Affiliation: Tel Aviv University
Weiss S, Dascal N. Molecular Aspects of Modulation of L-type Calcium Channels by Protein Kinase C. Curr Mol Pharmacol. 2015;8:43-53 pubmed
..This review summarizes past and new findings regarding the mechanism by which activated PKC modulates CaV1.2 channels in native tissues and heterologous expression systems, and suggests perspectives for future research. ..
Weiss S, Keren Raifman T, Oz S, Ben Mocha A, Haase H, Dascal N. Modulation of distinct isoforms of L-type calcium channels by G(q)-coupled receptors in Xenopus oocytes: antagonistic effects of G?? and protein kinase C. Channels (Austin). 2012;6:426-37 pubmed publisher
..Our results suggest a complex antagonistic interplay between G(q)-activated PKC and G?? in regulation of L-VDCC, in which multiple cytosolic segments of ?(1C) are involved. ..
Weiss S, Oz S, Benmocha A, Dascal N. Regulation of cardiac L-type Ca²? channel CaV1.2 via the ?-adrenergic-cAMP-protein kinase A pathway: old dogmas, advances, and new uncertainties. Circ Res. 2013;113:617-31 pubmed publisher
..This review summarizes the past and new findings, the mechanisms proposed and later proven, rejected or disputed, and emphasizes the essential issues that remain unresolved. ..