B Glaser

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi request reprint Genetic analysis of complex disease--a roadmap to understanding or a colossal waste of money
    Benjamin Glaser
    Endocrinology and Metabolism Service, Hadassah Hospital, Internal Medicine Department, Hadassah Hebrew University School of Medicine, Jerusalem, Israel
    Pediatr Endocrinol Rev 7:258-65. 2010
  2. ncbi request reprint The H syndrome: a genodermatosis characterized by indurated, hyperpigmented, and hypertrichotic skin with systemic manifestations
    Vered Molho-Pessach
    Department of Dermatology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Am Acad Dermatol 59:79-85. 2008
  3. pmc Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas
    Yaron Suissa
    Endocrinology and Metabolism Service, Department of Internal Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    PLoS ONE 8:e70397. 2013
  4. pmc Predicting diabetic nephropathy using a multifactorial genetic model
    Ilana Blech
    Endocrinology and Metabolism Service, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    PLoS ONE 6:e18743. 2011
  5. pmc Parental diabetes status reveals association of mitochondrial DNA haplogroup J1 with type 2 diabetes
    Jeanette Feder
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    BMC Med Genet 10:60. 2009
  6. pmc Differences in mtDNA haplogroup distribution among 3 Jewish populations alter susceptibility to T2DM complications
    Jeanette Feder
    Department of Life Sciences and National Institute of Biotechnology in the Negev, Ben Gurion University of the Negev, Beer Sheva, Israel
    BMC Genomics 9:198. 2008
  7. doi request reprint ABCC8 mutation allele frequency in the Ashkenazi Jewish population and risk of focal hyperinsulinemic hypoglycemia
    Benjamin Glaser
    Internal Medicine Department, Endocrinology and Metabolism Service, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Genet Med 13:891-4. 2011
  8. ncbi request reprint Dominant SUR1 mutation causing autosomal dominant type 2 diabetes
    Benjamin Glaser
    Endocrinology and Metabolism Service, Internal Medicine Department, Hebrew University Hadassah Medical Center, 91120, Jerusalem, Israel
    Lancet 361:272-3. 2003
  9. pmc Genetics of neonatal hyperinsulinism
    B Glaser
    Department of Endocrinology and Metabolism, The Hebrew University, Hadassah Medical School, Jerusalem, 91120, Israel
    Arch Dis Child Fetal Neonatal Ed 82:F79-86. 2000
  10. doi request reprint Insulin mutations in diabetes: the clinical spectrum
    Benjamin Glaser
    Endocrinology and Metabolism Service, Internal Medicine Department, Hadassah Hebrew University Medical School, Jerusalem, Israel
    Diabetes 57:799-800. 2008

Detail Information

Publications42

  1. ncbi request reprint Genetic analysis of complex disease--a roadmap to understanding or a colossal waste of money
    Benjamin Glaser
    Endocrinology and Metabolism Service, Hadassah Hospital, Internal Medicine Department, Hadassah Hebrew University School of Medicine, Jerusalem, Israel
    Pediatr Endocrinol Rev 7:258-65. 2010
    ..Even today, these studies are providing unique insights into the pathogenesis of complex disease, and these will undoubtedly be translated into additional tangible diagnostic or therapeutic tools in the coming years...
  2. ncbi request reprint The H syndrome: a genodermatosis characterized by indurated, hyperpigmented, and hypertrichotic skin with systemic manifestations
    Vered Molho-Pessach
    Department of Dermatology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Am Acad Dermatol 59:79-85. 2008
    ....
  3. pmc Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas
    Yaron Suissa
    Endocrinology and Metabolism Service, Department of Internal Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    PLoS ONE 8:e70397. 2013
    ..Thus, gastrin(+) cells are a distinct endocrine cell type in the pancreas and an alternative fate of Ngn3+ cells. ..
  4. pmc Predicting diabetic nephropathy using a multifactorial genetic model
    Ilana Blech
    Endocrinology and Metabolism Service, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    PLoS ONE 6:e18743. 2011
    ..In this proof-of-concept study, we tested the hypothesis that combined analysis of multiple genetic variants can improve prediction...
  5. pmc Parental diabetes status reveals association of mitochondrial DNA haplogroup J1 with type 2 diabetes
    Jeanette Feder
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    BMC Med Genet 10:60. 2009
    ..We hypothesized that association of mtDNA genetic variants with T2DM could be revealed while controlling for the effect of additional inherited factors, reflected in family history information...
