A Gertler

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi request reprint Novel Superactive Leptin Antagonists and their Potential Therapeutic Applications
    Arieh Gertler
    The Hebrew University, The Robert H Smith Faculty of Agriculture, Food and Environment, Rehovot 76100, Israel
    Curr Pharm Des 20:659-65. 2014
  2. ncbi request reprint Mechanism of ruminant placental lactogen action: molecular and in vivo studies
    Arieh Gertler
    Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Mol Genet Metab 75:189-201. 2002
  3. ncbi request reprint Fluorescence resonance energy transfer (FRET) microscopy in living cells as a novel tool for the study of cytokine action
    Arieh Gertler
    The Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
    J Dairy Res 72:14-9. 2005
  4. ncbi request reprint Development of leptin antagonists and their potential use in experimental biology and medicine
    Arieh Gertler
    The Institute of Biochemistry, Food Science, and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Trends Endocrinol Metab 17:372-8. 2006
  5. ncbi request reprint Large-scale preparation of biologically active recombinant ovine obese protein (leptin)
    A Gertler
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
    FEBS Lett 422:137-40. 1998
  6. ncbi request reprint Large-scale preparation of recombinant ovine prolactin and determination of its in vitro and in vivo activity
    H Leibovich
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Protein Expr Purif 22:489-96. 2001
  7. doi request reprint Nonsynonymous natural genetic polymorphisms in the bovine leptin gene affect biochemical and biological characteristics of the mature hormone
    S Reicher
    The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
    J Anim Sci 90:410-8. 2012
  8. ncbi request reprint Pituitary and placental ovine growth hormone variants differ in their receptor-binding ability and in their biological properties
    S Reicher
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Gen Comp Endocrinol 155:368-77. 2008
  9. ncbi request reprint Mutations of ovine and bovine placental lactogens change, in different ways, the biological activity mediated through homologous and heterologous lactogenic receptors
    D Helman
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
    J Endocrinol 169:43-54. 2001
  10. ncbi request reprint Extracellular domain of prolactin receptor from bovine mammary gland: expression in Escherichia coli, purification and characterization of its interaction with lactogenic hormones
    A Tchelet
    Department of Biochemistry, Food Science and Nutrition, Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot, Israel
    J Endocrinol 144:393-403. 1995

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Novel Superactive Leptin Antagonists and their Potential Therapeutic Applications
    Arieh Gertler
    The Hebrew University, The Robert H Smith Faculty of Agriculture, Food and Environment, Rehovot 76100, Israel
    Curr Pharm Des 20:659-65. 2014
    ..We also suggest the use of leptin antagonists as research reagents for creation of a novel, fast and reversible model of T2DM in mice. ..
  2. ncbi request reprint Mechanism of ruminant placental lactogen action: molecular and in vivo studies
    Arieh Gertler
    Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Mol Genet Metab 75:189-201. 2002
    ....
  3. ncbi request reprint Fluorescence resonance energy transfer (FRET) microscopy in living cells as a novel tool for the study of cytokine action
    Arieh Gertler
    The Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
    J Dairy Res 72:14-9. 2005
    ....
  4. ncbi request reprint Development of leptin antagonists and their potential use in experimental biology and medicine
    Arieh Gertler
    The Institute of Biochemistry, Food Science, and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Trends Endocrinol Metab 17:372-8. 2006
    ..The recent development of leptin muteins with antagonistic properties and other proteins that block leptin activity opens up new possibilities for their use in research and, eventually, therapy...
  5. ncbi request reprint Large-scale preparation of biologically active recombinant ovine obese protein (leptin)
    A Gertler
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
    FEBS Lett 422:137-40. 1998
    ....
  6. ncbi request reprint Large-scale preparation of recombinant ovine prolactin and determination of its in vitro and in vivo activity
    H Leibovich
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Protein Expr Purif 22:489-96. 2001
    ..In contrast to ovine growth hormone or ovine placental lactogen, recombinant oPRL had no galactopoietic effect in lactating ewes...
  7. doi request reprint Nonsynonymous natural genetic polymorphisms in the bovine leptin gene affect biochemical and biological characteristics of the mature hormone
    S Reicher
    The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
    J Anim Sci 90:410-8. 2012
    ..05) inhibitory effect than the WT LEP. It was concluded that natural genetic polymorphisms in the bLEP are associated with variation in the biochemical and physiological properties of the protein...
