N Zisapel

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. ncbi request reprint Sleep and sleep disturbances: biological basis and clinical implications
    N Zisapel
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Cell Mol Life Sci 64:1174-86. 2007
  2. pmc Exonal elements and factors involved in the depolarization-induced alternative splicing of neurexin 2
    G Rozic
    Department of Neurobiology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Mol Neurosci 50:221-33. 2013
  3. pmc Prolonged-release melatonin for insomnia - an open-label long-term study of efficacy, safety, and withdrawal
    Patrick Lemoine
    The Clinique Lyon Lumière, Meyzieu, France
    Ther Clin Risk Manag 7:301-11. 2011
  4. pmc Efficacy and safety of prolonged-release melatonin in insomnia patients with diabetes: a randomized, double-blind, crossover study
    Doron Garfinkel
    Geriatric Palliative Department, Shoham Geriatric Medical Center, Pardes Hana, Israel
    Diabetes Metab Syndr Obes 4:307-13. 2011
  5. pmc Dynamic changes in neurexins' alternative splicing: role of Rho-associated protein kinases and relevance to memory formation
    Gabriela Rozic
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 6:e18579. 2011
  6. pmc Diurnal rhythms in neurexins transcripts and inhibitory/excitatory synapse scaffold proteins in the biological clock
    Mika Shapiro-Reznik
    Department of Neurobiology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 7:e37894. 2012
  7. doi request reprint Drugs for insomnia
    Nava Zisapel
    Tel Aviv University, Department of Neurobiology, The George S Wise Faculty of Life Sciences and Neurim Pharmaceuticals, Tel Aviv 69978, Israel
    Expert Opin Emerg Drugs 17:299-317. 2012
  8. pmc Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety
    Alan G Wade
    CPS Research, Glasgow, UK
    BMC Med 8:51. 2010
  9. ncbi request reprint Melatonin-dopamine interactions: from basic neurochemistry to a clinical setting
    N Zisapel
    Department of Neurobiochemistry, Tel Aviv University, Israel
    Cell Mol Neurobiol 21:605-16. 2001
  10. ncbi request reprint Determination of the minimal clinically significant difference on a patient visual analog sleep quality scale
    Nava Zisapel
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    J Sleep Res 12:291-8. 2003

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Sleep and sleep disturbances: biological basis and clinical implications
    N Zisapel
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Cell Mol Life Sci 64:1174-86. 2007
    ..New treatment modalities for sleep disorders that will also improve daytime functioning remain a scientific and medical challenge...
  2. pmc Exonal elements and factors involved in the depolarization-induced alternative splicing of neurexin 2
    G Rozic
    Department of Neurobiology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Mol Neurosci 50:221-33. 2013
    ....
  3. pmc Prolonged-release melatonin for insomnia - an open-label long-term study of efficacy, safety, and withdrawal
    Patrick Lemoine
    The Clinique Lyon Lumière, Meyzieu, France
    Ther Clin Risk Manag 7:301-11. 2011
    ..A recent double-blind placebo-controlled study demonstrated 6-month efficacy and safety of PRM in insomnia patients aged 18-80 and lack of withdrawal and rebound symptoms upon discontinuation...
  4. pmc Efficacy and safety of prolonged-release melatonin in insomnia patients with diabetes: a randomized, double-blind, crossover study
    Doron Garfinkel
    Geriatric Palliative Department, Shoham Geriatric Medical Center, Pardes Hana, Israel
    Diabetes Metab Syndr Obes 4:307-13. 2011
    ..The efficacy and safety of prolonged-release melatonin 2 mg in the treatment of glucose, lipid metabolism, and sleep was studied in 36 type 2 diabetic patients with insomnia (11 men, 25 women, age 46-77 years)...
  5. pmc Dynamic changes in neurexins' alternative splicing: role of Rho-associated protein kinases and relevance to memory formation
    Gabriela Rozic
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 6:e18579. 2011
    ..Specific neurexins' transcripts may be involved in synaptic remodeling occurring at an intermediate (hours) time scale in the course of memory formation...
  6. pmc Diurnal rhythms in neurexins transcripts and inhibitory/excitatory synapse scaffold proteins in the biological clock
    Mika Shapiro-Reznik
    Department of Neurobiology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 7:e37894. 2012
    ..NRXNs gene transcripts may have a role in coupling the circadian clock to diurnal rhythms in excitatory/inhibitory synaptic balance...
