Haim Werner

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. ncbi request reprint Transcriptional regulation of IGF-I receptor gene expression by novel isoforms of the EWS-WT1 fusion protein
    Ina Finkeltov
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, 69978 Israel
    Oncogene 21:1890-8. 2002
  2. doi request reprint Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner
    Itay Bentov
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Endocrinology 149:1890-7. 2008
  3. ncbi request reprint Transcriptional and epigenetic control of IGF1R gene expression: implications in metabolism and cancer
    Haim Werner
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel Electronic address
    Growth Horm IGF Res 24:112-8. 2014
  4. pmc The mechanism of action of the histone deacetylase inhibitor vorinostat involves interaction with the insulin-like growth factor signaling pathway
    Rive Sarfstein
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 6:e24468. 2011
  5. pmc Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or -independent manners
    Rive Sarfstein
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 8:e61537. 2013
  6. doi request reprint IGF-1 and BRCA1 signalling pathways in familial cancer
    Haim Werner
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Lancet Oncol 13:e537-44. 2012
  7. ncbi request reprint Tumor suppressors govern insulin-like growth factor signaling pathways: implications in metabolism and cancer
    H Werner
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Oncogene 31:2703-14. 2012
  8. doi request reprint Controversies in the use of insulin analogues
    Haim Werner
    Tel Aviv University, Sackler School of Medicine, Department of Human Molecular Genetics and Biochemistry, Tel Aviv 69978, Israel
    Expert Opin Biol Ther 11:199-209. 2011
  9. pmc Basic and clinical significance of IGF-I-induced signatures in cancer
    Haim Werner
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    BMC Med 8:2. 2010
  10. doi request reprint The insulin-like growth factor-I receptor as an oncogene
    Haim Werner
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Arch Physiol Biochem 115:58-71. 2009

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Transcriptional regulation of IGF-I receptor gene expression by novel isoforms of the EWS-WT1 fusion protein
    Ina Finkeltov
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, 69978 Israel
    Oncogene 21:1890-8. 2002
    ..These data suggest that the molecular pathology of DSRCT is more complex than previously appreciated, and that this diversity may provide the foundation for predictive genotype-phenotype correlations in the future...
  2. doi request reprint Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner
    Itay Bentov
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Endocrinology 149:1890-7. 2008
    ..Stimulation of KLF6 expression by IGF-I in a p53-dependent manner may constitute a novel mechanism of action of IGF-I, with implications in normal cell cycle progression and cancer biology...
  3. ncbi request reprint Transcriptional and epigenetic control of IGF1R gene expression: implications in metabolism and cancer
    Haim Werner
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel Electronic address
    Growth Horm IGF Res 24:112-8. 2014
    ..Impaired regulation of the IGF1R gene is linked to defective cell division, chromosomal instability and increased incidence of cancer. ..
  4. pmc The mechanism of action of the histone deacetylase inhibitor vorinostat involves interaction with the insulin-like growth factor signaling pathway
    Rive Sarfstein
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 6:e24468. 2011
    ....
  5. pmc Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or -independent manners
    Rive Sarfstein
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 8:e61537. 2013
    ..Taken together, our results suggest that metformin therapy could be a novel and attractive therapeutic approach for human USC, a highly aggressive variant of endometrial cancer...
  6. doi request reprint IGF-1 and BRCA1 signalling pathways in familial cancer
    Haim Werner
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Lancet Oncol 13:e537-44. 2012
    ....
  7. ncbi request reprint Tumor suppressors govern insulin-like growth factor signaling pathways: implications in metabolism and cancer
    H Werner
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Oncogene 31:2703-14. 2012
    ..Deregulation of IGF axis components by mutated tumor-suppressor proteins may lead to metabolic perturbations, with ensuing pathological consequences...