  8. ncbi request reprint Pituitary and placental ovine growth hormone variants differ in their receptor-binding ability and in their biological properties
    S Reicher
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Gen Comp Endocrinol 155:368-77. 2008
    ..Thus the product of the oGH duplicated copy has higher affinity for GHR and higher somatogenic activity. As the GH2-Z gene copy is expressed in the placenta, allelic differences at the oGH locus may influence feto-placental development...
  9. ncbi request reprint Mutations of ovine and bovine placental lactogens change, in different ways, the biological activity mediated through homologous and heterologous lactogenic receptors
    D Helman
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
    J Endocrinol 169:43-54. 2001
    ....
  10. ncbi request reprint Extracellular domain of prolactin receptor from bovine mammary gland: expression in Escherichia coli, purification and characterization of its interaction with lactogenic hormones
    A Tchelet
    Department of Biochemistry, Food Science and Nutrition, Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot, Israel
    J Endocrinol 144:393-403. 1995
    ....
  11. ncbi request reprint Mitogenic and binding properties of monoclonal antibodies to the prolactin receptor in Nb2 rat lymphoma cells. Selective enhancement by anti-mouse IgG
    G Elberg
    Department of Biochemistry and Human Nutrition, Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot, Israel
    J Biol Chem 265:14770-6. 1990
    ..It may be induced by binding of the mAb to a site, which can be either identical or may even be distinct from that which binds the lactogenic hormone...
  12. ncbi request reprint Ovine placental lactogen-induced heterodimerization of ovine growth hormone and prolactin receptors in living cells is demonstrated by fluorescence resonance energy transfer microscopy and leads to prolonged phosphorylation of signal transducer and activa
    Eva Biener
    The Institute of Biochemistry, Food Science, and Nutrition, Faculty of Agricultural, and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Endocrinology 144:3532-40. 2003
    ....
  13. ncbi request reprint Large-scale preparation and in vitro characterization of biologically active human placental (20 and 22K) and pituitary (20K) growth hormones: placental growth hormones have no lactogenic activity in humans
    G Solomon
    Institute of Biochemistry, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Growth Horm IGF Res 16:297-307. 2006
    ..3-fold lower than that of hGH-N 22K. The latter finding raises the question of whether the lack of intrinsic lactogenic activity in the placental hGHs that dominate during pregnancy has any physiological relevance...
  14. ncbi request reprint Absorption of bioactive human growth hormone after oral administration in the common carp (Cyprinus carpio) and its enhancement by deoxycholate
    Y Hertz
    Department of Biochemistry and Human Nutrition, Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot, Israel
    J Comp Physiol B 161:159-63. 1991
    ..Additional studies are required to establish the appropriate conditions (diet composition, feeding level, and frequency, etc.) in which polypeptide hormones could be introduced orally to fish...
  15. pmc Mapping leptin-interacting sites in recombinant leptin-binding domain (LBD) subcloned from chicken leptin receptor
    L Niv-Spector
    Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Biochem J 390:475-84. 2005
    ..Contact-surface analysis identified the residues having the highest contribution to the recognition site to be Phe73, Phe77 and Leu79...
  16. ncbi request reprint Transactivation of erbB2 by short and long isoforms of leptin receptors
    Avital Eisenberg
    Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    FEBS Lett 565:139-42. 2004
    ..Using FRET technology in living cells, we found no evidence of complex formation between erbB2 and prolactin or leptin receptors, indicating that the transactivation occurs through an indirect interaction...
  17. ncbi request reprint Oral immunization of Carassius auratus with modified recombinant A-layer proteins entrapped in alginate beads
    Sarah Maurice
    Institute of Biochemistry, The Hebrew University of Jerusalem, P O Box 12, Rechovot 76100, Israel
    Vaccine 23:450-9. 2004
    ..In spite of the presence of an increased titer to A-protein, vaccinated fish did not demonstrate resistance to infection with atypical A. salmonicida...
