Research Topics
Species | A DarvasiSummaryAffiliation: The Hebrew University Country: Israel Publications
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Detail Information
Publications
Correlational analysis for identifying genes whose regulation contributes to chronic neuropathic painAnna Karin Persson
Center for Oral Biology, Novum, Karolinska Institutet, S 141 04 Huddinge, Sweden
Mol Pain 5:7. 2009..We sought genes for which the degree of regulation correlates with strain-specific pain phenotype...
Dissecting complex traits: the geneticists' "Around the world in 80 days"Ariel Darvasi
The Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Trends Genet 21:373-6. 2005..The identification of genes affecting complex traits is expected to provide significant insights into the biochemical mechanisms underlying these poorly understood traits...- Complexities in the genetic dissection of quantitative trait lociAriel Darvasi
The Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Trends Genet 18:489-91. 2002..Here we discuss this work in the general context of genetic dissection of complex traits and QTLs... - A highly significant association between a COMT haplotype and schizophreniaSagiv Shifman
Institute of Life Sciences, The Hebrew University of Jerusalem, Israel
Am J Hum Genet 71:1296-302. 2002..We found a highly significant association between schizophrenia and a COMT haplotype (P=9.5x10-8). The approach presented can be widely implemented for the genetic dissection of other common diseases... 
Type 2 diabetes susceptibility loci in the Ashkenazi Jewish populationMichal Bronstein
Department of Genetics, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel
Hum Genet 124:101-4. 2008..Our study, however, strongly supports the robustness of WGA studies for the identification of genes affecting complex traits in general and T2D in particular...- COMT: a common susceptibility gene in bipolar disorder and schizophreniaSagiv Shifman
Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Am J Med Genet B Neuropsychiatr Genet 128:61-4. 2004..We suggest that polymorphisms in the COMT gene may influence susceptibility to both diseases--and probably also a wider range of behavioral traits... - Linkage disequilibrium patterns of the human genome across populationsSagiv Shifman
The Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Hum Mol Genet 12:771-6. 2003..This has significant consequences when using LD mapping for the genetic dissection of complex traits, as higher density SNP maps will be required to scan the genome... - Preferential transmission of interleukin-1 receptor antagonist alleles in attention deficit hyperactivity disorderR H Segman
Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Mol Psychiatry 7:72-4. 2002..65, df 1, P = 0.03, RR = 0.763, 95% CI 0.59-0.98). If replicated, this finding may point to a role for brain cytokine activity in the etiopathogenesis of ADHD... - Mouse inbred strain sequence information and yin-yang crosses for quantitative trait locus fine mappingSagiv Shifman
The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Genetics 169:849-54. 2005..This suggests that with a large number of strains in hand, selecting a small number of strains may provide a significant contribution to the fine mapping of QTL... - Sex-specific variability and a 'cage effect' independently mask a neuropathic pain quantitative trait locus detected in a whole genome scanMarshall Devor
Department of Cell and Animal Biology, Institute of Life Sciences, and, Center for Research on Pain, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Eur J Neurosci 26:681-8. 2007..The high baseline variance in males can explain the difficulty in detecting the genetic effect, which was readily seen in females. Our study emphasizes the importance of sex and environment in the genetic analysis of pain... - Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in womenSagiv Shifman
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kindgdom
PLoS Genet 4:e28. 2008..58 (p = 8.8 x 10(-7); p = 1.6 x 10(-5) for gene-sex interaction). The female-specific association between RELN and schizophrenia is one of the few examples of a replicated sex-specific genetic association in any disease... - Identifying alternative hyper-splicing signatures in MG-thymoma by exon arraysLilach Soreq
Department of Physiology, The Hebrew University, Hadassah Medical School, Jerusalem, Israel
PLoS ONE 3:e2392. 2008..Here, we report the use of Affymetrix Human Exon Arrays to spot hyper-splicing events characteristic of myasthenia gravis (MG)-thymoma, thymic tumors which develop in patients with MG and discriminate them from colon cancer changes... - Further tests of the association between schizophrenia and single nucleotide polymorphism markers at the catechol-O-methyltransferase locus in an Askenazi Jewish population using microsatellite markersAnat Horowitz
The Life Science Institute, The Hebrew University of Jerusalem, Israel
Psychiatr Genet 15:163-9. 2005..Although significant, the extent of linkage disequilibrium in terms of r2 was small (in the order of 0.01)... - pain1: a neuropathic pain QTL on mouse chromosome 15 in a C3HxC58 backcrossMarshall Devor
Department of Cell and Animal Biology, and Center for Research on Pain, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Pain 116:289-93. 2005..We have confirmed the linkage of the QTL, named pain1, to the central region of chromosome 15. Our finding provides the necessary robustness to justify efforts towards identification of the underlying gene... - Quantitative trait locus mapping in dairy cattle by means of selective milk DNA pooling using dinucleotide microsatellite markers: analysis of milk protein percentageE Lipkin
Department of Genetics, Alexander Silberman Institute of Life Science, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Genetics 149:1557-67. 1998..In effect, the statistical power of 45,600 individual genotypings was obtained from 328 pool genotypings. This methodology can make genome-wide mapping of QTL accessible to moderately sized breeding organizations... - pain2: A neuropathic pain QTL identified on rat chromosome 2Jonathan Nissenbaum