  8. doi request reprint Controversies in the use of insulin analogues
    Haim Werner
    Tel Aviv University, Sackler School of Medicine, Department of Human Molecular Genetics and Biochemistry, Tel Aviv 69978, Israel
    Expert Opin Biol Ther 11:199-209. 2011
    ....
  9. pmc Basic and clinical significance of IGF-I-induced signatures in cancer
    Haim Werner
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    BMC Med 8:2. 2010
    ..show that IGF-I-induced gene expression in primary breast and lung fibroblasts accurately predict outcomes in breast and lung cancer patients.See the associated research paper by Rajski et al: http://www.biomedcentral.com/1741-7015/8/1...
  10. doi request reprint The insulin-like growth factor-I receptor as an oncogene
    Haim Werner
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Arch Physiol Biochem 115:58-71. 2009
    ..Finally, current attempts to target the IGF-IR as a therapeutic approach will be described...
  11. ncbi request reprint Similarities and differences between insulin and IGF-I: structures, receptors, and signalling pathways
    Haim Werner
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Arch Physiol Biochem 114:17-22. 2008
    ..This review provides a comparative analysis of the structures, receptors, and signalling pathways of insulin and IGF-I...
  12. ncbi request reprint A novel EWS-WT1 gene fusion product in desmoplastic small round cell tumor is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene
    Haim Werner
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, 69978 Tel Aviv, Israel
    Cancer Lett 247:84-90. 2007
    ..These findings raise the possibility that the oncogenic potential of EWS-WT1 fusions is not necessarily a consequence of the fusion protein product per se...
  13. ncbi request reprint The insulin-like growth factor-I receptor gene: a downstream target for oncogene and tumor suppressor action
    Haim Werner
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Trends Endocrinol Metab 17:236-42. 2006
    ..Loss-of-function mutation of tumor suppressors, a common theme in human cancer, can lead to aberrant regulation of IGF-IR gene expression...
  14. ncbi request reprint Dysregulation of the type 1 IGF receptor as a paradigm in tumor progression
    H Werner
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Israel
    Mol Cell Endocrinol 141:1-5. 1998
    ..Mutant forms of these and other tumour suppressors are potentially impaired in their ability to suppress expression of the IGF receptor gene, thus helping to expand neoplastic populations...
  15. ncbi request reprint The IGFI receptor gene: a molecular target for disrupted transcription factors
    Haim Werner
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Genes Chromosomes Cancer 36:113-20. 2003
    ..Understanding the molecular mechanisms responsible for transcriptional regulation of the IGFIR gene will prove important in designing novel therapies aimed at targeting the IGF axis...
  16. pmc Differences in bioactivity between human insulin and insulin analogues approved for therapeutic use- compilation of reports from the past 20 years
    Haim Werner
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Diabetol Metab Syndr 3:13. 2011
    ..Whether or not these differences have clinical bearings (and among which patient populations) remains to be determined...
  17. ncbi request reprint Regulation of the insulin-like growth factor-I receptor gene by oncogenes and antioncogenes: implications in human cancer
    H Werner
    Department of Clinical Biochemistry, Tel Aviv University, Tel Aviv, 69978, Israel
    Mol Genet Metab 71:315-20. 2000
    ..Interactions between stimulatory and inhibitory transcription factors may determine the level of expression of the IGF-I-R gene and, consequently, the proliferative status of the cell...
  18. ncbi request reprint Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutations
    Sharon Maor
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Cancer Lett 257:236-43. 2007
    ..In conclusion, our data suggests that the IGF-IR gene is a physiologically relevant downstream target for BRCA1 action...
  19. ncbi request reprint The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells
    Irit Nahor
    Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Israel
    Growth Horm IGF Res 15:388-96. 2005
    ..In summary, we have identified the IGF-IR gene as a novel downstream target for p63/p73 action...
  20. pmc Progression to metastatic stage in a cellular model of prostate cancer is associated with methylation of the androgen receptor gene and transcriptional suppression of the insulin-like growth factor-I receptor gene
    Hagit Schayek
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Exp Cell Res 316:1479-88. 2010
    ....
