Neora Yaal-Hahoshen

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. pmc Site-specific metastasis formation: chemokines as regulators of tumor cell adhesion, motility and invasion
    Adit Ben-Baruch
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Cell Adh Migr 3:328-33. 2009
  2. pmc Progression of luminal breast tumors is promoted by ménage à trois between the inflammatory cytokine TNFα and the hormonal and growth-supporting arms of the tumor microenvironment
    Polina Weitzenfeld
    Ela Kodesz Institute for Research on Cancer Development and Prevention, Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, 69978 Tel Aviv, Israel
    Mediators Inflamm 2013:720536. 2013
  3. pmc The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells
    Tal Leibovich-Rivkin
    Department Cell Research and Immunology, George S, Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    BMC Cancer 14:158. 2014
  4. pmc The Tumor-Promoting Flow of Cells Into, Within and Out of the Tumor Site: Regulation by the Inflammatory Axis of TNFα and Chemokines
    Adit Ben-Baruch
    Department Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel
    Cancer Microenviron 5:151-64. 2012
  5. ncbi request reprint Organ selectivity in metastasis: regulation by chemokines and their receptors
    Adit Ben-Baruch
    Cancer Biology Research Center, Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Clin Exp Metastasis 25:345-56. 2008
  6. ncbi request reprint The multifaceted roles of chemokines in malignancy
    A Ben-Baruch
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Cancer Metastasis Rev 25:357-71. 2006
  7. doi request reprint The involvement of the fractalkine receptor in the transmigration of neuroblastoma cells through bone-marrow endothelial cells
    Ido Nevo
    Department of Cell Research and Immunology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Cancer Lett 273:127-39. 2009
  8. ncbi request reprint CXCL8-induced FAK phosphorylation via CXCR1 and CXCR2: cytoskeleton- and integrin-related mechanisms converge with FAK regulatory pathways in a receptor-specific manner
    Efrat Cohen-Hillel
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Cytokine 33:1-16. 2006
  9. ncbi request reprint CXCL10 promotes invasion-related properties in human colorectal carcinoma cells
    Adi Zipin-Roitman
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Cancer Res 67:3396-405. 2007
  10. pmc Inflammatory mediators in breast cancer: coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition
    Gali Soria
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Sackler School of Medicine, Tel Aviv University, Israel
    BMC Cancer 11:130. 2011

Collaborators

  • Ur Metser
  • Isaac P Witz
  • O Levy-Nissenbaum
  • Gali Soria
  • Rami Ben-Yosef
  • Marcelo Ehrlich
  • Miguel Weil
  • Varda Rotter
  • Ofer Merimsky
  • Amnon Hizi
  • Tamar Safra
  • Karin Johrer
  • A Ben-Baruch
  • R Alon
  • Mordechai Gutman
  • Tsipi Meshel
  • Efrat Cohen-Hillel
  • Orit Sagi-Assif
  • David Sarid
  • Fani Sperber
  • Ido Nevo
  • Lilach Goldberg-Bittman
  • Tal Leibovich-Rivkin
  • Elina Azenshtein
  • Polina Weitzenfeld
  • Ilana Yron
  • Iafa Keydar
  • Sima Shina
  • Eran Neumark
  • Hila Attal
  • Shahar Lev-Ari
  • Bruria Shalmon
  • Pravin Mishra
  • Karin Haim
  • Roni Mintz
  • Nely Wigler
  • Maya Golan
  • Adi Zipin-Roitman
  • Ilan G Ron
  • Michal Dagan-Berger
  • Rotem Feniger-Barish
  • Daphna Brisker
  • Galia Luboshits
  • Anastasia Abashidze
  • Yulia Liubomirski
  • Efrat Matityahu
  • Hilla Solomon
  • Nurit Meron
  • Debabrata Banerjee
  • Nufar Marcus
  • Christina Katanov
  • Ben Zion Garty
  • Richard Greil
  • Leonor E Leider Trejo
  • Oleg Kharenko
  • Meora Feinmesser
  • Julia Greenberg
  • James H Resau
  • Wanghua Gong
  • Hadar Reichman
  • Ilan Tsarfaty
  • Yaffa Keidar
  • Lior Shoshan
  • Ji Ming Wang
  • Itai Barnea
  • Mimi Baratz
  • Anat Shalmon
  • Raphael M Pfeffer
  • Andrea Gat
  • Camila Avivi
  • Hanna Wald
  • Yair Maimon
  • Natalie Maimon
  • Yulia Grinberg
  • Arnon Nagler
  • Yuliana Weinstein
  • Eithan Galun
  • Amnon Peled
  • Valentin Grabovsky
  • Juliana Weinstein
  • Sylvia Marmor
  • Felix Kovner
  • Shani Avniel
  • Rami Ben Yosef
  • Perry Kahan
  • Annat Shalmon
  • Yona Stadler
  • Nely Barak
  • Shlomit Ben-Menachem
  • Hila Geminder

Detail Information

Publications35

  1. pmc Site-specific metastasis formation: chemokines as regulators of tumor cell adhesion, motility and invasion
    Adit Ben-Baruch
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Cell Adh Migr 3:328-33. 2009
    ..This is followed by discussion of open questions that need to be addressed in future research, and of the potential therapeutic implications of the findings that are available to date in this field...