  7. doi request reprint Drugs for insomnia
    Nava Zisapel
    Tel Aviv University, Department of Neurobiology, The George S Wise Faculty of Life Sciences and Neurim Pharmaceuticals, Tel Aviv 69978, Israel
    Expert Opin Emerg Drugs 17:299-317. 2012
    ..Summary of Product Characteristics and Medline search on "hypnotic" or specific drug names and "Insomnia")...
  8. pmc Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety
    Alan G Wade
    CPS Research, Glasgow, UK
    BMC Med 8:51. 2010
    ....
  9. ncbi request reprint Melatonin-dopamine interactions: from basic neurochemistry to a clinical setting
    N Zisapel
    Department of Neurobiochemistry, Tel Aviv University, Israel
    Cell Mol Neurobiol 21:605-16. 2001
    ..These interactions and the antioxidant nature of melatonin may be beneficial in the treatment of dopamine-related disorders...
  10. ncbi request reprint Determination of the minimal clinically significant difference on a patient visual analog sleep quality scale
    Nava Zisapel
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    J Sleep Res 12:291-8. 2003
    ..3 mm on the VAS. In conclusion, a change of 10 mm change in the 100-mm VAS QOS variable of the LSEQ, signifies an important change in patients' sleep quality...
  11. ncbi request reprint [Controlled release melatonin (Circadin) in the treatment of insomnia in older patients: efficacy and safety in patients with history of use and non-use of hypnotic drugs]
    Nava Zisapel
    Department of Neurobiology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Harefuah 148:337-41, 348. 2009
    ..Analyses presented here show that Circadin has comparable efficacy and safety in patients with and without history of hypnotic drug use...
  12. ncbi request reprint Subjective assessment of the effects of CNS-active drugs on sleep by the Leeds sleep evaluation questionnaire: a review
    N Zisapel
    Department of Neurobiochemistry, Faculty of Life Sciences, Tel Aviv University, Israel
    Hum Psychopharmacol 18:1-20. 2003
    ..Self-evaluations of sleep, as obtained by the LSEQ, can therefore provide consistent and meaningful measures for estimating the effectiveness of sleep modulators and sedative-hypnotic drugs...
  13. ncbi request reprint The use of melatonin for the treatment of insomnia
    N Zisapel
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Biol Signals Recept 8:84-9. 1999
    ..Specific melatonin formulations may be useful to treat circadian-rhythm-related sleep disorders and age-related insomnia...
  14. ncbi request reprint Melatonin elicits nuclear exclusion of the human androgen receptor and attenuates its activity
    A Rimler
    Department of Neurobiochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Prostate 49:145-54. 2001
    ..This is the first demonstration of a hormone-induced mislocalization of the AR in prostate epithelial cells and may represent a novel route for regulating AR activity...
  15. ncbi request reprint Involvement of the pineal gland in daily scheduling of the golden spiny mouse
    N Zisapel
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences Tel Aviv University, Israel
    Life Sci 63:751-7. 1998
    ..Thus, the modification of the daily scheduling of A. russatus by the photoperiod involves the pineal and/or the melatonin rhythm whereas non-photic cues effect a direct (perhaps masking), pineal-independent response to the competitor...
  16. ncbi request reprint Daily scheduling of the golden spiny mouse under photoperiodic and social cues
    N Zisapel
    Department of Neurobiochemistry, Tel Aviv University, Israel
    J Exp Zool 284:100-6. 1999
    ..These results indicate that the circadian system can adapt to major changes in daily scheduling without impairing daylength measurement, and consequently seasonal adaptation...
  17. ncbi request reprint High-affinity binding of melatonin to hemoglobin
    E Gilad
    Department of Biochemistry, Tel Aviv University, Israel
    Biochem Mol Med 56:115-20. 1995
    ..Hemoglobin may serve as a carrier protein for melatonin in the blood and discharge it in the target organs. Subsequently, the efficacy of melatonin's action as a hormone or antioxidant in target tissues may be enhanced...
  18. ncbi request reprint Rapid reversal of tolerance to benzodiazepine hypnotics by treatment with oral melatonin: a case report
    Y Dagan
    Sleep Disorders Laboratory, Tel Aviv University, Ramat Aviv, Israel
    Eur Neuropsychopharmacol 7:157-60. 1997
    ..The results of this single case study warrant further investigation of a larger population by means of a double-blind placebo-drug study...
  19. ncbi request reprint Involvement of cGMP in cellular melatonin responses
    M Bubis
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Israel
    Biol Cell 91:45-9. 1999
    ..The data presented indicate that inhibition of cGMP via a CTX sensitive G protein may be a major signal transduction pathway used by melatonin in melanoma cells...
