Research Topics
| I WeinerSummaryAffiliation: Tel Aviv University Country: Israel Publications
| Collaborators
|
Detail Information
Publications
Using the pharmacology of latent inhibition to model domains of pathology in schizophrenia and their treatmentIna Weiner
Department of Psychology, Tel Aviv University, Tel Aviv 69978, Israel
Behav Brain Res 204:369-86. 2009....
A comparison of drug effects in latent inhibition and the forced swim test differentiates between the typical antipsychotic haloperidol, the atypical antipsychotics clozapine and olanzapine, and the antidepressants imipramine and paroxetineI Weiner
Department of Psychology, Tel Aviv University, Tel Aviv, Israel
Behav Pharmacol 14:215-22. 2003..Thus, the comparison of drug effects in LI and FST enabled a discrimination between typical and atypical APDs without losing selectivity for APDs...- Disruption and potentiation of latent inhibition by risperidone: the latent inhibition model of atypical antipsychotic actionIna Weiner
Department of Psychology, Tel Aviv University, Tel Aviv 69978, Israel
Neuropsychopharmacology 28:499-509. 2003..It is suggested that the former and latter effects are subserved by D2 and 5HT2A antagonism, respectively... - The "two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatmentIna Weiner
Department of Psychology, Tel Aviv University, Tel Aviv, Israel
Psychopharmacology (Berl) 169:257-97. 2003..Consequently, disrupted LI is considered to provide an animal model of positive symptoms of schizophrenia with face, construct and predictive validity... - Differential involvement of the shell and core subterritories of the nucleus accumbens in latent inhibition and amphetamine-induced activityI Weiner
Department of Psychology, Tel Aviv University, Ramat Aviv, Israel
Behav Brain Res 81:123-33. 1996..These results provide evidence for functional differences between the shell and core subregions, as well as for the involvement of the mesolimbic DA system in LI... - Latent inhibition in 35-day-old rats is not an "adult" latent inhibition: implications for neurodevelopmental models of schizophreniaL Zuckerman
Department of Psychology, Tel Aviv University, 69978, Tel Aviv, Israel
Psychopharmacology (Berl) 169:298-307. 2003.... - Abnormally persistent latent inhibition induced by MK801 is reversed by risperidone and by positive modulators of NMDA receptor function: differential efficacy depending on the stage of the task at which they are administeredI Gaisler-Salomon
Department of Psychology, Tel Aviv University, Tel Aviv, Israel
Psychopharmacology (Berl) 196:255-67. 2008.... - Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic morphology in the offspring: a novel neurodevelopmental model of schizophreniaLee Zuckerman
Department of Psychology, Tel Aviv University, Tel Aviv, Israel
Neuropsychopharmacology 28:1778-89. 2003..Neuropsychopharmacology (2003) 28, 1778-1789. advance online publication, 16 July 2003; doi:10.1038/sj.npp.1300248.. - Systemic administration of MK-801 produces an abnormally persistent latent inhibition which is reversed by clozapine but not haloperidolI Gaisler-Salomon
Department of Psychology, Tel Aviv University, Tel Aviv, Israel
Psychopharmacology (Berl) 166:333-42. 2003.... - Abnormally persistent latent inhibition induced by lesions to the nucleus accumbens core, basolateral amygdala and orbitofrontal cortex is reversed by clozapine but not by haloperidolDaniela Schiller
Department of Psychology, Tel-Aviv University, P.O.B. 39040, Ramat Aviv, Tel-Aviv 69978, Israel
J Psychiatr Res 40:167-77. 2006..The identification of brain regions whose damage leads to persistent LI in the rat may provide valuable cues on dysfunctional brain circuits involved in negative symptoms and in the action of atypical APDs... - Scopolamine induces disruption of latent inhibition which is prevented by antipsychotic drugs and an acetylcholinesterase inhibitorSegev Barak
Department of Psychology, Tel Aviv University, Tel Aviv, Israel
Neuropsychopharmacology 32:989-99. 2007..We propose scopolamine-induced LI disruption as a model of cholinergic-related positive symptoms in schizophrenia... - Disruption of latent inhibition induced by ovariectomy can be reversed by estradiol and clozapine as well as by co-administration of haloperidol with estradiol but not by haloperidol aloneMichal Arad
Department of Psychology, Tel Aviv University, Tel Aviv, Israel
