Yackov Berkun

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi request reprint A single testing of serum amyloid a levels as a tool for diagnosis and treatment dilemmas in familial Mediterranean fever
    Yackov Berkun
    Department of Pediatrics, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    Semin Arthritis Rheum 37:182-8. 2007
  2. ncbi request reprint 2756GG genotype of methionine synthase reductase gene is more prevalent in rheumatoid arthritis patients treated with methotrexate and is associated with methotrexate-induced nodulosis
    Yackov Berkun
    Department of Pediatrics, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    J Rheumatol 34:1664-9. 2007
  3. ncbi request reprint Peritoneal adhesions and intestinal obstructions in patients with familial Mediterranean fever--are they more frequent?
    Yackov Berkun
    Department of Pediatrics, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    Semin Arthritis Rheum 36:316-21. 2007
  4. ncbi request reprint Heparin-induced recurrent anaphylaxis
    Y Berkun
    Allergy and Clinical Immunology Unit, Department of Medicine, Hadassah University Hospital, Jerusalem, Israel
    Clin Exp Allergy 34:1916-8. 2004
  5. pmc Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A1298C polymorphism of the MTHFR gene
    Y Berkun
    Department of Paediatrics, Bikur Cholim General Hospital, POB 492, Jerusalem 91004, Israel
    Ann Rheum Dis 63:1227-31. 2004
  6. ncbi request reprint Kingella kingae endocarditis and sepsis in an infant
    Yackov Berkun
    Department of Paediatrics, Bikur Cholim General Hospital, 492, 91004, Jerusalem, Israel
    Eur J Pediatr 163:687-8. 2004
  7. ncbi request reprint Evaluation of adverse reactions to local anesthetics: experience with 236 patients
    Yackov Berkun
    Department of Pediatrics, Bikur Cholim Hospital, Jerusalem, Israel
    Ann Allergy Asthma Immunol 91:342-5. 2003
  8. pmc A man with swollen calf and discoloration of the foot
    Y Berkun
    Department of Medicine, Clinical Immunology and Allergy Unit, Hadassah University Hospital, Jerusalem, Israel
    Postgrad Med J 78:300, 304. 2002
  9. doi request reprint NOD2/CARD15 gene mutations in patients with familial Mediterranean fever
    Yackov Berkun
    Department of Pediatrics and Pediatric Rheumatology, Hadassah Hebrew University Medical Center, Mount Scopus, Jerusalem, Israel
    Semin Arthritis Rheum 42:84-8. 2012
  10. doi request reprint Familial Mediterranean fever in children presenting with attacks of fever alone
    Shai Padeh
    Department of Pediatrics A, Edmond and Lily Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    J Rheumatol 37:865-9. 2010

Collaborators

Detail Information

Publications39

  1. ncbi request reprint A single testing of serum amyloid a levels as a tool for diagnosis and treatment dilemmas in familial Mediterranean fever
    Yackov Berkun
    Department of Pediatrics, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    Semin Arthritis Rheum 37:182-8. 2007
    ..The aim of the study was to determine various correlates of elevated SAA and evaluate the role of SAA measurement in the diagnosis and management of FMF...
  2. ncbi request reprint 2756GG genotype of methionine synthase reductase gene is more prevalent in rheumatoid arthritis patients treated with methotrexate and is associated with methotrexate-induced nodulosis
    Yackov Berkun
    Department of Pediatrics, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    J Rheumatol 34:1664-9. 2007
    ....
  3. ncbi request reprint Peritoneal adhesions and intestinal obstructions in patients with familial Mediterranean fever--are they more frequent?
    Yackov Berkun
    Department of Pediatrics, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    Semin Arthritis Rheum 36:316-21. 2007
    ..The aim of the study was to estimate the rate of spontaneous or postsurgical small-bowel obstruction (SBO) in FMF patients...
  4. ncbi request reprint Heparin-induced recurrent anaphylaxis
    Y Berkun
    Allergy and Clinical Immunology Unit, Department of Medicine, Hadassah University Hospital, Jerusalem, Israel
    Clin Exp Allergy 34:1916-8. 2004
    ..However, the mechanisms underlying these reactions and the role of mast cells in their pathogenesis have not been elucidated...
  5. pmc Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A1298C polymorphism of the MTHFR gene
    Y Berkun
    Department of Paediatrics, Bikur Cholim General Hospital, POB 492, Jerusalem 91004, Israel
    Ann Rheum Dis 63:1227-31. 2004
    ..There is an association between C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene and methotrexate related toxicity...
