A Darvasi

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. pmc Correlational analysis for identifying genes whose regulation contributes to chronic neuropathic pain
    Anna Karin Persson
    Center for Oral Biology, Novum, Karolinska Institutet, S 141 04 Huddinge, Sweden
    Mol Pain 5:7. 2009
  2. ncbi Dissecting complex traits: the geneticists' "Around the world in 80 days"
    Ariel Darvasi
    The Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Trends Genet 21:373-6. 2005
  3. ncbi Complexities in the genetic dissection of quantitative trait loci
    Ariel Darvasi
    The Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Trends Genet 18:489-91. 2002
  4. pmc A highly significant association between a COMT haplotype and schizophrenia
    Sagiv Shifman
    Institute of Life Sciences, The Hebrew University of Jerusalem, Israel
    Am J Hum Genet 71:1296-302. 2002
  5. doi Type 2 diabetes susceptibility loci in the Ashkenazi Jewish population
    Michal Bronstein
    Department of Genetics, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel
    Hum Genet 124:101-4. 2008
  6. ncbi COMT: a common susceptibility gene in bipolar disorder and schizophrenia
    Sagiv Shifman
    Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Am J Med Genet B Neuropsychiatr Genet 128:61-4. 2004
  7. ncbi Linkage disequilibrium patterns of the human genome across populations
    Sagiv Shifman
    The Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Hum Mol Genet 12:771-6. 2003
  8. ncbi Preferential transmission of interleukin-1 receptor antagonist alleles in attention deficit hyperactivity disorder
    R H Segman
    Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Mol Psychiatry 7:72-4. 2002
  9. pmc Mouse inbred strain sequence information and yin-yang crosses for quantitative trait locus fine mapping
    Sagiv Shifman
    The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Genetics 169:849-54. 2005
  10. ncbi Sex-specific variability and a 'cage effect' independently mask a neuropathic pain quantitative trait locus detected in a whole genome scan
    Marshall Devor
    Department of Cell and Animal Biology, Institute of Life Sciences, and, Center for Research on Pain, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Eur J Neurosci 26:681-8. 2007

Detail Information

Publications35

  1. pmc Correlational analysis for identifying genes whose regulation contributes to chronic neuropathic pain
    Anna Karin Persson
    Center for Oral Biology, Novum, Karolinska Institutet, S 141 04 Huddinge, Sweden
    Mol Pain 5:7. 2009
    ..We sought genes for which the degree of regulation correlates with strain-specific pain phenotype...
  2. ncbi Dissecting complex traits: the geneticists' "Around the world in 80 days"
    Ariel Darvasi
    The Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Trends Genet 21:373-6. 2005
    ..The identification of genes affecting complex traits is expected to provide significant insights into the biochemical mechanisms underlying these poorly understood traits...
  3. ncbi Complexities in the genetic dissection of quantitative trait loci
    Ariel Darvasi
    The Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Trends Genet 18:489-91. 2002
    ..Here we discuss this work in the general context of genetic dissection of complex traits and QTLs...
  4. pmc A highly significant association between a COMT haplotype and schizophrenia
    Sagiv Shifman
    Institute of Life Sciences, The Hebrew University of Jerusalem, Israel
    Am J Hum Genet 71:1296-302. 2002
    ..We found a highly significant association between schizophrenia and a COMT haplotype (P=9.5x10-8). The approach presented can be widely implemented for the genetic dissection of other common diseases...
  5. doi Type 2 diabetes susceptibility loci in the Ashkenazi Jewish population
    Michal Bronstein
    Department of Genetics, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel
    Hum Genet 124:101-4. 2008
    ..Our study, however, strongly supports the robustness of WGA studies for the identification of genes affecting complex traits in general and T2D in particular...
  6. ncbi COMT: a common susceptibility gene in bipolar disorder and schizophrenia
    Sagiv Shifman
    Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Am J Med Genet B Neuropsychiatr Genet 128:61-4. 2004
    ..We suggest that polymorphisms in the COMT gene may influence susceptibility to both diseases--and probably also a wider range of behavioral traits...
  7. ncbi Linkage disequilibrium patterns of the human genome across populations
    Sagiv Shifman
    The Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Hum Mol Genet 12:771-6. 2003
    ..This has significant consequences when using LD mapping for the genetic dissection of complex traits, as higher density SNP maps will be required to scan the genome...