  6. pmc Differences in mtDNA haplogroup distribution among 3 Jewish populations alter susceptibility to T2DM complications
    Jeanette Feder
    Department of Life Sciences and National Institute of Biotechnology in the Negev, Ben Gurion University of the Negev, Beer Sheva, Israel
    BMC Genomics 9:198. 2008
    ..Nevertheless these large-scale population screens often overlook the tremendous variation in the mitochondrial genome (mtDNA) and its involvement in complex disorders...
  7. doi request reprint ABCC8 mutation allele frequency in the Ashkenazi Jewish population and risk of focal hyperinsulinemic hypoglycemia
    Benjamin Glaser
    Internal Medicine Department, Endocrinology and Metabolism Service, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Genet Med 13:891-4. 2011
    ....
  8. ncbi request reprint Dominant SUR1 mutation causing autosomal dominant type 2 diabetes
    Benjamin Glaser
    Endocrinology and Metabolism Service, Internal Medicine Department, Hebrew University Hadassah Medical Center, 91120, Jerusalem, Israel
    Lancet 361:272-3. 2003
  9. pmc Genetics of neonatal hyperinsulinism
    B Glaser
    Department of Endocrinology and Metabolism, The Hebrew University, Hadassah Medical School, Jerusalem, 91120, Israel
    Arch Dis Child Fetal Neonatal Ed 82:F79-86. 2000
    ..Although the clinical ramifications of these findings are still limited, in some situations genetic studies might greatly aid in patient management...
  10. doi request reprint Insulin mutations in diabetes: the clinical spectrum
    Benjamin Glaser
    Endocrinology and Metabolism Service, Internal Medicine Department, Hadassah Hebrew University Medical School, Jerusalem, Israel
    Diabetes 57:799-800. 2008
  11. pmc Type 2 diabetes: hypoinsulinism, hyperinsulinism, or both?
    Benjamin Glaser
    Endocrinology and Metabolism Service, Internal Medicine Department, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    PLoS Med 4:e148. 2007
  12. pmc Lessons in human biology from a monogenic pancreatic β cell disease
    Benjamin Glaser
    Endocrinology and Metabolism Service, Internal Medicine Department, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Invest 121:3821-5. 2011
    ..The data validate and extend observations made in model organisms...
  13. ncbi request reprint Pendred syndrome
    Benjamin Glaser
    Endocrinology and Metabolism Service, Department of Internal Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Pediatr Endocrinol Rev 1:199-204; discussion 204. 2003
    ..This mechanism, although yet to be proven, suggests the intriguing possibility that early diagnosis and intervention could perhaps prevent at least some of the hearing loss...
  14. ncbi request reprint Hyperinsulinism caused by paternal-specific inheritance of a recessive mutation in the sulfonylurea-receptor gene
    B Glaser
    Department of Endocrinology and Metabolism, Hebrew University, Hadassah Medical School, Jerusalem, Israel
    Diabetes 48:1652-7. 1999
    ..001). In conclusion, we identified a novel mechanism to explain the pathophysiology of focal HI and provide evidence to suggest that this entity may be self-limiting, since affected beta-cells undergo apoptosis...
  15. ncbi request reprint Hyperinsulinism of the newborn
    B Glaser
    Department of Endocrinology and Metabolism, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Semin Perinatol 24:150-63. 2000
    ..Despite these recent discoveries, however, the metabolic origin of the disease is still unknown in about 50% of cases...
  16. ncbi request reprint Intragenic single nucleotide polymorphism haplotype analysis of SUR1 mutations in familial hyperinsulinism
    B Glaser
    Department of Endocrinology and Metabolism, Hebrew University, Hadassah Medical School, Jerusalem, Israel
    Hum Mutat 14:23-9. 1999
    ..Furthermore, our findings have implications concerning the HI-associated chromosomes on which no mutation has been identified...
  17. pmc A single-nucleotide polymorphism in the RAD51 gene modifies breast cancer risk in BRCA2 carriers, but not in BRCA1 carriers or noncarriers
    L Kadouri
    Sharett Institute of Oncology, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Br J Cancer 90:2002-5. 2004
    ..97; 95% CI 0.47-2.00). These results indicate significantly elevated risk for BC in carriers of BRCA2 mutations who also carry a RAD51-135c allele. In BRCA1 carriers and noncarriers, no effect for this SNP was found...
  18. pmc CAG and GGC repeat polymorphisms in the androgen receptor gene and breast cancer susceptibility in BRCA1/2 carriers and non-carriers
    L Kadouri
    Sharett Institute of Oncology, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Br J Cancer 85:36-40. 2001
    ..We conclude that, in contrast to previous observations, if there is any effect of the AR repeat length on BRCA1 penetrance, it is likely to be weak...
