Eyal Banin

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. pmc Exome sequencing identifies a founder frameshift mutation in an alternative exon of USH1C as the cause of autosomal recessive retinitis pigmentosa with late-onset hearing loss
    Samer Khateb
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    PLoS ONE 7:e51566. 2012
  2. doi request reprint Molecular anthropology meets genetic medicine to treat blindness in the North African Jewish population: human gene therapy initiated in Israel
    Eyal Banin
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Hum Gene Ther 21:1749-57. 2010
  3. doi request reprint Identification of mutations causing inherited retinal degenerations in the israeli and palestinian populations using homozygosity mapping
    Avigail Beryozkin
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Invest Ophthalmol Vis Sci 55:1149-60. 2014
  4. doi request reprint Novel null mutations in the EYS gene are a frequent cause of autosomal recessive retinitis pigmentosa in the Israeli population
    Dikla Bandah-Rozenfeld
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Invest Ophthalmol Vis Sci 51:4387-94. 2010
  5. ncbi request reprint Variable retinal phenotypes caused by mutations in the X-linked photopigment gene array
    Liliana Mizrahi-Meissonnier
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Invest Ophthalmol Vis Sci 51:3884-92. 2010
  6. ncbi request reprint Homozygosity for a novel ABCA4 founder splicing mutation is associated with progressive and severe Stargardt-like disease
    Anat Beit-Ya'acov
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Invest Ophthalmol Vis Sci 48:4308-14. 2007
  7. doi request reprint Zinc-desferrioxamine attenuates retinal degeneration in the rd10 mouse model of retinitis pigmentosa
    Alexey Obolensky
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    Free Radic Biol Med 51:1482-91. 2011
  8. pmc Homozygosity mapping reveals null mutations in FAM161A as a cause of autosomal-recessive retinitis pigmentosa
    Dikla Bandah-Rozenfeld
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Am J Hum Genet 87:382-91. 2010
  9. doi request reprint The spectrum of retinal diseases caused by NR2E3 mutations in Israeli and Palestinian patients
    Dikla Bandah
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Arch Ophthalmol 127:297-302. 2009
  10. ncbi request reprint Ocular Phenotype Analysis of a Family With Biallelic Mutations in the BEST1 Gene
    Dror Sharon
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Am J Ophthalmol 157:697-709.e2. 2014

Collaborators

Detail Information

Publications44

  1. pmc Exome sequencing identifies a founder frameshift mutation in an alternative exon of USH1C as the cause of autosomal recessive retinitis pigmentosa with late-onset hearing loss
    Samer Khateb
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    PLoS ONE 7:e51566. 2012
    ..This is the first report of a mutation in a known USH1 gene that causes late onset rather than congenital sensorineural hearing loss. The c.1220delG mutation of USH1C accounts for 23% of RP among Yemenite Jewish patients in our cohort...
  2. doi request reprint Molecular anthropology meets genetic medicine to treat blindness in the North African Jewish population: human gene therapy initiated in Israel
    Eyal Banin
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Hum Gene Ther 21:1749-57. 2010
    ..This process of genetically analyzing affected isolated populations as a screen for gene-based therapy suggests a new paradigm for disease diagnosis and treatment...
  3. doi request reprint Identification of mutations causing inherited retinal degenerations in the israeli and palestinian populations using homozygosity mapping
    Avigail Beryozkin
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Invest Ophthalmol Vis Sci 55:1149-60. 2014
    ..Our purpose was to use the homozygosity mapping approach, aiming to prioritize the set of genes and identify the molecular genetic causes underlying AR retinal degenerations in the Israeli and Palestinian populations...
  4. doi request reprint Novel null mutations in the EYS gene are a frequent cause of autosomal recessive retinitis pigmentosa in the Israeli population
    Dikla Bandah-Rozenfeld
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Invest Ophthalmol Vis Sci 51:4387-94. 2010
    ..To characterize the role of EYS, a recently identified retinal disease gene, in families with inherited retinal degenerations in the Israeli and Palestinian populations...
