M Weinreb

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. ncbi request reprint Systemic administration of an anabolic dose of prostaglandin E2 induces early-response genes in rat bones
    M Weinreb
    Department of Oral Biology, Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel
    Bone 20:347-53. 1997
  2. ncbi request reprint Experimental cholestatic liver disease through bile-duct ligation in rats results in skeletal fragility and impaired osteoblastogenesis
    Miron Weinreb
    Department of Oral Biology, Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Hepatol 40:385-90. 2004
  3. ncbi request reprint Prostaglandin E2 (PGE2) increases the number of rat bone marrow osteogenic stromal cells (BMSC) via binding the EP4 receptor, activating sphingosine kinase and inhibiting caspase activity
    M Weinreb
    Department of Oral Biology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Prostaglandins Leukot Essent Fatty Acids 75:81-90. 2006
  4. ncbi request reprint Inhibition of cyclo-oxigenase-2 activity does not abolish the anabolic effect of prostaglandin E2 in vivo or in vitro
    M Weinreb
    Department of Oral Biology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel
    J Endocrinol 174:127-35. 2002
  5. ncbi request reprint Rat osteoclast precursors in vivo express a vitronectin receptor and a chloride-bicarbonate exchanger
    M Weinreb
    Department of Oral Biology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel
    Connect Tissue Res 37:177-82. 1998
  6. doi request reprint Enamel matrix derivative induces the expression of tissue inhibitor of matrix metalloproteinase-3 in human gingival fibroblasts via extracellular signal-regulated kinase
    E Zeldich
    Department of Oral Biology, Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    J Periodontal Res 45:200-6. 2010
  7. doi request reprint Differential effects of prostaglandin E(2) and enamel matrix derivative on the proliferation of human gingival and dermal fibroblasts and gingival keratinocytes
    E Weinberg
    Department of Oral Biology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel 2010 John Wiley and Sons A S
    J Periodontal Res 45:731-40. 2010
  8. ncbi request reprint A selective EP4 receptor antagonist abrogates the stimulation of osteoblast recruitment from bone marrow stromal cells by prostaglandin E2 in vivo and in vitro
    D Shamir
    Department of Oral Biology, Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Bone 34:157-62. 2004
  9. ncbi request reprint Expression of the prostaglandin E(2) (PGE(2)) receptor subtype EP(4) and its regulation by PGE(2) in osteoblastic cell lines and adult rat bone tissue
    M Weinreb
    Department of Oral Biology, Goldschleger School of Dental Medicine, Tel-Aviv University, Tel-Aviv, Israel
    Bone 28:275-81. 2001
  10. ncbi request reprint EGFR in Enamel Matrix Derivative-induced gingival fibroblast mitogenesis
    E Zeldich
    Department of Oral Biology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    J Dent Res 87:850-5. 2008

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Systemic administration of an anabolic dose of prostaglandin E2 induces early-response genes in rat bones
    M Weinreb
    Department of Oral Biology, Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel
    Bone 20:347-53. 1997
    ..The induction of early-response genes may thus be the first step in a chain of events which leads to the anabolic effect of PGE2 in vivo...
  2. ncbi request reprint Experimental cholestatic liver disease through bile-duct ligation in rats results in skeletal fragility and impaired osteoblastogenesis
    Miron Weinreb
    Department of Oral Biology, Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Hepatol 40:385-90. 2004
    ....
  3. ncbi request reprint Prostaglandin E2 (PGE2) increases the number of rat bone marrow osteogenic stromal cells (BMSC) via binding the EP4 receptor, activating sphingosine kinase and inhibiting caspase activity
    M Weinreb
    Department of Oral Biology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Prostaglandins Leukot Essent Fatty Acids 75:81-90. 2006
    ..We propose that PGE(2) exerts an anti-apoptotic effect on BMSC, thereby increasing their number and subsequent osteoblastic differentiation. Such an effect could explain how PGE(2) stimulates bone formation in vivo...