  18. doi request reprint Purification and characterization of recombinant pufferfish (Takifugu rubripes) leptin
    M Yacobovitz
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Gen Comp Endocrinol 156:83-90. 2008
    ..No specific binding of either ovine or pufferfish leptins to tilapia liver membranes was detected. This work is the first report on the purification of leptin from any fish species...
  19. ncbi request reprint Spatio-temporal kinetics of growth hormone receptor signaling in single cells using FRET microscopy
    Eva Biener-Ramanujan
    The Institute of Biochemistry, Food Science, and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
    Growth Horm IGF Res 16:247-57. 2006
    ..Although GHR dimerization and STAT5 activation have been reported previously, this is the first spatially resolved demonstration of GHR-signaling kinetics in intact cells...
  20. ncbi request reprint Bacterial expression of prolactin family proteins
    Arieh Gertler
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agriculture, The Hebrew University of Jerusalem, Israel
    Methods Mol Med 122:341-54. 2006
    ..The methodology described in the present chapter allows large-scale preparation of pure, monomeric, biologically active oPL, oPRL, and rbPRLR-ECD suitable for performing in vitro and in vivo experiments...
  21. ncbi request reprint Subcloning, expression, purification, and characterization of recombinant human leptin-binding domain
    Yael Sandowski
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University, Rehovot 76100, Israel
    J Biol Chem 277:46304-9. 2002
    ..human leptin complex. Two main residues, Phe-500, located in loop L3, and Tyr-441, located in L1, are suggested to contribute to leptin binding...
  22. pmc Identification of the hydrophobic strand in the A-B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists
    Leonora Niv-Spector
    Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University, Rehovot 76100, Israel
    Biochem J 391:221-30. 2005
    ....
  23. ncbi request reprint Cellulose beads bound to cellulose binding domain-fused recombinant proteins; an adjuvant system for parenteral vaccination of fish
    Sarah Maurice
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agriculture, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Freiburg Building, Rm 10, P O Box 12, Rehovot, 76100, Israel
    Vaccine 21:3200-7. 2003
    ..The paper describes a simple and safe method to increase the potential immunogenicity of soluble recombinant proteins by employing relatively inexpensive cellulose particles...
  24. ncbi request reprint Preparation and expression of biologically active prolactin and growth hormone receptors and suppressor of cytokine signaling proteins 1, 2, 3, and 6 tagged with cyan and yellow fluorescent proteins
    Liora Ben-Yair
    Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, Institute of Biochemistry, The Hebrew University, Rehovot 76100, Israel
    Protein Expr Purif 25:456-64. 2002
    ..Cells transfected with eight of these tagged constructs expressed the fluorescent proteins in both the nucleus and cytosol; the tagged SOCS2 was localized mostly in the latter compartment...
  25. ncbi request reprint Regulation of heat-shock protein (hsp70) gene expression by hGH and IL2 in rat Nb2 lymphoma cells
    S Horn
    Department of Biochemistry, Food Science and Nutrition, Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot, Israel
    Mol Cell Endocrinol 105:139-46. 1994
    ..These results indicate that activation of PKC is one of the signaling pathways differentially involved in hGH and IL2 stimulation of cells.(ABSTRACT TRUNCATED AT 250 WORDS)..
  26. ncbi request reprint Comparison of R128Q mutations in human, ovine, and chicken leptins
    Nina Raver
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Gen Comp Endocrinol 126:52-8. 2002
    ..This made it impossible to correlate the results shown in the present work with the currently available models. Therefore, leptin may bind its receptors in a manner different than those proposed until now...
  27. ncbi request reprint Recombinant human CIS2 (SOCS2) protein: subcloning, expression, purification, and characterization
    Eva Biener
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food, and Environmental Quality Sciences, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Protein Expr Purif 25:305-12. 2002
    ..Recombinant CIS2 was compared by biochemical, immunological, and molecular methods to the CIS2 protein expressed in eukaryotic cells. This report describes the first substantial production of biologically active recombinant human CIS2...
  28. ncbi request reprint Quantitative FRET imaging of leptin receptor oligomerization kinetics in single cells
    Eva Biener
    The Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Biol Cell 97:905-19. 2005
    ....
  29. ncbi request reprint Large-scale preparation of biologically active mouse and rat leptins and their L39A/D40A/F41A muteins which act as potent antagonists
    Gili Salomon
    Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University, Rehovot 76100, Israel
    Protein Expr Purif 47:128-36. 2006
    ....