  5. ncbi request reprint Variable retinal phenotypes caused by mutations in the X-linked photopigment gene array
    Liliana Mizrahi-Meissonnier
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Invest Ophthalmol Vis Sci 51:3884-92. 2010
    ..To examine the involvement of the long (L) and middle (M) wavelength-sensitive cone opsin genes in cone-dominated phenotypes...
  6. ncbi request reprint Homozygosity for a novel ABCA4 founder splicing mutation is associated with progressive and severe Stargardt-like disease
    Anat Beit-Ya'acov
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Invest Ophthalmol Vis Sci 48:4308-14. 2007
    ..To clinically characterize and genetically analyze members of six families who reside in the same village and manifest a rare form of retinal degeneration...
  7. doi request reprint Zinc-desferrioxamine attenuates retinal degeneration in the rd10 mouse model of retinitis pigmentosa
    Alexey Obolensky
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    Free Radic Biol Med 51:1482-91. 2011
    ..Reducing iron-associated oxidative stress using complexes such as Zn/DFO may serve as a "common pathway" therapeutic approach to attenuate injury in retinal degeneration...
  8. pmc Homozygosity mapping reveals null mutations in FAM161A as a cause of autosomal-recessive retinitis pigmentosa
    Dikla Bandah-Rozenfeld
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Am J Hum Genet 87:382-91. 2010
    ....
  9. doi request reprint The spectrum of retinal diseases caused by NR2E3 mutations in Israeli and Palestinian patients
    Dikla Bandah
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Arch Ophthalmol 127:297-302. 2009
    ..To evaluate the involvement of NR2E3 in inherited retinal degenerative diseases in the Israeli and Palestinian populations and to study phenotypic variability in patients who are homozygous for the same mutation...
  10. ncbi request reprint Ocular Phenotype Analysis of a Family With Biallelic Mutations in the BEST1 Gene
    Dror Sharon
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Am J Ophthalmol 157:697-709.e2. 2014
    ..To investigate the genetic cause and perform a comprehensive clinical analysis of a Danish family with autosomal recessive bestrophinopathy; to investigate whether Bestrophin may be expressed in normal human retina...
  11. doi request reprint Mutations in CRB1 are a relatively common cause of autosomal recessive early-onset retinal degeneration in the Israeli and Palestinian populations
    Avigail Beryozkin
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Invest Ophthalmol Vis Sci 54:2068-75. 2013
    ..We evaluated the role of Crumbs homolog 1 (CRB1) in autosomal recessive (AR) retinal diseases in the Israeli and Palestinian populations using homozygosity mapping...
  12. doi request reprint Association of pattern dystrophy with an HTRA1 single-nucleotide polymorphism
    Tareq Jaouni
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, POB 12000, Jerusalem, Israel 91120
    Arch Ophthalmol 130:987-91. 2012
    ..To evaluate if adult-onset foveomacular vitelliform dystrophy (AOFVD) and butterfly-shaped pigment dystrophy (BSPD) are associated with risk single-nucleotide polymorphisms (SNPs) for age-related macular degeneration (AMD)...
  13. pmc Association of complement factor H Y402H polymorphism with phenotype of neovascular age related macular degeneration in Israel
    Itay Chowers
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Hebrew University School of Medicine, Jerusalem, Israel
    Mol Vis 14:1829-34. 2008
    ....
  14. doi request reprint A homozygous frameshift mutation in BEST1 causes the classical form of Best disease in an autosomal recessive mode
    Hanna Bitner
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Invest Ophthalmol Vis Sci 52:5332-8. 2011
    ..The objective was to characterize the molecular and clinical features of patients with the classical form of Best disease that is inherited in an autosomal recessive mode...
  15. ncbi request reprint Treatment of ocular tissues exposed to nitrogen mustard: beneficial effect of zinc desferrioxamine combined with steroids
    Yair Morad
    Department of Ophthalmology, Assaf Harofeh Medical Center, Zrifin 73000, Israel
    Invest Ophthalmol Vis Sci 46:1640-6. 2005
    ..The purpose of the present study was to investigate whether the effectiveness of both medications applied simultaneously is superior to the effectiveness of either one applied alone...