  2. pmc Progression of luminal breast tumors is promoted by ménage à trois between the inflammatory cytokine TNFα and the hormonal and growth-supporting arms of the tumor microenvironment
    Polina Weitzenfeld
    Ela Kodesz Institute for Research on Cancer Development and Prevention, Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, 69978 Tel Aviv, Israel
    Mediators Inflamm 2013:720536. 2013
    ..These dramatic findings indicate that TNF α can turn into a strong prometastatic factor, suggesting a paradigm shift in which clinically approved inhibitors of TNFα would be applied in breast cancer therapy...
  3. pmc The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells
    Tal Leibovich-Rivkin
    Department Cell Research and Immunology, George S, Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    BMC Cancer 14:158. 2014
    ....
  4. pmc The Tumor-Promoting Flow of Cells Into, Within and Out of the Tumor Site: Regulation by the Inflammatory Axis of TNFα and Chemokines
    Adit Ben-Baruch
    Department Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel
    Cancer Microenviron 5:151-64. 2012
    ..The review concludes by discussing the implications of such networks on disease course, and on the future design of therapeutic measures in cancer...
  5. ncbi request reprint Organ selectivity in metastasis: regulation by chemokines and their receptors
    Adit Ben-Baruch
    Cancer Biology Research Center, Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Clin Exp Metastasis 25:345-56. 2008
    ....
  6. ncbi request reprint The multifaceted roles of chemokines in malignancy
    A Ben-Baruch
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Cancer Metastasis Rev 25:357-71. 2006
    ..Together, these different chemokine functions establish a net of interactions between the tumor cells and their microenvironment, and partly dictate the fate of the malignancy cascade...
  7. doi request reprint The involvement of the fractalkine receptor in the transmigration of neuroblastoma cells through bone-marrow endothelial cells
    Ido Nevo
    Department of Cell Research and Immunology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Cancer Lett 273:127-39. 2009
    ..These results led us to hypothesize that the CX3CR1-CX3CL1 axis takes part in bone-marrow metastasis of neuroblastoma...
  8. ncbi request reprint CXCL8-induced FAK phosphorylation via CXCR1 and CXCR2: cytoskeleton- and integrin-related mechanisms converge with FAK regulatory pathways in a receptor-specific manner
    Efrat Cohen-Hillel
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Cytokine 33:1-16. 2006
    ..These observations lay the basis for future investigation of the equilibrium between CXCR1 and CXCR2 in cells expressing both receptors together, such as neutrophils, endothelial cells and tumor cells...
  9. ncbi request reprint CXCL10 promotes invasion-related properties in human colorectal carcinoma cells
    Adi Zipin-Roitman
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Cancer Res 67:3396-405. 2007
    ..Therefore, care should be taken when considering CXCL10 as a therapeutic antitumor modality for CRC treatment...
  10. pmc Inflammatory mediators in breast cancer: coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition
    Gali Soria
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Sackler School of Medicine, Tel Aviv University, Israel
    BMC Cancer 11:130. 2011
    ..In this study, we wished to determine whether there are associations between these factors along stages of breast cancer progression, and to identify the possible implications of these factors to disease course...
