Israel Agranat

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi request reprint Putting chirality to work: the strategy of chiral switches
    Israel Agranat
    Division of Biomedical Sciences, Imperial College Faculty of Medicine, Sir Alexander Fleming Building, London SW7 2AZ, United Kingdom
    Nat Rev Drug Discov 1:753-68. 2002
  2. doi request reprint The strategy of enantiomer patents of drugs
    Israel Agranat
    Organic Chemistry, Institute of Chemistry, The Hebrew University of Jerusalem, Philadelphia Building 201 205, Edmond J Safra Campus, Jerusalem 91904, Israel
    Drug Discov Today 15:163-70. 2010
  3. doi request reprint Racemization of the gastrointestinal antisecretory chiral drug esomeprazole magnesium via the pyramidal inversion mechanism: A theoretical study
    Hili Marom
    Organic Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    Chirality 22:798-807. 2010
  4. ncbi request reprint Trends in the development of chiral drugs
    Hava Caner
    Department of Organic Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    Drug Discov Today 9:105-10. 2004
  5. ncbi request reprint Pyramidal inversion mechanism of simple chiral and achiral sulfoxides: a theoretical study
    Hili Marom
    Department of Organic Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Chirality 19:559-69. 2007
  6. doi request reprint Electrostatic chiral distinction: tetrahedral model dimers
    Sarit Garten
    Department of Organic Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    Chirality 22:662-74. 2010
  7. ncbi request reprint Conformational spaces of the gastrointestinal antisecretory chiral drug omeprazole: stereochemistry and tautomerism
    Hava Caner
    Department of Organic Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    Chirality 18:10-6. 2006

Collaborators

  • Hili Marom
  • Hava Caner
  • Sarit Garten
  • P Ulrich Biedermann
  • Sid Topiol
  • James R Cheeseman
  • Efrat Groner
  • Liron Levy

Detail Information

Publications7

  1. ncbi request reprint Putting chirality to work: the strategy of chiral switches
    Israel Agranat
    Division of Biomedical Sciences, Imperial College Faculty of Medicine, Sir Alexander Fleming Building, London SW7 2AZ, United Kingdom
    Nat Rev Drug Discov 1:753-68. 2002
    ..Indeed, a well-timed chiral switch can offer enhanced therapy and further profitability as a 'line extension' of a major racemic drug with patents that are expiring...
  2. doi request reprint The strategy of enantiomer patents of drugs
    Israel Agranat
    Organic Chemistry, Institute of Chemistry, The Hebrew University of Jerusalem, Philadelphia Building 201 205, Edmond J Safra Campus, Jerusalem 91904, Israel
    Drug Discov Today 15:163-70. 2010
    ..General concern about evergreening by ENPTs is not justified. ENPTs should be evaluated on a case-by-case basis. ENPT litigations are especially susceptible to settlements...
  3. doi request reprint Racemization of the gastrointestinal antisecretory chiral drug esomeprazole magnesium via the pyramidal inversion mechanism: A theoretical study
    Hili Marom
    Organic Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    Chirality 22:798-807. 2010
    ..The energy barrier (DeltaG(++)) for the(S,M) <=>(S,P) diastereomerization of (S)-omeprazole due to the rotation around the pyridine chiral axis was very low, 5.8 kcal/mole at B3LYP/6-311G(d,p)...
  4. ncbi request reprint Trends in the development of chiral drugs
    Hava Caner
    Department of Organic Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    Drug Discov Today 9:105-10. 2004
  5. ncbi request reprint Pyramidal inversion mechanism of simple chiral and achiral sulfoxides: a theoretical study
    Hili Marom
    Department of Organic Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Chirality 19:559-69. 2007
    ..Introducing electron withdrawing groups (cyano) at the para positions of the phenyl ring(s) causes a further decrease of the energy barrier...
  6. doi request reprint Electrostatic chiral distinction: tetrahedral model dimers
    Sarit Garten
    Department of Organic Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    Chirality 22:662-74. 2010
    ..These studies can now form the basis to fold in higher levels of complexity into the models so as to gain further insights into the nature of chiral distinction...
  7. ncbi request reprint Conformational spaces of the gastrointestinal antisecretory chiral drug omeprazole: stereochemistry and tautomerism
    Hava Caner
    Department of Organic Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    Chirality 18:10-6. 2006
    ..The "extended M" conformation of the 6-methoxy tautomer of (S)-omeprazole was found to be the most stable conformer...