Yinon Ben-Neriah

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi request reprint NF-kappaB inhibition: a double-edged sword in cancer?
    Eli Pikarsky
    Department of Pathology, Hebrew University Hadassah Medical School, Ein Kerem Campus, Kiryat Hadassah, Jerusalem 91120, Israel
    Eur J Cancer 42:779-84. 2006
  2. ncbi request reprint Regulatory functions of ubiquitination in the immune system
    Yinon Ben-Neriah
    The Lautenberg Center for Immunology, The Hebrew University Hadassah Medical School, Jerusalem, 91120, Israel
    Nat Immunol 3:20-6. 2002
  3. doi request reprint Inflammation meets cancer, with NF-κB as the matchmaker
    Yinon Ben-Neriah
    Lautenberg Center for Immunology, Institute for Medical Research Israel Canada, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Nat Immunol 12:715-23. 2011
  4. pmc Of mice and men
    Yinon Ben-Neriah
    The Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    EMBO Rep 5:668-73. 2004
  5. pmc beta-TrCP inhibition reduces prostate cancer cell growth via upregulation of the aryl hydrocarbon receptor
    Udi Gluschnaider
    Department of Pathology and the Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    PLoS ONE 5:e9060. 2010
  6. pmc Pseudosubstrate regulation of the SCF(beta-TrCP) ubiquitin ligase by hnRNP-U
    Matti Davis
    The Lautenberg Center for Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Genes Dev 16:439-51. 2002
  7. pmc Ubiquitination and degradation of the inhibitors of NF-kappaB
    Naama Kanarek
    Department of Immunology and Genetics and Biotechnology, Hebrew University Hadassah Medical School, Institute of Medical Research Israel Canada, Jerusalem, 91120, Israel
    Cold Spring Harb Perspect Biol 2:a000166. 2010
  8. doi request reprint A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism
    Ariel Pribluda
    The Lautenberg Center for Immunology, Institute of Medical Research, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Cancer Cell 24:242-56. 2013
  9. doi request reprint CKIα ablation highlights a critical role for p53 in invasiveness control
    Ela Elyada
    The Lautenberg Center for Immunology, IMRIC, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Nature 470:409-13. 2011
  10. ncbi request reprint NF-kappaB functions as a tumour promoter in inflammation-associated cancer
    Eli Pikarsky
    Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    Nature 431:461-6. 2004