  16. doi request reprint An ancient autosomal haplotype bearing a rare achromatopsia-causing founder mutation is shared among Arab Muslims and Oriental Jews
    Lina Zelinger
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Hum Genet 128:261-7. 2010
    ..The data present here demonstrate a large (11 Mbp) genomic region that is likely to originate from an ancient common ancestor of Middle-Eastern Arab Muslims and Jews who lived approximately 5,000 years ago...
  17. pmc A missense mutation in DHDDS, encoding dehydrodolichyl diphosphate synthase, is associated with autosomal-recessive retinitis pigmentosa in Ashkenazi Jews
    Lina Zelinger
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Am J Hum Genet 88:207-15. 2011
    ..Our results support a pivotal role of DHDDS in retinal function and may allow for new therapeutic interventions for RP...
  18. pmc A novel de novo PAX6 mutation in an Ashkenazi-Jewish family with aniridia
    Dikla Bandah
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Mol Vis 14:142-5. 2008
    ..To report a novel de novo PAX6 mutation in an Ashkenazi-Jewish family with autosomal dominant aniridia...
  19. ncbi request reprint Novel USH2A mutations in Israeli patients with retinitis pigmentosa and Usher syndrome type 2
    Nadia Kaiserman
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    Arch Ophthalmol 125:219-24. 2007
    ..To identify USH2A mutations in Israeli patients with autosomal-recessive Usher syndrome type 2 (USH2) and retinitis pigmentosa (RP)...
  20. ncbi request reprint Does postmenopausal hormone replacement therapy affect intraocular pressure?
    Yoram Abramov
    Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Ein Kerem, Jerusalem, Israel
    J Glaucoma 14:271-5. 2005
    ..To assess the effects of postmenopausal hormone replacement therapy (HRT) on intraocular pressure (IOP)...
  21. doi request reprint Cone dystrophy with supernormal rod response: novel KCNV2 mutations in an underdiagnosed phenotype
    Lina Zelinger
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Ophthalmology 120:2338-43. 2013
    ..To study the clinical variability and KCNV2 mutation spectrum in cone dystrophy with supernormal rod response (CDSRR) in the Israeli population...
  22. doi request reprint Retinal function and structure in the hypotransferrinemic mouse
    Michal Lederman
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Invest Ophthalmol Vis Sci 53:605-12. 2012
    ..The authors characterized the consequences of genetically reduced retinal transferrin production on retinal structure and function...
  23. pmc Sequence variants in HTRA1 and LOC387715/ARMS2 and phenotype and response to photodynamic therapy in neovascular age-related macular degeneration in populations from Israel
    Itay Chowers
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Mol Vis 14:2263-71. 2008
    ..We tested whether these SNPs are associated with AMD in Israeli populations, if they underlie variable phenotype and response to therapy in neovascular AMD (NVAMD), and if HTRA1 expression in vivo is associated with its promoter variant...
  24. ncbi request reprint A non-ancestral RPGR missense mutation in families with either recessive or semi-dominant X-linked retinitis pigmentosa
    Eyal Banin
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Am J Med Genet A 143:1150-8. 2007
    ..Our results indicate that an additional gene (or genes), linked to RPGR, modulate disease expression in severely affected carriers. These may be related to the high myopia concomitantly found in affected carriers from the Israeli family...
  25. pmc Mutations in IMPG2, encoding interphotoreceptor matrix proteoglycan 2, cause autosomal-recessive retinitis pigmentosa
    Dikla Bandah-Rozenfeld
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Am J Hum Genet 87:199-208. 2010
    ..Our data therefore show that mutations in a structural component of the interphotoreceptor matrix can cause arRP...