  6. ncbi request reprint Kingella kingae endocarditis and sepsis in an infant
    Yackov Berkun
    Department of Paediatrics, Bikur Cholim General Hospital, 492, 91004, Jerusalem, Israel
    Eur J Pediatr 163:687-8. 2004
  7. ncbi request reprint Evaluation of adverse reactions to local anesthetics: experience with 236 patients
    Yackov Berkun
    Department of Pediatrics, Bikur Cholim Hospital, Jerusalem, Israel
    Ann Allergy Asthma Immunol 91:342-5. 2003
    ..Adverse reactions to local anesthetics (LAs) are frequently reported. Although most of these reactions are not immune mediated, many patients are referred to allergy clinics and undergo extensive evaluation...
  8. pmc A man with swollen calf and discoloration of the foot
    Y Berkun
    Department of Medicine, Clinical Immunology and Allergy Unit, Hadassah University Hospital, Jerusalem, Israel
    Postgrad Med J 78:300, 304. 2002
  9. doi request reprint NOD2/CARD15 gene mutations in patients with familial Mediterranean fever
    Yackov Berkun
    Department of Pediatrics and Pediatric Rheumatology, Hadassah Hebrew University Medical Center, Mount Scopus, Jerusalem, Israel
    Semin Arthritis Rheum 42:84-8. 2012
    ..Although mutations in the MEFV gene were shown to modify Crohn's disease, the role of NOD2/CARD15 gene mutations in the FMF disease phenotype was never studied before...
  10. doi request reprint Familial Mediterranean fever in children presenting with attacks of fever alone
    Shai Padeh
    Department of Pediatrics A, Edmond and Lily Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    J Rheumatol 37:865-9. 2010
    ..Our objective was clinical and genetic characterization of FMF and its development in pediatric patients who first presented with attacks of fever alone...
  11. doi request reprint The familial Mediterranean fever gene as a modifier of periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome
    Yackov Berkun
    Department of Pediatrics, Edmond and Lily Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    Semin Arthritis Rheum 40:467-72. 2011
    ..We aimed at investigating the effect of MEFV gene mutations on disease phenotype in PFAPA...
  12. doi request reprint Role of the R92Q TNFRSF1A mutation in patients with familial Mediterranean fever
    Dina Marek-Yagel
    Sheba Medical Center, Ramat Gan, and Tel Aviv University, Ramat Aviv, Israel
    Arthritis Care Res (Hoboken) 62:1294-8. 2010
    ..To define the frequency of the R92Q tumor necrosis factor receptor-associated periodic syndrome (TRAPS) mutation in patients with familial Mediterranean fever (FMF) and to study the role of this mutation in FMF...
  13. doi request reprint Cellular interactions of synovial fluid γδ T cells in juvenile idiopathic arthritis
    Anna Bendersky
    Laboratory of Immunoregulation, Sheba Medical Center, Tel Hashomer, Israel
    J Immunol 188:4349-59. 2012
    ....
  14. doi request reprint Colchicine is a safe drug in children with familial Mediterranean fever
    Shai Padeh
    Department of Pediatrics, Edmond and Lily Safra Children s Hospital, Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer, Israel
    J Pediatr 161:1142-6. 2012
    ..To identify any adverse effects of colchicine in a pediatric patients with familial Mediterranean fever (FMF)...
  15. doi request reprint Familial Mediterranean Fever in the first two years of life: a unique phenotype of disease in evolution
    Shai Padeh
    Department of Pediatrics A, Edmond and Lily Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    J Pediatr 156:985-9. 2010
    ..To characterize the clinical and genetic features of familial Mediterranean fever (FMF)...
  16. ncbi request reprint Chronic chilblains: the clinical presentation and disease course in a large paediatric series
    Shai Padeh
    Department of Pediatrics A, Edmond and Lily Safra Children s Hospital, Tel Hashomer, Israel
    Clin Exp Rheumatol 31:463-8. 2013
    ..Pernio, or chronic chilblains, is a localised inflammatory lesion of the skin resulting from an abnormal response to cold. The aim of this study was to better characterise the clinical presentation of chronic chilblains in children...
  17. doi request reprint Clinical disease among patients heterozygous for familial Mediterranean fever
    Dina Marek-Yagel
    Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Israel, and Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Arthritis Rheum 60:1862-6. 2009
    ..To define the molecular basis of familial Mediterranean fever (FMF) in patients with only 1 mutation in the MEFV gene...
