O Froy

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. doi request reprint Timed high-fat diet resets circadian metabolism and prevents obesity
    Hadas Sherman
    Institute of Biochemistry, Food Science, and Nutrition, Robert H Smith Faculty of Agriculture, Food, and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
    FASEB J 26:3493-502. 2012
  2. ncbi request reprint The relationship between nutrition and circadian rhythms in mammals
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Front Neuroendocrinol 28:61-71. 2007
  3. ncbi request reprint The interrelations among feeding, circadian rhythms and ageing
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Prog Neurobiol 82:142-50. 2007
  4. doi request reprint Relationship between calorie restriction and the biological clock: lessons from long-lived transgenic mice
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, Rehovot, Israel
    Rejuvenation Res 11:467-71. 2008
  5. doi request reprint The suprachiasmatic nuclei are involved in determining circadian rhythms during restricted feeding
    O Froy
    Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Neuroscience 155:1152-9. 2008
  6. doi request reprint Effect of intermittent fasting on circadian rhythms in mice depends on feeding time
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Mech Ageing Dev 130:154-60. 2009
  7. ncbi request reprint Cytochrome P450 and the biological clock in mammals
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Curr Drug Metab 10:104-15. 2009
  8. doi request reprint Defensins in systemic lupus erythematosus
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, Israel
    Ann N Y Acad Sci 1173:365-9. 2009
  9. doi request reprint Metabolism and circadian rhythms--implications for obesity
    Oren Froy
    Institute of Biochemistry, Food Science, and Nutrition, Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
    Endocr Rev 31:1-24. 2010
  10. pmc Effect of feeding regimens on circadian rhythms: implications for aging and longevity
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Aging (Albany NY) 2:7-27. 2010