  30. doi request reprint A simple novel method for the preparation of noncovalent homodimeric, biologically active human interleukin 10 in Escherichia coli-enhancing protein expression by degenerate PCR of 5' DNA in the open reading frame
    Shelley Klompus
    Faculty of Agricultural, Food and Environmental Quality Sciences, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, Israel
    Protein Expr Purif 62:199-205. 2008
    ..The yield of recombinant hIL-10 from 10L of fermentation culture was 60mg and a protocol for its long-term storage as a carrier-free lyophilized powder at -20 degrees was developed...
  31. ncbi request reprint Preparation of leptin antagonists by site-directed mutagenesis of human, ovine, rat, and mouse leptin's site III: implications on blocking undesired leptin action in vivo
    Gili Solomon
    Faculty of Agricultural, Food, and Environmental Quality Sciences, The Hebrew University of Jerusalem, POB 12, Rehovot 76100, Israel
    Ann N Y Acad Sci 1091:531-9. 2006
    ..Some muteins were pegylated using 40 kDa PEG. Although pegylation decreased the in vitro activity, increasing circulation half-life can recompensate this deficit, so pegylated antagonists are expected to be more potent in vivo...
  32. doi request reprint The obese phenotype-inducing N82K mutation in human leptin disrupts receptor-binding and biological activity
    Leonora Niv-Spector
    Institute of Biochemistry, Food Science and Nutrition, The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
    Mol Genet Metab 100:193-7. 2010
    ....
  33. ncbi request reprint Ovine placental lactogen specifically binds to endometrial glands of the ovine uterus
    Sekoni Noel
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 68:772-80. 2003
    ..Thus, effects of oPL on the endometrial glands may be mediated by receptors for oPRL and oGH...
  34. ncbi request reprint Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation
    Nele Martens
    Neuroendocrine Immunology, and Pharmacology Department, Medical School, Free University, B 1090 Brussels, Belgium
    J Biol Chem 280:13817-23. 2005
    ....
  35. ncbi request reprint Long-term consequences of maternal high-fat feeding on hypothalamic leptin sensitivity and diet-induced obesity in the offspring
    Jacqueline Férézou-Viala
    Neurobiologie de l Olfaction et de la Prise Alimentaire, UMR 1197, Bâtiment 447, Universite Paris Sud, F 91 405 Orsay Cedex, France
    Am J Physiol Regul Integr Comp Physiol 293:R1056-62. 2007
    ..We conclude that maternal high-fat diet programs a hypothalamic leptin resistance in offspring, which, however, fails to increase the body weight gain until adulthood...
  36. ncbi request reprint Leptin modulates the expression of secreted and membrane-associated mucins in colonic epithelial cells by targeting PKC, PI3K, and MAPK pathways
    Mahmoud El Homsi
    INSERM UMR865, Faculté de Médecine R Laennec, 7 rue Guillaume Paradin, 69008 Lyon, France
    Am J Physiol Gastrointest Liver Physiol 293:G365-73. 2007
    ..These data are consistent with a role for leptin in regulation of the intestinal barrier function...
  37. doi request reprint The effect of neonatal leptin treatment on postnatal weight gain in male rats is dependent on maternal nutritional status during pregnancy
    Mark H Vickers
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Endocrinology 149:1906-13. 2008
    ..These data further reinforce the importance of leptin in determining long-term energy homeostasis, and suggest that leptin's effects are modulated by gender and both prenatal and postnatal nutritional status...
  38. ncbi request reprint Leptin downregulates heat shock protein-70 (HSP-70) gene expression in chicken liver and hypothalamus
    Denise Figueiredo
    Laboratory of Physiology, Immunology and Genetics of Domestic Animals, Catholic University of Leuven, 3001 Heverlee, Belgium
    Cell Tissue Res 329:91-101. 2007
    ..Furthermore, HSP-70 gene expression was gender-dependent with significantly (P < 0.05) higher levels in male than in female chickens...