  20. ncbi request reprint Melatonin production in healthy infants: evidence for seasonal variations
    Y Sivan
    Pediatric Intensive Care Unit, Dana Children's Hospital, Tel Aviv Medical Center, Tel Aviv, Israel
    Pediatr Res 49:63-8. 2001
    ..The strong effect of season on the normal excretion of nocturnal 6SMT at 8 but not 16 wk of age suggests prenatal influence of the photoperiod on the ontogeny of melatonin...
  21. ncbi request reprint Evaluation of signal transduction pathways mediating the nuclear exclusion of the androgen receptor by melatonin
    Z Lupowitz
    Department of Neurobiochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Israel
    Cell Mol Life Sci 58:2129-35. 2001
    ..These results define a novel signaling pathway that regulates AR localization and androgen responses in target cells...
  22. ncbi request reprint Circadian rhythm sleep disorders: pathophysiology and potential approaches to management
    N Zisapel
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Israel
    CNS Drugs 15:311-28. 2001
    ..The use of bright light or melatonin for circadian rhythm sleep disorders is thus considered exploratory at this stage...
  23. ncbi request reprint Ca2+ -dependent splicing of neurexin IIalpha
    G Rozic-Kotliroff
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Biochem Biophys Res Commun 352:226-30. 2007
    ..These data indicate neuronal activity-dependent splicing of NRXN2alpha. This dynamic process may be important for maintenance of mature neuronal circuits...
  24. ncbi request reprint Role of protein kinase Calpha in melatonin signal transduction
    S R Sampson
    Faculty of Life Sciences, Gonda Goldschmied Center, Bar Ilan University, Ramat Gan, Tel Aviv, Israel
    Mol Cell Endocrinol 252:82-7. 2006
    ..These data indicate that PKCalpha activation is a critical step in AR nuclear exclusion by melatonin. They also imply that PKCalpha-activation is a potentially effective way to control of the AR activity in prostate cancer cells...
  25. ncbi request reprint Seasonal thermogenic acclimation of diurnally and nocturnally active desert spiny mice
    N Kronfeld-Schor
    Department of Zoology, Tel Aviv University, Tel Aviv 69978, Israel
    Physiol Biochem Zool 73:37-44. 2000
    ..The low LPL activity in brown adipose tissue of desert-adapted A. russatus may facilitate lipid uptake in white adipose tissue, an advantage in desert conditions where food is scarce and irregularly distributed in space and time...
  26. ncbi request reprint Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects
    Patrick Lemoine
    The Clinique Lyon Lumière, Meyzieu, France
    J Sleep Res 16:372-80. 2007
    ....
  27. ncbi request reprint Massage therapy by mothers enhances the adjustment of circadian rhythms to the nocturnal period in full-term infants
    Sari Goldstein Ferber
    Department of Neonatology, Wolfson Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv
    J Dev Behav Pediatr 23:410-5. 2002
    ..25 +/- 121.25 microg/night, respectively; <.05). It is concluded that massage therapy by mothers in the perinatal period serves as a strong time cue, enhancing coordination of the developing circadian system with environmental cues...
  28. ncbi request reprint Nocturnal 6-sulfatoxymelatonin excretion in insomnia and its relation to the response to melatonin replacement therapy
    Damien Leger
    Centre du Sommeil, Hotel Dieu de Paris, Paris, France
    Am J Med 116:91-5. 2004
    ..We examined the excretion of the major melatonin metabolite 6-sulfatoxymelatonin in insomnia patients aged >or=55 years and its relation with the subsequent response to melatonin therapy...
  29. ncbi request reprint Nap and melatonin-induced changes in hippocampal activation and their role in verbal memory consolidation
    Tali Gorfine
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    J Pineal Res 43:336-42. 2007
    ....
  30. ncbi request reprint Sleep-anticipating effects of melatonin in the human brain
    Tali Gorfine
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Neuroimage 31:410-8. 2006
    ..Our findings highlight the role of melatonin in priming sleep-associated brain activation patterns in anticipation of sleep...
  31. ncbi request reprint Impaired nocturnal melatonin secretion in non-dipper hypertensive patients
    Michael Jonas
    Department of Internal Medicine D The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Blood Press 12:19-24. 2003
    ..Melatonin plays a role in the biologic regulation of circadian rhythms, including sleep. Melatonin has also been shown to modulate vascular smooth muscle tone and to induce hemodynamic effects in humans...