  8. ncbi Preferential transmission of interleukin-1 receptor antagonist alleles in attention deficit hyperactivity disorder
    R H Segman
    Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Mol Psychiatry 7:72-4. 2002
    ..65, df 1, P = 0.03, RR = 0.763, 95% CI 0.59-0.98). If replicated, this finding may point to a role for brain cytokine activity in the etiopathogenesis of ADHD...
  9. pmc Mouse inbred strain sequence information and yin-yang crosses for quantitative trait locus fine mapping
    Sagiv Shifman
    The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Genetics 169:849-54. 2005
    ..This suggests that with a large number of strains in hand, selecting a small number of strains may provide a significant contribution to the fine mapping of QTL...
  10. ncbi Sex-specific variability and a 'cage effect' independently mask a neuropathic pain quantitative trait locus detected in a whole genome scan
    Marshall Devor
    Department of Cell and Animal Biology, Institute of Life Sciences, and, Center for Research on Pain, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Eur J Neurosci 26:681-8. 2007
    ..The high baseline variance in males can explain the difficulty in detecting the genetic effect, which was readily seen in females. Our study emphasizes the importance of sex and environment in the genetic analysis of pain...
  11. pmc Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women
    Sagiv Shifman
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kindgdom
    PLoS Genet 4:e28. 2008
    ..58 (p = 8.8 x 10(-7); p = 1.6 x 10(-5) for gene-sex interaction). The female-specific association between RELN and schizophrenia is one of the few examples of a replicated sex-specific genetic association in any disease...
  12. pmc Identifying alternative hyper-splicing signatures in MG-thymoma by exon arrays
    Lilach Soreq
    Department of Physiology, The Hebrew University, Hadassah Medical School, Jerusalem, Israel
    PLoS ONE 3:e2392. 2008
    ..Here, we report the use of Affymetrix Human Exon Arrays to spot hyper-splicing events characteristic of myasthenia gravis (MG)-thymoma, thymic tumors which develop in patients with MG and discriminate them from colon cancer changes...
  13. ncbi Further tests of the association between schizophrenia and single nucleotide polymorphism markers at the catechol-O-methyltransferase locus in an Askenazi Jewish population using microsatellite markers
    Anat Horowitz
    The Life Science Institute, The Hebrew University of Jerusalem, Israel
    Psychiatr Genet 15:163-9. 2005
    ..Although significant, the extent of linkage disequilibrium in terms of r2 was small (in the order of 0.01)...
  14. ncbi pain1: a neuropathic pain QTL on mouse chromosome 15 in a C3HxC58 backcross
    Marshall Devor
    Department of Cell and Animal Biology, and Center for Research on Pain, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Pain 116:289-93. 2005
    ..We have confirmed the linkage of the QTL, named pain1, to the central region of chromosome 15. Our finding provides the necessary robustness to justify efforts towards identification of the underlying gene...
  15. pmc Quantitative trait locus mapping in dairy cattle by means of selective milk DNA pooling using dinucleotide microsatellite markers: analysis of milk protein percentage
    E Lipkin
    Department of Genetics, Alexander Silberman Institute of Life Science, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Genetics 149:1557-67. 1998
    ..In effect, the statistical power of 45,600 individual genotypings was obtained from 328 pool genotypings. This methodology can make genome-wide mapping of QTL accessible to moderately sized breeding organizations...
  16. ncbi pain2: A neuropathic pain QTL identified on rat chromosome 2
    Jonathan Nissenbaum
    Department of Genetics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Pain 135:92-7. 2008
    ..This chromosomal position indicates that it is possibly a new QTL, and hence we name it pain2. Further work is needed to replicate and to uncover the underlying gene(s) in both species...
  17. ncbi Mice congenic for a locus that determines phenotype in the neuroma model of neuropathic pain
    Pnina Raber
    Department of Cell and Animal Biology, Institute of Life Sciences and Center for Research on Pain, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Exp Neurol 202:200-6. 2006
    ....
  18. ncbi A survey of the 22q11 microdeletion in a large cohort of schizophrenia patients
    Anat Horowitz
    The Life Science Institute, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Schizophr Res 73:263-7. 2005
    ..Moreover, the rate of false positives is very low (P-value in the range of 10(-4) to 10(-3)). Approximately 1% of the patient cohort was found to carry 22q11 deletions...
  19. pmc Susceptibility to chronic pain following nerve injury is genetically affected by CACNG2
    Jonathan Nissenbaum
    Department of Genetics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Genome Res 20:1180-90. 2010
    ..Our findings provide novel information on the genetic basis of neuropathic pain and new insights into pain physiology that may ultimately enable better treatments...