  21. ncbi request reprint Caveolin-1 up-regulates IGF-I receptor gene transcription in breast cancer cells via Sp1- and p53-dependent pathways
    Chen Glait
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Exp Cell Res 312:3899-908. 2006
    ..In summary, we identified the IGF-IR gene as a downstream target for Cav-1 action in breast cancer cells...
  22. ncbi request reprint WT1-p53 interactions in insulin-like growth factor-I receptor gene regulation
    Gila Idelman
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 278:3474-82. 2003
    ..In summary, the transcriptional activity of WT1 proteins and their ability to function as tumor suppressors or oncogenes depends on the cellular status of p53...
  23. pmc Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor (IGF-IR) gene transcription in an androgen receptor-dependent manner
    Hagit Schayek
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Cancer Res 15:1558-65. 2009
    ..The involvement of BRCA1 in prostate cancer, however, has not yet been elucidated. The purpose of the present study was to examine the functional correlations between BRCA1 and the IGF system in prostate cancer...
  24. ncbi request reprint p53 Regulates insulin-like growth factor-I receptor gene expression in uterine serous carcinoma and predicts responsiveness to an insulin-like growth factor-I receptor-directed targeted therapy
    Zohar Attias-Geva
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Eur J Cancer 48:1570-80. 2012
    ..The interplay between the p53 and IGF-I signalling pathways is of major basic and translational relevance...
  25. ncbi request reprint The WT1 Wilms' tumor suppressor gene product interacts with estrogen receptor-alpha and regulates IGF-I receptor gene transcription in breast cancer cells
    Naama Reizner
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Mol Endocrinol 35:135-44. 2005
    ....
  26. doi request reprint IGF1R-directed targeted therapy enhances the cytotoxic effect of chemotherapy in endometrial cancer
    Connie Bitelman
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Cancer Lett 335:153-9. 2013
    ..These findings indicate that specific inhibition of IGF1R could be a useful therapeutic approach for Type 1 and Type 2 endometrial cancer...
  27. pmc Differential regulation of insulin-like growth factor-I receptor gene expression by wild type and mutant androgen receptor in prostate cancer cells
    Hagit Schayek
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Mol Cell Endocrinol 323:239-45. 2010
    ..Our results suggest that prostate cancer progression is associated with a decrease in IGF-IR expression that could be the result of impaired ability of AR to stimulate IGF-IR gene expression...
  28. doi request reprint Insulin-like growth factor-I receptor (IGF-IR) targeting with monoclonal antibody cixutumumab (IMC-A12) inhibits IGF-I action in endometrial cancer cells
    Zohar Attias-Geva
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur J Cancer 47:1717-26. 2011
    ..In summary, in a cellular model of endometrial cancer cixutumumab was able to inhibit the IGF-I-induced activation of intracellular cascades, apoptosis and proliferation...
  29. ncbi request reprint Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1
    Sharon Maor
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Endocrinol 191:605-12. 2006
    ..Dysregulated expression of the IGF-IR gene may have pathologic consequences with relevance in breast cancer etiology...
  30. ncbi request reprint Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer
    Rive Sarfstein
    Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Mol Cell Endocrinol 252:241-6. 2006
    ..This review highlights selected examples of tumor suppressors, including BRCA1, p53, and WT1, whose mechanism of action involves regulation of IGF-IR gene expression...
  31. doi request reprint Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells
    Doron Weinstein
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Diabetes Metab Res Rev 25:41-9. 2009
    ....
  32. ncbi request reprint Signal transducer and activator of transcription-1 (STAT1), but not STAT5b, regulates IGF-I receptor gene expression in an osteosarcoma cell line
    Michal Shalita-Chesner
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Pediatr Endocrinol Metab 17:211-8. 2004
    ..Taken together, our results suggest that the IGF-IR gene is a novel target for STAT1 action and that at least part of the inhibitory effects of STAT1 may involve repression of the strongly antiapoptotic IGF-IR gene...