  11. ncbi request reprint Fulvestrant in heavily pretreated metastatic breast cancer: is it still effective as a very advanced line of treatment?
    Tamar Safra
    Department of Oncology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Isr Med Assoc J 10:339-43. 2008
    ..Over 75% of postmenopausal patients with metastatic breast cancer have hormone receptor-positive tumors. Endocrine therapy, with its more favorable toxicity profile than chemotherapy, is the preferred treatment modality for these patients...
  12. ncbi request reprint The expression of the chemokine receptor CXCR3 and its ligand, CXCL10, in human breast adenocarcinoma cell lines
    Lilach Goldberg-Bittman
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Immunol Lett 92:171-8. 2004
    ..The concomitant expression of CXCR3 and CXCL10 in breast tumor cells suggests that a CXCR3-CXCL10 axis may function in these cells, and paves the way for an in depth analysis of CXCL10-CXCR3 interactions in breast tumor cells...
  13. ncbi request reprint Cellular characteristics of neuroblastoma cells: regulation by the ELR--CXC chemokine CXCL10 and expression of a CXCR3-like receptor
    Lilach Goldberg-Bittman
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Cytokine 29:105-17. 2005
    ....
  14. ncbi request reprint Interleukin 8 and cell migration to inflammatory sites: the regulation of focal adhesion kinase under conditions of migratory desensitization
    Efrat Cohen-Hillel
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
    Isr Med Assoc J 9:579-83. 2007
    ..This over-phosphorylation of FAK was induced by IL-8 only when the receptor transmitting the chemokine signals was CXCR2 and not CXCR1, indicating that the two IL-8 receptors diverge in their signaling properties...
  15. doi request reprint Concomitant expression of the chemokines RANTES and MCP-1 in human breast cancer: a basis for tumor-promoting interactions
    Gali Soria
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Cytokine 44:191-200. 2008
    ..These observations support a major tumor-promoting role for co-expression of the chemokines in breast malignancy, and agree with the significant association of joint RANTES and MCP-1 expression with advanced stages of breast cancer...
  16. doi request reprint Reduced expression of chemoattractant receptors by polymorphonuclear leukocytes in Hyper IgE Syndrome patients
    Roni Mintz
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Immunol Lett 130:97-106. 2010
    ....
  17. pmc Epidermal growth factor and estrogen act by independent pathways to additively promote the release of the angiogenic chemokine CXCL8 by breast tumor cells
    Karin Haim
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Neoplasia 13:230-43. 2011
    ..The independent activities of EGF and estrogen on CXCL8 transcription reinforce the need to introduce simultaneous targeting of ErbBs and ERα to achieve effective therapy in breast cancer...
  18. ncbi request reprint Intracellular trafficking of human CXCR1 and CXCR2: regulation by receptor domains and actin-related kinases
    Efrat Matityahu
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Eur J Immunol 32:3525-35. 2002
    ..In all, CXCR1 and CXCR2 internalization and recycling are tightly regulated by receptor domains and by actin-related kinases...
  19. pmc Human endogenous retrovirus (HERV-K) reverse transcriptase as a breast cancer prognostic marker
    Maya Golan
    Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Neoplasia 10:521-33. 2008
    ..Furthermore, these results provide evidence for the possible involvement of endogenous retrovirus in human breast carcinoma...
  20. ncbi request reprint The tumor microenvironment: CXCR4 is associated with distinct protein expression patterns in neuroblastoma cells
    Ido Nevo
    Department of Cell Research and Immunology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Immunol Lett 92:163-9. 2004
    ..We hypothesize that these differences are due to an autocrine SDF-1alpha-CXCR4 axis...
  21. doi request reprint Chemokines in human breast tumor cells: modifying their expression levels and determining their effects on the malignancy phenotype
    Gali Soria
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Methods Enzymol 460:3-16. 2009
    ..In the breast malignancy context, the guidelines presented herein should enable researchers in the field to establish essential means for determination of chemokine roles in this disease...
  22. doi request reprint Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy
    Pravin Mishra
    Department of Medicine and Pharmacology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA
    J Leukoc Biol 89:31-9. 2011
    ..The overall findings suggest that chemokines stand at the crossroads of tumor-CAF interactions that lead to increased malignancy in many cancer diseases...