  32. ncbi request reprint Cross-cultural validation of the Leeds sleep evaluation questionnaire (LSEQ) in insomnia patients
    Ricardo Tarrasch
    Department of Psychology, Faculty of Social Sciences, Tel Aviv University, Israel
    Hum Psychopharmacol 18:603-10. 2003
    ....
  33. ncbi request reprint Nuclear exclusion of the androgen receptor by melatonin
    Avi Rimler
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, 69978 Tel Aviv, Israel
    J Steroid Biochem Mol Biol 81:77-84. 2002
    ..The nuclear localization of the AR is a hallmark of its cellular activity. These data point to AR nuclear exclusion as a possible mechanism to attenuate androgen responses in target tissues...
  34. ncbi request reprint Melatonin production in infants
    Riva Tauman
    Pediatric Intensive Care Unit, Dana Children s Hospital, Tel Aviv Medical Center, Israel
    Pediatr Neurol 26:379-82. 2002
    ..low melatonin excretion in the first weeks of life correlates with delayed psychomotor achievements at 3 and 6 months of age. this association suggests a causal or predictive link between melatonin and neurodevelopment in infants...
  35. ncbi request reprint Nocturnal patterns and up-regulated excretion of the melatonin metabolite 6-sulfatoxymelatonin in the diurnal rodent Psammomys obesus post-weaning under a short photoperiod
    Alina Neuman
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Comp Biochem Physiol A Mol Integr Physiol 142:297-307. 2005
    ..Possibly, this pattern may be physiologically important to facilitate T(b) maintenance in the cold nights of winter in the desert...
  36. ncbi request reprint Gi and RGS proteins provide biochemical control of androgen receptor nuclear exclusion
    Avi Rimler
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Mol Neurosci 31:1-12. 2007
    ..They also reveal a role for a Gq protein downstream of PKC activation in AR nuclear localization...
  37. ncbi request reprint Differential effects of melatonin and its downstream effector PKCalpha on subcellular localization of RGS proteins
    Avi Rimler
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    J Pineal Res 40:144-52. 2006
    ..These observations provide further insight into melatonin's ability to fine-tune multiple membrane G-proteins signaling in cells...
  38. doi request reprint Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways
    Seithikurippu R Pandi-Perumal
    Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, Room BB813, NY 10032, USA
    Prog Neurobiol 85:335-53. 2008
    ..It further considers their relevance to circadian physiology and pathogenesis of certain human diseases, with a focus on the brain, the cardiovascular and immune systems, and cancer...
  39. ncbi request reprint Melatonin reduces night blood pressure in patients with nocturnal hypertension
    Ehud Grossman
    Department of Internal Medicine D and Hypertension Unit, The Chaim Sheba Medical Center, Tel Hashomer, Affiliated with Sackler School of Medicine, Tel Aviv University, Israel
    Am J Med 119:898-902. 2006
    ..We therefore studied the potency of melatonin to reduce nighttime blood pressure (BP) in treated hypertensive patients with nocturnal hypertension...
  40. ncbi request reprint Melatonin rhythms in stroke patients
    Yichayaou Beloosesky
    Department of Geriatrics, Rabin Medical Center, Golda Campus, Sackler School of Medicine, Tel Aviv University, Petach Tikva, Israel
    Neurosci Lett 319:103-6. 2002
    ..We conclude that circadian oscillator is preserved in extensive cortical as well as in deep and lacunar strokes. Extensive cortical stroke might delay the melatonin surge during the first post-stroke days...
  41. ncbi request reprint Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomes
    Alan G Wade
    CPS Research, Glasgow, UK
    Curr Med Res Opin 23:2597-605. 2007
    ..The efficacy and safety of a prolonged release melatonin formulation (PR-melatonin; Circadin* 2 mg) were examined in insomnia patients aged 55 years and older...
  42. ncbi request reprint Differential regulation by melatonin of cell growth and androgen receptor binding to the androgen response element in prostate cancer cells
    Avi Rimler
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978 Israel
    Neuro Endocrinol Lett 23:45-9. 2002
    ..The aim of this study was to investigate whether melatonin inhibits effects of AR on cell growth in PC3-AR cells and whether inhibition of AR DNA binding is involved...
  43. ncbi request reprint Melatonin and the human hippocampus, a time dependent interplay
    Tali Gorfine
    Department of Neurobiochemistry, Tel Aviv University, Tel Aviv, Israel
    J Pineal Res 43:80-6. 2007
    ....