  39. ncbi request reprint Preparation and characterization of recombinant chicken growth hormone (chGH) and its putative antagonist chGH G119R mutein
    Helena E Paczoska-Eliasiewicz
    Department of Animal Physiology, University of Agriculture, Al Mickiewicza 24 28, 30 059 Krakow, Poland
    Ann N Y Acad Sci 1091:501-8. 2006
    ..These results emphasize the importance of species specificity and indicate the possibility of antagonistic activity of chGH G119R...
  40. ncbi request reprint Divergent effects of leptin on luteinizing hormone and insulin secretion are dose dependent
    Dorota A Zieba
    Animal Reproduction Laboratory, Texas A and M University Agricultural Research Station, Beeville, Texas 78102 9410, USA
    Exp Biol Med (Maywood) 228:325-30. 2003
    ..Collectively, our results show that leptin has potent positive effects on both LH and insulin secretion in fasted cows, but the anterior pituitary and endocrine pancreas appear to become downregulated in the presence of excess ligand...
  41. ncbi request reprint The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin
    Nele Martens
    Neuroendocrine Immunology Group, Pharmacology Department, Medical School, Free University of Brussels VUB, 1090, Belgium
    Exp Cell Res 298:239-48. 2004
    ..Taken together, our data indicate that SOCS-7 interacts with vinexin and the actin cytoskeleton...
  42. ncbi request reprint Prolactin regulation of neonatal ovine uterine gland morphogenesis
    Karen D Carpenter
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Endocrinology 144:110-20. 2003
    ..Collectively, results indicate that PRL regulates endometrial adenogenesis in the neonatal ovine uterus...
  43. ncbi request reprint Exogenous leptin advances puberty in domestic hen
    Helena Elzbieta Paczoska-Eliasiewicz
    Department of Animal Physiology, University of Agriculture, Krakow, Poland
    Domest Anim Endocrinol 31:211-26. 2006
    ..In conclusion, we have shown that in female chickens exogenous leptin advances the onset of puberty by attenuation of ovarian apoptosis and enhancement of folliculogenesis...
  44. ncbi request reprint Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neuronal cell line by a phosphatidylinositol 3-kinase- dependent mechanism
    Yacir Benomar
    Neuroendocrinologie Moléculaire de la Prise Alimentaire, Neurobiologie de l Olfaction et de la Prise Alimentaire, Institut National de la Recherche Agronomique, Universite Paris XI, Orsay, France
    Endocrinology 147:2550-6. 2006
    ..These pathways might contribute to an in vivo glucoregulatory reflex involving a neuronal network and to the anorectic effect of insulin and leptin...
  45. ncbi request reprint Early signaling interactions between the insulin and leptin pathways in bovine myogenic cells
    A Lulu Strat
    Department of Animal and Veterinary Science, University of Idaho, Moscow, 8344, USA
    Biochim Biophys Acta 1744:164-75. 2005
    ....
  46. ncbi request reprint Prenatal influences on leptin sensitivity and susceptibility to diet-induced obesity
    Stefan O Krechowec
    Liggins Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Endocrinol 189:355-63. 2006
    ..Our study suggests that prenatal nutrition can shape future susceptibility to obesity through alterations in leptin sensitivity and changes in energy metabolism during adult life...
  47. ncbi request reprint Synergistic action of growth hormone and insulin-like growth factor I (IGF-I) on proliferation and estradiol secretion in porcine granulosa and theca cells cultured alone or in coculture
    Jolanta Kolodziejczyk
    Laboratory of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060 Krakow, Poland
    Theriogenology 60:559-70. 2003
    ..The promotion of the mitogenic activity in Tc by IGF-I during all stages of follicular development suggests an important role for theca cells in follicular growth...
  48. ncbi request reprint Is leptin an important physiological regulator of CRP?
    Arieh Gertler
    Nat Med 13:18-9; author reply 19-21. 2007
  49. ncbi request reprint The regulation of stearoyl-CoA desaturase gene expression is tissue specific in chickens
    Sami Dridi
    Laboratory of Physiology, Immunology, and Genetics of Domestic Animals, Catholic University of Leuven, KU Leuven, 3001 Heverlee, Belgium
    J Endocrinol 192:229-36. 2007
    ..05). In conclusion, SCD is ubiquitously expressed in chickens and it is regulated by leptin, cerulenin, nutritional state, and gender in a tissue-specific manner...