  26. ncbi request reprint Ischemic preconditioning of the rat retina: protective role of ferritin
    Alexey Obolensky
    Department of Ophthalmology, The Hebrew University Hadassah Schools of Medicine and Dental Medicine, Jerusalem 91120, Israel
    Free Radic Biol Med 44:1286-94. 2008
    ..The results suggest a mechanism whereby IPC activates an iron signaling pathway leading to a marked increase in ferritin levels, which mediates resistance to prolonged ischemia...
  27. pmc Fundus albipunctatus: novel mutations and phenotypic description of Israeli patients
    Eran Pras
    Department of Ophthalmology, Assaf Harofeh Medical Center, Zerifin, Israel
    Mol Vis 18:1712-8. 2012
    ..To characterize the genetic defects associated with fundus albipunctatus (FAP) in patients in Israel...
  28. pmc Degeneration modulates retinal response to transient exogenous oxidative injury
    Michal Lederman
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, and the Hebrew University Hadassah School of Medicine, Jerusalem, Israel Department of Cellular Biochemistry and Human Genetics, Hadassah Hebrew University Medical Center, and the Hebrew University Hadassah School of Medicine, Jerusalem, Israel
    PLoS ONE 9:e87751. 2014
    ..Oxidative injury is involved in retinal and macular degeneration. We aim to assess if retinal degeneration associated with genetic defect modulates the retinal threshold for encountering additional oxidative challenges...
  29. ncbi request reprint A homozygous nonsense CEP250 mutation combined with a heterozygous nonsense C2orf71 mutation is associated with atypical Usher syndrome
    Samer Khateb
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Med Genet 51:460-9. 2014
    ..Usher syndrome (USH) is a heterogeneous group of inherited retinitis pigmentosa (RP) and sensorineural hearing loss (SNHL) caused by mutations in at least 12 genes. Our aim is to identify additional USH-related genes...
  30. doi request reprint Effect of para-aminobenzoic acid on the course of retinal degeneration in the rd10 mouse
    Tural Galbinur
    Department of Ophthalmology, The Hebrew University Hadassah Schools of Medicine and Dental Medicine, Jerusalem, Israel
    J Ocul Pharmacol Ther 25:475-82. 2009
    ..Our aim was to evaluate the efficacy of PABA in attenuating oxidative injury and rate of retinal degeneration in the rd10 mouse...
  31. ncbi request reprint A complex expression pattern of Pax6 in the pigeon retina
    Dikla Bandah
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Invest Ophthalmol Vis Sci 48:2503-9. 2007
    ..Previous studies have provided evidence of the involvement of Pax6 in macular development. The purpose was to perform a comprehensive expression analysis of Pax6 isoforms in different regions of the pigeon retina...
  32. ncbi request reprint Retinal incorporation and differentiation of neural precursors derived from human embryonic stem cells
    Eyal Banin
    Department of Ophthalmology, The Hadassah Human Embryonic Stem Cell Research Center, The Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, P O Box 12, 000, Ein Kerem, Jerusalem 91120, Israel
    Stem Cells 24:246-57. 2006
    ..This may be the first step toward further developments that eventually may allow the use of hESCs for transplantation in retinal degenerations...
  33. ncbi request reprint Application of the standard photodynamic treatment protocol for symptomatic circumscribed choroidal hemangioma
    Joaquin Vicuna-Kojchen
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Ophthalmologica 220:351-5. 2006
    ..To describe the results of photodynamic therapy (PDT) using a standard protocol, developed for treating choroidal neovascularization (CNV), for the treatment of circumscribed choroidal hemangioma (CCH)...
  34. ncbi request reprint Injury induced by chemical warfare agents: characterization and treatment of ocular tissues exposed to nitrogen mustard
    Eyal Banin
    Department of Ophthalmology, Hebrew University Hadassah School of Medicine, Jerusalem, Israel
    Invest Ophthalmol Vis Sci 44:2966-72. 2003
    ..The purpose of the present study was to examine the efficacy of novel metallocomplexes, known to inhibit the formation of highly reactive free radicals, to reduce ocular injury induced by nitrogen mustard (NM)...