Department of Genetics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Pain 135:92-7. 2008..This chromosomal position indicates that it is possibly a new QTL, and hence we name it pain2. Further work is needed to replicate and to uncover the underlying gene(s) in both species... - Mice congenic for a locus that determines phenotype in the neuroma model of neuropathic painPnina Raber
Department of Cell and Animal Biology, Institute of Life Sciences and Center for Research on Pain, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Exp Neurol 202:200-6. 2006.... - A survey of the 22q11 microdeletion in a large cohort of schizophrenia patientsAnat Horowitz
The Life Science Institute, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Schizophr Res 73:263-7. 2005..Moreover, the rate of false positives is very low (P-value in the range of 10(-4) to 10(-3)). Approximately 1% of the patient cohort was found to carry 22q11 deletions... - Susceptibility to chronic pain following nerve injury is genetically affected by CACNG2Jonathan Nissenbaum
Department of Genetics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Genome Res 20:1180-90. 2010..Our findings provide novel information on the genetic basis of neuropathic pain and new insights into pain physiology that may ultimately enable better treatments... - An efficient haplotyping method with DNA poolsEster Inbar
Life Sciences Institute, Givat-Ram, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Nucleic Acids Res 30:e76. 2002..The proposed method allows the efficient determination of haplotypes composed of two SNPs in close vicinity (up to 20 kb)... - Quantitative technologies for allele frequency estimation of SNPs in DNA poolsSagiv Shifman
Department of Evolution, Systematics and Ecology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Mol Cell Probes 16:429-34. 2002..We found that the influence of the error variance attributed to pool construction on quantification accuracy is insignificant and is SNP dependent... - Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's diseaseLiat BenMoyal-Segal
The Life Sciences Institute, The Hebrew University of Jerusalem, Israel
FASEB J 19:452-4. 2005..Our findings suggest that inherited interactive weakness of AChE and PON1 expression increases the insecticide-induced occurrence of Parkinson's disease... - Power and efficiency of the TDT and case-control design for association scansRalph McGinnis
GlaxoSmithKline Pharmaceuticals, Harlow, Essex, United Kingdom
Behav Genet 32:135-44. 2002..Nevertheless, possible population stratification needs to be addressed when the case-control design is applied... - Experimental designs for QTL fine mapping in rodentsAnne Shalom
Life Sciences Institute, Hebrew University of Jerusalem, Jerusalem, Israel
Methods Mol Biol 195:199-223. 2002 - Genetic dissection of common diseasesNaomi B Zak
IDgene Pharmaceutical Ltd Jerusalem, Israel
Isr Med Assoc J 4:438-43. 2002..The properties of single nucleotide polymorphisms, which are presently the markers of choice, are discussed, and the technologies that are currently available for SNP genotyping are briefly presented... - Type 2 diabetes whole-genome association study in four populations: the DiaGen consortiumJukka T Salonen
Oy Jurilab, and Research Institute of Public Health, University of Kuopio, Kuopio, Finland, and Hope Hospital, Salford, UK
Am J Hum Genet 81:338-45. 2007..The most significant replicated result was found at the AHI1-LOC441171 gene region... - An integrated in silico gene mapping strategy in inbred miceAlessandra C L Cervino
Department of Informatics, Scripps Florida, Jupiter, Florida 33458, USA
Genetics 175:321-33. 2007..We therefore recommend using an integrated work flow that uses other genomic information such as linkage regions, regions of shared ancestry, and gene expression information to obtain a list of candidate genes from the genome... - Closing in on complex traitsAriel Darvasi
Nat Genet 38:861-2. 2006 - Using advanced intercross lines for high-resolution mapping of HDL cholesterol quantitative trait lociXiaosong Wang
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Genome Res 13:1654-64. 2003..All the major HDL QTLs in our study had homologous counterparts in humans, implying that their underlying genes regulate HDL in humans... - A complete genetic association scan of the 22q11 deletion region and functional evidence reveal an association between DGCR2 and schizophreniaSagiv Shifman
Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford, UK
Hum Genet 120:160-70. 2006..The genetic and functional evidences here reported suggest a possible role of the DGCR2 gene in the pathology of schizophrenia and also in the therapeutic effects of antipsychotic drugs... - The involvement of ErbB4 with schizophrenia: association and expression studiesGilad Silberberg
Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Am J Med Genet B Neuropsychiatr Genet 141:142-8. 2006..081). This study provides a direct link between ErbB4 and the disease. We propose that NRG1 and its receptor ErbB4 are components of a biological pathway, involved in the pathophysiology of schizophrenia... - The beauty of admixtureAriel Darvasi
Nat Genet 37:118-9. 2005 - Genomics: Gene expression meets geneticsAriel Darvasi
Nature 422:269-70. 2003 - The nature and identification of quantitative trait loci: a community's viewOduola Abiola
Nat Rev Genet 4:911-6. 2003..Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?.. - Mono-nucleotide repeats (MNRs): a neglected polymorphism for generating high density genetic maps in silicoHelit Cohen
Department of Biotechnology and Food Engineering, Technion, Israel Institute of Technology, Haifa, Israel
Hum Genet 115:213-20. 2004..Thus, MNRs have potential for in silico saturation of sequenced eukaryote genomes with informative genetic markers...