Collaborators

Detail Information

Publications39

  1. doi request reprint Timed high-fat diet resets circadian metabolism and prevents obesity
    Hadas Sherman
    Institute of Biochemistry, Food Science, and Nutrition, Robert H Smith Faculty of Agriculture, Food, and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
    FASEB J 26:3493-502. 2012
    ..Taken together, our findings suggest that timing can prevent obesity and rectify the harmful effects of a HF diet...
  2. ncbi request reprint The relationship between nutrition and circadian rhythms in mammals
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Front Neuroendocrinol 28:61-71. 2007
    ..In conclusion, there is a large body of evidence that links feeding regimens, food components, and the biological clock...
  3. ncbi request reprint The interrelations among feeding, circadian rhythms and ageing
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Prog Neurobiol 82:142-50. 2007
    ..This surmise is novel, and we provide evidence to support it. Furthermore, we discuss other feeding regimens and their effects on circadian rhythms and/or life span...
  4. doi request reprint Relationship between calorie restriction and the biological clock: lessons from long-lived transgenic mice
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, Rehovot, Israel
    Rejuvenation Res 11:467-71. 2008
    ..As CR resets circadian rhythms, and the circadian clock controls many physiological and biochemical systems, we suggest that the biological clock could be an important mediator of longevity in calorically restricted animals...
  5. doi request reprint The suprachiasmatic nuclei are involved in determining circadian rhythms during restricted feeding
    O Froy
    Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Neuroscience 155:1152-9. 2008
    ..In summary, herein we reinforce a role for calorie restriction in resetting the SCN clock, and unravel a role for the SCN in determining peripheral rhythms under RF...
  6. doi request reprint Effect of intermittent fasting on circadian rhythms in mice depends on feeding time
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Mech Ageing Dev 130:154-60. 2009
    ..Taken together, our results show that IF can affect circadian rhythms differently depending on the timing of food availability, and suggest that this regimen induces a metabolic state that affects the suprachiasmatic nuclei (SCN) clock...
  7. ncbi request reprint Cytochrome P450 and the biological clock in mammals
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Curr Drug Metab 10:104-15. 2009
    ....
  8. doi request reprint Defensins in systemic lupus erythematosus
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, Israel
    Ann N Y Acad Sci 1173:365-9. 2009
    ..Given their immunomodulatory role, alpha-defensin secretion might activate the adaptive immune system leading to the stimulation of the immune system, as is manifested in SLE...
  9. doi request reprint Metabolism and circadian rhythms--implications for obesity
    Oren Froy
    Institute of Biochemistry, Food Science, and Nutrition, Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
    Endocr Rev 31:1-24. 2010
    ..This review will focus on the interconnection between the circadian clock and metabolism, with implications for obesity and how the circadian clock is influenced by hormones, nutrients, and timed meals...
  10. pmc Effect of feeding regimens on circadian rhythms: implications for aging and longevity
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Aging (Albany NY) 2:7-27. 2010
    ..This review will summarize recent findings concerning the relationships between feeding regimens, circadian rhythms, and metabolism with implications for ageing attenuation and life span extension...
  11. doi request reprint Defensin carriers for better mucosal immunity in the digestive system
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Int J Pharm 393:263-7. 2010
    ..These results indicate that defensins encapsulated within alginate carriers could possibly be used for better mucosal immunity in the digestive system...
  12. doi request reprint Spontaneous caloric restriction associated with increased leptin levels in obesity-resistant αMUPA mice
    O Froy
    Robert H Smith Faculty of Agriculture, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, Israel
    Int J Obes (Lond) 35:226-35. 2011
    ..MUPA mice are obesity resistant and they share many similarities with calorically restricted animals. However, extensive metabolic characterization of this unique transgenic model has never been performed...
  13. doi request reprint The circadian clock and metabolism
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
    Clin Sci (Lond) 120:65-72. 2011
    ..The present review will summarize recent findings concerning the relationship between metabolism and circadian rhythms...
  14. doi request reprint Circadian rhythms, aging, and life span in mammals
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
    Physiology (Bethesda) 26:225-35. 2011
    ..This review focuses on recent findings concerning the relationships between circadian rhythms, aging attenuation, and life-span extension in mammals...
  15. ncbi request reprint Long-lived alphaMUPA transgenic mice exhibit pronounced circadian rhythms
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, Rehovot, Israel
    Am J Physiol Endocrinol Metab 291:E1017-24. 2006
    ..Thus we surmise that CR could lead to pronounced and synchronized biological rhythms. Because the biological clock controls mitochondrial, hormonal, and physiological parameters, system synchronicity could lead to extended life span...
  16. ncbi request reprint Differential effect of insulin treatment on decreased levels of beta-defensins and Toll-like receptors in diabetic rats
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
    Mol Immunol 44:796-802. 2007
    ..These findings may lay the grounds for future design of novel treatments that will induce defensins and TLRs and, as a result, bolster the immune system in diabetic patients...
  17. ncbi request reprint Convergent evolution of invertebrate defensins and nematode antibacterial factors
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Trends Microbiol 13:314-9. 2005
    ....
  18. ncbi request reprint Mouse intestinal cryptdins exhibit circadian oscillation
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, Rehovot, Israel
    FASEB J 19:1920-2. 2005
    ..With the assumption of similar control in humans, our results may imply that defensin expression peaks during the day...
  19. ncbi request reprint Arthropod defensins illuminate the divergence of scorpion neurotoxins
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food, and Environmental Quality, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
    J Pept Sci 10:714-8. 2004
    ..Interestingly, phylogenetic analysis of defensins and scorpion neurotoxins illuminates for the first time a putative evolutionary trajectory for scorpion sodium and potassium channel neurotoxins...
  20. ncbi request reprint Regulation of mammalian defensin expression by Toll-like receptor-dependent and independent signalling pathways