Psychopharmacology (Berl) 206:731-40. 2009..Accordingly, the estrogen hypothesis of schizophrenia proposes that estrogen has a neuroprotective effect in women vulnerable to schizophrenia... - Amelioration of behavioral deficits in a rat model of Huntington's disease by an excitotoxic lesion to the globus pallidusLiat Ayalon
Department of Psychology, Tel-Aviv University, Ramat-Aviv, Tel Aviv 69978, Israel
Exp Neurol 186:46-58. 2004.... - Maternal immune activation leads to behavioral and pharmacological changes in the adult offspringLee Zuckerman
Department of Psychology, Tel Aviv University, Ramat-Aviv, Tel Aviv 69978, Israel
J Psychiatr Res 39:311-23. 2005..These results show that the maternal immune response is sufficient to cause behavioral and pharmacological alterations relevant to schizophrenia in the adult offspring... - Towards an animal model of an antipsychotic drug-resistant cognitive impairment in schizophrenia: scopolamine induces abnormally persistent latent inhibition, which can be reversed by cognitive enhancers but not by antipsychotic drugsSegev Barak
Department of Psychology, Tel Aviv University, Tel Aviv, Israel
Int J Neuropsychopharmacol 12:227-41. 2009..Thus, scopolamine-induced persistent LI may provide a pharmacological LI model for screening cognitive enhancers that are efficient for the treatment of APD-resistant cognitive impairments in schizophrenia... - Clozapine administration in adolescence prevents postpubertal emergence of brain structural pathology in an animal model of schizophreniaYael Piontkewitz
Department of Psychology, Tel Aviv University, Israel
Biol Psychiatry 66:1038-46. 2009..We used a neurodevelopmental animal model of schizophrenia to assess the efficacy of the atypical antipsychotic clozapine to prevent neuroanatomical deterioration... - Lesions to the basolateral amygdala and the orbitofrontal cortex but not to the medial prefrontal cortex produce an abnormally persistent latent inhibition in ratsD Schiller
Department of Psychology, Tel-Aviv University, Ramat Aviv, Tel-Aviv 69978, P.O.B. 39040, Israel
Neuroscience 128:15-25. 2004.... - Amphetamine-induced disruption of latent inhibition depends on the nature of the stimulusI Weiner
Department of Psychology, Tel Aviv University, Ramat Aviv, Israel
Behav Pharmacol 8:442-57. 1997..The effects of amphetamine on LI were not related to its effects on behavioural suppression after footshock, or on activity... - The effects of electrolytic lesion to the shell subterritory of the nucleus accumbens on delayed non-matching-to-sample and four-arm baited eight-arm radial-maze tasksG Gal
Department of Psychology, Tel Aviv University, Israel
Behav Neurosci 111:92-103. 1997..The results suggest that the inappropriate use of response strategy by shell animals was a result of their inability to switch from initial response strategy to a later, more appropriate, memory-dependent strategy... - Gender-dependent differences in latent inhibition following prenatal stress and corticosterone administrationU Shalev
Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
Behav Brain Res 126:57-63. 2001.... - Pro-cognitive and antipsychotic efficacy of the alpha7 nicotinic partial agonist SSR180711 in pharmacological and neurodevelopmental latent inhibition models of schizophreniaSegev Barak
Department of Psychology, Tel Aviv University, Tel Aviv, Israel
Neuropsychopharmacology 34:1753-63. 2009..These findings suggest that SSR180711 may be beneficial not only for the treatment of cognitive symptoms in schizophrenia, as reported multiple times previously, but also positive symptoms... - The connections of the primate subthalamic nucleus: indirect pathways and the open-interconnected scheme of basal ganglia-thalamocortical circuitryD Joel
Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
Brain Res Brain Res Rev 23:62-78. 1997..The clinical implications of this scheme for Huntington's disease are discussed... - Fluctuation of latent inhibition along the estrous cycle in the rat: modeling the cyclicity of symptoms in schizophrenic women?Michal Arad
Department of Psychology, Tel Aviv University, Tel Aviv 69978, Israel
Psychoneuroendocrinology 33:1401-10. 2008..The latter constellation may mimic states of increased vulnerability to psychosis coupled with reduced treatment response documented in schizophrenic women during periods associated with low levels of hormones... 
