Research Topics
Genomes and Genes
| Yinon Ben-NeriahSummaryAffiliation: The Hebrew University Country: Israel Publications
| Collaborators
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Detail Information
Publications
NF-kappaB inhibition: a double-edged sword in cancer?Eli Pikarsky
Department of Pathology, Hebrew University Hadassah Medical School, Ein Kerem Campus, Kiryat Hadassah, Jerusalem 91120, Israel
Eur J Cancer 42:779-84. 2006..Further cancer model studies should help to clarify this issue, complementing the intensive drug development effort of the pharmaceutical industry around NF-kappaB...- Regulatory functions of ubiquitination in the immune systemYinon Ben-Neriah
The Lautenberg Center for Immunology, The Hebrew University Hadassah Medical School, Jerusalem, 91120, Israel
Nat Immunol 3:20-6. 2002..Therefore, it is not surprising that the ever-evolving immune system is an excellent mirror for the multiple roles played by ubiquitination within an organism... 
Of mice and menYinon Ben-Neriah
The Lautenberg Center for Immunology, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel
EMBO Rep 5:668-73. 2004
Inflammation meets cancer, with NF-κB as the matchmakerYinon Ben-Neriah
Lautenberg Center for Immunology, Institute for Medical Research Israel Canada, Hebrew University Hadassah Medical School, Jerusalem, Israel
Nat Immunol 12:715-23. 2011..Understanding the activity and function of NF-κB in the context of tumorigenesis is critical for its successful taming, an important challenge for modern cancer biology...- beta-TrCP inhibition reduces prostate cancer cell growth via upregulation of the aryl hydrocarbon receptorUdi Gluschnaider
Department of Pathology and the Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
PLoS ONE 5:e9060. 2010..Thus, alternative strategies targeting novel molecular mechanisms are required. beta-TrCP is an E3 ligase that targets various substrates essential for many aspects of tumorigenesis... - Pseudosubstrate regulation of the SCF(beta-TrCP) ubiquitin ligase by hnRNP-UMatti Davis
The Lautenberg Center for Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Genes Dev 16:439-51. 2002..Our study points to a novel regulatory mechanism, which secures the localization, stability, substrate binding threshold, and efficacy of a specific protein-ubiquitin ligase... - Ubiquitination and degradation of the inhibitors of NF-kappaBNaama Kanarek
Department of Immunology and Genetics and Biotechnology, Hebrew University Hadassah Medical School, Institute of Medical Research Israel Canada, Jerusalem, 91120, Israel
Cold Spring Harb Perspect Biol 2:a000166. 2010..Here, we review the process of signal-induced IkappaB ubiquitination and degradation by comparing the degradation of several IkappaBs and discussing the characteristics of IkappaBs' ubiquitin machinery... - CKIα ablation highlights a critical role for p53 in invasiveness controlEla Elyada
The Lautenberg Center for Immunology, IMRIC, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Nature 470:409-13. 2011..PSIS transcription and tumour invasion were suppressed by p21, independently of cell cycle control. Restraining tissue invasion through suppressing PSIS expression is thus a novel tumour-suppressor function of wild-type p53... - Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF{beta}-TrCP by single substrate depletionNaama Kanarek
The Lautenberg Center for Immunology, Jerusalem, Israel
Genes Dev 24:470-7. 2010..Our studies highlight an unexpected functional reserve of this central E3, as well as a bottleneck in a specific tissue: a single substrate whose stabilization is incompatible with testicular differentiation... - Metalloprotease type III effectors that specifically cleave JNK and NF-κBKobi Baruch
Department of Microbiology and Molecular Genetics, IMRIC, The Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, Israel
EMBO J 30:221-31. 2011..This is a remarkable example of a pathogen using multiple effectors to manipulate systematically the host inflammatory response signalling network... - NF-kappaB functions as a tumour promoter in inflammation-associated cancerEli Pikarsky
Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
Nature 431:461-6. 2004..Our studies thus indicate that NF-kappaB is essential for promoting inflammation-associated cancer, and is therefore a potential target for cancer prevention in chronic inflammatory diseases... - Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathwaySharon Amit
The Lautenberg Center for Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Genes Dev 16:1066-76. 2002..Wnt3A signaling and Dvl overexpression suppress S45 phosphorylation, thereby precluding the initiation of the cascade. Thus, a single, CKI-dependent phosphorylation event serves as a molecular switch for the Wnt pathway... - Regulation of NF-κB by ubiquitination and degradation of the IκBsNaama Kanarek
Lautenberg Centre for Immunology and Cancer Research, Institute for Medical Research Israel Canada, The Hebrew University, Hadassah Medical School, Jerusalem, Israel
Immunol Rev 246:77-94. 2012..However, we may still need to advance our understanding of the mechanism of IκB degradation as well as of the diverse functions of β-TrCP in vivo... - Nuclear factor-kappaB protects the liver against genotoxic stress and functions independently of p53Iris Lavon