  19. ncbi request reprint Familial hyperinsulinism caused by an activating glucokinase mutation
    B Glaser
    Department of Endocrinology and Metabolism, Hebrew University Hadassah Medical School, Jerusalem, Israel
    N Engl J Med 338:226-30. 1998
  20. ncbi request reprint In-hospital treatment of hyperglycemia: effects of intensified subcutaneous insulin treatment
    Hila Elinav
    Endocrinology and Metabolism Service and the Hadassah Diabetes Center, Department of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Curr Med Res Opin 23:757-65. 2007
    ..No methods for achievement of proper glycemic control in this population have been validated in the in-hospital setting...
  21. ncbi request reprint p57(KIP2) expression in normal islet cells and in hyperinsulinism of infancy
    S A Kassem
    Department of Endocrinology and Metabolism, Hebrew University, Hadassah Medical Center, Jerusalem, Israel
    Diabetes 50:2763-9. 2001
    ..Manipulation of p57(KIP2) expression in beta-cells may provide a mechanism by which proliferation can be modulated, and thus this gene is a potential therapeutic target for reversing the beta-cell failure observed in diabetes...
  22. ncbi request reprint Monilethrix: a keratin hHb6 mutation is co-dominant with variable expression
    A Zlotogorski
    Department of Dermatology, Hadassah University Hospital, Jerusalem, Israel
    Exp Dermatol 7:268-72. 1998
    ..This represents the first report of a co-dominant keratin hHb6 mutation resulting in severe disease...
  23. ncbi request reprint Reproducibility of glucose measurements using the glucose sensor
    Muriel Metzger
    Diabetes Center, Endocrinology and Metabolism Service, Hadassah University Hospital, Jerusalem, Israel
    Diabetes Care 25:1185-91. 2002
    ..Its use is currently limited to the health care team. Our aim was to evaluate the reproducibility of data provided by the device by comparing data provided by two sensors worn simultaneously by the same subject...
  24. ncbi request reprint Hyperinsulinism of infancy: novel ABCC8 and KCNJ11 mutations and evidence for additional locus heterogeneity
    Sharona Tornovsky
    Endocrinology and Metabolism Service, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    J Clin Endocrinol Metab 89:6224-34. 2004
    ..In four patients (27%), no mutations were identified. Thus, further genetic heterogeneity is suggested in this disorder. These patients represent a cohort that can be used for searching for mutations in other candidate genes...
  25. doi request reprint Glucose metabolism: key endogenous regulator of β-cell replication and survival
    D Dadon
    Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Diabetes Obes Metab 14:101-8. 2012
    ..Understanding and uncoupling the mitogenic and toxic effects of glucose metabolism on β-cells may allow for the development of effective regenerative therapies for diabetes...
  26. ncbi request reprint Lipid cell tumor of the ovary: steroid hormone secretory pattern and localization using 75Se-selenomethylcholesterol
    J S Younis
    Department of Obstetrics and Gynecology, Hadassah University Hospital, Jerusalem, Israel
    Gynecol Obstet Invest 27:110-2. 1989
    ..Localization was accomplished noninvasively using 75Se-selenomethylcholesterol. Peripheral and ovarian vein steroid concentrations suggest that the tumor produced androgens preferentially by way of the delta 4 steroidogenesis pathway...
  27. pmc Novel de novo mutation in sulfonylurea receptor 1 presenting as hyperinsulinism in infancy followed by overt diabetes in early adolescence
    Maha Abdulhadi-Atwan
    Division of Pediatric Endocrinology, Department of Pediatrics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Diabetes 57:1935-40. 2008
    ..We aimed to genotype the ATP-sensitive K(+) channel in a 10.5-year-old girl presenting with overt diabetes following hyperinsulinism in infancy...
  28. doi request reprint Preliminary evidence that a functional polymorphism in type 1 deiodinase is associated with enhanced potentiation of the antidepressant effect of sertraline by triiodothyronine
    Rena Cooper-Kazaz
    Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Affect Disord 116:113-6. 2009
    ..Triiodothyronine (T3) is used to potentiate the clinical effect of antidepressant drugs. Inter-individual differences in efficacy may be related to genetically-based variability in thyroid function...
  29. ncbi request reprint Searching for type 2 diabetes genes on chromosome 20
    Marshall Alan Permutt
    Washington University School of Medicine, Division of Endocrinology, Diabetes and Metabolism, St Louis, Missouri, USA
    Diabetes 51:S308-15. 2002
    ..In addition, HNF4a and Mybl2 were screened for mutations and new polymorphisms. No mutations were identified, and a new nonsynonymous SNP (R687C in exon 14 of Mybl2) was found. The limits to this type of association study are discussed...