Collaborators

Detail Information

Publications30

  1. ncbi request reprint NF-kappaB inhibition: a double-edged sword in cancer?
    Eli Pikarsky
    Department of Pathology, Hebrew University Hadassah Medical School, Ein Kerem Campus, Kiryat Hadassah, Jerusalem 91120, Israel
    Eur J Cancer 42:779-84. 2006
    ..Further cancer model studies should help to clarify this issue, complementing the intensive drug development effort of the pharmaceutical industry around NF-kappaB...
  2. ncbi request reprint Regulatory functions of ubiquitination in the immune system
    Yinon Ben-Neriah
    The Lautenberg Center for Immunology, The Hebrew University Hadassah Medical School, Jerusalem, 91120, Israel
    Nat Immunol 3:20-6. 2002
    ..Therefore, it is not surprising that the ever-evolving immune system is an excellent mirror for the multiple roles played by ubiquitination within an organism...
  3. doi request reprint Inflammation meets cancer, with NF-κB as the matchmaker
    Yinon Ben-Neriah
    Lautenberg Center for Immunology, Institute for Medical Research Israel Canada, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Nat Immunol 12:715-23. 2011
    ..Understanding the activity and function of NF-κB in the context of tumorigenesis is critical for its successful taming, an important challenge for modern cancer biology...
  4. pmc Of mice and men
    Yinon Ben-Neriah
    The Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    EMBO Rep 5:668-73. 2004
  5. pmc beta-TrCP inhibition reduces prostate cancer cell growth via upregulation of the aryl hydrocarbon receptor
    Udi Gluschnaider
    Department of Pathology and the Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    PLoS ONE 5:e9060. 2010
    ..Thus, alternative strategies targeting novel molecular mechanisms are required. beta-TrCP is an E3 ligase that targets various substrates essential for many aspects of tumorigenesis...
  6. pmc Pseudosubstrate regulation of the SCF(beta-TrCP) ubiquitin ligase by hnRNP-U
    Matti Davis
    The Lautenberg Center for Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Genes Dev 16:439-51. 2002
    ..Our study points to a novel regulatory mechanism, which secures the localization, stability, substrate binding threshold, and efficacy of a specific protein-ubiquitin ligase...
  7. pmc Ubiquitination and degradation of the inhibitors of NF-kappaB
    Naama Kanarek
    Department of Immunology and Genetics and Biotechnology, Hebrew University Hadassah Medical School, Institute of Medical Research Israel Canada, Jerusalem, 91120, Israel
    Cold Spring Harb Perspect Biol 2:a000166. 2010
    ..Here, we review the process of signal-induced IkappaB ubiquitination and degradation by comparing the degradation of several IkappaBs and discussing the characteristics of IkappaBs' ubiquitin machinery...
  8. doi request reprint A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism
    Ariel Pribluda
    The Lautenberg Center for Immunology, Institute of Medical Research, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Cancer Cell 24:242-56. 2013
    ..SIR/para-inflammation suppression may therefore constitute a key mechanism in the anticarcinogenic effects of nonsteroidal anti-inflammatory drugs. ..
  9. doi request reprint CKIα ablation highlights a critical role for p53 in invasiveness control
    Ela Elyada
    The Lautenberg Center for Immunology, IMRIC, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Nature 470:409-13. 2011
    ..PSIS transcription and tumour invasion were suppressed by p21, independently of cell cycle control. Restraining tissue invasion through suppressing PSIS expression is thus a novel tumour-suppressor function of wild-type p53...
  10. ncbi request reprint NF-kappaB functions as a tumour promoter in inflammation-associated cancer
    Eli Pikarsky
    Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    Nature 431:461-6. 2004
    ..Our studies thus indicate that NF-kappaB is essential for promoting inflammation-associated cancer, and is therefore a potential target for cancer prevention in chronic inflammatory diseases...
  11. pmc Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway
    Sharon Amit
    The Lautenberg Center for Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Genes Dev 16:1066-76. 2002
    ..Wnt3A signaling and Dvl overexpression suppress S45 phosphorylation, thereby precluding the initiation of the cascade. Thus, a single, CKI-dependent phosphorylation event serves as a molecular switch for the Wnt pathway...
  12. pmc Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF{beta}-TrCP by single substrate depletion
    Naama Kanarek
    The Lautenberg Center for Immunology, Jerusalem, Israel
    Genes Dev 24:470-7. 2010
    ..Our studies highlight an unexpected functional reserve of this central E3, as well as a bottleneck in a specific tissue: a single substrate whose stabilization is incompatible with testicular differentiation...
  13. pmc Metalloprotease type III effectors that specifically cleave JNK and NF-κB
    Kobi Baruch
    Department of Microbiology and Molecular Genetics, IMRIC, The Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, Israel
    EMBO J 30:221-31. 2011
    ..This is a remarkable example of a pathogen using multiple effectors to manipulate systematically the host inflammatory response signalling network...
  14. pmc Genome-wide analysis of androgen receptor targets reveals COUP-TF1 as a novel player in human prostate cancer
    Ruth Perets
    Department of Pathology and Lautenberg center for immunology, IMRIC, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    PLoS ONE 7:e46467. 2012
    ..This study extends the pool of recognized putative AR targets and identifies a negatively regulated target of AR - COUP-TF1 - which could possibly play a role in human prostate cancer...