  33. doi request reprint Transcription factor E2F1 is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene
    Hagit Schayek
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Growth Horm IGF Res 20:68-72. 2010
    ..Among other candidate genes, DNA microarrays identified the IGF-IR gene as a putative E2F1 target. The aim of this study was to investigate the involvement of E2F1 in regulation of IGF-IR gene transcription...
  34. ncbi request reprint BRCA1-Sp1 interactions in transcriptional regulation of the IGF-IR gene
    Shirley Abramovitch
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Israel
    FEBS Lett 541:149-54. 2003
    ..In summary, our data suggest that the IGF-IR gene is a novel downstream target for BRCA1 action...
  35. doi request reprint The mitogenicity of insulin analogues in vitro relative to insulin and IGF-I - Response to Kazda et al
    Doron Weinstein
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Israel
    Diabetes Metab Res Rev 26:348. 2010
    ..Lispro insulin in a malignant cell line resembled IGF-I more closely than insulin...
  36. doi request reprint Insulin-like growth factor-I receptor inhibition by specific tyrosine kinase inhibitor NVP-AEW541 in endometrioid and serous papillary endometrial cancer cell lines
    Zohar Attias-Geva
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Gynecol Oncol 121:383-9. 2011
    ..The aim of the present study was to investigate the anti-proliferative activity of NVP-AEW541 in Type I (endometrioid) and Type II (uterine serous papillary endometrial carcinoma, USPC) endometrial cancer cell lines...
  37. ncbi request reprint The WT1 Wilms' tumor suppressor gene: a novel target for insulin-like growth factor-I action
    Itay Bentov
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Endocrinology 144:4276-9. 2003
    ..Reduced levels of WT1 may facilitate IGF-I-stimulated cell cycle progression. Most importantly, inhibition of WT1 gene expression by IGF-I may have significant implications in terms of cancer initiation and/or progression...
  38. ncbi request reprint The WT1 Wilms' tumor suppressor gene is a downstream target for insulin-like growth factor-I (IGF-I) action in PC12 cells
    Rive Sarfstein
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Neurochem 99:818-26. 2006
    ..In summary, our results show that the wt1 gene is a novel target for IGF-I action in neurally derived cells...
  39. ncbi request reprint Ataxia-telangiectasia mutated gene controls insulin-like growth factor I receptor gene expression in a deoxyribonucleic acid damage response pathway via mechanisms involving zinc-finger transcription factors Sp1 and WT1
    Limor Shahrabani-Gargir
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Endocrinology 145:5679-87. 2004
    ..Deregulated expression of the IGF-IR gene after ionizing radiation may be linked to genomic instability and enhanced transforming capacity...
  40. doi request reprint Targeting the IGF1 axis in cancer proliferation
    Ilan Bruchim
    Tel Aviv University, Sackler School of Medicine, Department of Human Molecular Genetics and Biochemistry, Tel Aviv, Israel
    Expert Opin Ther Targets 13:1179-92. 2009
    ..g., oncogenes, tumor suppressors). In addition, we review a number of specific malignancies in which the IGF system is involved and summarize recent data on preclinical and clinical studies employing IGF1R-targeted modalities...
  41. ncbi request reprint Caveolin-1 controls BRCA1 gene expression and cellular localization in human breast cancer cells
    Chen Glait
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    FEBS Lett 580:5268-74. 2006
    ..In addition, immunostaining experiments demonstrate that Cav-1 induced the cytoplasmic sequestration of BRCA1...
  42. doi request reprint The intricate involvement of the Insulin-like growth factor receptor signaling in mild traumatic brain injury in mice
    Vardit Rubovitch
    Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Neurobiol Dis 38:299-303. 2010
    ..In addition, this data imply an intriguing and complex role of the IGF-1 signaling axis in the cellular and behavioral events following mTBI...