The Lautenberg Center for Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Cancer Res 63:25-30. 2003..These findings may have important implications with respect to the potential use of NF-kappaB modulators in cancer therapy... - NF-kappaB activation in cancer: a challenge for ubiquitination- and proteasome-based therapeutic approachSharon Amit
The Lautenberg Center for Immunology, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel
Semin Cancer Biol 13:15-28. 2003..We, therefore, compare the related activation pathways and discuss the possibility of differential targeting of the involved ubiquitination machinery... - Genome-Wide Analysis of Androgen Receptor Targets Reveals COUP-TF1 as a Novel Player in Human Prostate CancerRuth Perets
Department of Pathology and Lautenberg center for immunology, IMRIC, The Hebrew University Hadassah Medical School, Jerusalem, Israel Division of Oncology, Rambam Health Care Campus, Haifa, Israel
PLoS ONE 7:e46467. 2012..This study extends the pool of recognized putative AR targets and identifies a negatively regulated target of AR - COUP-TF1 - which could possibly play a role in human prostate cancer... - Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalkMoshe Biton
Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
Nat Immunol 12:239-46. 2011..Our findings indicate that epithelial microRNAs are key regulators of gut homeostasis and mucosal immunity... - Enhanced heat shock protein 70 expression alters proteasomal degradation of IkappaB kinase in experimental acute respiratory distress syndromeYoram G Weiss
Department of Anesthesiology and Critical Care Medicine and the Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University School of Medicine, Jerusalem, Israel
Crit Care Med 35:2128-38. 2007..We tested the hypothesis that Hsp70 attenuates NF-kappaB activation at multiple points in the IkappaBalpha degradative pathway... - The type III secretion effector NleE inhibits NF-kappaB activationChen Nadler
Department of Microbiology and Molecular Genetics, IMRIC, Faculty of Medicine, The Hebrew University, Jerusalem, Israel
PLoS Pathog 6:e1000743. 2010..In conclusion, this study describes two effectors, NleB and NleE, with no similarity to other known proteins, used by pathogens to manipulate NF-kappaB signaling pathways... - Behind the scenes of anergy: a tale of three E3sMatti Davis
Lautenberg Center for Immunology, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel
Nat Immunol 5:238-40. 2004 - Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappa B activationArieh Moussaieff
Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Jerusalem 91120, Israel
Mol Pharmacol 72:1657-64. 2007..Cembrenoid diterpenoids, specifically IA and its derivatives, may thus constitute a potential novel group of NF-kappaB inhibitors, originating from an ancient anti-inflammatory herbal remedy... - Contradictory functions of NF-kappaB in liver physiology and cancerGilad W Vainer
Department of Pathology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Cancer Lett 267:182-8. 2008..In this review, we will focus on the seemingly contradictory role of NF-kappaB in liver homeostasis, as well as in liver cancer... - Pinning NF-kappaB to the nucleusYinon Ben-Neriah
The Lautenberg Center for Immunology, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel
Mol Cell 12:1344-5. 2003..The proposed mechanism involves protection of Pin1-bound p65 against SOCS-1-mediated ubiquitination... - Incensole acetate: a novel neuroprotective agent isolated from Boswellia carteriiArieh Moussaieff
Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Jerusalem, Israel
J Cereb Blood Flow Metab 28:1341-52. 2008..This study attributes the anti-inflammatory activity of Boswellia resin to IA and related cembranoid diterpenes and suggests that they may serve as novel neuroprotective agents... - betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932Valerie Lang
Division of Immune Cell Biology, National Institute for Medical Research, London NW7 1AA, United Kingdom
Mol Cell Biol 23:402-13. 2003..Thus, it appears that reduced p105 recruitment of betaTrCP and subsequent ubiquitination may contribute to delayed p105 proteolysis after TNF-alpha stimulation relative to that for IkappaBalpha... - Inhibition of NF-kappaB activation and expression of inflammatory mediators by polyacetylene spiroketals from Plagius flosculosusMarco A Calzado
Department of Chemistry and Biochemistry, University of Bern, Switzerland
Biochim Biophys Acta 1729:88-93. 2005..Accordingly, compound 1, which is also found in the widely used medicinal herb chamomile, interfered with the LPS-induced production of IL-1, IL-6, TNF, and PGE2 in primary human monocytes... - Inflammation and cancer: is the link as simple as we think?Brian J Nickoloff
Oncology Institute, Cardinal Bernadin Cancer Center, Loyola University Chicago Medical Center, Chicago, Illinois, USA
J Invest Dermatol 124:x-xiv. 2005 - Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cellsJongdae Lee
Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0663, USA
Nat Cell Biol 8:1327-36. 2006..Our data provide a case for organ-specific innate immunity in which TLR expression in polarized IECs has uniquely evolved to maintain colonic homeostasis and regulate tolerance and inflammation... - Epithelial NF-kappaB maintains host gut microflora homeostasisYinon Ben-Neriah
Nat Immunol 8:479-81. 2007