  20. pmc An efficient haplotyping method with DNA pools
    Ester Inbar
    Life Sciences Institute, Givat Ram, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Nucleic Acids Res 30:e76. 2002
    ..The proposed method allows the efficient determination of haplotypes composed of two SNPs in close vicinity (up to 20 kb)...
  21. ncbi Quantitative technologies for allele frequency estimation of SNPs in DNA pools
    Sagiv Shifman
    Department of Evolution, Systematics and Ecology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Mol Cell Probes 16:429-34. 2002
    ..We found that the influence of the error variance attributed to pool construction on quantification accuracy is insignificant and is SNP dependent...
  22. ncbi Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's disease
    Liat BenMoyal-Segal
    The Life Sciences Institute, The Hebrew University of Jerusalem, Israel
    FASEB J 19:452-4. 2005
    ..Our findings suggest that inherited interactive weakness of AChE and PON1 expression increases the insecticide-induced occurrence of Parkinson's disease...
  23. ncbi Power and efficiency of the TDT and case-control design for association scans
    Ralph McGinnis
    GlaxoSmithKline Pharmaceuticals, Harlow, Essex, United Kingdom
    Behav Genet 32:135-44. 2002
    ..Nevertheless, possible population stratification needs to be addressed when the case-control design is applied...
  24. ncbi Experimental designs for QTL fine mapping in rodents
    Anne Shalom
    Life Sciences Institute, Hebrew University of Jerusalem, Jerusalem, Israel
    Methods Mol Biol 195:199-223. 2002
  25. ncbi Genetic dissection of common diseases
    Naomi B Zak
    IDgene Pharmaceutical Ltd Jerusalem, Israel
    Isr Med Assoc J 4:438-43. 2002
    ..The properties of single nucleotide polymorphisms, which are presently the markers of choice, are discussed, and the technologies that are currently available for SNP genotyping are briefly presented...
  26. pmc Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium
    Jukka T Salonen
    Oy Jurilab, and Research Institute of Public Health, University of Kuopio, Kuopio, Finland, and Hope Hospital, Salford, UK
    Am J Hum Genet 81:338-45. 2007
    ..The most significant replicated result was found at the AHI1-LOC441171 gene region...
  27. pmc An integrated in silico gene mapping strategy in inbred mice
    Alessandra C L Cervino
    Department of Informatics, Scripps Florida, Jupiter, Florida 33458, USA
    Genetics 175:321-33. 2007
    ..We therefore recommend using an integrated work flow that uses other genomic information such as linkage regions, regions of shared ancestry, and gene expression information to obtain a list of candidate genes from the genome...
  28. ncbi Closing in on complex traits
    Ariel Darvasi
    Nat Genet 38:861-2. 2006
  29. pmc Using advanced intercross lines for high-resolution mapping of HDL cholesterol quantitative trait loci
    Xiaosong Wang
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genome Res 13:1654-64. 2003
    ..All the major HDL QTLs in our study had homologous counterparts in humans, implying that their underlying genes regulate HDL in humans...
  30. ncbi A complete genetic association scan of the 22q11 deletion region and functional evidence reveal an association between DGCR2 and schizophrenia
    Sagiv Shifman
    Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford, UK
    Hum Genet 120:160-70. 2006
    ..The genetic and functional evidences here reported suggest a possible role of the DGCR2 gene in the pathology of schizophrenia and also in the therapeutic effects of antipsychotic drugs...
  31. ncbi The involvement of ErbB4 with schizophrenia: association and expression studies
    Gilad Silberberg
    Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Med Genet B Neuropsychiatr Genet 141:142-8. 2006
    ..081). This study provides a direct link between ErbB4 and the disease. We propose that NRG1 and its receptor ErbB4 are components of a biological pathway, involved in the pathophysiology of schizophrenia...
  32. ncbi The beauty of admixture
    Ariel Darvasi
    Nat Genet 37:118-9. 2005
  33. ncbi Genomics: Gene expression meets genetics
    Ariel Darvasi
    Nature 422:269-70. 2003
  34. pmc The nature and identification of quantitative trait loci: a community's view
    Oduola Abiola
    Nat Rev Genet 4:911-6. 2003
    ..Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?..
  35. ncbi Mono-nucleotide repeats (MNRs): a neglected polymorphism for generating high density genetic maps in silico
    Helit Cohen
    Department of Biotechnology and Food Engineering, Technion, Israel Institute of Technology, Haifa, Israel
    Hum Genet 115:213-20. 2004
    ..Thus, MNRs have potential for in silico saturation of sequenced eukaryote genomes with informative genetic markers...