  43. pmc Insulin-like growth factor-I receptor (IGF-IR) translocates to nucleus and autoregulates IGF-IR gene expression in breast cancer cells
    Rive Sarfstein
    Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 287:2766-76. 2012
    ..The clinical implications of these findings and, in particular, the impact of IGF-IR/IR nuclear localization on targeted therapy require further investigation...
  44. doi request reprint BRCA1 is expressed in uterine serous carcinoma (USC) and controls insulin-like growth factor I receptor (IGF-IR) gene expression in USC cell lines
    Keren Amichay
    Gynecologic Oncology Unit, Meir Medical Center, Kfar Saba, Israel
    Int J Gynecol Cancer 22:748-54. 2012
    ..The insulin-like growth factor I receptor (IGF-IR) and BRCA1 affect cell growth and apoptosis. Little information is available about BRCA1 activity on the IGF signaling pathway. This study evaluated the effect of BRCA1 on IGF-IR expression...
  45. ncbi request reprint Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53
    Moran Rubinstein
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Endocrinology 145:3769-77. 2004
    ..The regulation of IGF-IR gene expression by KLF6 may have significant implications in terms of cancer initiation and/or progression...
  46. doi request reprint Minireview: nuclear insulin and insulin-like growth factor-1 receptors: a novel paradigm in signal transduction
    Rive Sarfstein
    PhD, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Endocrinology 154:1672-9. 2013
    ..Although research on the role of nuclear InsR/IGF1R is still in its infancy, we believe that this rapidly developing area may have a major basic and translational impact on the fields of metabolism, diabetes, and cancer...
  47. doi request reprint Does IGF-1 administration after a mild traumatic brain injury in mice activate the adaptive arm of ER stress?
    Vardit Rubovitch
    Department Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Neurochem Int 58:443-6. 2011
    ..IGF-1 administration following mTBI did not change ATF6 or grp78 levels, but significantly elevated CHOP. These results suggest that IGF-1 may exert its neuroprotection via PERK/CHOP, the adaptive arm of the unfolded protein response...
  48. ncbi request reprint Effects of omega-3 and omega-6 fatty acids on IGF-I receptor signalling in colorectal cancer cells
    Hila Seti
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Arch Physiol Biochem 115:127-36. 2009
    ..In summary, our results provide evidence that omega-3 and omega-6 fatty acids modulate IGF-I action in colon cancer cells...
  49. pmc The molecular and cellular basis of exostosis formation in hereditary multiple exostoses
    Meirav Trebicz-Geffen
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Int J Exp Pathol 89:321-31. 2008
    ..Hence, elevation of HS content in the pericellular regions should be a potential molecular target for correction...
  50. ncbi request reprint IGF, IGF receptor and overgrowth syndromes
    Itay Bentov
    Department of Clinical Biochemistry, Sackler Faculty of Medicine, Tel Aviv University and Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Pediatr Endocrinol Rev 1:352-60. 2004
    ..The aim of this review is to examine recent data linking the phenotype of overgrowth syndromes, visceral growth and increased risk of neoplasia, with the molecular machinery of the IGF system...
  51. doi request reprint Targeting IGF-1 signaling pathways in gynecologic malignancies
    Ilan Bruchim
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Expert Opin Ther Targets 17:307-20. 2013
    ..These novel IGF-1R targeting agents have produced significant experimental and clinical results in many cancers and generated considerable optimism in the field of cancer therapy...
  52. ncbi request reprint Transcriptional regulation of IGF-I receptor gene expression by the PAX3-FKHR oncoprotein
    D Ayalon
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Growth Horm IGF Res 11:289-97. 2001
    ..Furthermore, transfection of the chimera induced a significant increase in the endogenous levels of IGF-I-R protein, suggesting that the IGF-I-R gene is a physiologically-relevant molecular target for the PAX3-FKHR oncogene...