  35. ncbi request reprint [Experimental therapeutic modalities for retinitis pigmentosa]
    Eyal Banin
    Department of Ophthalmology, Hadassah Hebrew University Hospital and Medical School, Jerusalem
    Harefuah 143:368-71, 389. 2004
    ....
  36. doi request reprint Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells
    Maria Idelson
    The Hadassah Human Embryonic Stem Cell Research Center, The Goldyne Savad Institute of Gene Therapy and Department of Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Cell Stem Cell 5:396-408. 2009
    ..These results are an important step toward the future use of hESCs to replenish RPE in blinding diseases...
  37. ncbi request reprint [Visual field disturbances in epileptic patients treated with vigabatrin (sevril)]
    Varda Gross-Tsur
    Neuropediatric Unit, Shaare Zedek Medical Center, Jerusalem, Israel
    Harefuah 141:247-9, 315. 2002
    ..In view of the gravity and prevalence of visual field constriction, use of the AED vigabatrin should be weighed against its clinical benefits...
  38. doi request reprint P35S mutation in the NOG gene associated with Teunissen-Cremers syndrome and features of multiple NOG joint-fusion syndromes
    Nir Hirshoren
    Department of Otolaryngology Head and Neck Surgery, Hadassah Hebrew University Medical Center, 91120 Jerusalem, Israel
    Eur J Med Genet 51:351-7. 2008
    ..Interestingly, we found that the mutation P35S described in this family has already been reported in patients affected with SYM1 as well as with BDB syndromes...
  39. ncbi request reprint [Experimental therapeutic modalities for retinitis pigmentosa]
    Itay Chowers
    Department of Ophthalmology, Hadassah Hebrew University Hospital and Medical School, Jerusalem
    Harefuah 142:277-80, 317. 2003
    ..The encouraging progress made in these various experimental directions lends hope that efficient treatment for at least some of the patients suffering from these blinding diseases is within sight...
  40. pmc Phenotypic variability among adult siblings with Sjögren-Larsson syndrome
    Alexander Lossos
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Arch Neurol 63:278-80. 2006
    ..Cerebral proton magnetic resonance spectroscopy in those with SLS demonstrates an abnormal white matter peak at 1.3 ppm, consistent with long-chain fatty alcohol accumulation...
  41. ncbi request reprint Gene delivery by viral vectors in primary cultures of lacrimal gland tissue
    Eyal Banin
    Department of Ophthalmology, The Hebrew University Hadassah Hospital and Medical School, Jerusalem, Israel
    Invest Ophthalmol Vis Sci 44:1529-33. 2003
    ..To test the feasibility of gene transfer into lacrimal gland tissue in primary culture, using different viral vectors...
  42. ncbi request reprint Retinal function abnormalities in patients treated with vigabatrin
    Eyal Banin
    Department of Ophthalmology, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Arch Ophthalmol 121:811-6. 2003
    ..To evaluate central and peripheral retinal function in patients treated with vigabatrin, an antiepileptic drug associated with peripheral visual field constriction (VFC)...
  43. ncbi request reprint Susac syndrome
    Menachem Gross
    Department of Otolaryngology Head and Neck Surgery, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Otol Neurotol 25:470-3. 2004
    ..The objective of this study was to describe the clinical manifestations; radiographic, audiometric, and retinal fluorescein angiography findings; pathogenesis and treatment of Susac syndrome with review of the literature...
  44. ncbi request reprint The effect of hormone therapy on the risk for age-related maculopathy in postmenopausal women
    Yoram Abramov
    Department of Obstetrics and Gynecology and the Department of Ophthalmology, Hadassah Medical Center, Ein Kerem, Jerusalem, Israel
    Menopause 11:62-8. 2004
    ..To evaluate the effect of postmenopausal hormone therapy (HT) as well as the use of oral contraceptives and lifetime endogenous hormone exposure on the risk for age-related maculopathy (ARM) in postmenopausal women...