Contrasting effects of increased and decreased dopamine transmission on latent inhibition in ovariectomized rats and their modulation by 17beta-estradiol: an animal model of menopausal psychosis?Michal Arad
Department of Psychology, Tel Aviv University, Tel Aviv, Israel
Neuropsychopharmacology 35:1570-82. 2010..In addition, our data show that 17beta-estradiol exerts antipsychotic activity...- Long-term functional consequences of quinolinic acid striatal lesions and their alteration following an addition of a globus pallidus lesion assessed using pharmacological magnetic resonance imagingRicardo Tarrasch
Psychology Department, Tel Aviv University, Tel Aviv, Israel
Exp Neurol 196:244-53. 2005..These results are further discussed in view of our previous demonstration that lesions to the GP can reverse several behavioral deficits produced by a striatal lesion... - Deficits induced by quinolinic acid lesion to the striatum in a position discrimination and reversal task are ameliorated by permanent and temporary lesion to the globus pallidus: a potential novel treatment in a rat model of Huntington's diseaseDaphna Joel
Department of Psychology, Tel Aviv University, Tel Aviv, Israel
Mov Disord 18:1499-507. 2003.... - The switching model of latent inhibition: an update of neural substratesI Weiner
Department of Psychology, Tel Aviv University, Ramat Aviv, Israel
Behav Brain Res 88:11-25. 1997..LI is unaffected by lesions and DA manipulations of medial prefrontal cortex and lesions of basolateral amygdala. The implications of these findings for LI as an animal model of schizophrenia are discussed... - Fimbria-fornix cut affects spontaneous activity, two-way avoidance and delayed non matching to sample, but not latent inhibitionI Weiner
Department of Psychology, Tel Aviv University, Ramat Aviv, Israel
Behav Brain Res 96:59-70. 1998..The implications of these results for the neural circuitry of LI are discussed... - Differential role of muscarinic transmission within the entorhinal cortex and basolateral amygdala in the processing of irrelevant stimuliSegev Barak
Department of Psychology, Tel Aviv University, Tel Aviv, Israel
Neuropsychopharmacology 35:1073-82. 2010.... - Latent inhibition is disrupted by nucleus accumbens shell lesion but is abnormally persistent following entire nucleus accumbens lesion: The neural site controlling the expression and disruption of the stimulus preexposure effectGilad Gal
Department of Psychology, Tel-Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
Behav Brain Res 162:246-55. 2005..Moreover, they suggest that the two subregions of the NAC contribute competitively and cooperatively to this process, selecting the response appropriate to the stimulus-no event or the stimulus-reinforcement association in conditioning... - The relation between latent inhibition and symptom-types in young schizophrenicsEfrat Cohen
Department of Psychology, Tel Aviv University, Ramat Aviv 69978, Israel
Behav Brain Res 149:113-22. 2004..The pattern of data suggests that past inconsistencies in the LI-schizophrenia literature may be the result of opposing processes that are associated with positive and negative symptoms... - The connections of the dopaminergic system with the striatum in rats and primates: an analysis with respect to the functional and compartmental organization of the striatumD Joel
Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
Neuroscience 96:451-74. 2000..Finally, we incorporate the striatal connections with the dopaminergic system into an open-interconnected scheme of basal ganglia-thalamocortical circuitry... - Basolateral amygdala lesions in the rat produce an abnormally persistent latent inhibition with weak preexposure but not with context shiftDaniela Schiller
Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
Behav Brain Res 163:115-21. 2005..It is suggested that the BLA is involved in LI modulation based on the impact of preexposure and conditioning but not on contextual information... - Dissociating scopolamine-induced disrupted and persistent latent inhibition: stage-dependent effects of glycine and physostigmineSegev Barak
Department of Psychology, Tel Aviv University, Tel Aviv 69978, Israel
Psychopharmacology (Berl) 209:175-84. 2010..The two LI abnormalities show distinct response to antipsychotic drugs (APDs), with LI disruption, but not LI persistence, reversed by APDs... - Post-pubertal emergence of disrupted latent inhibition following prenatal immune activationLee Zuckerman
Department of Psychology, Tel Aviv University, 69978, Tel Aviv, Israel
Psychopharmacology (Berl) 169:308-13. 2003..CONCLUSIONS: These results support the hypothesis that immune activation during pregnancy may lead to long-term abnormalities mimicking those observed in schizophrenia... - Risperidone administered during asymptomatic period of adolescence prevents the emergence of brain structural pathology and behavioral abnormalities in an animal model of schizophreniaYael Piontkewitz
Department of Psychology, Tel Aviv University, Tel Aviv, Israel
Schizophr Bull 37:1257-69. 2011..Furthermore, highly selective 5HT(2A) receptor antagonists may be promising targets for psychosis prevention... - Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophreniaTatiana Lipina
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
Psychopharmacology (Berl) 179:54-67. 2005..Research has implicated dysfunction of neurotransmission at the NMDA-type glutamate receptor in this disorder...