  53. ncbi request reprint Regulation of insulin-like growth factor-I receptor gene expression by tumor necrosis factor-alpha and interferon-gamma
    M Shalita-Chesner
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Mol Cell Endocrinol 176:1-12. 2001
    ..Taken together, these results suggest that a novel potential mechanism by which TNF-alpha and IFN-gamma affect cellular proliferation involves suppression of IGF-l-R promoter activity, as well as destabilization of IGF-l-R transcripts...
  54. ncbi request reprint BRCA1 suppresses insulin-like growth factor-I receptor promoter activity: potential interaction between BRCA1 and Sp1
    S B Maor
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel
    Mol Genet Metab 69:130-6. 2000
    ..Activation of the overexpressed receptor by locally produced or circulating IGFs may be a crucial step in breast and ovarian cancer progression...
  55. ncbi request reprint The emerging role of the insulin-like growth factors in oral biology
    H Werner
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Dent Res 83:832-6. 2004
    ..Understanding the role and regulation of IGF system components in salivary glands and other oral structures will be of significant basic and clinical relevance...
  56. ncbi request reprint Folic acid and its metabolites modulate IGF-I receptor gene expression in colon cancer cells in a p53-dependent manner
    Z Attias
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Endocr Relat Cancer 13:571-81. 2006
    ..Folic acid deficiency, on the other hand, may lead to increased IGF-IR gene expression, with ensuing pathological activation by endocrine and/or autocrine/paracrine IGF-I...
  57. ncbi request reprint Functional and physical interactions between BRCA1 and p53 in transcriptional regulation of the IGF-IR gene
    S Abramovitch
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Israel
    Horm Metab Res 35:758-62. 2003
    ..Inability of mutant tumor suppressors to repress IGF-IR gene expression may result in increased IGF-IR levels and IGF binding, leading to a reduction in apoptosis and enhanced survival capacity of malignant cells...
  58. ncbi request reprint Insulin-like growth factor-I controls BRCA1 gene expression through activation of transcription factor Sp1
    S Maor
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, and Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, USA
    Horm Metab Res 39:179-85. 2007
    ..Dysregulated BRCA1 expression resulting from aberrant IGF signaling may have important consequences relevant to breast cancer pathogenesis...
  59. ncbi request reprint Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling
    Dana Ravid
    Department of Biological Regulation, Weizmann Institute of Science, Candiotty 138, PO Box 26, Rehovot 76100, Israel
    Oncogene 24:1338-47. 2005
    ..We conclude that expression of caveolin-1 in human breast cancer cells enhances matrix-independent cell survival that is mediated by upregulation of IGF-I receptor expression and signaling...
  60. ncbi request reprint Modulation of brain insulin-like growth factor I (IGF-I) binding sites and hypothalamic GHRH and somatostatin levels by exogenous growth hormone and IGF-I in juvenile rats
    Rina Eshet
    Laboratory of Endocrinology and Diabetes, Felsenstein Medical Research Center, Petah Tikva, Israel
    J Mol Neurosci 22:179-88. 2004
    ..Because IGF-I is a potent neurotrophic agent, this effect may have important implications for states of neurodegenerative diseases...
  61. ncbi request reprint Autocrine activation of the local insulin-like growth factor I system is up-regulated by estrogen receptor (ER)-independent estrogen actions and accounts for decreased ER expression in type 2 diabetic mesangial cells
    Michael Karl
    Vascular Biology Institute, University of Miami School of Medicine, 1600 N W 10th Avenue, RMSB, Room 1043 R104, Miami, Florida 33136, USA
    Endocrinology 146:889-900. 2005
    ..The later estrogen effects appear to outweigh the antisclerotic effects of ER activation. This may in part account for loss of estrogen protection against the progression of diabetic GS in women with type 2 diabetes...