Yoram Altschuler

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi request reprint The apical compartment: trafficking pathways, regulators and scaffolding proteins
    Yoram Altschuler
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Ein Kerem Campus, 91120, Jerusalem, Israel
    Curr Opin Cell Biol 15:423-9. 2003
  2. ncbi request reprint Nanoparticle-cell interactions: drug delivery implications
    Oshrat Harush-Frenkel
    Department of Pharmaceutics and Pharmacology, The Hebrew University of Jerusalem, 91120, Israel
    Crit Rev Ther Drug Carrier Syst 25:485-544. 2008
  3. pmc Caveolin 2 regulates endocytosis and trafficking of the M1 muscarinic receptor in MDCK epithelial cells
    Miriam Shmuel
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Mol Biol Cell 18:1570-85. 2007
  4. ncbi request reprint ARNO through its coiled-coil domain regulates endocytosis at the apical surface of polarized epithelial cells
    Miriam Shmuel
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Biol Chem 281:13300-8. 2006
  5. pmc Toxicity mechanisms of amphotericin B and its neutralization by conjugation with arabinogalactan
    Sarah Kagan
    Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Antimicrob Agents Chemother 56:5603-11. 2012
  6. ncbi request reprint EFA6 regulates endosomal trafficking and affects early endosomes in polarized MDCK cells
    Tamar Shultz
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Biochem Biophys Res Commun 351:106-12. 2006
  7. ncbi request reprint Beta-tubulin cofactor D and ARL2 take part in apical junctional complex disassembly and abrogate epithelial structure
    Tamar Shultz
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Israel
    FASEB J 22:168-82. 2008
  8. doi request reprint Surface charge of nanoparticles determines their endocytic and transcytotic pathway in polarized MDCK cells
    Oshrat Harush-Frenkel
    Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, POB 12065, Jerusalem 91120, Israel
    Biomacromolecules 9:435-43. 2008
  9. pmc Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling
    Tziona Ben Gedalya
    Department of Cellular Biochemistry and Human Genetics, Faculty of Medicine, Hebrew University, Ein Kerem, Jerusalem 91120, Israel
    Traffic 10:218-34. 2009
  10. pmc Actin is required for endocytosis at the apical surface of Madin-Darby canine kidney cells where ARF6 and clathrin regulate the actin cytoskeleton
    Tehila Hyman
    Department of Pharmacology School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem Ein Kerem Campus, Jerusalem 91120, Israel
    Mol Biol Cell 17:427-37. 2006

Collaborators

  • Lorraine C Santy
  • James Casanova
  • Miriam Shmuel
  • Oshrat Harush-Frenkel
  • Tamar Shultz
  • Tehila Hyman
  • Sarah Kagan
  • Tziona Ben Gedalya
  • Simon Benita
  • Phuong U Le
  • Itzhack Polacheck
  • Diana Ickowicz
  • Miriam Pitusi
  • Abraham J Domb
  • Edward Sionov
  • Aryeh Weiss
  • Shimon Farber
  • Dennis J Selkoe
  • Ronit Sharon
  • Eitan Israeli
  • Virginie Loeb
  • Eva Rozentur
  • Alexander Rouvinski
  • Efrat Nodel-Berner
  • Nadav Nash-Livni
  • Scott Frank
  • Dana Avrahami
  • Miri Shmuel
  • Ivan R Nabi
  • Ginette Guay

Detail Information

Publications11

  1. ncbi request reprint The apical compartment: trafficking pathways, regulators and scaffolding proteins
    Yoram Altschuler
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Ein Kerem Campus, 91120, Jerusalem, Israel
    Curr Opin Cell Biol 15:423-9. 2003
    ....
  2. ncbi request reprint Nanoparticle-cell interactions: drug delivery implications
    Oshrat Harush-Frenkel
    Department of Pharmaceutics and Pharmacology, The Hebrew University of Jerusalem, 91120, Israel
    Crit Rev Ther Drug Carrier Syst 25:485-544. 2008
    ....
  3. pmc Caveolin 2 regulates endocytosis and trafficking of the M1 muscarinic receptor in MDCK epithelial cells
    Miriam Shmuel
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Mol Biol Cell 18:1570-85. 2007
    ..These results provide evidence that caveolins play a role in the attenuation of the M1 muscarinic receptor's intracellular trafficking to and from the PM...
  4. ncbi request reprint ARNO through its coiled-coil domain regulates endocytosis at the apical surface of polarized epithelial cells
    Miriam Shmuel
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Biol Chem 281:13300-8. 2006
    ..We conclude that ARNO acts together with ARF6 to regulate apical endocytosis...
  5. pmc Toxicity mechanisms of amphotericin B and its neutralization by conjugation with arabinogalactan
    Sarah Kagan
    Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Antimicrob Agents Chemother 56:5603-11. 2012
    ..Based on these results, we provide an explanation of how the conjugation of AMB with AG neutralizes its toxicity in mammalian cells and add to the knowledge of the mechanism of action of free AMB in both fungal and mammalian cells...
  6. ncbi request reprint EFA6 regulates endosomal trafficking and affects early endosomes in polarized MDCK cells
    Tamar Shultz
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Biochem Biophys Res Commun 351:106-12. 2006
    ..These results suggest that the physiological function of ARF6 within the endocytic system is regulated by the exchange factor it associates with...
  7. ncbi request reprint Beta-tubulin cofactor D and ARL2 take part in apical junctional complex disassembly and abrogate epithelial structure
    Tamar Shultz
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Israel
    FASEB J 22:168-82. 2008
    ..We conclude that ARL2 and beta-tubulin cofactor D participate in AJC disassembly and epithelial depolarization...
  8. doi request reprint Surface charge of nanoparticles determines their endocytic and transcytotic pathway in polarized MDCK cells
    Oshrat Harush-Frenkel
    Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, POB 12065, Jerusalem 91120, Israel
    Biomacromolecules 9:435-43. 2008
    ..Taken together, these observations indicate that cationic nanoparticles, in addition to their potential for drug delivery to epithelia, may be promising carriers for transcytosing drugs to the blood stream...
  9. pmc Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling
    Tziona Ben Gedalya
    Department of Cellular Biochemistry and Human Genetics, Faculty of Medicine, Hebrew University, Ein Kerem, Jerusalem 91120, Israel
    Traffic 10:218-34. 2009
    ..We suggest that alphaS and PUFAs normally function in endocytic mechanisms and are specifically involved in SV recycling upon neuronal stimulation...
  10. pmc Actin is required for endocytosis at the apical surface of Madin-Darby canine kidney cells where ARF6 and clathrin regulate the actin cytoskeleton
    Tehila Hyman
    Department of Pharmacology School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem Ein Kerem Campus, Jerusalem 91120, Israel
    Mol Biol Cell 17:427-37. 2006
    ..These observations indicate that concomitant to actin recruitment, the apical clathrin endocytic system is deeply involved in the morphology of the apical plasma membrane...
  11. ncbi request reprint Caveolin-1 is a negative regulator of caveolae-mediated endocytosis to the endoplasmic reticulum
    Phuong U Le
    Department of Pathology and Cell Biology, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 277:3371-9. 2002
    ..Caveolin-1 stabilizes the plasma membrane association of caveolae and thereby acts as a negative regulator of the caveolae-mediated endocytosis of AMF-R to the endoplasmic reticulum...