Hanna Engelberg Kulka
Affiliation: The Hebrew University
Engelberg Kulka H, Hazan R, Amitai S. mazEF: a chromosomal toxin-antitoxin module that triggers programmed cell death in bacteria. J Cell Sci. 2005;118:4327-32 pubmed
..The mazEF-mediated death pathway can act as a defense mechanism that prevents the spread of bacterial phage infection, allowing bacterial populations to behave like multicellular organisms. ..
Engelberg Kulka H, Amitai S, Kolodkin Gal I, Hazan R. Bacterial programmed cell death and multicellular behavior in bacteria. PLoS Genet. 2006;2:e135 pubmed
..We relate these two bacterial PCD systems to the ways in which bacterial populations resemble multicellular organisms. ..
Nigam A, Ziv T, Oron Gottesman A, Engelberg Kulka H. Stress-Induced MazF-Mediated Proteins in Escherichia coli. MBio. 2019;10: pubmed publisher
..Here, we performed a proteomic analysis of all the E. coli stress-induced proteins that are mediated by chromosomally borne MazF through STM. ..
Kumar S, Engelberg Kulka H. Quorum sensing peptides mediating interspecies bacterial cell death as a novel class of antimicrobial agents. Curr Opin Microbiol. 2014;21:22-7 pubmed publisher
..We suggest that members of the EDF family may become the basis for a novel class of antimicrobial agents to trigger death from outside the bacterial cells. ..
Nigam A, Kumar S, Engelberg Kulka H. Quorum Sensing Extracellular Death Peptides Enhance the Endoribonucleolytic Activities of Mycobacterium tuberculosis MazF Toxins. MBio. 2018;9: pubmed publisher
..The current report provides a basis for the use of the EDF peptides EcEDF and PaEDF as novel antibiotics against M. tuberculosis. ..
Kumar S, Kolodkin Gal I, Vesper O, Alam N, Schueler Furman O, Moll I, et al
. Escherichia coli Quorum-Sensing EDF, A Peptide Generated by Novel Multiple Distinct Mechanisms and Regulated by trans-Translation. MBio. 2016;7:e02034-15 pubmed publisher
..trans-Translation is described as a regulatory system attenuating EDF generation and leading to low levels of EDF in the single cell, as expected for QS. ..
Oron Gottesman A, Sauert M, Moll I, Engelberg Kulka H. A Stress-Induced Bias in the Reading of the Genetic Code in Escherichia coli. MBio. 2016;7: pubmed publisher
..This is because under stress, MazF generates a stress-induced translation machinery (STM) in which MazF cleaves in-frame ACA sites of the processed mRNAs. ..
Engelberg Kulka H, Reches M, Narasimhan S, Schoulaker Schwarz R, Klemes Y, Aizenman E, et al
. rexB of bacteriophage lambda is an anti-cell death gene. Proc Natl Acad Sci U S A. 1998;95:15481-6 pubmed
..Thus, the rex operon may be considered as the "survival operon" of phage lambda. ..