  4. ncbi request reprint Inhibition of cyclo-oxigenase-2 activity does not abolish the anabolic effect of prostaglandin E2 in vivo or in vitro
    M Weinreb
    Department of Oral Biology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel
    J Endocrinol 174:127-35. 2002
    ..We conclude that while the level of COX-2 mRNA is increased in vivo by administration of PGE(2), inhibition of its activity (i.e. generation of endogenous PGs) does not abolish the anabolic effect of PGE(2)...
  5. ncbi request reprint Rat osteoclast precursors in vivo express a vitronectin receptor and a chloride-bicarbonate exchanger
    M Weinreb
    Department of Oral Biology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel
    Connect Tissue Res 37:177-82. 1998
    ....
  6. doi request reprint Enamel matrix derivative induces the expression of tissue inhibitor of matrix metalloproteinase-3 in human gingival fibroblasts via extracellular signal-regulated kinase
    E Zeldich
    Department of Oral Biology, Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    J Periodontal Res 45:200-6. 2010
    ..In the present study, the modulation of MMP and TIMP expression by EMD was investigated...
  7. doi request reprint Differential effects of prostaglandin E(2) and enamel matrix derivative on the proliferation of human gingival and dermal fibroblasts and gingival keratinocytes
    E Weinberg
    Department of Oral Biology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel 2010 John Wiley and Sons A S
    J Periodontal Res 45:731-40. 2010
    ..Prostaglandins and EMD may also affect skin healing by targeting dermal fibroblasts (DFs). Thus, we compared the effects of these two agents on the proliferation of hGFs, human gingival keratinocytes (hGKs) and hDFs...
  8. ncbi request reprint A selective EP4 receptor antagonist abrogates the stimulation of osteoblast recruitment from bone marrow stromal cells by prostaglandin E2 in vivo and in vitro
    D Shamir
    Department of Oral Biology, Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Bone 34:157-62. 2004
    ..These data indicate that PGE2 stimulates osteoblastic commitment of BMSC via activation of the EP4 receptor...
  9. ncbi request reprint Expression of the prostaglandin E(2) (PGE(2)) receptor subtype EP(4) and its regulation by PGE(2) in osteoblastic cell lines and adult rat bone tissue
    M Weinreb
    Department of Oral Biology, Goldschleger School of Dental Medicine, Tel-Aviv University, Tel-Aviv, Israel
    Bone 28:275-81. 2001
    ..Taken together, these data implicate EP(4) as the major cyclic AMP-related PGE(2) receptor subtype expressed in bone tissue and osteoblastic cells and indicate that this receptor is upregulated by its ligand, PGE(2)...
  10. ncbi request reprint EGFR in Enamel Matrix Derivative-induced gingival fibroblast mitogenesis
    E Zeldich
    Department of Oral Biology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    J Dent Res 87:850-5. 2008
    ..Taken together, these results indicate that, at least in human gingival fibroblasts, EMD-induced ERK activation and proliferation are partially due to a Src-dependent, metalloproteinase-mediated transactivation of EGFR...
  11. ncbi request reprint Enamel matrix derivative protects human gingival fibroblasts from TNF-induced apoptosis by inhibiting caspase activation
    E Zeldich
    Department of Oral Biology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    J Cell Physiol 213:750-8. 2007
    ....
  12. ncbi request reprint Systemic prostaglandin E2 increases cancellous bone formation and mass in aging rats and stimulates their bone marrow osteogenic capacity in vivo and in vitro
    S Keila
    Department of Oral Biology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel
    J Endocrinol 168:131-9. 2001
    ..The PGE(2)-stimulated bone formation, which augments bone mass, most likely results from recruitment of osteoblasts from their bone marrow stromal precursors...
  13. ncbi request reprint Biodegradation of three different collagen membranes in the rat calvarium: a comparative study
    Ofer Moses
    Department of Periodontology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    J Periodontol 79:905-11. 2008
    ..The purpose of this study was to quantitatively evaluate the biodegradation of three different commercially available collagen membranes...