  30. ncbi request reprint Compound heterozygosity for the common sulfonylurea receptor mutations can cause mild diazoxide-sensitive hyperinsulinism
    Benjamin Dekel
    Department of Pediatrics, Sheba Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, Israel
    Clin Pediatr (Phila) 41:183-6. 2002
    ..We suggest that diazoxide unresponsiveness is not always present in patients with SUR1 mutations and that the probable cause of the milder phenotype in this compund heterozygote state..
  31. ncbi request reprint Glibenclamide treatment in permanent neonatal diabetes mellitus due to an activating mutation in Kir6.2
    Amnon Zung
    Pediatric Endocrinology Unit, Kaplan Medical Center, Affiliated with Hadassah Medical School, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    J Clin Endocrinol Metab 89:5504-7. 2004
    ..This study demonstrates the feasibility of oral sulfonylurea treatment in PNDM patients with Kir6.2 mutations even during infancy, and the superiority of this approach over insulin administration...
  32. ncbi request reprint Ashkenazi Jewish mtDNA haplogroup distribution varies among distinct subpopulations: lessons of population substructure in a closed group
    Jeanette Feder
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur J Hum Genet 15:498-500. 2007
    ..Our results underline the essentiality of adjusting data of population genetic variation for substructure during the design of association studies, even in apparently closed populations...
  33. pmc Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium
    Weihua Guan
    Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Hum Hered 66:35-49. 2008
    ..The International Type 2 Diabetes Linkage Analysis Consortium was formed to localize type 2 diabetes predisposing variants based on 23 autosomal linkage scans...
  34. ncbi request reprint CT of the ear in Pendred syndrome
    Moshe Goldfeld
    Departments of Radiology and Internal Medicine, Western Galilee Hospital, Nahariya 22100, Israel
    Radiology 235:537-40. 2005
    ..To prospectively determine the structural anomalies of the inner ear by using thin-section computed tomography (CT) in an extended family with Pendred syndrome...
  35. ncbi request reprint Rapid and sustained relief from the symptoms of carcinoid syndrome: results from an open 6-month study of the 28-day prolonged-release formulation of lanreotide
    Philippe Ruszniewski
    Hopital Beaujon, Clichy, France
    Neuroendocrinology 80:244-51. 2004
    ..Treatment was well tolerated. 28-day PR lanreotide was effective in reducing the symptoms and biochemical markers associated with carcinoid syndrome...
  36. ncbi request reprint Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations
    Jeanette J McCarthy
    San Diego State University, San Diego, CA 92182 4162, USA
    Hum Hered 55:163-70. 2003
    ..We examined polymorphisms in the HDL receptor, SR-BI, for association with plasma HDL cholesterol levels...
  37. ncbi request reprint Germline fumarate hydratase mutations and evidence for a founder mutation underlying multiple cutaneous and uterine leiomyomata
    Gary S Chuang
    Department of Dermatology, Columbia University, New York, New York, USA
    J Am Acad Dermatol 52:410-6. 2005
    ..Collectively, identification of 5 novel and 3 recurrent mutations further supports the role of FH in the pathogenesis of MCL...
  38. ncbi request reprint Polyglutamine repeat length in the AIB1 gene modifies breast cancer susceptibility in BRCA1 carriers
    Luna Kadouri
    Sharett Institute of Oncology, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Int J Cancer 108:399-403. 2004
    ..Longer repeat length correlates with elevated risk, whereas in carriers of a shorter AIB1 allele BC risk was reduced. The AIB1 polyglutamine length did not affect BC risk among BRCA2 mutation carriers...
  39. ncbi request reprint Sulfonylurea-responsive diabetes in childhood
    Zohar Landau
    Diabetes Unit, E Wolfson Medical Center, Holon, Israel
    J Pediatr 150:553-5. 2007
    ..All affected individuals carried the same KCNJ11 gene mutation. In all, sulfonylurea treatment permitted cessation of insulin treatment, with improved glycemic control...
  40. pmc Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value
    Stephane Cauchi
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    PLoS ONE 3:e2031. 2008
    ..Our aims were to validate these markers in other European and non-European populations, then to assess their combined effect in a large French study comparing T2D and normal glucose tolerant (NGT) individuals...
  41. pmc Common variants in WFS1 confer risk of type 2 diabetes
    Manjinder S Sandhu
    UK Medical Research Council MRC Epidemiology Unit, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Nat Genet 39:951-3. 2007
    ..Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes...
  42. ncbi request reprint A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population
    Latisha D Love-Gregory
    Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 53:1134-40. 2004
    ..Notably, the associations and the partitioned linkage profiles near P2 were independently observed in a Finnish sample, suggesting the presence of potential regulatory element(s) that may contribute to the risk for type 2 diabetes...