasticity...
  4. doi request reprint A randomized add-on trial of high-dose D-cycloserine for treatment-resistant depression
    Uriel Heresco-Levy
    Psychiatry Department, Ezrath Nashim Herzog Memorial Hospital, Jerusalem, Israel
    Int J Neuropsychopharmacol 16:501-6. 2013
    ..These findings indicate that NMDAR glycine site antagonism may be a cost-effective target for development of mechanistically novel antidepressants. Larger-sized DCS trials are warranted...
  5. ncbi request reprint Glutamatergic neurotransmission modulators as emerging new drugs for schizophrenia
    Uriel Heresco-Levy
    Ezrath Nashim Sarah Herzog Memorial Hospital, Psychiatry Department, Hadassah Medical School, Hebrew University, PO Box 3900, Jerusalem 91035, Israel
    Expert Opin Emerg Drugs 10:827-44. 2005
    ..Ongoing and planned research is expected to provide, in the near future, critical information regarding the practical utility and tolerability of glutamatergic approaches for schizophrenia pharmacotherapy...
  6. ncbi request reprint Comparative effects of glycine and D-cycloserine on persistent negative symptoms in schizophrenia: a retrospective analysis
    Uriel Heresco-Levy
    Ezrath Nashim Sarah Herzog Memorial Hospital, P O Box 35300, Givat Shaul, Jerusalem, Israel
    Schizophr Res 66:89-96. 2004
    ..Overall, the findings indicate that agents which potentiate NMDA transmission may be therapeutically beneficial in treatment of persistent symptoms of schizophrenia...
  7. ncbi request reprint High glycine levels are associated with prepulse inhibition deficits in chronic schizophrenia patients
    Uriel Heresco-Levy
    Psychiatry and Research Department, Ezrath Nashim Herzog Memorial Hospital, P O Box 3900, Givat Shaul 91351, Jerusalem, Israel
    Schizophr Res 91:14-21. 2007
    ..4, p=0.03). These preliminary findings indirectly support previous observations on ketamine effects upon PPI in humans and suggest a dissociation of symptomatology and PPI changes as function of NMDAR modulation in schizophrenia...
  8. doi request reprint Pilot controlled trial of D-serine for the treatment of post-traumatic stress disorder
    Uriel Heresco-Levy
    Psychiatry and Research Departments, Ezrath Nashim Herzog Memorial Hospital, Jerusalem, Israel
    Int J Neuropsychopharmacol 12:1275-82. 2009
    ..07) towards improved CAPS total scores. These preliminary findings indicate that NMDAR glycine site-based pharmacotherapy may be effective in PTSD and warrant larger-sized clinical trials with optimized DSR dosages...
  9. ncbi request reprint Placebo-controlled trial of D-cycloserine added to conventional neuroleptics, olanzapine, or risperidone in schizophrenia
    Uriel Heresco-Levy
    Ezrath Nashim Herzog Memorial Hospital, Jerusalem, Israel
    Am J Psychiatry 159:480-2. 2002
    ..The authors investigated the clinical effects of D-cycloserine when added to treatment with conventional neuroleptics, olanzapine, or risperidone for treatment-resistant schizophrenia...
  10. ncbi request reprint Relation of plasma glycine, serine, and homocysteine levels to schizophrenia symptoms and medication type
    Guy Neeman
    Ezrath Nashim Herzog Memorial Hospital, P O Box 3900, Jerusalem 91035, Israel
    Am J Psychiatry 162:1738-40. 2005
    ..The authors measured plasma levels of these amino acids in a group of patients with chronic schizophrenia and related them to the patients' symptom profiles and types of antipsychotic medication...
  11. ncbi request reprint Placebo-controlled trial of lamotrigine added to conventional and atypical antipsychotics in schizophrenia
    Ilana Kremer
    Psychiatry Department, Haemek Hospital, Afula, Israel
    Biol Psychiatry 56:441-6. 2004
    ..Similar effects were not observed in an open trial in which lamotrigine was used as adjuvant to nonclozapine antipsychotics...
  12. ncbi request reprint Interactive effect of cytochrome P450 17alpha-hydroxylase and dopamine D3 receptor gene polymorphisms on abnormal involuntary movements in chronic schizophrenia
    Ronnen H Segman
    Biological Psychiatry Laboratory, Department of Psychiatry Hadassah, Hebrew University Medical Center, Jerusalem, Israel
    Biol Psychiatry 51:261-3. 2002
    ..We investigated the association of a T -->C variation in the cytochrome P 450 17alpha-hydroxylase gene with tardive dyskinesia in patients with chronic schizophrenia...
  13. ncbi request reprint High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia
    Uriel Heresco-Levy
    Ezrath Nashim Herzog Memorial Hospital, Department of Psychiatry, Hadassah Medical School Hebrew University, Jerusalem, Israel
    Biol Psychiatry 55:165-71. 2004
    ..In this study, we assessed whether high-dose glycine may also be therapeutically beneficial when added to olanzapine and risperidone treatment...