  14. ncbi request reprint Enamel matrix derivative stimulates human gingival fibroblast proliferation via ERK
    E Zeldich
    Department of Oral Biology, Tel Aviv University, Israel
    J Dent Res 86:41-6. 2007
    ..This study characterized the mitogenic effect of Emdogain on primary human gingival fibroblasts, its cooperation with serum growth factors, and the key mediatory role of the ERK cascade...
  15. ncbi request reprint Effect of enamel matrix protein derivative on healing of surgical supra-infrabony periodontal defects in the rat molar: a histomorphometric study
    Carlos E Nemcovsky
    Department of Periodontology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    J Periodontol 77:996-1002. 2006
    ..Enamel matrix protein derivative (EMD) has proven to enhance periodontal regeneration in human and animal studies. The present histomorphometric study evaluated healing of combined supra-infrabony periodontal defects with EMD...
  16. doi request reprint Simultaneous versus two-stage implant placement and guided bone regeneration in the canine: histomorphometry at 8 and 16 months
    Zvi Artzi
    Department of Periodontology, Tel Aviv University, Tel Aviv, Israel
    J Clin Periodontol 37:1029-38. 2010
    ..To compare the effect of timing of implant placement and guided bone regeneration (GBR) procedure on osseointegration and newly formed bone at 8 and 16 months...
  17. doi request reprint Bio-degradation of a resorbable collagen membrane (Bio-Gide) applied in a double-layer technique in rats
    Avital Kozlovsky
    Department of Periodontology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Oral Implants Res 20:1116-23. 2009
    ..The aim of this study was to evaluate histologically the bio-degradation of two layers of Bio-Gide((R)) (BG) membrane, as compared with that of a single layer...
  18. doi request reprint Effect of systemic tetracycline on the degradation of tetracycline-impregnated bilayered collagen membranes: an animal study
    Ofer Moses
    Department of Periodontology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Implant Dent Relat Res 12:331-7. 2010
    ..Preprocedural immersion of collagen membranes in TTC and systemic administration of TTC may be possible alternatives to reduce the biodegradation of native collagen membranes...
  19. ncbi request reprint Histomorphometric evaluation of natural mineral combined with a synthetic cell-binding peptide (P-15) in critical-size defects in the rat calvaria
    Zvi Artzi
    Department of Periodontology, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Oral Maxillofac Implants 23:1063-70. 2008
    ..The objective of this study was to histomorphometrically evaluate the synthetic peptide analog P-15 bound to anorganic bovine mineral (Pepgen/P15) in critical-size defects in the rat calvaria...
  20. doi request reprint Systemic tetracycline delays degradation of three different collagen membranes in rat calvaria
    Ofer Moses
    Department of Periodontology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Oral Implants Res 20:189-95. 2009
    ..The aim of this study was to quantitatively evaluate the effect of systemic tetracycline (TTC) on the degradation of three different collagen membranes...
  21. ncbi request reprint Biomaterial resorption rate and healing site morphology of inorganic bovine bone and beta-tricalcium phosphate in the canine: a 24-month longitudinal histologic study and morphometric analysis
    Zvi Artzi
    Department of Periodontology, Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Oral Maxillofac Implants 19:357-68. 2004
    ..An inorganic xenograft (inorganic bovine bone [IBB]) and a porous alloplast (beta-tricalcium phosphate [beta-TCP]) material were compared at different healing periods in experimental bone defects in dogs...
  22. ncbi request reprint Histomorphometric assessment of bone formation in sinus augmentation utilizing a combination of autogenous and hydroxyapatite/biphasic tricalcium phosphate graft materials: at 6 and 9 months in humans
    Zvi Artzi
    Department of Periodontology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Oral Implants Res 19:686-92. 2008
    ..The aim of this study was to examine the efficacy of a new biphasic hydroxyapatite/tricalcium phosphate (HA/TCP) bone substitute in combination with particulate autogenous bone in sinus floor augmentation procedures...