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food, and Environmental Quality, The Hebrew University of Jerusalem, Rehovot, Israel
    Cell Microbiol 7:1387-97. 2005
    ..Thus, not only do defensins eliminate pathogens, but they also recruit the adaptive immune system in instances of infection and/or inflammation...
  21. doi request reprint Peroxisome proliferator-activated receptor α (PPARα) activation advances locomotor activity and feeding daily rhythms in mice
    R Gutman
    Institute of Biochemistry, Food Science and Nutrition, Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
    Int J Obes (Lond) 36:1131-4. 2012
    ..As disrupted circadian rhythms lead to obesity, PPARα activation can serve as a clinical target for the modulation of both circadian rhythms and metabolism...
  22. doi request reprint Expression of human beta-defensin 1 is regulated via c-Myc and the biological clock
    Hadas Sherman
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Mol Immunol 45:3163-7. 2008
    ..Thus, hBD-1 expression is mediated by c-Myc and the CLOCK:BMAL1 heterodimer, whereas CRY1 expression represses this complex. These changes in hBD-1 levels lead to its circadian oscillation...
  23. doi request reprint High-fat diet followed by fasting disrupts circadian expression of adiponectin signaling pathway in muscle and adipose tissue
    Maayan Barnea
    Institute of Biochemistry, Food Science and Nutrition, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
    Obesity (Silver Spring) 18:230-8. 2010
    ..In turn, the circadian clock affects the daily rhythm of these adiponectin signaling components...
  24. ncbi request reprint New insight on scorpion divergence inferred from comparative analysis of toxin structure, pharmacology and distribution
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Toxicon 42:549-55. 2003
    ....
  25. ncbi request reprint Differential expression of rat beta-defensins
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, Rehovot, Israel
    IUBMB Life 57:41-3. 2005
    ..These findings demonstrate a different expression pattern for rBD-2 than what has been reported. We conclude that the rat may be a useful model to investigate the function and contribution of beta-defensins to host defense...
  26. pmc High alpha-defensin levels in patients with systemic lupus erythematosus
    Zev M Sthoeger
    Department of Medicine B, Kaplan Medical Center, Rehovot, Israel
    Immunology 127:116-22. 2009
    ..Given the immunomodulatory role of alpha-defensins, it is possible that their secretion may activate the adaptive immune system leading to a systemic response...
  27. doi request reprint High-fat diet delays and fasting advances the circadian expression of adiponectin signaling components in mouse liver
    Maayan Barnea
    Institute of Biochemistry, Food Science, and Nutrition, Faculty of Agricultural, Food, and Environmental Quality, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Endocrinology 150:161-8. 2009
    ....
  28. doi request reprint Glucose and insulin are needed for optimal defensin expression in human cell lines
    Maayan Barnea
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Biochem Biophys Res Commun 367:452-6. 2008
    ..Thus, our findings suggest for the first time that insulin signaling is important for hBD-1 optimal expression by elevating intracellular glucose levels and by mediating gene expression...
  29. ncbi request reprint Circadian oscillation of innate immunity components in mouse small intestine
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Mol Immunol 44:1954-60. 2007
    ..As the clock regulates intestinal motility and function, resetting of the clock in the small intestine may help not only to restore activity but also to gain better protection against pathogens...
  30. ncbi request reprint Albumin and amino acids upregulate the expression of human beta-defensin 1
    Hadas Sherman
    Institute of Biochemistry, Food Science, and Nutrition, Faculty of Agriculture, Food, and Environmental Quality, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Mol Immunol 43:1617-23. 2006
    ..This sequence of events bolsters of the immune system, which may lead to fewer infectious complications, less antibiotics usage, and a shorter hospital stay, as indeed has been shown in patients fed immune-enhancing formulas...
  31. ncbi request reprint Arthropod and mollusk defensins--evolution by exon-shuffling
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
    Trends Genet 19:684-7. 2003
    ..Unlike other exon-shuffling events, in which modules are added into existing proteins, arthropod and mollusk defensins represent the first instance of exon-shuffling of autonomous modules...
  32. ncbi request reprint A one-tube site-directed mutagenesis method using PCR and primer extension
    Nava Chapnik
    Institute of Biochemistry, Food Science, and Nutrition, Faculty of Agricultural, Food, and Environmental Quality, Hebrew University of Jerusalem, Rehovot 76100, Israel
    Anal Biochem 372:255-7. 2008
  33. ncbi request reprint Illuminating the circadian clock in monarch butterfly migration
    Oren Froy
    Department of Neurobiology, University of Massachusetts Medical School, LRB 728, 364 Plantation Street, Worcester, MA 01605, USA
    Science 300:1303-5. 2003
    ..Tracing these distinct light-input pathways into the brain should aid our understanding of the clock-compass mechanisms necessary for successful migration...
  34. ncbi request reprint An 'Old World' scorpion beta-toxin that recognizes both insect and mammalian sodium channels
    Dalia Gordon
    Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Israel
    Eur J Biochem 270:2663-70. 2003
    ....
  35. ncbi request reprint Molecular basis of the high insecticidal potency of scorpion alpha-toxins
    Izhar Karbat
    Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Tel Aviv, Israel
    J Biol Chem 279:31679-86. 2004
    ....
  36. ncbi request reprint Connecting the navigational clock to sun compass input in monarch butterfly brain
    Ivo Sauman
    Institute of Entomology, Czech Academy of Sciences, Ceske Budejovice, Czech Republic
    Neuron 46:457-67. 2005
    ..To provide a link between the clock and the sun compass, we identified a CRYPTOCHROME-staining neural pathway that likely connects the circadian clock to polarized light input entering brain...
  37. ncbi request reprint The two CRYs of the butterfly
    Haisun Zhu
    Curr Biol 15:R953-4. 2005
  38. ncbi request reprint Dissection of the functional surface of an anti-insect excitatory toxin illuminates a putative "hot spot" common to all scorpion beta-toxins affecting Na+ channels
    Lior Cohen
    Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Tel Aviv, Israel
    J Biol Chem 279:8206-11. 2004
    ..Furthermore, the unique structure of the C-terminal region most likely determines the specificity of excitatory toxins for insect NaChs...
  39. ncbi request reprint Redox potential: differential roles in dCRY and mCRY1 functions
    Oren Froy
    Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Curr Biol 12:147-52. 2002
    ..The data provide a multistep redox model for the light-dependent activities of dCRY and suggest that such a model does not apply to mCRY1 transcriptional responses...