  14. ncbi request reprint Pilot-controlled trial of D-cycloserine for the treatment of post-traumatic stress disorder
    Uriel Heresco-Levy
    Ezrath Nashim Herzog Memorial Hospital, and Department of Psychiatry, Hadassah Medical School Hebrew University, Jerusalem, Israel
    Int J Neuropsychopharmacol 5:301-7. 2002
    ..This pilot study is the first to assess the efficacy of a NMDA receptor modulator for PTSD treatment and its results warrant further, larger-scale investigation...
  15. ncbi request reprint Reduced prepulse inhibition is associated with increased hypnotizability
    Pesach Lichtenberg
    Department of Psychiatry, Ezrath Nashim Herzog Memorial Hospital, and Hadassah Medical School of the Hebrew University of Jerusalem, Jerusalem, Israel
    Int J Neuropsychopharmacol 11:541-5. 2008
    ..We conclude that hypnotizability and PPI may be negatively correlated. These findings lend further support for the role of dopaminergic neurotransmission mechanisms in the determination of hypnotizability levels...
  16. doi request reprint Defensive self-presentation style is associated with reduced prepulse inhibition
    Raz Levin
    Ezrath Nashim Herzog Memorial Hospital, Jerusalem, Israel
    Eur Neuropsychopharmacol 21:810-3. 2011
    ..Its findings suggest that very basic perceptual deficits that can be assessed using the PPI paradigm, may reflect information processing abnormalities that impact negatively upon the perception of complex social interactions...
  17. doi request reprint D-serine adjuvant treatment alleviates behavioural and motor symptoms in Parkinson's disease
    Evgenia Gelfin
    Psychiatry Department, Herzog Memorial Hospital, Jerusalem, Israel
    Int J Neuropsychopharmacol 15:543-9. 2012
    ..001) and significantly reduced UPDRS (p=0.02), SAS (p=0.009) and PANSS (0.05) total scores. These preliminary findings suggest that DSR treatment may be beneficial in PD. Larger-sized studies with optimized DSR dosages are warranted...
  18. ncbi request reprint Shiatsu as an adjuvant therapy for schizophrenia: an open-label pilot study
    Pesach Lichtenberg
    Department of Psychiatry, Herzog Memorial Hospital, Jerusalem, Israel
    Altern Ther Health Med 15:44-6. 2009
    ..Studies have suggested a possible role for shiatsu in treating a variety of mental and physical ailments...
  19. doi request reprint Hypnotizability and sensorimotor gating: a dopaminergic mechanism of hypnosis
    Raz Levin
    Department of Psychiatry, Herzog Memorial Hospital, Givat Shaul, Jerusalem, Israel
    Int J Clin Exp Hypn 59:399-405. 2011
    ....
  20. ncbi request reprint Pfropfschizophrenia in the age of deinstitutionalization: whose problem?
    Sara Catinari
    Research Department, Ezrath Nashim Herzog Memorial Hospital, Jerusalem, Israel
    Compr Psychiatry 46:200-5. 2005
    ..The multiple problems that these patients encounter in various educational and health care agencies and what questions need to be asked to better elucidate these patients' needs are assessed...
  21. ncbi request reprint Glutamatergic neurotransmission modulation and the mechanisms of antipsychotic atypicality
    Uriel Heresco-Levy
    Department of Psychiatry, Ezrath Nashim Sarah Herzog Memorial Hospital, Hadassah Medical School, Hebrew University, PO Box 35300, Jerusalem 91351, Israel
    Prog Neuropsychopharmacol Biol Psychiatry 27:1113-23. 2003
    ....
  22. ncbi request reprint Angiotensin converting enzyme gene insertion/deletion polymorphism: case-control association studies in schizophrenia, major affective disorder, and tardive dyskinesia and a family-based association study in schizophrenia
    Ronnen H Segman
    Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Am J Med Genet 114:310-4. 2002
    ..Particularly in the case of schizophrenia, these findings do not support an association of the ACE I/D polymorphism with the phenotypes examined...
  23. doi request reprint Hypnotizability is associated with a protective but not acquisitive self-presentation style
    Raz Levin
    Herzog Memorial Hospital, Jerusalem, Israel
    Int J Clin Exp Hypn 61:183-92. 2013
    ..43, p = .002) but not between hypnotizability and RSMS (r = .070, p = .631). These results suggest that a protective self-presentation style may incline certain individuals to cooperate with hypnotic suggestions...
  24. ncbi request reprint Politics and psychopathology in an Arab-Israeli patient
    Pesach Lichtenberg
    Department of Psychiatry, Herzog Hospital, Jerusalem, Israel
    Psychiatry 66:360-3. 2003
  25. doi request reprint Hypnotizability and blink rate: a test of the dopamine hypothesis
    Pesach Lichtenberg
    S Herzog Memorial Hospital and Hebrew University Hadassah Medical School, Jerusalem, Israel
    Int J Clin Exp Hypn 56:243-54. 2008
    ..The results do not provide evidence for a role of dopamine in determining hypnotizability...