  23. ncbi request reprint Maxillary incisor root resorption after rapid palatal expansion in Felis catus
    Alexander D Vardimon
    Department of Orthodontics, The Maurice and Gabrila Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur J Oral Sci 113:41-6. 2005
    ..This suggests a cause (tipping and root proximity) and effect (root resorption) relationship. Data suggest that first maxillary incisor susceptibility to root resorption during RPE is associated with severe tipping and root proximity...
  24. ncbi request reprint Experimental intrabony and periodontal defects treated with natural mineral combined with a synthetic cell-binding Peptide in the canine: morphometric evaluations
    Zvi Artzi
    Department of Periodontology, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    J Periodontol 77:1658-64. 2006
    ..Its efficacy as filler biomaterial in guided tissue regeneration (GTR) and guided bone regeneration (GBR) procedures was evaluated histologically and morphometrically...
  25. ncbi request reprint Impact of implant overloading on the peri-implant bone in inflamed and non-inflamed peri-implant mucosa
    Avital Kozlovsky
    Department of Periodontology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Oral Implants Res 18:601-10. 2007
    ..To assess the impact of overloading on peri-implant bone level and the bone-to-implant contact (BIC) in the presence of healthy or inflamed peri-implant tissues...
  26. ncbi request reprint The amount of newly formed bone in sinus grafting procedures depends on tissue depth as well as the type and residual amount of the grafted material
    Zvi Artzi
    Department of Periodontology, School of Dental Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 61390, Israel
    J Clin Periodontol 32:193-9. 2005
    ..The objective of the present study was to evaluate the osteoconductive capability of two different scaffold fillers in inducing newly formed bone in this procedure...
  27. ncbi request reprint Periodontal healing following orthodontic movement of rat molars with intact versus damaged periodontia towards a bony defect
    Carlos E Nemcovsky
    Department of Periodontology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur J Orthod 29:338-44. 2007
    ..Orthodontic movement, shortly after periodontal surgery, had no detrimental effect on periodontal soft tissue healing or on diminished but non-inflamed periodontal tissues...
  28. ncbi request reprint In vitro effects of enamel matrix proteins on rat bone marrow cells and gingival fibroblasts
    S Keila
    Department of Oral Biology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    J Dent Res 83:134-8. 2004
    ..These in vitro data on BMSC and GF could explain the promotive effect of EMD on bone formation and connective tissue regeneration, respectively...
  29. doi request reprint Streptozotocin-induced diabetes in rats diminishes the size of the osteoprogenitor pool in bone marrow
    E Weinberg
    Department of Oral Biology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    Diabetes Res Clin Pract 103:35-41. 2014
    ..Since bone formation greatly depends on the recruitment of osteoblasts from their bone marrow precursors, we tested whether experimental type 1 diabetes in rats diminishes the number of bone marrow osteoprogenitors...
  30. ncbi request reprint Human parathyroid hormone 1-34 prevents bone loss in experimental biliary cirrhosis in rats
    Rivka Dresner-Pollak
    Endocrinology and Metabolism Service, Department of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Gastroenterology 134:259-67. 2008
    ..The effect of intermittent administration of human parathyroid hormone (hPTH) 1-34 on bone mass and architecture in bile duct-ligated (BDL) rats was studied...
  31. ncbi request reprint Interleukin 10-deficient mice develop osteopenia, decreased bone formation, and mechanical fragility of long bones
    Rivka Dresner-Pollak
    Endocrinology and Metabolism Service, Hadassah University Hospital, P O Box 12000, Jerusalem IL 91120, Israel
    Gastroenterology 127:792-801. 2004
    ..We investigated bone metabolism in interleukin-10-deficient ( IL-10-/- ) mice, an animal model with IBD features...
  32. ncbi request reprint Bone mineral metabolism and histomorphometry in rats with cholestatic liver disease
    Zvi Ackerman
    Department of Medicine, Hadassah University Hospital, Mount Scopus, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Liver 22:166-72. 2002
    ..The etiology of osteopenia in cholestatic liver disease is uncertain. An animal model is needed in order to study the efficacy of therapeutic agents...