  18. doi request reprint Increased intracranial pressure related to systemic lupus erythematosus: a 26-year experience
    Alon Y Hershko
    Clinical Immunology and Rheumatology Units, Department of Medicine Hadassah University Hospital, Jerusalem, Israel
    Semin Arthritis Rheum 38:110-5. 2008
    ..To assess whether increased intracranial pressure (IIP) is associated or coincidental with systemic lupus erythematosus (SLE) and to characterize the patients with this condition, its commonly used treatment, and outcome...
  19. doi request reprint T-cell compartment in synovial fluid of pediatric patients with JIA correlates with disease phenotype
    Ninette Amariglio
    Cancer Research Center, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Clin Immunol 31:1021-8. 2011
    ..Oligoarthritis, which is considered a pauciarticular subtype since it involves up to four joints upon presentation, is further divided into persistent or extended forms based on disease progression...
  20. doi request reprint Children with oligoarticular juvenile idiopathic arthritis are at considerable risk for growth retardation
    Shai Padeh
    Department of Pediatrics, Sackler School of Medicine, Tel Aviv University, Israel
    J Pediatr 159:832-837.e1-2. 2011
    ..To assess linear growth in patients with persistent oligoarticular juvenile idiopathic arthritis (JIA) treated by intra-articular corticosteroid injections (IACSI)...
  21. ncbi request reprint Increased morbidity and mortality in patients with antiphospholipid syndrome undergoing valve replacement surgery
    Yackov Berkun
    Department of Pediatrics, Bikur Cholim Hospital, Jerusalem, Israel
    J Thorac Cardiovasc Surg 127:414-20. 2004
    ..We analyzed the results of valve replacement in patients with this condition at our institution...
  22. doi request reprint Differentiation of post-streptococcal reactive arthritis from acute rheumatic fever
    Judith Barash
    Pediatric Day Care and Pediatric Rheumatology Service, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem, Israel
    J Pediatr 153:696-9. 2008
    ....
  23. doi request reprint Pregnancy outcomes in women with familial Mediterranean fever receiving colchicine: is amniocentesis justified?
    Eli Ben-Chetrit
    Shaare Zedek Medical Center, Jerusalem, Israel
    Arthritis Care Res (Hoboken) 62:143-8. 2010
    ..To evaluate the outcome of pregnancies in women with familial Mediterranean fever (FMF) who are taking colchicine, and to reconsider the justification for amniocentesis in these women...
  24. doi request reprint GammadeltaT cells in juvenile idiopathic arthritis: higher percentages of synovial Vdelta1+ and Vgamma9+ T cell subsets are associated with milder disease
    Yackov Berkun
    Department of Pediatrics, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, 52621 Israel
    J Rheumatol 38:1123-9. 2011
    ..To analyze γδT cell subsets in peripheral blood (PB) and synovial fluid (SF) of patients with juvenile idiopathic arthritis (JIA), and to correlate γδT cell subsets with clinical characteristics...
  25. doi request reprint Intracardiac thrombus and pulmonary aneurysms in an adolescent with Behçet disease
    Asaf Vivante
    Department of Pediatrics, Lily and Edmond Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    Rheumatol Int 29:575-7. 2009
    ..The patient was successfully treated with colchicine, prednisone, cyclophosphamide and enoxaparine. A discussion about PAA and intracardiac thrombi and their role in BD is provided in this case...
  26. doi request reprint Dermatologic manifestations of ataxia-telangiectasia syndrome
    Shoshana Greenberger
    Department of Dermatology, Sheba Medical Center, Ramat Gan, Israel
    J Am Acad Dermatol 68:932-6. 2013
    ..Previous reports on the cutaneous manifestations of ataxia-telangiectasia (A-T) have relied on data from small series, in patients not genetically tested for A-T...
  27. doi request reprint Pentraxin 3 is a marker of early joint inflammation in patients with juvenile idiopathic arthritis
    Shai Padeh
    Department of Pediatrics A, Edmond and Lily Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    Immunol Res 56:444-50. 2013
    ..Higher SF-PTX3 levels were associated with several clinical features reflecting disease severity and prognostic data. Measuring SF-PTX3 levels may help in providing a more focused and patient-adjusted treatment...
  28. doi request reprint Impact of persistent antiphospholipid antibodies on risk of incident symptomatic thromboembolism in children: a systematic review and meta-analysis
    Gili Kenet
    The Israel National Haemophilia Centre, Sheba Medical Centre, Tel Hashomer, Israel
    Semin Thromb Hemost 37:802-9. 2011
    ..9/2.2-10.9). The present meta-analysis indicates that detection of persistent aPL is clinically meaningful in children with, or at risk for, TE and underscores the importance of pediatric thrombophilia screening programs...