  26. ncbi request reprint Glycine and D-cycloserine attenuate vacuous chewing movements in a rat model of tardive dyskinesia
    Shai Shoham
    Research Department, Ezrath Nashim Herzog Memorial Hospital, Jerusalem, Israel
    Brain Res 1004:142-7. 2004
    ..These findings indicate that the use of GLY and DCS results in attenuation of VCM in rats and may have an effect on TD in humans. Clinical trials with this type of compounds for patients suffering from TD are warranted...
  27. ncbi request reprint Association between the insulin-like growth factor 2 gene (IGF2) and scores on the Eating Attitudes Test in nonclinical subjects: a family-based study
    Rachel Bachner-Melman
    Scheinfeld Center for Human Genetics in the Social Sciences, Department of Psychology, Hebrew University, Jerusalem 91905, Israel
    Am J Psychiatry 162:2256-62. 2005
    ..This investigation extended these studies and investigated the psychological and behavioral implications of this hormone's impact on metabolism and body composition...
  28. ncbi request reprint [Expressed emotions (EE) towards schizophrenic patients among staff members of psychiatric wards and hostels: comparison and clinical implications]
    Gaby Sheflerz
    Herzog Memorial Hospital, Jerusalem
    Harefuah 145:718-22, 783. 2006
    ..The study highlights issues to be considered to ensure optimal functioning of the hostel as an appropriate setting for the treatment of schizophrenic patients...
  29. ncbi request reprint Combined analysis of 635 patients confirms an age-related association of the serotonin 2A receptor gene with tardive dyskinesia and specificity for the non-orofacial subtype
    Bernard Lerer
    Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Int J Neuropsychopharmacol 8:411-25. 2005
    ..Together with other genetic variants associated with TD the findings could be used to assess risk in patients who are candidates for treatment with typical antipsychotic medications...
  30. doi request reprint Association between arginine vasopressin 1a receptor (AVPR1a) promoter region polymorphisms and prepulse inhibition
    Raz Levin
    Neurobiology, Hebrew University, Jerusalem, Israel
    Psychoneuroendocrinology 34:901-8. 2009
    ..This is the first report in humans demonstrating a role of the AVPR1a gene in contributing to the PPI response to auditory stimuli...
  31. ncbi request reprint Psychiatric manifestations in Turner Syndrome: a brief survey
    Sara Catinari
    Psychiatry Department, Ezrath Nashim Herzog Memorial Hospital, Jerusalem, Israel
    Isr J Psychiatry Relat Sci 43:293-5. 2006
    ..This article reviews existing case reports and seeks common characteristics among them, which may include mild psychosis with stress-precipitated onset, prominent mood features, and some features that may resemble organic disease...
  32. ncbi request reprint Preventive pharmacological treatment --an evolving new concept in schizophrenia
    Rony Sabbag
    Hadassah Medical School, Hebrew University, Jerusalem, Israel
    Isr J Psychiatry Relat Sci 48:82-90. 2011
    ....
  33. ncbi request reprint [Hypnosis: clinical applications]
    Noam Weizman
    Hadassah Medical School, Hebrew University, Jerusalem
    Harefuah 143:42-6, 85, 84. 2004
    ..Hypnosis has a wide variety of applications in medicine. In recent years, recognition has grown for the need to subject the effectiveness of hypnosis to accepted research standards of clinical medicine...
  34. ncbi request reprint The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST): the efficacy of glutamatergic agents for negative symptoms and cognitive impairments
    Robert W Buchanan
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Am J Psychiatry 164:1593-602. 2007
    ..Agents that act at the glycine site of the N-methyl-D-aspartic acid (NMDA) glutamatergic receptor have been suggested as promising treatments for moderate to severe negative symptoms and cognitive impairments...
  35. ncbi request reprint A "work in-progress": novel approaches to the treatment of schizophrenia
    Stephen I Deutsch
    Isr J Psychiatry Relat Sci 42:2-4. 2005
  36. ncbi request reprint Association of the serotonin transporter gene with smoking behavior
    Ilana Kremer
    Department of Psychiatry, Emek Hospital, Afula, Israel
    Am J Psychiatry 162:924-30. 2005
    ....
  37. ncbi request reprint Demographic, clinical and treatment characteristics among Meuhedet sick fund mental health referrals
    Arie Mishkin
    Kupat Holim Meuhedet Mental Health Clinic, 3 Ben Sira Street, Jerusalem, Israel 94181
    Isr J Psychiatry Relat Sci 40:297-303. 2003
    ..Consequently there is an urgent need for assessing relevant parameters of the patient populations and treatment patterns presently characterizing sick fund's mental health delivery frameworks...
  38. ncbi request reprint Characteristics of schizophrenia residents and staff rejection in community mental health hostels
    Eynat Levy
    Beersheba Mental Health Center, Ben Gurion University of the Negev, Beersheba, Israel
    Isr J Psychiatry Relat Sci 42:23-32. 2005
    ..The quality of staff-patient relationships is a crucial determinant of the rehabilitational process outcome...