  23. ncbi request reprint The angiogenic factors CXCL8 and VEGF in breast cancer: regulation by an array of pro-malignancy factors
    Elina Azenshtein
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Cancer Lett 217:73-86. 2005
    ..These findings provide evidence for a complex set of pro-malignancy factors that may control the expression of angiogenic mediators at breast tumor sites...
  24. doi request reprint The inflammatory chemokines CCL2 and CCL5 in breast cancer
    Gali Soria
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Cancer Lett 267:271-85. 2008
    ....
  25. ncbi request reprint Intracellular cross-talk between the GPCR CXCR1 and CXCR2: role of carboxyl terminus phosphorylation sites
    Hila Attal
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Exp Cell Res 314:352-65. 2008
    ..Overall, we show that cross-talk between two GPCR is manifested by impairment of their intracellular trafficking, primarily of ligand-induced down-regulation, via carboxyl terminus phosphorylation sites...
  26. ncbi request reprint Long-term survival of a patient with widespread metastases from epithelial ovarian carcinoma receiving mind-body therapies: case report and review of the literature
    Shahar Lev-Ari
    Unit of Complementary Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Integr Cancer Ther 5:395-9. 2006
    ..The authors review the relevant literature on this subject and describe what they believe to be the first report of long-term survival of such a patient...
  27. ncbi request reprint Focal asymmetric breast density: mammographic, sonographic and pathological correlation in 97 lesions--a call to restrain biopsies
    Fani Sperber
    Department of Radiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Isr Med Assoc J 9:720-3. 2007
    ..The imaging parameters that mandate further diagnostic workup in focal asymmetric breast densities are not clearly defined...
  28. ncbi request reprint Invasive breast cancer treated with taxol and epirubicin neo-adjuvant chemotherapy: the role in the outcome of the "crosstalk" between Erb receptors and p53
    David Sarid
    Department of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Anticancer Res 28:3147-52. 2008
    ..To correlate p53 and ErbB receptors status with disease-free survival (DFS) and overall survival (OS) in locally advanced breast cancer...
  29. ncbi request reprint Neoadjuvant treatment with paclitaxel and epirubicin in invasive breast cancer: a phase II study
    David Sarid
    Department of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
    Clin Drug Investig 26:691-701. 2006
    ....
  30. ncbi request reprint The chemokine CCL5 as a potential prognostic factor predicting disease progression in stage II breast cancer patients
    Neora Yaal-Hahoshen
    Department of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Clin Cancer Res 12:4474-80. 2006
    ....
  31. ncbi request reprint Preoperative clinical, mammographic and sonographic assessment of neoadjuvant chemotherapy response in breast cancer
    Fani Sperber
    Breast Imaging Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Isr Med Assoc J 8:342-6. 2006
    ..The current methods for pre- and post-chemotherapy examination of the extent of disease in the breast and lymph nodes do not provide sufficiently accurate information and, not infrequently, the surgeon has to re-operate...
  32. ncbi request reprint Progression of mouse mammary tumors: MCP-1-TNFalpha cross-regulatory pathway and clonal expression of promalignancy and antimalignancy factors
    Eran Neumark
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Int J Cancer 106:879-86. 2003
    ..Our results also suggest that the expression of such factors is determined by several nonmutually exclusive regulatory mechanisms...
  33. ncbi request reprint Breast carcinoma: a report on the potential usage of the CC chemokine RANTES as a marker for a progressive disease
    Nely Wigler
    Department of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Isr Med Assoc J 4:940-3. 2002
    ..High incidence and intensity of RANTES (CC chemokine) expression were noted in advanced breast carcinoma...
  34. ncbi request reprint Role of CXCR3 carboxyl terminus and third intracellular loop in receptor-mediated migration, adhesion and internalization in response to CXCL11
    Michal Dagan-Berger
    Gene Therapy Institute, Hadassah University Hospital, PO Box 12000, Jerusalem, Israel
    Blood 107:3821-31. 2006
    ..Thus, distinct conformational changes induced by a given CXCR3 ligand trigger different downstream effectors of adhesion, motility, and CXCR3 desensitization...
  35. ncbi request reprint The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity
    Elina Azenshtein
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Cancer Res 62:1093-102. 2002
    ....