  29. doi request reprint Environmental factors and the geoepidemiology of juvenile idiopathic arthritis
    Yackov Berkun
    Department of Pediatrics, Edmond and Lily Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    Autoimmun Rev 9:A319-24. 2010
    ..Although many new data on the importance of the environment in JIA etiopathogenesis have appeared, the causal-result association between environmental factors and JIA remains complex and further studies are needed...
  30. doi request reprint Altered dendritic cells with tolerizing phenotype in patients with systemic lupus erythematosus
    Yackov Berkun
    The Laboratory for Cellular and Molecular Immunology, Rheumatology Unit, Department of Medicine, Hadassah Hebrew University, Jerusalem, Israel
    Eur J Immunol 38:2896-904. 2008
    ..These results suggest that a substantial portion of SLE patients fail to generate DC with a tolerizing phenotype...
  31. doi request reprint The Thr224Asn mutation in the VPS45 gene is associated with the congenital neutropenia and primary myelofibrosis of infancy
    Polina Stepensky
    Department of Pediatric Hematology Oncology, Hadassah, Hebrew University Medical Center, Jerusalem, Israel
    Blood 121:5078-87. 2013
    ..This is the first report of a Vps45-related disease in humans, manifesting by neutropenia, thrombasthenia, myelofibrosis, and progressive bone marrow failure...
  32. pmc Cellular and clinical report of new Griscelli syndrome type III cases
    Wendy Westbroek
    Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, NIH, Bethesda MD, USA
    Pigment Cell Melanoma Res 25:47-56. 2012
    ..Additionally, co-immunoprecipitation assays showed that MLPH(R35W) lost its interaction with RAB27A, indicating pathogenicity of the R35W mutation...
  33. ncbi request reprint Periodic fever accompanied by aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA syndrome) in adults
    Shai Padeh
    Department of Pediatrics A, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 10:358-60. 2008
    ..It usually begins before the age of 5 years and in most cases resolves spontaneously before age 10...
  34. ncbi request reprint Pediatric antiphospholipid syndrome
    Yackov Berkun
    Pediatric Rheumatology Unit, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 10:45-7. 2008
  35. ncbi request reprint [Anti-IgE--a new treatment for allergic diseases]
    Yackov Berkun
    Department of Pediatrics, Bikur Cholim Hospital, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Harefuah 141:260-2, 314. 2002
    ..Clinical efficacy and good tolerability were demonstrated. This novel therapeutic approach also appears to be promising for potential treatment of patients suffering concomitantly from several allergic disorders...
  36. ncbi request reprint Antiphospholipid syndrome and recurrent thrombosis in children
    Y Berkun
    Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    Arthritis Rheum 55:850-5. 2006
    ..Our aims were to analyze the clinical and laboratory manifestations in a pediatric APS cohort and to assess the influence of inherited thrombophilia factors on the outcome of children with APS...
  37. doi request reprint Age-related efficacy of Shigella O-specific polysaccharide conjugates in 1-4-year-old Israeli children
    Justen H Passwell
    Safra Children s Hospital, Sheba Medical Center, Tel Hashomer 52621, Israel
    Vaccine 28:2231-5. 2010
    ..We reported the safety and immunogenicity of Shigella O-specific polysaccharide-protein conjugates in adults and young children and efficacy of Shigella sonnei conjugate in young adults...
  38. doi request reprint Acute otitis media in the first two months of life: characteristics and diagnostic difficulties
    Y Berkun
    Department of Pediatrics, Bikur Cholim Hospital, Jerusalem, Israel
    Arch Dis Child 93:690-4. 2008
    ..To assess the clinical and laboratory features of acute otitis media (AOM) in infants younger than 2 months, to look for factors predicting bacterial otitis, and to evaluate the accuracy of AOM diagnosis among paediatricians...
  39. ncbi request reprint Perceived efficacy among patients of various methods of complementary alternative medicine for rheumatologic diseases
    G S Breuer
    Rheumatology Service, Department of Internal Medicine, Shaare Zedek Medical Center and the Hebrew University Medical School, Jerusalem, Israel
    Clin Exp Rheumatol 23:693-6. 2005
    ..The purpose of this cross-sectional survey was to obtain and analyze data on self-perceived efficacy of different types of complementary alternative medicine (CAM) by patients with various rheumatologic conditions...