  15. doi request reprint Regulation of NF-κB by ubiquitination and degradation of the IκBs
    Naama Kanarek
    Lautenberg Centre for Immunology and Cancer Research, Institute for Medical Research Israel Canada, The Hebrew University, Hadassah Medical School, Jerusalem, Israel
    Immunol Rev 246:77-94. 2012
    ..However, we may still need to advance our understanding of the mechanism of IκB degradation as well as of the diverse functions of β-TrCP in vivo...
  16. ncbi request reprint Nuclear factor-kappaB protects the liver against genotoxic stress and functions independently of p53
    Iris Lavon
    The Lautenberg Center for Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Cancer Res 63:25-30. 2003
    ..These findings may have important implications with respect to the potential use of NF-kappaB modulators in cancer therapy...
  17. ncbi request reprint NF-kappaB activation in cancer: a challenge for ubiquitination- and proteasome-based therapeutic approach
    Sharon Amit
    The Lautenberg Center for Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Semin Cancer Biol 13:15-28. 2003
    ..We, therefore, compare the related activation pathways and discuss the possibility of differential targeting of the involved ubiquitination machinery...
  18. doi request reprint Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk
    Moshe Biton
    Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Nat Immunol 12:239-46. 2011
    ..Our findings indicate that epithelial microRNAs are key regulators of gut homeostasis and mucosal immunity...
  19. ncbi request reprint Behind the scenes of anergy: a tale of three E3s
    Matti Davis
    Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Nat Immunol 5:238-40. 2004
  20. pmc The type III secretion effector NleE inhibits NF-kappaB activation
    Chen Nadler
    Department of Microbiology and Molecular Genetics, IMRIC, Faculty of Medicine, The Hebrew University, Jerusalem, Israel
    PLoS Pathog 6:e1000743. 2010
    ..In conclusion, this study describes two effectors, NleB and NleE, with no similarity to other known proteins, used by pathogens to manipulate NF-kappaB signaling pathways...
  21. ncbi request reprint Enhanced heat shock protein 70 expression alters proteasomal degradation of IkappaB kinase in experimental acute respiratory distress syndrome
    Yoram G Weiss
    Department of Anesthesiology and Critical Care Medicine and the Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University School of Medicine, Jerusalem, Israel
    Crit Care Med 35:2128-38. 2007
    ..We tested the hypothesis that Hsp70 attenuates NF-kappaB activation at multiple points in the IkappaBalpha degradative pathway...
  22. ncbi request reprint Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappa B activation
    Arieh Moussaieff
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Jerusalem 91120, Israel
    Mol Pharmacol 72:1657-64. 2007
    ..Cembrenoid diterpenoids, specifically IA and its derivatives, may thus constitute a potential novel group of NF-kappaB inhibitors, originating from an ancient anti-inflammatory herbal remedy...
  23. ncbi request reprint Pinning NF-kappaB to the nucleus
    Yinon Ben-Neriah
    The Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Mol Cell 12:1344-5. 2003
    ..The proposed mechanism involves protection of Pin1-bound p65 against SOCS-1-mediated ubiquitination...
  24. doi request reprint Contradictory functions of NF-kappaB in liver physiology and cancer
    Gilad W Vainer
    Department of Pathology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Cancer Lett 267:182-8. 2008
    ..In this review, we will focus on the seemingly contradictory role of NF-kappaB in liver homeostasis, as well as in liver cancer...
  25. doi request reprint Incensole acetate: a novel neuroprotective agent isolated from Boswellia carterii
    Arieh Moussaieff
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Jerusalem, Israel
    J Cereb Blood Flow Metab 28:1341-52. 2008
    ..This study attributes the anti-inflammatory activity of Boswellia resin to IA and related cembranoid diterpenes and suggests that they may serve as novel neuroprotective agents...
  26. ncbi request reprint Inhibition of NF-kappaB activation and expression of inflammatory mediators by polyacetylene spiroketals from Plagius flosculosus
    Marco A Calzado
    Department of Chemistry and Biochemistry, University of Bern, Switzerland
    Biochim Biophys Acta 1729:88-93. 2005
    ..Accordingly, compound 1, which is also found in the widely used medicinal herb chamomile, interfered with the LPS-induced production of IL-1, IL-6, TNF, and PGE2 in primary human monocytes...
  27. pmc betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932
    Valerie Lang
    Division of Immune Cell Biology, National Institute for Medical Research, London NW7 1AA, United Kingdom
    Mol Cell Biol 23:402-13. 2003
    ..Thus, it appears that reduced p105 recruitment of betaTrCP and subsequent ubiquitination may contribute to delayed p105 proteolysis after TNF-alpha stimulation relative to that for IkappaBalpha...
  28. ncbi request reprint Epithelial NF-kappaB maintains host gut microflora homeostasis
    Yinon Ben-Neriah
    Nat Immunol 8:479-81. 2007
  29. ncbi request reprint Inflammation and cancer: is the link as simple as we think?
    Brian J Nickoloff
    Oncology Institute, Cardinal Bernadin Cancer Center, Loyola University Chicago Medical Center, Chicago, Illinois, USA
    J Invest Dermatol 124:x-xiv. 2005
  30. ncbi request reprint Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells
    Jongdae Lee
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0663, USA
    Nat Cell Biol 8:1327-36. 2006
    ..Our data provide a case for organ-specific innate immunity in which TLR expression in polarized IECs has uniquely evolved to maintain colonic homeostasis and regulate tolerance and inflammation...